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Strain Registration

Strain: NAft:HS

Symbol: NAft:HS
Strain: HS
Substrain: NAft
Full Name: Heterogeneous stock
RGD ID: 6480190
Citation ID: RRID:RGD_6480190
Ontology ID: RS:0003205
Type: outbred
Available Source: Not Available
Origination: Psychiatry and Forensic Medicine, Institute of Neurosciences, School of Medicine, Autonomous University of Barcelona, Barcelona, Spain
Description: From Dr. Eva Redei, Center for Comparative Medicine, Northwestern University to Dr. Alberto Fernandez-Teruel, Barcelona
Last Known Status: Unknown





1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NAft:HSRatabnormal femur head morphology  IAGP 6480192compared to female WKY/NHsdRGD 
NAft:HSRatabnormal femur neck morphology  IAGP 6480192narrower femur neck widthRGD 
NAft:HSRatdecreased anxiety-related response sexual_dimorphismIAGP 6480211compared to malesRGD 
NAft:HSRatdecreased areal bone mineral density  IAGP 6480192femaleRGD 
NAft:HSRatdecreased bone mineral content  IAGP 6480192compared to female BUF/NHsdRGD 
NAft:HSRatdecreased fear-related response sexual_dimorphismIAGP 6480211compared to malesRGD 
NAft:HSRathyperactivity sexual_dimorphismIAGP 6480211compared to malesRGD 
NAft:HSRatimpaired active avoidance behavior  IAGP 6480191compared to RHA/N-diRGD 
NAft:HSRatincreased anxiety-related response  IAGP 6480191compared to RHA/N-diRGD 
NAft:HSRatincreased body weight  IAGP 6480192compared to females of ACI/N more ...RGD 
NAft:HSRatlong femur  IAGP 6480192compared to females of BN/SsNHsd and WKY/NHsdRGD 
1 to 11 of 11 rows

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NAft:HSRatNAft:HS  IEA 7241799 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NAft:HSRatfemur morphology trait  EXP 11528619 RGD 
NAft:HSRatfemur strength trait  EXP 11528619 RGD 
NAft:HSRatlumbar vertebra area  EXP 11528619 RGD 


#
Reference Title
Reference Citation
1. Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility. Alam I, etal., Bone. 2011 May 1;48(5):1169-77. Epub 2011 Feb 18.
2. Fine mapping of bone structure and strength QTLs in heterogeneous stock rat. Alam I, etal., Bone. 2015 Dec;81:417-26. doi: 10.1016/j.bone.2015.08.013. Epub 2015 Aug 19.
3. Gene expression in amygdala as a function of differential trait anxiety levels in genetically heterogeneous NIH-HS rats. Diaz-Moran S, etal., Behav Brain Res. 2013 Sep 1;252:422-31. doi: 10.1016/j.bbr.2013.05.066. Epub 2013 Jun 15.
4. Effects of environmental and physiological covariates on sex differences in unconditioned and conditioned anxiety and fear in a large sample of genetically heterogeneous (N/Nih-HS) rats. Lopez-Aumatell R, etal., Behav Brain Funct. 2011 Nov 25;7:48.
5. Unlearned anxiety predicts learned fear: a comparison among heterogeneous rats and the Roman rat strains. Lopez-Aumatell R, etal., Behav Brain Res. 2009 Aug 24;202(1):92-101. Epub 2009 Mar 28.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines


1 to 8 of 8 rows
Symbol
Name
Trait
Bss113 Bone structure and strength QTL 113 femur morphology trait   (VT:0000559)    
Bss114 Bone structure and strength QTL 114 femur strength trait   (VT:0010010)    
Bss115 Bone structure and strength QTL 115 femur morphology trait   (VT:0000559)    
Bss117 Bone structure and strength QTL 117 femur strength trait   (VT:0010010)    
Bss118 Bone structure and strength QTL 118 femur strength trait   (VT:0010010)    
Bss119 Bone structure and strength QTL 119 lumbar vertebra area   (VT:0010570)    
Bss120 Bone structure and strength QTL 120 femur morphology trait   (VT:0000559)    
Bss121 Bone structure and strength QTL 121 femur morphology trait   (VT:0000559)    
1 to 8 of 8 rows


Note Type Note Reference
strain_other High and low anxious rats were tested by unconditional anxiety tests; after 3 weeks hippocampus was dissected; microarray study showed 29 down-regulated and 37 up-regulated genes between the two groups 9587424
strain_other High and low anxious rats were tested by unconditional anxiety tests; after 3 weeks amygdala was dissected; microarray study showed 6 down-regulated and 28 up-regulated genes between the two groups 9587421

Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-03-14 NAft:HS  Heterogeneous stock  NJfln:HS  Heterogeneous stock  Symbol updated 68687 APPROVED
2012-03-14 NAft:HS  Heterogeneous stock  NAft:HS  Heterogeneous stock  Name updated 68913 APPROVED
2012-03-14 NAft:HS  Heterogeneous stock  NJfln:HS  Heterogeneous stock  Symbol updated 68687 APPROVED
2012-03-14 NAft:HS  Heterogeneous stock  NJfln:HS  Heterogeneous stock  Name updated 68913 APPROVED