Por (cytochrome p450 oxidoreductase) - Rat Genome Database

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Gene: Por (cytochrome p450 oxidoreductase) Rattus norvegicus
Analyze
Symbol: Por
Name: cytochrome p450 oxidoreductase
RGD ID: 68335
Description: Enables several functions, including iron-cytochrome-c reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Involved in several processes, including cellular response to hormone stimulus; negative regulation of hydrolase activity; and positive regulation of steroid biosynthetic process. Located in membrane and mitochondrion. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (cytochrome p450 oxidoreductase); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; doxorubicin pharmacokinetics pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CPR; CYPOR; cytochrome P450 reductase; NADPH--cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21220,951,058 - 20,999,198 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,951,058 - 20,999,245 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,092,790 - 22,140,733 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01222,705,228 - 22,753,069 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01221,771,683 - 21,819,534 (-)NCBIRnor_WKY
Rnor_6.01223,998,411 - 24,017,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,998,411 - 24,046,814 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,995,663 - 26,014,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,078,629 - 22,097,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,065,892 - 22,141,603 (-)NCBI
Celera1222,713,689 - 22,732,174 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(R)-lipoic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,8-Dinitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichlorobenzonitrile  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-Amino-9H-pyrido[2,3-b]indole  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-Dichlorobenzidine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-acetylaminofluorene  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-Hydroxyflavone  (ISO)
6',7'-Dihydroxybergamottin  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-hydroxy-2'-deoxyguanosine  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9-hydroxyellipticine  (ISO)
acetic acid  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ametryn  (ISO)
amiodarone  (EXP)
amitraz  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
andrographolide  (ISO)
anthocyanin  (EXP)
aristolochic acid  (EXP,ISO)
Aroclor 1254  (EXP)
asiatic acid  (EXP)
astaxanthin  (EXP)
atrazine  (ISO)
azoxystrobin  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
Benzyl viologen  (EXP)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvone  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (ISO)
chlorpyrifos  (EXP)
cholic acid  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
citral  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP,ISO)
ferricyanide  (EXP)
ferroheme b  (ISO)
fipronil  (ISO)
fluconazole  (EXP,ISO)
flusilazole  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gemfibrozil  (EXP)
gentamycin  (EXP)
geranial  (EXP)
geraniol  (EXP)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycolithocholic acid  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
heme b  (ISO)
hemin  (ISO)
hesperetin  (EXP)
hexachlorobenzene  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxyl  (ISO)
hyperforin  (ISO)
ifosfamide  (ISO)
imidacloprid  (EXP)
imipramine  (EXP)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
kojic acid  (EXP)
leflunomide  (EXP,ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
masoprocol  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
menadione  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
mitomycin C  (ISO)
mono(glucosyluronic acid)bilirubin  (ISO)
monocrotaline  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-Nitrosodi-n-propylamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nemorubicin  (ISO)
nevirapine  (EXP)
nimesulide  (EXP)
nitrofurantoin  (EXP,ISO)
nitrofurazone  (EXP)
Oxadiazon  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenolphthalein  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
pioglitazone  (EXP)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
propiconazole  (EXP,ISO)
prostaglandin F2alpha  (EXP)
purpurin  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
sarin  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sevoflurane  (EXP)
silibinin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
styrene  (ISO)
styrene oxide  (ISO)
Sudan I  (EXP)
sulforaphane  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
taurodeoxycholic acid  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tebuconazole  (ISO)
terbutryn  (ISO)
tert-butyl ethyl ether  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thiabendazole  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
thyroxine  (ISO)
tirapazamine  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
tranylcypromine  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
usnic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
warfarin  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (EXP)
zinc atom  (EXP)
zinc pyrithione  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. P450 oxidoreductase expressed in rat chondrocytes modulates chondrogenesis via cholesterol- and Indian Hedgehog-dependent mechanisms. Aguilar A, etal., Endocrinology. 2009 Jun;150(6):2732-9. Epub 2009 Mar 5.
2. Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points. Anandatheerthavarada HK, etal., EMBO J. 2001 May 15;20(10):2394-403.
3. Engineering of proteolytically stable NADPH-cytochrome P450 reductase. Bonina TA, etal., Biochemistry (Mosc). 2005 Mar;70(3):357-65.
4. Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat. Cherala G, etal., Drug Metab Dispos. 2007 Jul;35(7):1057-63. Epub 2007 Mar 28.
5. Lysophosphatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D. Cho EY, etal., Biochem Biophys Res Commun. 2008 Nov 21;376(3):584-9. Epub 2008 Sep 16.
6. Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P. Dhir V, etal., Mol Endocrinol. 2007 Aug;21(8):1958-68. Epub 2007 May 15.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Basic concepts and recent developments in human steroid hormone biosynthesis. Ghayee HK and Auchus RJ, Rev Endocr Metab Disord. 2007 Dec;8(4):289-300.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase. Guengerich FP Arch Biochem Biophys. 2005 Aug 15;440(2):204-11.
11. Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain. Hall CN, etal., Biochem J. 2009 Apr 15;419(2):411-8.
12. Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. Hamdane D, etal., J Biol Chem. 2009 Apr 24;284(17):11374-84. Epub 2009 Jan 26.
13. Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase. Higashimoto Y, etal., Biochem Biophys Res Commun. 2008 Mar 21;367(4):852-8. Epub 2008 Jan 14.
14. Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. Higashimoto Y, etal., J Biol Chem. 2005 Jan 7;280(1):729-37. Epub 2004 Oct 31.
15. The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase. Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN. Higashimoto Y, etal., J Biol Chem. 2006 Oct 20;281(42):31659-67. Epub 2006 Aug 22.
16. Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis. Huang N, etal., Am J Hum Genet. 2005 May;76(5):729-49. Epub 2005 Mar 25.
17. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
18. Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production. Inaoka Y, etal., Reprod Biol Endocrinol. 2008 Dec 16;6:62.
19. Functional expression and characterization of cytochrome P450 52A21 from Candida albicans. Kim D, etal., Arch Biochem Biophys. 2007 Aug 15;464(2):213-20. Epub 2007 Mar 16.
20. Characterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates. Li H, etal., J Biol Chem. 2006 May 5;281(18):12546-54. Epub 2006 Mar 9.
21. CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis. Locuson CW, etal., Drug Metab Dispos. 2007 Jul;35(7):1174-81. Epub 2007 Apr 19.
22. Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate. McGuire JJ, etal., Biochem Pharmacol. 1998 Oct 1;56(7):881-93.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
25. Expression of rat NADPH-cytochrome P-450 reductase cDNA in Saccharomyces cerevisiae. Murakami H, etal., DNA 1986 Feb;5(1):1-10.
26. Expressions of genes encoding drug-metabolizing enzymes are altered after sevoflurane, isoflurane, propofol or dexmedetomidine anesthesia. Nakazato K, etal., Biomed Res. 2009 Feb;30(1):17-24.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Effect of L-carnitine supplementation on xenobiotic-metabolizing hepatic enzymes exposed to methanol. Olszowy Z, etal., Exp Toxicol Pathol. 2006 Jul;57(5-6):427-35. Epub 2006 Apr 17.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Coding nucleotide sequence of rat NADPH-cytochrome P-450 oxidoreductase cDNA and identification of flavin-binding domains. Porter TD and Kasper CB, Proc Natl Acad Sci U S A 1985 Feb;82(4):973-7.
32. NADPH-cytochrome P-450 oxidoreductase gene organization correlates with structural domains of the protein. Porter TD, etal., Biochemistry 1990 Oct 23;29(42):9814-8.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase. Shen AL, etal., J Biol Chem. 2002 Feb 22;277(8):6536-41. Epub 2001 Dec 12.
37. Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. Shimada T, etal., Arch Biochem Biophys. 2005 Mar 1;435(1):207-16.
38. Oxidative aldehyde deformylation catalyzed by NADPH-cytochrome P450 reductase and the flavoprotein domain of neuronal nitric oxide synthase. Vatsis KP and Coon MJ, Biochem Biophys Res Commun. 2005 Dec 2;337(4):1107-11. Epub 2005 Oct 5.
39. Hypophysectomy differentially alters P-450 protein levels and enzyme activities in rat liver: pituitary control of hepatic NADPH cytochrome P-450 reductase. Waxman DJ, etal., Mol Pharmacol. 1989 Apr;35(4):519-25.
40. A physiogenomic approach to study the regulation of blood pressure. Westhoff TH, etal., Physiol Genomics. 2005 Sep 21;23(1):46-53. Epub 2005 Jun 7.
41. Antioxidant effects of flavonoids used as food additives (purple corn color, enzymatically modified isoquercitrin, and isoquercitrin) on liver carcinogenesis in a rat medium-term bioassay. Yokohira M, etal., J Food Sci. 2008 Sep;73(7):C561-8. Epub 2008 Jul 24.
Additional References at PubMed
PMID:9237990   PMID:9618440   PMID:11371558   PMID:15031143   PMID:16249336   PMID:17693640   PMID:19023562   PMID:19448135   PMID:19908820   PMID:19946888   PMID:20624491   PMID:21345800  
PMID:21462923   PMID:22871113   PMID:24853741   PMID:25450017   PMID:25512382   PMID:27189945   PMID:28684414   PMID:29308883   PMID:34196520  


Genomics

Comparative Map Data
Por
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21220,951,058 - 20,999,198 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,951,058 - 20,999,245 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,092,790 - 22,140,733 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01222,705,228 - 22,753,069 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01221,771,683 - 21,819,534 (-)NCBIRnor_WKY
Rnor_6.01223,998,411 - 24,017,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,998,411 - 24,046,814 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,995,663 - 26,014,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,078,629 - 22,097,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,065,892 - 22,141,603 (-)NCBI
Celera1222,713,689 - 22,732,174 (-)NCBICelera
Cytogenetic Map12q12NCBI
POR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38775,915,155 - 75,986,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl775,899,200 - 75,986,855 (+)EnsemblGRCh38hg38GRCh38
GRCh37775,544,473 - 75,616,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,382,356 - 75,454,109 (+)NCBINCBI36Build 36hg18NCBI36
Build 34775,227,957 - 75,260,823NCBI
Celera770,412,991 - 70,484,717 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,631,215 - 70,702,985 (+)NCBIHuRef
CHM1_1775,474,511 - 75,546,243 (+)NCBICHM1_1
T2T-CHM13v2.0777,202,773 - 77,274,511 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2774,877,484 - 74,949,237 (+)NCBI
Por
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,698,894 - 135,764,180 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,698,887 - 135,764,180 (+)EnsemblGRCm39 Ensembl
GRCm385135,670,040 - 135,735,326 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,670,033 - 135,735,326 (+)EnsemblGRCm38mm10GRCm38
MGSCv375136,165,084 - 136,211,195 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,973,841 - 136,019,952 (+)NCBIMGSCv36mm8
Celera5132,696,393 - 132,742,504 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.34NCBI
Por
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,698,589 - 14,748,520 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,698,589 - 14,748,520 (+)NCBIChiLan1.0ChiLan1.0
LOC100990437
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1782,364,311 - 82,437,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,364,418 - 82,437,530 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0768,035,021 - 68,105,934 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
POR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,247,780 - 7,316,282 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,263,574 - 7,316,297 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,984,488 - 9,012,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.067,068,561 - 7,137,106 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,074,449 - 7,192,344 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,077,907 - 7,106,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,041,376 - 7,069,585 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,204,608 - 7,232,825 (+)NCBIUU_Cfam_GSD_1.0
LOC101965545
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,708,573 - 131,760,586 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,274,059 - 2,328,008 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365432,275,981 - 2,327,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,212,735 - 10,281,823 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,212,734 - 10,272,184 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103246654
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,145,070 - 10,230,836 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,197,503 - 10,230,468 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,191,559 - 6,265,374 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101712555
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,733,427 - 14,791,065 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,739,458 - 14,790,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Por
603 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000001961
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat

Markers in Region
PMC180925P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,956,036 - 20,956,789 (+)MAPPERmRatBN7.2
Rnor_6.01224,003,392 - 24,004,144NCBIRnor6.0
Rnor_5.01226,000,644 - 26,001,396UniSTSRnor5.0
RGSC_v3.41222,083,610 - 22,084,362UniSTSRGSC3.4
Celera1222,718,658 - 22,719,410UniSTS
Cytogenetic Map12q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 3 6 74 35 41 11 3
Low 5 5 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001961   ⟹   ENSRNOP00000001961
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,951,058 - 20,971,860 (-)Ensembl
Rnor_6.0 Ensembl1223,998,411 - 24,046,814 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100114   ⟹   ENSRNOP00000081146
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,951,058 - 20,962,132 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101964   ⟹   ENSRNOP00000078537
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,951,058 - 20,999,245 (-)Ensembl
RefSeq Acc Id: NM_031576   ⟹   NP_113764
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21220,951,058 - 20,999,198 (-)NCBI
Rnor_6.01223,998,411 - 24,017,063 (-)NCBI
Rnor_5.01225,995,663 - 26,014,366 (-)NCBI
RGSC_v3.41222,078,629 - 22,097,301 (-)RGD
Celera1222,713,689 - 22,732,174 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089289   ⟹   XP_038945217
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21220,951,058 - 20,962,149 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_113764   ⟸   NM_031576
- UniProtKB: P00388 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001961   ⟸   ENSRNOT00000001961
RefSeq Acc Id: XP_038945217   ⟸   XM_039089289
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS87 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081146   ⟸   ENSRNOT00000100114
RefSeq Acc Id: ENSRNOP00000078537   ⟸   ENSRNOT00000101964
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00388-F1-model_v2 AlphaFold P00388 1-678 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68335 AgrOrtholog
BioCyc Gene G2FUF-19628 BioCyc
Ensembl Genes ENSRNOG00000001442 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001961.3 UniProtKB/TrEMBL
  ENSRNOP00000078537 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000081146 ENTREZGENE
  ENSRNOP00000081146.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001961.4 UniProtKB/TrEMBL
  ENSRNOT00000100114 ENTREZGENE
  ENSRNOT00000100114.1 UniProtKB/TrEMBL
  ENSRNOT00000101964 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.990.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CysJ-like_FAD-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavdoxin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin/NO_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29441 UniProtKB/Swiss-Prot
NCBI Gene 29441 ENTREZGENE
Pfam FAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB POR RGD
PhenoGen Por PhenoGen
PIRSF P450R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FLAVODOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FPNCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FAD_FR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FLAVODOXIN_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZS87 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q089_RAT UniProtKB/TrEMBL
  NCPR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Por  cytochrome p450 oxidoreductase  Por  P450 (cytochrome) oxidoreductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Por  P450 (cytochrome) oxidoreductase       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference