Bss118 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bss118 (Bone structure and strength QTL 118) Rattus norvegicus

Symbol: Bss118
Name: Bone structure and strength QTL 118
RGD ID: 11528648
Trait: femur strength trait   (VT:0010010)    
Measurement Type: femur ultimate displacement   (CMO:0002719)    
LOD Score: 6.658
P Value: 2.2E-7
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,638,763 - 43,376,331RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01142,784,725 - 45,474,665RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01145,975,219 - 48,667,416RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41141,400,037 - 44,300,147RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: NAft:HS 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
NAft:HS  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Fine mapping of bone structure and strength QTLs in heterogeneous stock rat. Alam I, etal., Bone. 2015 Dec;81:417-26. doi: 10.1016/j.bone.2015.08.013. Epub 2015 Aug 19.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1304614Epha6Eph receptor A6113975750140708901Rat
1305535Arl6ARF like GTPase 6114071187840738254Rat
1305628Crybg3crystallin beta-gamma domain containing 3114074919840861753Rat
708521Riox2ribosomal oxygenase 2114086136540884782Rat
1584981Nlrp4a-ps1NLR family, pyrin domain containing 4A, pseudogene 1114088428140905699Rat
621564Gabrr3gamma-aminobutyric acid type A receptor subunit rho3114090281240955263Rat
1333369Or5ac25olfactory receptor family 5 subfamily AC member 25114099973441000654Rat
1333619Or5ac24olfactory receptor family 5 subfamily AC member 24114100899041009910Rat
1333309Or5ac23olfactory receptor family 5 subfamily AC member 23114101703341017950Rat
1332924Or5ac23bolfactory receptor family 5 subfamily AC member 23B114103367041034587Rat
1333081Or5ac22olfactory receptor family 5 subfamily AC member 22114105917041060087Rat
1334206Or5ac21olfactory receptor family 5 subfamily AC member 21114107561241076532Rat
1333204Or5ac20-ps1olfactory receptor family 5 subfamily AC member 20, pseudogene 1114111185341112768Rat
1334340Or5h26olfactory receptor family 5 subfamily H member 26114113428641135215Rat
1333449Or5h27olfactory receptor family 5 subfamily H member 27114115137241157144Rat
41029306LOC120095566olfactory receptor 5AC1-like114116051841161438Rat
1334226Or5ac19olfactory receptor family 5 subfamily AC member 19114118427841185201Rat
1333463Olr1537olfactory receptor 1537114121143641212356Rat
1332608Or5h27bolfactory receptor family 5 subfamily H member 27B114123137741232306Rat
1333239Or5h26bolfactory receptor family 5 subfamily H member 26B114124218241243111Rat
1332965Or5k3olfactory receptor family 5 subfamily K member 3114125902641259952Rat
2321335Dppa2l-ps1developmental pluripotency-associated 2 like, pseudogene 1114128999041291084Rat
1334428Or5ac15olfactory receptor family 5 subfamily AC member 15114129629641297216Rat
1332699Or5h25c-ps1olfactory receptor family 5 subfamily H member 25C, pseudogene 1114131677641317700Rat
1333347Or5h25bolfactory receptor family 5 subfamily H member 25B114133311241334035Rat
1334123Or5h25olfactory receptor family 5 subfamily H member 25114135634641357269Rat
1333633Or5h25dolfactory receptor family 5 subfamily H member 25D114136705141367974Rat
1333775Or5h24olfactory receptor family 5 subfamily H member 24114137800041378923Rat
1333231Or5h24bolfactory receptor family 5 subfamily H member 24B114138858541389508Rat
1333850Or5h19-ps1olfactory receptor family 5 subfamily H member 19, pseudogene 1114140506841405998Rat
1333073Or5h18olfactory receptor family 5 subfamily H member 18114140519441423800Rat
1333634Or5bv1-ps1olfactory receptor family 5 subfamily BV member 1, pseudogene 1114142793941428782Rat
1332847Or5h17olfactory receptor family 5 subfamily H member 17114146211641463045Rat
1332676Or5at2-ps1olfactory receptor family 5 subfamily AT member 2, pseudogene 1114148826041489090Rat
1332966Or5h17bolfactory receptor family 5 subfamily H member 17B114149485741503724Rat
1332787Or5at1-ps1olfactory receptor family 5 subfamily AT member 1, pseudogene 1114151110141512226Rat
1332995Or5h17colfactory receptor family 5 subfamily H member 17C114151786541518794Rat
1333626Or5k17olfactory receptor family 5 subfamily K member 17114158879541589748Rat
1333528Or5k16olfactory receptor family 5 subfamily K member 16114160071641601669Rat
1333735Or5k15olfactory receptor family 5 subfamily K member 15114161240141613354Rat
1333804Or5k8olfactory receptor family 5 subfamily K member 8114164417641645105Rat
1333929Or5k14olfactory receptor family 5 subfamily K member 14114166915541670084Rat
1332816Olr1563olfactory receptor 1563114172396541724894Rat
1333068Olr1564olfactory receptor 1564114175630441757230Rat
1588125Or5k1-ps1olfactory receptor family 5 subfamily K member 1, pseudogene 1114182633741827302Rat
41374848LOC120095756small nucleolar RNA SNORA17114184305941843187Rat
1359273Cldnd1claudin domain containing 1114188312041889471Rat
1306639Gpr15G protein-coupled receptor 15114189830041899646Rat
1311817Cpoxcoproporphyrinogen oxidase114193658541946568Rat
1590640Ftdc2ferritin domain containing 2114196794741973373Rat
11424835LOC108352322ferritin heavy chain-like114198171941990330Rat
1303279St3gal6ST3 beta-galactoside alpha-2,3-sialyltransferase 6114206128242121801Rat
11379447LOC108352323uncharacterized LOC108352323114210220042107136Rat
620543Dcbld2discoidin, CUB and LCCL domain containing 2114212552542179927Rat
41319680LOC120095647uncharacterized LOC120095647114212974442136208Rat
1590575Rps28l1ribosomal protein S28 like 1114225453342260302Rat
1589464Mapk3-ps3mitogen activated protein kinase 3, pseudogene 3114235289542364220Rat
1597040Ptma-ps7prothymosin alpha, pseudogene 7114237405442374940Rat
40945973LOC120095648uncharacterized LOC120095648114249835442535259Rat
41238407LOC120095745small nucleolar RNA SNORA17114266317342663305Rat
1309361Col8a1collagen type VIII alpha 1 chain114277685142906432Rat
1309437Cmss1cms1 ribosomal small subunit homolog114293439043232624Rat
1565927Filip1lfilamin A interacting protein 1-like114293735343177085Rat
1306090Tmem30ctransmembrane protein 30C114323966143258506Rat
11393230Rps13-ps3ribosomal protein S13, pseudogene 3114325865143260045Rat
1586130Rpsa-ps2ribosomal protein SA, pseudogene 2114327873543279707Rat
1307925Tbc1d23TBC1 domain family, member 23114330335543361507Rat
41238602Trnaa-agc25transfer RNA alanine (anticodon AGC) 25114331457243314644Rat
11409922LOC108352326ribosome biogenesis protein NSA2 homolog pseudogene114336196643362910Rat
1310494Nit2nitrilase family, member 2114336383943378713Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
40546D11Rat71162114094618840946344Ratregion
42950D11Rat109200114239671342396899Ratregion
41634D11Rat96171114191806341918216Ratregion
44880D11Got38250114297814042978390Ratregion
44881D11Got37259114327745143277710Ratregion
44884D11Got41213114315041143150624Ratregion
44889D11Wox10107114193600541936116Ratregion
44890D11Got35190114219155842191749Ratregion
1636377D11Uwm2142114297811942978261Ratregion
7193090D11Wox10107114193600541936116Ratregion
7206408mMECIR5250114069119340692710Ratregion
5028633RH125651246114188315441883400Ratregion
5029259RH144116223114069734740697570Ratregion
5030157BF389142183114293844042938623Ratregion
5025144AU015720227114336121343361440Ratregion
5025190RH127361208114158817641588384Ratregion
5025850RH129929201114323236143232562Ratregion
5051579AW489850121114188422041884341Ratregion
5056525RH144429157114336048443360640Ratregion
5057402AA945780136114188339041883526Ratregion
5058816BI278071187114235241842352605Ratregion
5058876AI071090184114193749541937679Ratregion
5058422BI290110111114086028240860393Ratregion
5059210BF387674184114209527842095462Ratregion
5051577AI84919589114188422041884309Ratregion
5041790RH129060196114337454443374740Ratregion
5046558RH131822205114212256942122774Ratregion
5047702RH132479180114337480943374989Ratregion
5045736RH131349163114193665241936815Ratregion
5049278RH133388189114219307042193259Ratregion
5049568RH133556191114073764940737840Ratregion
5043152RH129862214114337471543374929Ratregion
5078114RH140152206114212144642121652Ratregion
5079056RH140710179114212564142125820Ratregion
5080226RH141458217114212080742121024Ratregion
5071634RH135196217114248540042485616Ratregion
5066930AU048066262114191799941918256Ratregion
5067964AU047431124114081980440819928Ratregion
5060618BE11068497114309251943092616Ratregion
5061302BI293688185114299415142994336Ratregion
5081212RH142029205114193511041935315Ratregion
5085980AI411100163114337457743374740Ratregion
5086616AA818342181114290907642909257Ratregion
5084062AI175437120114293737942937499Ratregion
5505508RH666070114213827642139144Ratregion
5507007fj02a09.x10114321282643213450Ratregion
5507007fj02a09.x10114321284643213450Ratregion
5502349RH124562159114188330941883468Ratregion
5500615RH1362620114336267243362889Ratregion
5502907Mapk30114235231542353222Ratregion
11528645rs105204296114107208041072080Ratregion
11528646rs1074208840114063876340638763Ratregion
11528647rs198448974114337633143376331Ratregion
Position Markers

Flank 1: (rs107420884)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21140,638,763 - 40,638,763RGD
Rnor_6.01142,784,725 - 42,784,725RGD
Peak: (rs105204296)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21141,072,080 - 41,072,080RGD
Rnor_6.01145,611,977 - 45,611,977RGD
Flank 2: (rs198448974)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21143,376,331 - 43,376,331RGD
Rnor_6.01145,474,665 - 45,474,665RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
11528648Bss118Bone structure and strength QTL 1186.6582e-07femur strength trait (VT:0010010)femur ultimate displacement (CMO:0002719)114063876343376331Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general number of animals used: 1524 HS rats (728 male, 796 female) were used. 11528619
qtl_general measurement method: Rats on a standard diet were euthanized at 17 to 20 weeks of age, and right femurs were analyzed using a material testing machine (Alliance RT/5,MTS Systems Corp., Eden Prairie, USA). 11528619