Fkbp6 (FKBP prolyl isomerase family member 6) - Rat Genome Database

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Gene: Fkbp6 (FKBP prolyl isomerase family member 6) Rattus norvegicus
Analyze
Symbol: Fkbp6
Name: FKBP prolyl isomerase family member 6
RGD ID: 1308926
Description: Predicted to enable Hsp90 protein binding activity and identical protein binding activity. Involved in spermatogenesis. Predicted to be located in cytosol and synaptonemal complex. Predicted to be active in cytoplasm. Used to study male infertility. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)); INTERACTS WITH bisphenol A; 17alpha-ethynylestradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 36 kDa FK506 binding protein; FK506 binding protein 6; FK506 binding protein 6, 36kDa; FK506-binding protein 6; FKBP prolyl isomerase 6; FKBP-36; immunophilin FKBP36; inactive peptidyl-prolyl cis-trans isomerase FKBP6; inactive PPIase FKBP6; peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP6; PPiase; rotamase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   TT/Sgn  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21221,318,251 - 21,390,350 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1221,319,568 - 21,390,350 (+)Ensembl
Rnor_6.01224,365,941 - 24,438,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,367,199 - 24,438,019 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,363,264 - 26,435,311 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,474,002 - 22,544,784 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11222,464,474 - 22,476,654 (+)NCBI
Celera1223,082,103 - 23,152,967 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (ISO,ISS)
synaptonemal complex  (ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Testicular disruption in the As (aspermia) mutant rat, with special reference to the aggregate of ribosomes. Atagi Y, etal., J Vet Med Sci. 1993 Apr;55(2):301-6.
2. Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Crackower MA, etal., Science. 2003 May 23;300(5623):1291-5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A novel human gene FKBP6 is deleted in Williams syndrome. Meng X, etal., Genomics. 1998 Sep 1;52(2):130-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7493967   PMID:18408354   PMID:22902560   PMID:26567527  


Genomics

Comparative Map Data
Fkbp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21221,318,251 - 21,390,350 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1221,319,568 - 21,390,350 (+)Ensembl
Rnor_6.01224,365,941 - 24,438,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,367,199 - 24,438,019 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,363,264 - 26,435,311 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,474,002 - 22,544,784 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11222,464,474 - 22,476,654 (+)NCBI
Celera1223,082,103 - 23,152,967 (+)NCBICelera
Cytogenetic Map12q12NCBI
FKBP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38773,328,161 - 73,358,625 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl773,328,161 - 73,358,637 (+)EnsemblGRCh38hg38GRCh38
GRCh37772,742,164 - 72,772,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36772,380,236 - 72,410,577 (+)NCBINCBI36hg18NCBI36
Build 34771,884,933 - 72,217,283NCBI
Celera768,220,437 - 68,250,915 (+)NCBI
Cytogenetic Map7q11.23NCBI
HuRef768,623,892 - 68,654,372 (+)NCBIHuRef
CHM1_1772,888,174 - 72,918,659 (+)NCBICHM1_1
T2T-CHM13v2.0774,528,332 - 74,558,802 (+)NCBI
CRA_TCAGchr7v2772,075,227 - 72,105,718 (+)NCBI
Fkbp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,320,558 - 135,380,662 (-)NCBIGRCm39mm39
GRCm39 Ensembl5135,320,558 - 135,378,898 (-)Ensembl
GRCm385135,291,704 - 135,351,809 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,291,704 - 135,350,044 (-)EnsemblGRCm38mm10GRCm38
MGSCv375135,767,574 - 135,825,861 (-)NCBIGRCm37mm9NCBIm37
MGSCv365135,576,331 - 135,634,618 (-)NCBImm8
Celera5132,303,410 - 132,361,697 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.11NCBI
Fkbp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,291,260 - 14,318,310 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,291,445 - 14,318,310 (-)NCBIChiLan1.0ChiLan1.0
FKBP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1780,481,443 - 80,511,813 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl780,481,443 - 80,511,813 (+)Ensemblpanpan1.1panPan2
FKBP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,836,043 - 6,868,268 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,836,086 - 6,868,818 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,533,363 - 8,565,559 (-)NCBI
ROS_Cfam_1.066,656,533 - 6,688,674 (-)NCBI
ROS_Cfam_1.0 Ensembl66,656,576 - 6,688,946 (-)Ensembl
UMICH_Zoey_3.166,626,768 - 6,658,955 (-)NCBI
UNSW_CanFamBas_1.066,589,432 - 6,621,560 (-)NCBI
UU_Cfam_GSD_1.066,752,768 - 6,784,970 (-)NCBI
Fkbp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,367,109 - 131,398,573 (-)NCBI
SpeTri2.0NW_0049365432,638,189 - 2,646,589 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKBP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,669,664 - 10,682,618 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,659,456 - 10,716,210 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,365,246 - 10,407,830 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FKBP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1289,688,493 - 9,718,633 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660706,744,849 - 6,774,903 (+)NCBIVero_WHO_p1.0
Fkbp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,369,164 - 14,400,480 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474014,369,214 - 14,400,560 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Fkbp6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,329,204 - 21,329,685 (+)MAPPERmRatBN7.2
Rnor_6.01224,376,848 - 24,377,328NCBIRnor6.0
Rnor_5.01226,374,151 - 26,374,631UniSTSRnor5.0
RGSC_v3.41222,483,639 - 22,484,119UniSTSRGSC3.4
Celera1223,091,638 - 23,092,118UniSTS
Cytogenetic Map12q12UniSTS
D5S503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,381,405 - 21,382,889 (+)MAPPERmRatBN7.2
Rnor_6.01224,429,050 - 24,430,532NCBIRnor6.0
Rnor_5.01226,426,353 - 26,427,835UniSTSRnor5.0
RGSC_v3.41222,535,841 - 22,537,323UniSTSRGSC3.4
Celera1223,143,832 - 23,145,506UniSTS
Cytogenetic Map12q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat


Related Rat Strains
The following Strains have been annotated to Fkbp6

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:57
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000001971
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26
Low 4 1 1 5 8 1
Below cutoff 31 4 1 4 1 3 4 17 2 3 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001971   ⟹   ENSRNOP00000001971
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,319,568 - 21,390,350 (+)Ensembl
Rnor_6.0 Ensembl1224,367,199 - 24,438,019 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094090   ⟹   ENSRNOP00000086905
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,319,568 - 21,390,350 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098264   ⟹   ENSRNOP00000083089
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,319,682 - 21,390,350 (+)Ensembl
RefSeq Acc Id: NM_001105922   ⟹   NP_001099392
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21221,319,568 - 21,390,350 (+)NCBI
Rnor_6.01224,367,211 - 24,437,993 (+)NCBI
Rnor_5.01226,363,264 - 26,435,311 (+)NCBI
RGSC_v3.41222,474,002 - 22,544,784 (+)RGD
Celera1223,082,103 - 23,152,967 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249131   ⟹   XP_006249193
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21221,319,645 - 21,390,313 (+)NCBI
Rnor_6.01224,367,308 - 24,438,088 (+)NCBI
Rnor_5.01226,363,264 - 26,435,311 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769130   ⟹   XP_008767352
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21221,318,251 - 21,340,953 (+)NCBI
Rnor_6.01224,365,941 - 24,380,793 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598299   ⟹   XP_017453788
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21221,318,252 - 21,390,345 (+)NCBI
Rnor_6.01224,365,941 - 24,438,087 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001099392   ⟸   NM_001105922
- UniProtKB: D3ZQF4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249193   ⟸   XM_006249131
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008767352   ⟸   XM_008769130
- Peptide Label: isoform X1
- UniProtKB: D3ZQF4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017453788   ⟸   XM_017598299
- Peptide Label: isoform X1
- UniProtKB: D3ZQF4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001971   ⟸   ENSRNOT00000001971
RefSeq Acc Id: ENSRNOP00000086905   ⟸   ENSRNOT00000094090
RefSeq Acc Id: ENSRNOP00000083089   ⟸   ENSRNOT00000098264
Protein Domains
PPIase FKBP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQF4-F1-model_v2 AlphaFold D3ZQF4 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698555
Promoter ID:EPDNEW_R9080
Type:multiple initiation site
Name:Fkbp6_1
Description:FK506 binding protein 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01224,367,204 - 24,367,264EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
12 26374541 26374542 G T snv FHH/EurMcwi (MCW), SR/JrHsd (MCW)
12 26374616 26374617 A G snv IS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
12 22484029 22484030 G T snv SR/JrHsd (MCW), FHH/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308926 AgrOrtholog
BioCyc Gene G2FUF-19615 BioCyc
Ensembl Genes ENSRNOG00000001451 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001971 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000083089 ENTREZGENE
  ENSRNOP00000083089.1 UniProtKB/TrEMBL
  ENSRNOP00000086905.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001971 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000094090.1 UniProtKB/TrEMBL
  ENSRNOT00000098264 ENTREZGENE
  ENSRNOT00000098264.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FKBP6/shu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPIase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPIase_FKBP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:288597 UniProtKB/Swiss-Prot
NCBI Gene 288597 ENTREZGENE
PANTHER PTHR46674 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FKBP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fkbp6 PhenoGen
PROSITE FKBP_PPIASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_REGION UniProtKB/Swiss-Prot
SMART TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZW77_RAT UniProtKB/TrEMBL
  A0A8I6A6Z3_RAT UniProtKB/TrEMBL
  D3ZQF4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-10-12 Fkbp6  FKBP prolyl isomerase family member 6  Fkbp6  FKBP prolyl isomerase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-11-09 Fkbp6  FKBP prolyl isomerase 6  Fkbp6  FK506 binding protein 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Fkbp6  FK506 binding protein 6  Fkbp6  FK506 binding protein 6, 36kDa  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Fkbp6  FK506 binding protein 6, 36kDa  Fkbp6  FK506 binding protein 6   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fkbp6  FK506 binding protein 6   Fkbp6_predicted  FK506 binding protein 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fkbp6_predicted  FK506 binding protein 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED