Mdh2 (malate dehydrogenase 2, NAD (mitochondrial)) - Rat Genome Database

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Gene: Mdh2 (malate dehydrogenase 2, NAD (mitochondrial)) Mus musculus
Analyze
Symbol: Mdh2
Name: malate dehydrogenase 2, NAD (mitochondrial)
RGD ID: 10889
MGI Page MGI
Description: Enables L-malate dehydrogenase (NAD+) activity. Involved in gluconeogenesis; malate-aspartate shuttle; and tricarboxylic acid cycle. Located in membrane. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: malate dehydrogenase, mitochondrial; MDH; Mdh-2; mitochondrial malate dehydrogenase 2, NAD; Mo; Mor; Mor-1; Mor1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm11241   Gm12369   Gm12375  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,807,503 - 135,819,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,807,334 - 135,819,252 (+)EnsemblGRCm39 Ensembl
GRCm385135,778,649 - 135,790,386 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,778,480 - 135,790,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv375136,254,519 - 136,266,256 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,063,276 - 136,075,013 (+)NCBIMGSCv36mm8
Celera5132,786,019 - 132,797,756 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
Brodifacoum  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
celastrol  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
D-gluconic acid  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
Diosbulbin B  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
etoposide  (EXP)
fenbendazole  (ISO)
fenofibrate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
gedunin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
mitoxantrone  (EXP)
Monobutylphthalate  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
ouabain  (ISO)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP)
Propiverine  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP)
trimellitic anhydride  (EXP)
triptonide  (EXP)
trovafloxacin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Effects of ischemia and pharmacological treatment on subcellular fractions from neonatal rat brain. Curti D, etal., Farmaco Sci. 1982 Apr;37(4):275-82.
2. Adriamycin induced myocardial failure in rats: Protective role of Centella asiatica. Gnanapragasam A, etal., Mol Cell Biochem. 2006 Jun 20;.
3. Sublocalization of an invasion-inducing locus and other genes on human chromosome 7. Habets GG, etal., Cytogenet Cell Genet 1992;60(3-4):200-5.
4. Effect of alpha-tocopherol on mitochondrial electron transport in experimental myocardial infarction in rats. Ithayarasi AP and Shyamala Devi C, Indian J Biochem Biophys. 1998 Apr;35(2):115-9.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
7. Preparation and properties of mitochondria derived from synaptosomes. Lai JC and Clark JB, Biochem J. 1976 Feb 15;154(2):423-32.
8. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
9. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
12. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Rat gene mapping using PCR-analyzed microsatellites. Serikawa T, etal., Genetics 1992 Jul;131(3):701-21.
18. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
Additional References at PubMed
PMID:662012   PMID:1203052   PMID:1446073   PMID:3038184   PMID:3082971   PMID:3379635   PMID:5496232   PMID:7587381   PMID:8268655   PMID:8858346   PMID:10349636   PMID:11042159  
PMID:11076861   PMID:11779826   PMID:12029364   PMID:12477932   PMID:12520002   PMID:12581790   PMID:12865426   PMID:14610273   PMID:14681479   PMID:15306695   PMID:15782199   PMID:15809022  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:16751257   PMID:16916647   PMID:17626619   PMID:17634366   PMID:18614015   PMID:18662986   PMID:18799693   PMID:19423573   PMID:19465692  
PMID:20080761   PMID:21278135   PMID:21677750   PMID:21873635   PMID:22673621   PMID:22794259   PMID:23665500   PMID:24134846   PMID:24952961   PMID:26590968   PMID:27160897   PMID:27215380  
PMID:27561680   PMID:27721240   PMID:28245920   PMID:28433711   PMID:29199018   PMID:29222160   PMID:29382714   PMID:30333137   PMID:30550785   PMID:30562941   PMID:30713523   PMID:31040226  
PMID:31162944   PMID:31648943   PMID:32325033   PMID:33895326   PMID:35012549   PMID:35063410   PMID:36114006   PMID:36220812   PMID:36293380   PMID:37142655   PMID:38187761   PMID:38355793  
PMID:38418556  


Genomics

Comparative Map Data
Mdh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,807,503 - 135,819,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,807,334 - 135,819,252 (+)EnsemblGRCm39 Ensembl
GRCm385135,778,649 - 135,790,386 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,778,480 - 135,790,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv375136,254,519 - 136,266,256 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,063,276 - 136,075,013 (+)NCBIMGSCv36mm8
Celera5132,786,019 - 132,797,756 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.4NCBI
MDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38776,048,106 - 76,067,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl776,048,051 - 76,067,508 (+)EnsemblGRCh38hg38GRCh38
GRCh37775,677,424 - 75,696,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,515,329 - 75,533,867 (+)NCBINCBI36Build 36hg18NCBI36
Build 34775,322,043 - 75,340,579NCBI
Celera770,545,928 - 70,564,452 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,763,958 - 70,782,483 (+)NCBIHuRef
CHM1_1775,607,380 - 75,625,901 (+)NCBICHM1_1
T2T-CHM13v2.0777,335,642 - 77,355,027 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2775,010,457 - 75,028,995 (+)NCBI
Mdh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,530,886 - 26,543,841 (-)NCBIGRCr8
mRatBN7.21220,894,269 - 20,907,225 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,894,262 - 20,907,271 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,036,216 - 22,049,189 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,648,634 - 22,661,607 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,715,096 - 21,728,069 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,941,451 - 23,954,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,941,448 - 23,954,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,938,703 - 25,951,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,021,302 - 22,034,257 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,008,565 - 22,021,518 (-)NCBI
Celera1222,657,034 - 22,669,988 (-)NCBICelera
Cytogenetic Map12q12NCBI
Mdh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,819,406 - 14,837,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,819,406 - 14,833,547 (+)NCBIChiLan1.0ChiLan1.0
MDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2693,888,151 - 93,906,812 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17142,152,789 - 142,171,414 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0767,953,759 - 67,973,270 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,497,799 - 82,517,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,497,800 - 82,516,526 (+)Ensemblpanpan1.1panPan2
MDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,389,266 - 7,405,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha69,085,235 - 9,101,096 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.067,209,447 - 7,225,514 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,209,439 - 7,225,504 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,178,719 - 7,194,795 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,142,165 - 7,158,017 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,305,587 - 7,321,452 (+)NCBIUU_Cfam_GSD_1.0
Mdh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,827,961 - 131,842,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,194,032 - 2,208,651 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,194,074 - 2,208,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,120,083 - 10,132,752 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,120,121 - 10,132,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,953,279 - 9,965,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,294,021 - 10,313,079 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,294,021 - 10,313,970 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,107,854 - 6,127,132 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mdh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,837,023 - 14,850,988 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,837,699 - 14,850,126 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mdh2
416 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:688
Count of miRNA genes:443
Interacting mature miRNAs:515
Transcripts:ENSMUST00000019323, ENSMUST00000130795, ENSMUST00000138101, ENSMUST00000143747
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse

Markers in Region
Mdh2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G2UniSTS
cM Map578.0UniSTS
D12Wox10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385135,790,180 - 135,790,264UniSTSGRCm38
MGSCv375136,266,050 - 136,266,134UniSTSGRCm37
Celera5132,797,550 - 132,797,634UniSTS
Cytogenetic Map5G2UniSTS
cM Map578.0UniSTS
Mor1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385135,790,176 - 135,790,295UniSTSGRCm38
MGSCv375136,266,046 - 136,266,165UniSTSGRCm37
Celera5132,797,546 - 132,797,665UniSTS
Cytogenetic Map5G2UniSTS
cM Map578.0UniSTS
Mor1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385135,790,077 - 135,790,295UniSTSGRCm38
MGSCv375136,265,947 - 136,266,165UniSTSGRCm37
Celera5132,797,447 - 132,797,665UniSTS
Cytogenetic Map5G2UniSTS
cM Map578.0UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC083948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ402950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000019323   ⟹   ENSMUSP00000019323
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,807,334 - 135,819,245 (+)Ensembl
GRCm38.p6 Ensembl5135,778,480 - 135,790,391 (+)Ensembl
Ensembl Acc Id: ENSMUST00000130795
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,807,531 - 135,813,468 (+)Ensembl
GRCm38.p6 Ensembl5135,778,677 - 135,784,614 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138101   ⟹   ENSMUSP00000136225
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,807,516 - 135,819,252 (+)Ensembl
GRCm38.p6 Ensembl5135,778,662 - 135,790,398 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143747
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,807,576 - 135,812,606 (+)Ensembl
GRCm38.p6 Ensembl5135,778,722 - 135,783,752 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196285   ⟹   ENSMUSP00000143748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,807,543 - 135,815,200 (+)Ensembl
GRCm38.p6 Ensembl5135,778,689 - 135,786,346 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197909
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,807,490 - 135,809,095 (+)Ensembl
GRCm38.p6 Ensembl5135,778,636 - 135,780,241 (+)Ensembl
Ensembl Acc Id: ENSMUST00000200556   ⟹   ENSMUSP00000142993
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5135,807,539 - 135,816,505 (+)Ensembl
GRCm38.p6 Ensembl5135,778,685 - 135,787,651 (+)Ensembl
RefSeq Acc Id: NM_008617   ⟹   NP_032643
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395135,807,503 - 135,819,240 (+)NCBI
GRCm385135,778,649 - 135,790,386 (+)ENTREZGENE
MGSCv375136,254,519 - 136,266,256 (+)RGD
Celera5132,786,019 - 132,797,756 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032643   ⟸   NM_008617
- Peptide Label: precursor
- UniProtKB: Q8CF79 (UniProtKB/Swiss-Prot),   Q0QF44 (UniProtKB/Swiss-Prot),   Q8R1P0 (UniProtKB/Swiss-Prot),   P08249 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000136225   ⟸   ENSMUST00000138101
Ensembl Acc Id: ENSMUSP00000143748   ⟸   ENSMUST00000196285
Ensembl Acc Id: ENSMUSP00000019323   ⟸   ENSMUST00000019323
Ensembl Acc Id: ENSMUSP00000142993   ⟸   ENSMUST00000200556
Protein Domains
Lactate/malate dehydrogenase C-terminal   Lactate/malate dehydrogenase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08249-F1-model_v2 AlphaFold P08249 1-338 view protein structure

Promoters
RGD ID:6888336
Promoter ID:EPDNEW_M7619
Type:initiation region
Name:Mdh2_1
Description:Mus musculus malate dehydrogenase 2, NAD , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385135,778,655 - 135,778,715EPDNEW
RGD ID:6838447
Promoter ID:MM_KWN:44376
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000111162,   ENSMUST00000111163,   NM_029659,   OTTMUST00000054703,   OTTMUST00000054708,   OTTMUST00000054709,   OTTMUST00000054710,   OTTMUST00000054711,   UC008ZYY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365136,254,131 - 136,255,162 (-)MPROMDB
RGD ID:6849834
Promoter ID:EP32002
Type:multiple initiation site
Name:MM_MDHM
Description:Malate dehydrogenase mitochondrial, MDH2 or MOR1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:housekeeping gene
Experiment Methods:Nuclease protection with homologous sequence ladder; Primer extension with homologous sequence ladder
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv375136,254,515 - 136,254,575EPD
MGSCv365136,254,515 - 136,254,575EPD
RGD ID:6848829
Promoter ID:MM_TRO:7859
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:MTR005600.5.2599.4,   MTR005600.5.2599.5
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365136,265,086 - 136,265,586 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97050 AgrOrtholog
Ensembl Genes ENSMUSG00000019179 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000019323 ENTREZGENE
  ENSMUST00000019323.11 UniProtKB/Swiss-Prot
  ENSMUST00000138101.2 UniProtKB/TrEMBL
  ENSMUST00000196285.2 UniProtKB/TrEMBL
  ENSMUST00000200556.5 UniProtKB/TrEMBL
Gene3D-CATH 3.90.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro L-lactate/malate_DH UniProtKB/Swiss-Prot
  Lactate/malate_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate/malate_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malate_DH_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malate_DH_type1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17448 UniProtKB/Swiss-Prot
MGD MGI:97050 ENTREZGENE
NCBI Gene 17448 ENTREZGENE
PANTHER MALATE AND LACTATE DEHYDROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MALATE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ldh_1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldh_1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mdh2 PhenoGen
PIRSF Lac_mal_DH UniProtKB/Swiss-Prot
PROSITE MDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56327 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JF23_MOUSE UniProtKB/TrEMBL
  A0A0G2JGY4_MOUSE UniProtKB/TrEMBL
  J3QMC8_MOUSE UniProtKB/TrEMBL
  MDHM_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0QF44 ENTREZGENE
  Q8CF79 ENTREZGENE
  Q8R1P0 ENTREZGENE
UniProt Secondary Q0QF44 UniProtKB/Swiss-Prot
  Q8CF79 UniProtKB/Swiss-Prot
  Q8R1P0 UniProtKB/Swiss-Prot