RGD Reference Report - Effect of alpha-tocopherol on mitochondrial electron transport in experimental myocardial infarction in rats. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Effect of alpha-tocopherol on mitochondrial electron transport in experimental myocardial infarction in rats.

Authors: Ithayarasi, AP  Shyamala Devi, C 
Citation: Ithayarasi AP and Shyamala Devi C, Indian J Biochem Biophys. 1998 Apr;35(2):115-9.
RGD ID: 1582468
Pubmed: PMID:9753871   (View Abstract at PubMed)

The effect of alpha-tocopherol pretreatment (6 mg/100 g body wt/day, orally for a period of 90 days) on mitochondrial electron transport in myocardial infarction induced by isoproterenol (20 mg/100 g body wt, subcutaneously for two days) was studied in rats. A significant decrease was observed in the activities of isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, NADH dehydrogenase and cytochrome oxidase in heart mitochondria of isoproterenol administered rats. The cytochrome content and the oxidation of succinate in state 3 and state 4 decreased significantly in the cardiac mitochondria treatment. In alpha-tocopherol pretreated rats, the activities of TCA cycle enzymes, concentration of cytochromes and the oxidation of succinate in state 3 and state 4 were retained at near normal values, following isoproterenol administration.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MDH2Humanmyocardial infarction  ISOMdh2 (Rattus norvegicus) RGD 
Mdh2Mousemyocardial infarction  ISOMdh2 (Rattus norvegicus) RGD 
Mdh2Ratmyocardial infarction  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mdh2  (malate dehydrogenase 2)

Genes (Mus musculus)
Mdh2  (malate dehydrogenase 2, NAD (mitochondrial))

Genes (Homo sapiens)
MDH2  (malate dehydrogenase 2)


Additional Information