Bss119 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Bss119 (Bone structure and strength QTL 119) Rattus norvegicus

Symbol: Bss119
Name: Bone structure and strength QTL 119
RGD ID: 11530002
Trait: lumbar vertebra area   (VT:0010570)    
Measurement Type: lumbar vertebra area   (CMO:0001688)    
LOD Score: 16.39
P Value: 4.0E-17
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,873,419 - 21,346,740RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01223,920,656 - 24,394,383RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01225,918,064 - 26,391,686RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41222,000,595 - 22,501,174RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: NAft:HS 



Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
NAft:HS  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Fine mapping of bone structure and strength QTLs in heterogeneous stock rat. Alam I, etal., Bone. 2015 Dec;81:417-26. doi: 10.1016/j.bone.2015.08.013. Epub 2015 Aug 19.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1587868Srrm3serine/arginine repetitive matrix 3122080887820878557Rat
11499585LOC108352435uncharacterized LOC108352435122088043520891489Rat
619719Mdh2malate dehydrogenase 2122089426920907225Rat
1305845Styxl1serine/threonine/tyrosine interacting-like 1122090741020940232Rat
1311474Tmem120atransmembrane protein 120A122094224320950908Rat
68335Porcytochrome p450 oxidoreductase122095105820999198Rat
1308231Rhbdd2rhomboid domain containing 2122104360521054305Rat
1310245Ccl24C-C motif chemokine ligand 24122110083521104832Rat
1587817Ccl26C-C motif chemokine ligand 26122110938421114336Rat
1583828Rps13-ps4ribosomal protein S13, pseudogene 4122112530921125763Rat
620305Hip1huntingtin interacting protein 1122113336421267796Rat
41306277LOC120095918uncharacterized LOC120095918122115005021151606Rat
620680Pom121POM121 transmembrane nucleoporin122127371321294299Rat
41275322LOC120095917uncharacterized LOC120095917122127463921276764Rat
1309268Nsun5NOP2/Sun RNA methyltransferase 5122129363721299319Rat
631346Trim50tripartite motif-containing 50122130078421317668Rat
1308926Fkbp6FKBP prolyl isomerase family member 6122131825121390350Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10888D12Wox1089122089438020894469Ratregion
37878D12Rat33239122114617721146418Ratregion
39236D12Rat51213122127306221273283Ratregion
44969D12Got102135122111996721120102Ratregion
44973D12Got103251122087451320874764Ratregion
1629647D12Got220119122088154520881664Ratregion
5034339Fkbp6480122132920421329685Ratregion
5035208BM390639203122089592320896126Ratregion
5031165BE116737176122114569821145874Ratregion
5053073RH142438173122089429520894468Ratregion
5044252RH130496189122129430721294496Ratregion
5048884RH133161208122126428421264492Ratregion
5039492RH127736541122089444920894990Ratregion
5040162RH128125209122126731721267526Ratregion
5040586RH128368216122118577921185995Ratregion
5071224RH134959188122130086021301048Ratregion
5071830RH135309202122117085121171053Ratregion
5072234RH136731142122103984321039985Ratregion
5068616AU047037210122116606721166275Ratregion
5065896AA964673117122126528921265406Ratregion
5082979BF390551160122111409721114257Ratregion
5087446PMC180925P1753122095603620956789Ratregion
5088827AU048794232122116014721160379Ratregion
5499663MARC_6945-6946:992007577:2582122094952920950111Ratregion
5500713RH911941560122119362221195182Ratregion
11529999rs197969186122087341920873419Ratregion
11529998rs196994347122103096521030965Ratregion
11530000rs197046678122134674021346740Ratregion
Position Markers

Flank 1: (rs197969186)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21220,873,419 - 20,873,419RGD
Rnor_6.01223,920,656 - 23,920,656RGD
Peak: (rs196994347)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21221,030,965 - 21,030,965RGD
Rnor_6.01224,078,608 - 24,078,608RGD
Flank 2: (rs197046678)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21221,346,740 - 21,346,740RGD
Rnor_6.01224,394,383 - 24,394,383RGD


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
11530002Bss119Bone structure and strength QTL 11916.394e-17lumbar vertebra area (VT:0010570)lumbar vertebra area (CMO:0001688)122087341921346740Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general number of animals used: 1524 HS rats (728 male, 796 female) were used. 11528619
qtl_general measurement method: Rats on a standard diet were euthanized at 17 to 20 weeks of age, and lumbar vertebrae (L3-5) were scanned using DXA (PIXImus II mouse densitometer; Lunar Corp., Madison, WI, USA) with ultra-high resolution (0.18x0.18 mm/pixel). 11528619