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DOXORUBICIN PHARMACOKINETICS PATHWAY (PW:0001565)

View Ontology Report

Description

Doxorubucin (DOX, trade name Adriamycin) is an anthracycline derived from Streptomyces bacterium Streptomyces peucetius var. caesius. DOX is used in the treatment of several solid cancers, leukemia and lymphomas. The drug is composed of a planar aromatic ring with an anthraquinone chromophore and a sugar group. Once taken up by the cell and inside the nucleus for which it has a high affinity, the planar ring structure intercalates between adjacent DNA base pairs, preferentia

Pathway Diagram:

Elsevier Inc. doxorubicin ---> doxorubicinol Ralbp1 Abcg2 Abcc3 Abcb1a Abcc2 Nos3 Nqo1 Xdh Cbr3 Cbr1 Akr1a1 Akr1c3 Slc22a16 ROS generation deglycosidation further processing doxorubicinol ---> elimination doxorubicin aglycone ---> elimination elimination doxorubicin one-electron reduction doxorubicin ---> doxorubicin semiquinone two-electron reduction Slc22a16 ---> doxorubicin doxorubicin semiquinone ---> elimination doxorubicin ---> elimination doxorubicin aglycone doxorubicinol doxorubicin semiquinone doxorubicin ---> doxorubicin aglycone
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Genes in Pathway:

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doxorubicin pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00650 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 ISO SMPDB PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 ISO RGD PMID:21048526 RGD:10395261 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 ISO SMPDB PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO SMPDB PMID:21048526, PMID:19442138 SMP:00650, RGD:10395261, RGD:10395262 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 ISO SMPDB PMID:21048526 SMP:00650, RGD:10395261 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB PMID:21048526, PMID:19442138 SMP:00650, RGD:10395261, RGD:10395262 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbr3 carbonyl reductase 3 ISO SMPDB PMID:21048526, PMID:19442138 SMP:00650, RGD:10395261, RGD:10395262 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 ISO SMPDB SMP:00650 NCBI chr13:89,606,848...89,623,506
Ensembl chr13:89,606,840...89,619,398
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 ISO SMPDB SMP:00650 NCBI chr 3:79,721,686...79,728,863
Ensembl chr 3:79,721,694...79,728,879
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 ISO SMPDB SMP:00650 NCBI chr 7:12,318,776...12,326,403
Ensembl chr 7:12,318,757...12,326,392
JBrowse link
G Nos3 nitric oxide synthase 3 ISO SMPDB PMID:19442138 SMP:00650, RGD:10395262 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 ISO SMPDB PMID:19442138 SMP:00650, RGD:10395262 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Por cytochrome p450 oxidoreductase ISO SMPDB SMP:00650 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ralbp1 ralA binding protein 1 ISO SMPDB PMID:21048526 SMP:00650, RGD:10395261 NCBI chr 9:113,579,107...113,598,477
Ensembl chr 9:113,579,107...113,598,480
JBrowse link
G Slc22a16 solute carrier family 22 member 16 ISO SMPDB PMID:21048526 SMP:00650, RGD:10395261 NCBI chr20:45,658,398...45,669,192 JBrowse link
G Xdh xanthine dehydrogenase ISO SMPDB PMID:19442138 SMP:00650, RGD:10395262 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the doxorubicin pharmacokinetics pathway
Disease TermsGene Symbols
acquired immunodeficiency syndromeAbcb1a
acute chest syndromeNos3
acute kidney failureNos3 , Nqo1 , Xdh
Acute Liver FailureAbcc2 , Nos3
Acute Lung InjuryNqo1 , Xdh
acute lymphoblastic leukemiaAbcb1a , Abcc2 , Abcg2 , Nos3 , Nqo1
acute megakaryocytic leukemiaAbcg2
acute myeloid leukemiaAbcc3 , Abcg2 , Nos3 , Nqo1
adenocarcinomaNos3
adenomaAbcg2
adrenocortical carcinomaAbcb1a
allergic rhinitisAbcb1a
alopeciaAbcc2
Alzheimer's diseaseAbcb1a , Abcc1 , Ndufs3 , Nos3
Alzheimer's disease 1Nos3
amenorrheaPor
angle-closure glaucomaNos3
Animal Mammary NeoplasmsXdh
anterior ischemic optic neuropathyNos3
Anthracycline-induced CardiotoxicityAbcb1a
Antley-Bixler syndromePor
Antley-Bixler Syndrome with Genital Anomalies and Disordered SteroidogenesisPor
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISPor
aortic valve diseaseNos3
Arterial ThrombosisXdh
arteriosclerosisNos3
Arteriovenous FistulaNos3
asthmaAbcb1a , Abcc1 , Nos3 , Nqo1
atherosclerosisNos3
atrial fibrillationNos3
autistic disorderAbcc1 , Xdh
Autoinflammation with Infantile EnterocolitisXdh
autosomal dominant nonsyndromic deafness 77Abcc1
autosomal dominant polycystic kidney diseaseAbcg2
B-Cell Chronic Lymphocytic LeukemiaAbcg2
B-cell lymphomaAbcg2
B-lymphoblastic leukemia/lymphomaAkr1c3
bacterial pneumoniaAbcc1
Behcet's diseaseAbcb1a , Nos3
bilirubin metabolic disorderAbcc2 , Abcc3
bipolar disorderNdufs7
bladder neck obstructionNos3
Brain HypoxiaNos3
Brain InjuriesNqo1 , Xdh
brain ischemiaNos3
breast cancerAkr1a1 , Nos3 , Nqo1
Breast Cancer, FamilialAbcc1
breast carcinomaAbcg2
Breast NeoplasmsAbcb1a , Abcc1 , Abcg2 , Ndufs3 , Nos3 , Nqo1
Bronchial HyperreactivityNos3
bronchiolitis obliteransNos3
cannabis abuseAbcb1a
Carbon Monoxide PoisoningXdh
Carbon Tetrachloride PoisoningNqo1
carcinomaAbcb1a , Xdh
CardiomegalyNdufs3 , Nos3
cardiomyopathyCbr1 , Ndufs2 , Nos3 , Xdh
CardiotoxicityNos3
cardiovascular system diseaseNos3 , Xdh
carotid artery diseaseXdh
Carotid Artery InjuriesNos3
castration-resistant prostate carcinomaAkr1c3
cataractXdh
central sleep apneaNos3
cerebral creatine deficiency syndromeNdufs7
Cerebral HemorrhageNqo1
cerebral infarctionNos3
Charcot-Marie-Tooth disease dominant intermediate CAkr1a1
Chemical and Drug Induced Liver InjuryAbcb1a , Abcc1 , Abcc2 , Akr1a1 , Ndufs3 , Nqo1
Child Behavior DisordersNos3
cholangiocarcinomaAbcc2
cholestasisAbcc2 , Abcc3 , Nos3 , Nqo1 , Xdh
Chromosome 8, TrisomyNqo1
Chronic Cerebral HypoperfusionNos3
Chronic Hepatitis CAbcb1a
chronic kidney diseaseCbr1 , Nos3 , Nqo1 , Xdh
chronic myeloid leukemiaAbcb1a , Abcc2 , Abcg2 , Nqo1
chronic obstructive pulmonary diseaseAbcc1 , Nos3 , Nqo1
cleft lipNos3
cleft palateNos3
colitisNos3
colon cancerNqo1
Colonic NeoplasmsCbr1 , Xdh
colorectal adenocarcinomaAbcb1a
Colorectal NeoplasmsAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2 , Nqo1
congenital adrenal hyperplasiaPor
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyPor
congenital diaphragmatic herniaNos3
congenital disorder of glycosylation type IIcNdufs3
congenital heart diseaseAbcb1a
congestive heart failureNos3 , Xdh
contact dermatitisNqo1
coronary artery diseaseNos3
coronary artery vasospasmNos3
COVID-19Abcb1a , Akr1c3 , Cbr1 , Ndufs7 , Slc22a16
Critical IllnessAbcb1a
Crohn's diseaseAbcb1a
Cronkhite-Canada syndromeAbcb1a
cryoglobulinemiaAbcb1a
cystic fibrosisNos3
cytochrome P450 oxidoreductase deficiencyPor
diabetes mellitusAbcg2
diabetic angiopathyNos3
Diabetic CardiomyopathiesNos3 , Xdh
Diabetic GastroparesisNos3
Diabetic NephropathiesNdufs3 , Nos3 , Nqo1 , Xdh
diabetic retinopathyNos3
Diaphragmatic HerniaNos3
diarrheaAbcb1a , Abcc2 , Abcg2
diffuse large B-cell lymphomaAbcb1a , Abcg2
disease of cellular proliferationAbcb1a , Nos3 , Nqo1
disease of mental healthAbcb1a
Disease ProgressionAbcb1a , Abcc1
disorder of sexual developmentAkr1c3 , Por
drug allergyAbcc2
Drug-Induced EnteropathyNos3
drug-induced hepatitisAbcc2
Drug-Induced Immune ThrombocytopeniaAbcc2
Drug-induced NeutropeniaAbcb1a , Abcc2
Drug-Related Side Effects and Adverse ReactionsAbcb1a , Abcc1 , Abcc2 , Abcg2
Dubin-Johnson syndromeAbcc2 , Abcc3
ductal carcinoma in situAkr1c3
DwarfismXdh
EczemaXdh
encephalitisAbcb1a
end stage renal diseaseAbcb1a , Abcc2 , Abcc3 , Cbr1 , Nos3
endometrial carcinomaNos3
Endometrial NeoplasmsAkr1c3
endometriosisAkr1c3
EndotoxemiaAbcb1a , Abcc2 , Nos3
EosinophiliaAbcb1a
epilepsyAbcb1a , Abcc1
erythropoietic protoporphyriaAbcg2
Escherichia Coli InfectionsAbcb1a
Esophageal NeoplasmsAbcb1a , Nos3
esophagus squamous cell carcinomaAbcc2
essential hypertensionNos3
Experimental ArthritisAbcb1a , Abcg2 , Nos3 , Nqo1 , Xdh
Experimental Diabetes MellitusAbcb1a , Abcc2 , Abcc3 , Abcg2 , Cbr1 , Ndufs2 , Ndufs3 , Nos3 , Nqo1 , Xdh
Experimental Liver CirrhosisAbcb1a , Abcc2 , Akr1c3 , Nos3
Experimental Liver NeoplasmsNqo1 , Xdh
Experimental NeoplasmsNqo1
Experimental Pancreatitis, Chronic Nqo1
extrahepatic cholestasisNos3
familial hyperlipidemiaAbcb1a , Nos3
familial Mediterranean feverAbcb1a
familial temporal lobe epilepsy 3Abcb1a
Familial Thoracic Aortic Aneurysm 4Abcc1
fatty liver diseaseAbcc2 , Abcc3 , Nqo1
Fetal Growth RetardationAbcb1a , Nos3 , Xdh
FeverCbr1
gastric ulcerNos3
Gastrointestinal DiseasesAbcc2
gastrointestinal stromal tumorNdufs2
genetic diseaseAbcc2 , Ndufs2 , Ndufs3
Genetic Predisposition to DiseaseAbcb1a
Genetic TranslocationAbcb1a
Germ Cell and Embryonal NeoplasmsAbcb1a
gliosarcomaPor
goutAbcg2 , Xdh
Graft Occlusion, VascularNos3
guanidinoacetate methyltransferase deficiencyNdufs7
head and neck squamous cell carcinomaAbcb1a , Abcc1 , Abcc2 , Abcg2
heart diseaseAbcb1a , Abcc1 , Abcc2 , Xdh
Helicobacter InfectionsAbcb1a
Hematologic NeoplasmsAbcb1a
hemolytic-uremic syndromeNqo1
HemorrhageNqo1
Hemorrhagic ShockNos3
Hepatic InsufficiencyNos3
hepatocellular carcinomaAbcb1a , Abcc3 , Cbr1 , Xdh
HepatomegalyAbcc3 , Nos3
hepatopulmonary syndromeNos3
high grade gliomaNos3
Hirschsprung's diseasePor
holocarboxylase synthetase deficiencyCbr1 , Cbr3
human immunodeficiency virus infectious diseaseAbcb1a
Huntington's diseaseNos3
hydronephrosisXdh
HyperemiaNos3
hyperglycemiaNos3 , Nqo1
hyperinsulinismNos3
HyperoxaluriaXdh
HyperoxiaNos3 , Nqo1
Hyperoxic Lung InjuryNqo1 , Xdh
hyperprolactinemiaAbcc3
hypertensionAbcc1 , Nos3 , Nqo1 , Ralbp1 , Xdh
Hypertension Resistant to Conventional TherapyNos3
HypertriglyceridemiaNos3
hypertrophic cardiomyopathyNdufs2
hyperuricemiaAbcg2 , Xdh
hypoparathyroidism-deafness-renal disease syndromeAkr1c3
HypotensionPor , Xdh
hypothyroidismNos3
HypoxiaNos3
impotenceNos3
InflammationAbcb1a
inflammatory bowel disease 13Abcb1a
inherited metabolic disorderNdufs2
Insulin ResistanceNos3
intellectual disabilityNdufs3 , Ndufs7
interstitial nephritisXdh
intestinal perforationNos3
Intestinal Reperfusion InjuryNos3 , Nqo1 , Xdh
intestinal volvulusAbcc1
Intimal HyperplasiaNos3
intracranial aneurysmNos3
Intracranial HemorrhagesNos3
invasive ductal carcinomaAbcb1a
irritable bowel syndromeNos3
irritant dermatitisCbr1
ischemiaNos3 , Xdh
juvenile rheumatoid arthritisSlc22a16
kidney diseaseAbcb1a , Abcc3 , Nqo1
kidney failureXdh
Kidney NeoplasmsAbcb1a
Kidney Reperfusion InjuryAkr1a1 , Nos3 , Nqo1 , Xdh
Kuhnt-Junius degenerationNos3
Latent TuberculosisAbcb1a
Lead PoisoningNqo1
learning disabilityPor
Leber hereditary optic neuropathyNdufs2
Left Ventricular HypertrophyNos3 , Nqo1 , Xdh
Leigh diseaseNdufs2 , Ndufs3 , Ndufs7
leiomyomaNos3
Lesch-Nyhan syndromeXdh
leukemiaAkr1c3 , Nqo1
Limb IschemiaNos3
liver benign neoplasmNqo1
liver cirrhosisNos3 , Nqo1
liver diseaseNqo1
Liver InjuryAbcg2
Liver Reperfusion InjuryNos3 , Xdh
long QT syndromeNos3
lung adenocarcinomaAkr1a1
lung cancerNqo1
lung carcinomaNqo1
lung diseaseNos3 , Nqo1
Lung InjuryNqo1 , Por
Lung NeoplasmsNqo1
lung non-small cell carcinomaAbcb1a , Abcc2 , Nqo1
Lung Reperfusion InjuryNos3 , Nqo1
lymphangioleiomyomatosisNos3
Lymphatic MetastasisNos3
macular degenerationNqo1
macular retinal edemaNos3
major depressive disorderXdh
malariaAbcb1a
male infertilityNos3
Mammary Neoplasms, ExperimentalAbcb1a , Abcg2 , Xdh
membranous glomerulonephritisNqo1
mental depressionNqo1
Mercury PoisoningNqo1
Metabolic SyndromeNos3
microphthalmiaRalbp1
middle cerebral artery infarctionNqo1 , Xdh
migraineNos3
mitochondrial complex I deficiencyNdufs2 , Ndufs3 , Ndufs7
mitochondrial encephalomyopathyNdufs2
Mouth NeoplasmsCbr3
multiple myelomaAbcg2 , Nqo1
Multiple Organ FailureXdh
multiple sclerosisNdufs2
muscular diseaseXdh
Musculoskeletal AbnormalitiesPor
myelodysplastic syndromeNqo1
myeloid leukemiaNqo1
myeloid neoplasmAkr1c3 , Nqo1
myocardial infarctionNos3
Myocardial IschemiaNos3 , Ralbp1
Myocardial Reperfusion InjuryNos3 , Xdh
Nasal PolypsAbcb1a , Nos3
nasal type extranodal NK/T-cell lymphomaAbcb1a
NauseaAbcb1a
Neoplasm MetastasisAbcb1a , Nos3
Neoplasms, Hormone-DependentAkr1c3
Neoplastic Cell TransformationAkr1c3 , Por
nephritisNos3
nephroblastomaAbcb1a
Nerve DegenerationXdh
nervous system diseaseAbcb1a , Abcc2 , Abcg2
neural tube defectPor
neuroblastomaAbcb1a
neurodegenerative diseaseNqo1
neutropeniaAbcb1a , Xdh
non-alcoholic fatty liver diseaseAbcb1a , Abcc2 , Abcc3 , Nqo1
nuclear type mitochondrial complex I deficiency 1Ndufs2 , Ndufs3 , Ndufs7
nuclear type mitochondrial complex I deficiency 3Ndufs7
nuclear type mitochondrial complex I deficiency 6Ndufs2
nuclear type mitochondrial complex I deficiency 8Ndufs3
obesityAkr1c3 , Nos3 , Nqo1 , Xdh
obstructive sleep apneaAbcb1a , Nos3
Occupational DiseasesNqo1
oligospermiaNos3
optic atrophyNdufs3
Orthostatic HypotensionAbcb1a
ovarian cancerAbcb1a , Nos3
Ovarian NeoplasmsAbcb1a , Abcg2
Overactive Urinary BladderNqo1
overnutritionNos3
PainAbcb1a , Nos3
Pain, PostoperativeAbcb1a
pancreatic adenocarcinomaRalbp1
pancreatic cancerAbcc2 , Abcc3
pancreatitisXdh
papillomaNqo1
parathyroid carcinomaNdufs2
Parkinson's diseaseAbcb1a , Nqo1
ParkinsonismNdufs3
Perennial Allergic RhinitisNos3
perinatal necrotizing enterocolitisAbcb1a , Akr1a1 , Nos3
peripheral nervous system diseaseAbcb1a , Abcc1
peritonitisXdh
persistent fetal circulation syndromeNos3
Phyllodes TumorNos3
placental abruptionNos3
pleomorphic xanthoastrocytomaAbcb1a , Por
PneumoperitoneumXdh
PoisoningAbcb1a , Nqo1
polycystic kidney diseaseNos3
polycystic ovary syndromeAkr1c3
portal hypertensionNos3 , Xdh
pre-eclampsiaAkr1c3 , Nos3
Preeclampsia/Eclampsia 1Nos3
Pregnancy-Induced HypertensionNos3
primary biliary cholangitisAbcc2 , Abcg2 , Nos3
primary open angle glaucomaNos3
primary ovarian insufficiencyNos3 , Por
prostate cancerAkr1c3 , Nos3
Prostatic NeoplasmsAkr1c3 , Cbr1 , Nos3 , Nqo1 , Ralbp1
prostatitisNqo1
protein-losing enteropathyXdh
pseudoxanthoma elasticumAbcc1 , Abcc2
pulmonary edemaNos3
pulmonary embolismNos3 , Xdh
pulmonary emphysemaNos3 , Nqo1
pulmonary eosinophiliaNos3
pulmonary hypertensionNos3
Pulmonary Hypertension, Hypoxia-Induced Nos3
pulmonary tuberculosisAbcb1a
Puromycin Aminonucleoside NephrosisXdh
Radiation PneumonitisNos3
renal cell carcinomaAbcb1a , Abcg2
renal fibrosisNqo1 , Xdh
renal hypertensionNos3
Renal IschemiaXdh
renovascular hypertensionNos3
Reperfusion InjuryAbcb1a , Abcg2 , Nos3 , Xdh
respiratory allergyNos3
Retina Reperfusion InjuryNos3 , Xdh
retinal degenerationNos3
retinopathy of prematurityNos3
rheumatoid arthritisAbcb1a , Abcc2 , Abcc3 , Abcg2
Right Ventricular HypertrophyNos3
schizophreniaAbcc1 , Akr1c3
secondary hyperparathyroidismAbcg2
secondary Parkinson diseaseAbcb1a
SepsisNos3 , Xdh
ShockXdh
sickle cell anemiaNos3
small cell carcinomaNqo1
Spinal Cord CompressionNos3
Spinal Cord InjuriesNos3 , Nqo1 , Xdh
spinocerebellar ataxia type 17Nqo1
ST Elevation Myocardial InfarctionAbcb1a
status epilepticusAbcb1a , Abcc2 , Abcg2 , Nqo1
Stomach NeoplasmsAkr1c3 , Nos3
StrokeNos3
Subacute Necrotizing Encephalopathy of Leigh, InfantileNdufs3 , Ndufs7
Subarachnoid HemorrhageNos3 , Nqo1
Sudden Hearing LossNos3
T-cell acute lymphoblastic leukemiaAbcg2 , Akr1c3
telangiectasisNos3
temporal lobe epilepsyAbcb1a
TeratozoospermiaNos3
Testis Reperfusion InjuryNos3 , Xdh
thrombocytopeniaCbr1 , Xdh
ThromboembolismNos3
Thrombotic MicroangiopathiesNos3
toxic encephalopathyAbcb1a , Abcg2 , Nqo1
transient cerebral ischemiaNos3 , Nqo1
Transplant RejectionNos3 , Xdh
type 1 diabetes mellitusNos3
type 2 diabetes mellitusAbcb1a , Abcc2 , Abcg2 , Nos3
ulcerative colitisAbcb1a
Urachal CystXdh
uremiaNos3
ureteral obstructionNos3 , Nqo1
urinary bladder cancerNos3 , Nqo1 , Por , Ralbp1 , Xdh
urinary system cancerNqo1
vasculitisNos3
Vaso-occlusive CrisisNos3
Venous ThrombosisNos3
Ventricular Dysfunction, RightNos3
Ventricular Premature ComplexesNos3
Ventricular TachycardiaNos3
vestibular diseaseNos3
visual epilepsyAbcb1a , Abcc2 , Nqo1
Volvulus Of MidgutAbcc1
VomitingAbcb1a
vulva cancerNos3
warfarin sensitivityNqo1
Wounds, PenetratingXdh
xanthinuriaXdh
Xanthinuria, Type IXdh
Xanthinuria, Type IIXdh
Pathway Annotations Associated with Genes in the doxorubicin pharmacokinetics pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayAkr1c3 , Cbr1
adenine phoshoribosyltransferase deficiency pathwayXdh
adenosine monophosphate deaminase deficiency pathwayXdh
adenylosuccinate lyase deficiency pathwayXdh
AICA-ribosuria pathwayXdh
aldosterone biosynthetic pathwayPor
Alzheimer's disease pathwayNdufs2 , Ndufs3 , Ndufs7
antipyrine drug pathwayAkr1c3 , Cbr1
arachidonic acid metabolic pathwayAkr1c3 , Cbr1 , Cbr3
arginine and proline metabolic pathwayNos3
axitinib pharmacokinetics pathwayAbcb1a
azathioprine pharmacodynamics pathwayXdh
bile acid signaling pathwayAbcc2
bile acid transport pathwayAbcb1a , Abcc2 , Abcc3 , Abcg2
caffeine metabolic pathwayXdh
caffeine pharmacokinetics pathwayXdh
calcium/calcium-mediated signaling pathwayNos3
celecoxib pharmacodynamics pathwayAkr1c3 , Cbr1
ceramide signaling pathwayRalbp1
clopidogrel pharmacodynamics pathwayAbcb1a
clopidogrel pharmacokinetics pathwayAbcb1a
cortisol biosynthetic pathwayPor
diclofenac pharmacodynamics pathwayAkr1c3 , Cbr1
diflunisal pharmacodynamics pathwayAkr1c3 , Cbr1
docetaxel pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
dopa responsive dystonia pathwayCbr1
doxorubicin pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2 , Akr1a1 , Akr1c3 , Cbr1 , Cbr3 , Ndufs2 , Ndufs3 , Ndufs7 , Nos3 , Nqo1 , Por , Ralbp1 , Slc22a16 , Xdh
eicosanoid signaling pathwayNos3
erlotinib pharmacodynamics pathwayAbcb1a , Abcg2
estradiol biosynthetic pathwayPor
etodolac pharmacodynamics pathwayAkr1c3 , Cbr1
etoposide pharmacodynamics pathwayAbcb1a , Abcc3
etoposide pharmacokinetics pathwayAbcb1a , Abcc3
fenoprofen pharmacodynamics pathwayAkr1c3 , Cbr1
flurbiprofen pharmacodynamics pathwayAkr1c3 , Cbr1
gefitinib pharmacokinetics pathwayAbcb1a , Abcg2
gluconeogenesis pathwayAkr1a1
glycerolipid metabolic pathwayAkr1a1
glycolysis pathwayAkr1a1
glycolysis/gluconeogenesis pathwayAkr1a1
Huntington's disease pathwayNdufs2 , Ndufs3 , Ndufs7
hypoxia inducible factor pathwayAbcb1a , Abcg2
ibuprofen pharmacodynamics pathwayAkr1c3 , Cbr1
indometacin pharmacodynamics pathwayAkr1c3 , Cbr1
indometacin pharmacodynamics pathwayAkr1c3 , Cbr1
irinotecan pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
irinotecan pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
isoprenoid metabolic pathwayAkr1c3
Kelley-Seegmiller syndrome pathwayXdh
ketoprofen pharmacodynamics pathwayAkr1c3 , Cbr1
ketorolac pharmacodynamics pathwayAkr1c3 , Cbr1
lamivudine pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2
Lesch-Nyhan syndrome pathwayXdh
leukotriene C4 synthase deficiency pathwayAkr1c3 , Cbr1
lornoxicam pharmacodynamics pathwayAkr1c3 , Cbr1
losartan pharmacokinetics pathwayAbcb1a
magnesium salicylate pharmacodynamics pathwayAkr1c3 , Cbr1
mefenamic acid pharmacodynamics pathwayAkr1c3 , Cbr1
meloxicam pharmacodynamics pathwayAkr1c3 , Cbr1
mercaptopurine pharmacodynamics pathwayXdh
mercaptopurine pharmacokinetics pathwayXdh
molybdenum cofactor deficiency pathwayXdh
multidrug resistance-associated protein mediated transport pathwayAbcc1 , Abcc2 , Abcc3
mycophenolic acid pharmacokinetics pathwayAbcb1a , Abcc2 , Abcg2
nabumetone pharmacodynamics pathwayAkr1c3 , Cbr1
naproxen pharmacodynamics pathwayAkr1c3 , Cbr1
nuclear factor, erythroid 2 like 2 signaling pathwayNqo1
oxidative phosphorylation pathwayNdufs2 , Ndufs3 , Ndufs7
oxidative stress response pathwayNqo1
pancreatic cancer pathwayRalbp1
paracetamol drug pathwayAkr1c3 , Cbr1
paracetamol pharmacokinetics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Abcg2
Parkinson's disease pathwayNdufs2 , Ndufs3 , Ndufs7
phenytoin pharmacodynamics pathwayNqo1
piroxicam pharmacodynamics pathwayAkr1c3 , Cbr1
prostaglandin biosynthetic pathwayAkr1a1 , Akr1c3 , Cbr1
purine metabolic pathwayXdh
purine nucleoside phosphorylase deficiency pathwayXdh
salicylic acid pharmacodynamics pathwayAkr1c3 , Cbr1
Segawa syndrome pathwayCbr1
sodium salicylate pharmacodynamics pathwayAkr1c3 , Cbr1
sphingosine 1-phosphate signaling pathwayAbcc1
statin pharmacokinetics pathwayAbcb1a , Abcc2 , Abcg2
steroid hormone biosynthetic pathwayPor
sulindac pharmacodynamics pathwayAkr1c3 , Cbr1
tamoxifen pharmacokinetics pathwayAbcb1a
tenoxicam pharmacodynamics pathwayAkr1c3 , Cbr1
testosterone biosynthetic pathwayPor
tiaprofenic acid pharmacodynamics pathwayAkr1c3 , Cbr1
tioguanine pharmacodynamics pathwayXdh
tolmetin pharmacodynamics pathwayAkr1c3 , Cbr1
tramadol pharmacokinetics pathwayAbcc2
tyrosinemia type III pathwayAbcb1a , Abcc1 , Abcc2 , Abcg2
valdecoxib pharmacodynamics pathwayAkr1c3 , Cbr1
vascular endothelial growth factor signaling pathwayNos3
venlafaxine pharmacokinetics pathwayAbcb1a
vinblastine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vincristine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vindesine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vinorelbine pharmacodynamics pathwayAbcb1a , Abcc1 , Abcc2 , Abcc3 , Ralbp1
vitamin K metabolic pathwayNqo1
xanthinuria type I pathwayXdh
xanthinuria pathwayXdh
xanthinuria type II pathwayXdh
Phenotype Annotations Associated with Genes in the doxorubicin pharmacokinetics pathway

References Associated with the doxorubicin pharmacokinetics pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: