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GENE - TERM ANNOTATION REPORT

RGD ID: 619719
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdh2
Name: malate dehydrogenase 2
Acc ID: GO:0006099
Term: tricarboxylic acid cycle
Definition: A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
Definition Source(s): ISBN:0198506732
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdh2involved_inISOMdh2 (Mus musculus)1624291RGD PMID:35063410

PMID:35063410
Mdh2involved_inIBAFB:FBgn0262559 or MGI:97050 or PANTHER:PTN000899458 or Mdh2 (Rattus norvegicus)1600115GO_CentralGO_REF:0000033

GO_REF:0000033
Mdh2involved_inIEAUniProtKB-KW:KW-08161600115UniProtGO_REF:0000043

GO_REF:0000043
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