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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619719
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdh2
Name: malate dehydrogenase 2
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdh2decreases activityEXP 6480464CTDNicotine results in decreased activity of MDH2 proteinPMID:29972271
Mdh2multiple interactionsEXP 6480464CTDFolic Acid inhibits the reaction [Nicotine results in decreased activity of MDH2 protein]PMID:29972271
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