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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68335
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Por
Name: cytochrome p450 oxidoreductase
Acc ID: CHEBI:78887
Term: tirapazamine
Definition: A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.
Chemical ID: MESH:C049947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pormultiple interactionsISORGD:684686480464CTDPOR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine]

PMID:10919648
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.