MDH2 (malate dehydrogenase 2) - Rat Genome Database

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Gene: MDH2 (malate dehydrogenase 2) Sus scrofa
Analyze
Symbol: MDH2
Name: malate dehydrogenase 2
RGD ID: 14097995
Description: ENCODES a protein that exhibits protein homodimerization activity; protein-folding chaperone binding; identical protein binding (ortholog); INVOLVED IN aerobic respiration (ortholog); malate metabolic process (ortholog); NADH metabolic process (ortholog); PARTICIPATES IN citric acid cycle pathway; fructose-1,6-bisphosphatase deficiency pathway; fumaric aciduria pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); brain disease (ortholog); brain ischemia (ortholog); FOUND IN mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; MDH; mitochondrial malate dehydrogenase 2, NAD; MMDH
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,120,083 - 10,132,752 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,120,121 - 10,132,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,953,279 - 9,965,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
membrane  (IEA)
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IBA,IEA)

References
Additional References at PubMed
PMID:3038184   PMID:6959107   PMID:8117664   PMID:8672129   PMID:14681463   PMID:16751257   PMID:17145712   PMID:19717454   PMID:22301074   PMID:22641032   PMID:25478785   PMID:30032202  


Genomics

Comparative Map Data
MDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,120,083 - 10,132,752 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,120,121 - 10,132,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,953,279 - 9,965,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38776,048,106 - 76,067,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl776,048,051 - 76,067,508 (+)EnsemblGRCh38hg38GRCh38
GRCh37775,677,424 - 75,696,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,515,329 - 75,533,867 (+)NCBINCBI36Build 36hg18NCBI36
Build 34775,322,043 - 75,340,579NCBI
Celera770,545,928 - 70,564,452 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,763,958 - 70,782,483 (+)NCBIHuRef
CHM1_1775,607,380 - 75,625,901 (+)NCBICHM1_1
T2T-CHM13v2.0777,335,642 - 77,355,027 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2775,010,457 - 75,028,995 (+)NCBI
Mdh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,807,503 - 135,819,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,807,334 - 135,819,252 (+)EnsemblGRCm39 Ensembl
GRCm385135,778,649 - 135,790,386 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,778,480 - 135,790,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv375136,254,519 - 136,266,256 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,063,276 - 136,075,013 (+)NCBIMGSCv36mm8
Celera5132,786,019 - 132,797,756 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.4NCBI
Mdh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,530,886 - 26,543,841 (-)NCBIGRCr8
mRatBN7.21220,894,269 - 20,907,225 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,894,262 - 20,907,271 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,036,216 - 22,049,189 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,648,634 - 22,661,607 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,715,096 - 21,728,069 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,941,451 - 23,954,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,941,448 - 23,954,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,938,703 - 25,951,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,021,302 - 22,034,257 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,008,565 - 22,021,518 (-)NCBI
Celera1222,657,034 - 22,669,988 (-)NCBICelera
Cytogenetic Map12q12NCBI
Mdh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,819,406 - 14,837,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,819,406 - 14,833,547 (+)NCBIChiLan1.0ChiLan1.0
MDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2693,888,151 - 93,906,812 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17142,152,789 - 142,171,414 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0767,953,759 - 67,973,270 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,497,799 - 82,517,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,497,800 - 82,516,526 (+)Ensemblpanpan1.1panPan2
MDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,389,266 - 7,405,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha69,085,235 - 9,101,096 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.067,209,447 - 7,225,514 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,209,439 - 7,225,504 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,178,719 - 7,194,795 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,142,165 - 7,158,017 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,305,587 - 7,321,452 (+)NCBIUU_Cfam_GSD_1.0
Mdh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,827,961 - 131,842,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,194,032 - 2,208,651 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,194,074 - 2,208,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,294,021 - 10,313,079 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,294,021 - 10,313,970 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,107,854 - 6,127,132 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mdh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,837,023 - 14,850,988 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,837,699 - 14,850,126 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MDH2
597 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 2 3
Low 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001244153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK232730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK235773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK235801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK238803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ402968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP565297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01047474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSSCT00000028089   ⟹   ENSSSCP00000025866
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl310,120,083 - 10,132,724 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000080030   ⟹   ENSSSCP00000070379
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl310,120,126 - 10,132,752 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000104049   ⟹   ENSSSCP00000074898
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl310,120,126 - 10,132,752 (-)Ensembl
RefSeq Acc Id: NM_001244153   ⟹   NP_001231082
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1310,120,121 - 10,132,705 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001231082   ⟸   NM_001244153
- UniProtKB: A0A480KJB8 (UniProtKB/TrEMBL),   A0A4X1UJD6 (UniProtKB/TrEMBL),   A0A5G2RGL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000070379   ⟸   ENSSSCT00000080030
RefSeq Acc Id: ENSSSCP00000025866   ⟸   ENSSSCT00000028089
RefSeq Acc Id: ENSSSCP00000074898   ⟸   ENSSSCT00000104049

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000025486 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015043553 UniProtKB/TrEMBL
  ENSSSCG00055003242 UniProtKB/TrEMBL
  ENSSSCG00060063644 UniProtKB/TrEMBL
  ENSSSCG00065045584 UniProtKB/TrEMBL
  ENSSSCG00070017776 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000028089.4 UniProtKB/TrEMBL
  ENSSSCT00000080030 ENTREZGENE
  ENSSSCT00000080030.2 UniProtKB/TrEMBL
  ENSSSCT00000104049.1 UniProtKB/TrEMBL
  ENSSSCT00015058425.1 UniProtKB/TrEMBL
  ENSSSCT00055006383.1 UniProtKB/TrEMBL
  ENSSSCT00060086894.1 UniProtKB/TrEMBL
  ENSSSCT00065062420.1 UniProtKB/TrEMBL
  ENSSSCT00070035107.1 UniProtKB/TrEMBL
  ENSSSCT00070035112.1 UniProtKB/TrEMBL
  ENSSSCT00070035119.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro L-lactate/malate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate/malate_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate/malate_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malate_DH_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malate_DH_type1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene MDH2 ENTREZGENE
PANTHER MALATE AND LACTATE DEHYDROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MALATE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ldh_1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldh_1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Lac_mal_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56327 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480KJB8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UJD6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1ULP4_PIG UniProtKB/TrEMBL
  A0A5G2RGL7 ENTREZGENE
  A0A8W4F6V3_PIG UniProtKB/TrEMBL
  I3LP41_PIG UniProtKB/TrEMBL
  MDHM_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q0QF26_PIG UniProtKB/TrEMBL
UniProt Secondary A0A5G2RGL7 UniProtKB/TrEMBL
  Q95308 UniProtKB/Swiss-Prot
VGNC ID VGNC:110289 ENTREZGENE