Nrdc (nardilysin convertase) - Rat Genome Database

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Gene: Nrdc (nardilysin convertase) Mus musculus
Analyze
Symbol: Nrdc
Name: nardilysin convertase
RGD ID: 11020
MGI Page MGI
Description: Predicted to enable peptidase activity. Involved in negative regulation of cold-induced thermogenesis; positive regulation of membrane protein ectodomain proteolysis; and regulation of nervous system development. Located in mitochondrion. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and upper jaw. Orthologous to human NRDC (nardilysin convertase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2600011I06Rik; AI875733; MGC25477; N-arginine dibasic convertase; nardilysin; nardilysin, N-arginine dibasic convertase, NRD convertase 1; NRD; NRD convertase; NRD-C; Nrd1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394108,857,852 - 108,918,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4108,857,852 - 108,918,974 (+)EnsemblGRCm39 Ensembl
GRCm384109,000,655 - 109,061,777 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,000,655 - 109,061,777 (+)EnsemblGRCm38mm10GRCm38
MGSCv374108,673,410 - 108,734,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364108,498,737 - 108,559,703 (+)NCBIMGSCv36mm8
Celera4107,342,897 - 107,403,815 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9479496   PMID:10349636   PMID:10922068   PMID:11042131   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11478915   PMID:11544199   PMID:12054470   PMID:12477932  
PMID:12590613   PMID:14610273   PMID:15489334   PMID:15539558   PMID:15582152   PMID:15629122   PMID:15809022   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18355445   PMID:18614015  
PMID:18799693   PMID:19935654   PMID:21077326   PMID:21574244   PMID:21873635   PMID:22294699   PMID:23954170   PMID:24099785   PMID:24492630   PMID:24849253   PMID:26365490   PMID:27385158  
PMID:28230087   PMID:29093577   PMID:29669932   PMID:29688375   PMID:29798841   PMID:32325033   PMID:32683751   PMID:33642545   PMID:35236897   PMID:37142655   PMID:37839992   PMID:38605037  
PMID:38648679  


Genomics

Comparative Map Data
Nrdc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394108,857,852 - 108,918,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4108,857,852 - 108,918,974 (+)EnsemblGRCm39 Ensembl
GRCm384109,000,655 - 109,061,777 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,000,655 - 109,061,777 (+)EnsemblGRCm38mm10GRCm38
MGSCv374108,673,410 - 108,734,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364108,498,737 - 108,559,703 (+)NCBIMGSCv36mm8
Celera4107,342,897 - 107,403,815 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.77NCBI
NRDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38151,789,210 - 51,878,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl151,789,191 - 51,878,805 (-)EnsemblGRCh38hg38GRCh38
GRCh37152,254,882 - 52,344,399 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36152,027,452 - 52,117,197 (-)NCBINCBI36Build 36hg18NCBI36
Build 34151,966,904 - 52,056,443NCBI
Celera150,541,402 - 50,631,711 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef150,371,501 - 50,461,746 (-)NCBIHuRef
CHM1_1152,372,212 - 52,461,925 (-)NCBICHM1_1
T2T-CHM13v2.0151,669,503 - 51,759,610 (-)NCBIT2T-CHM13v2.0
Nrdc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85128,983,395 - 129,047,578 (+)NCBIGRCr8
mRatBN7.25123,755,807 - 123,818,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5123,755,806 - 123,818,595 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5126,372,097 - 126,434,688 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,095,183 - 128,157,761 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,146,456 - 128,209,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,629,949 - 128,694,209 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,629,942 - 128,694,060 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05132,471,862 - 132,534,473 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45130,345,980 - 130,408,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15130,351,205 - 130,413,960 (+)NCBI
Celera5122,487,057 - 122,549,568 (+)NCBICelera
Cytogenetic Map5q34NCBI
Nrdc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554647,222,948 - 7,298,234 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554647,222,948 - 7,298,234 (+)NCBIChiLan1.0ChiLan1.0
NRDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21174,980,901 - 175,072,651 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,122,404 - 174,213,193 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0151,038,711 - 51,130,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1152,535,563 - 52,625,998 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl152,535,603 - 52,625,998 (-)Ensemblpanpan1.1panPan2
NRDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1159,413,878 - 9,505,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl159,413,295 - 9,505,448 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,565,904 - 9,656,554 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0159,538,552 - 9,629,226 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl159,538,557 - 9,629,226 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1159,348,951 - 9,440,061 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0159,438,324 - 9,528,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,456,202 - 9,547,376 (+)NCBIUU_Cfam_GSD_1.0
Nrdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505866,286,628 - 66,374,923 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365229,041,111 - 9,129,327 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365229,041,204 - 9,129,674 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6160,299,131 - 160,388,502 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16160,299,101 - 160,388,511 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26148,002,234 - 148,091,486 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12081,075,671 - 81,175,469 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2081,075,869 - 81,175,447 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603336,067,000 - 36,168,310 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrdc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248591,284,266 - 1,352,226 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248591,284,251 - 1,351,497 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nrdc
2343 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1460
Count of miRNA genes:628
Interacting mature miRNAs:783
Transcripts:ENSMUST00000065977, ENSMUST00000102736, ENSMUST00000106644, ENSMUST00000125063, ENSMUST00000125645, ENSMUST00000143015, ENSMUST00000143604, ENSMUST00000148444, ENSMUST00000150177, ENSMUST00000150784, ENSMUST00000150796, ENSMUST00000155228
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226782Tibl2_mtibia length 2, 5 week (mouse)490888237111257197Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
14696687Gdq1_mgrooming duration QTL 1, males (mouse)496888237111857197Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481213991115213991Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482244395116244582Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479365751113365867Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479365751113365867Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479365751113365867Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476763107110763305Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479365751113365867Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1300689Dob1_mDietary obesity 1 (mouse)Body weight4101574601123127211Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined477957579111957775Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)488982069116271120Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse

Markers in Region
AI875733  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384109,060,995 - 109,061,075UniSTSGRCm38
MGSCv374108,733,600 - 108,733,680UniSTSGRCm37
Celera4107,403,039 - 107,403,119UniSTS
Cytogenetic Map4C7UniSTS
Whitehead/MRC_RH41488.8UniSTS
D17948  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384109,061,762 - 109,061,943UniSTSGRCm38
MGSCv374108,734,367 - 108,734,548UniSTSGRCm37
Celera4107,403,806 - 107,403,987UniSTS
Cytogenetic Map4C7UniSTS
Whitehead_YAC6 UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001346554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001347169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_146150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK031548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL627406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE949999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY732391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF168810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U86112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000065977   ⟹   ENSMUSP00000068328
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,857,852 - 108,918,974 (+)Ensembl
GRCm38.p6 Ensembl4109,000,655 - 109,061,777 (+)Ensembl
Ensembl Acc Id: ENSMUST00000102736   ⟹   ENSMUSP00000099797
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,857,852 - 108,918,974 (+)Ensembl
GRCm38.p6 Ensembl4109,000,655 - 109,061,777 (+)Ensembl
Ensembl Acc Id: ENSMUST00000106644   ⟹   ENSMUSP00000102255
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,857,967 - 108,918,358 (+)Ensembl
GRCm38.p6 Ensembl4109,000,770 - 109,061,161 (+)Ensembl
Ensembl Acc Id: ENSMUST00000125063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,916,188 - 108,917,877 (+)Ensembl
GRCm38.p6 Ensembl4109,058,991 - 109,060,680 (+)Ensembl
Ensembl Acc Id: ENSMUST00000125645   ⟹   ENSMUSP00000122808
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,873,972 - 108,901,863 (+)Ensembl
GRCm38.p6 Ensembl4109,016,775 - 109,044,666 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143015
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,912,146 - 108,914,068 (+)Ensembl
GRCm38.p6 Ensembl4109,054,949 - 109,056,871 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143604
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,896,954 - 108,901,325 (+)Ensembl
GRCm38.p6 Ensembl4109,039,757 - 109,044,128 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148444
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,903,507 - 108,908,097 (+)Ensembl
GRCm38.p6 Ensembl4109,046,310 - 109,050,900 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,889,610 - 108,900,624 (+)Ensembl
GRCm38.p6 Ensembl4109,032,413 - 109,043,427 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150784
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,897,399 - 108,918,672 (+)Ensembl
GRCm38.p6 Ensembl4109,040,202 - 109,061,475 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,916,131 - 108,916,997 (+)Ensembl
GRCm38.p6 Ensembl4109,058,934 - 109,059,800 (+)Ensembl
Ensembl Acc Id: ENSMUST00000155228
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4108,881,403 - 108,889,915 (+)Ensembl
GRCm38.p6 Ensembl4109,024,206 - 109,032,718 (+)Ensembl
RefSeq Acc Id: NM_001346554   ⟹   NP_001333483
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394108,857,852 - 108,918,974 (+)NCBI
GRCm384109,000,655 - 109,061,777 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001347169   ⟹   NP_001334098
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394108,857,852 - 108,918,974 (+)NCBI
GRCm384109,000,655 - 109,061,777 (+)NCBI
Sequence:
RefSeq Acc Id: NM_146150   ⟹   NP_666262
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394108,857,852 - 108,918,968 (+)NCBI
GRCm384109,000,655 - 109,061,771 (+)NCBI
MGSCv374108,673,410 - 108,734,376 (+)RGD
Celera4107,342,897 - 107,403,815 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_666262   ⟸   NM_146150
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8BHG1 (UniProtKB/Swiss-Prot),   Q8R320 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001334098   ⟸   NM_001347169
- Peptide Label: isoform 1
- UniProtKB: A2A9Q2 (UniProtKB/TrEMBL),   Q8R320 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001333483   ⟸   NM_001346554
- Peptide Label: isoform 3
- UniProtKB: A6PWC3 (UniProtKB/TrEMBL),   Q8R320 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000122808   ⟸   ENSMUST00000125645
Ensembl Acc Id: ENSMUSP00000068328   ⟸   ENSMUST00000065977
Ensembl Acc Id: ENSMUSP00000102255   ⟸   ENSMUST00000106644
Ensembl Acc Id: ENSMUSP00000099797   ⟸   ENSMUST00000102736
Protein Domains
Peptidase M16 C-terminal   Peptidase M16 middle/third   Peptidase M16 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BHG1-F1-model_v2 AlphaFold Q8BHG1 1-1161 view protein structure

Promoters
RGD ID:6884150
Promoter ID:EPDNEW_M5525
Type:initiation region
Name:Nrd1_2
Description:Mus musculus nardilysin, N-arginine dibasic convertase, NRD convertase1 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5526  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384109,000,903 - 109,000,963EPDNEW
RGD ID:6884176
Promoter ID:EPDNEW_M5526
Type:single initiation site
Name:Nrd1_1
Description:Mus musculus nardilysin, N-arginine dibasic convertase, NRD convertase1 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5525  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384109,016,789 - 109,016,849EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1201386 AgrOrtholog
Ensembl Genes ENSMUSG00000053510 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000065977 ENTREZGENE
  ENSMUST00000065977.11 UniProtKB/Swiss-Prot
  ENSMUST00000102736 ENTREZGENE
  ENSMUST00000102736.9 UniProtKB/TrEMBL
  ENSMUST00000106644 ENTREZGENE
  ENSMUST00000106644.9 UniProtKB/TrEMBL
  ENSMUST00000125645.2 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalloenz_LuxS/M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:230598 UniProtKB/Swiss-Prot
MGD MGI:1201386 ENTREZGENE
NCBI Gene Nrdc ENTREZGENE
PANTHER INSULIN-DEGRADING ENZYME-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NARDILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nrdc PhenoGen
PROSITE INSULINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63411 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A9Q2 ENTREZGENE, UniProtKB/TrEMBL
  A6PWC3 ENTREZGENE, UniProtKB/TrEMBL
  NRDC_MOUSE UniProtKB/Swiss-Prot
  Q3V3G9_MOUSE UniProtKB/TrEMBL
  Q8BHG1 ENTREZGENE
  Q8R1H1_MOUSE UniProtKB/TrEMBL
  Q8R320 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z153_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-15 Nrdc  nardilysin convertase  Nrd1  nardilysin, N-arginine dibasic convertase, NRD convertase 1  Symbol and/or name updated 27372883 PROVISIONAL