Gabrr3 (gamma-aminobutyric acid type A receptor subunit rho3) - Rat Genome Database

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Gene: Gabrr3 (gamma-aminobutyric acid type A receptor subunit rho3) Rattus norvegicus
Analyze
Symbol: Gabrr3
Name: gamma-aminobutyric acid type A receptor subunit rho3
RGD ID: 621564
Description: Enables protein domain specific binding activity. Predicted to be involved in several processes, including chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in neuron projection and synapse. Orthologous to human GABRR3 (gamma-aminobutyric acid type A receptor subunit rho3); INTERACTS WITH ammonium chloride; bisphenol A; capsaicin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GABA receptor rho-3 subunit; GABA(A) receptor subunit rho-3; GABA(C) receptor; gamma-aminobutyric acid (GABA) A receptor, rho 3; gamma-aminobutyric acid (GABA) receptor, rho 3; gamma-aminobutyric acid receptor subunit rho-3; gamma-aminobutyric acid type A receptor rho3 subunit; Loc192258
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21140,902,812 - 40,955,263 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,902,812 - 40,955,263 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,634,771 - 49,694,334 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01142,306,048 - 42,365,611 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01141,434,713 - 41,494,277 (-)NCBIRnor_WKY
Rnor_6.01143,046,987 - 43,099,754 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,046,987 - 43,099,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,236,525 - 46,289,103 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41141,667,754 - 41,720,246 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11141,725,342 - 41,777,835 (-)NCBI
Celera1140,744,702 - 40,797,196 (-)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. Croci C, etal., J Biol Chem 2003 Feb 21;278(8):6128-35.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA. Ogurusu T and Shingai R, Biochim Biophys Acta 1996 Feb 7;1305(1-2):15-8.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18201822  


Genomics

Comparative Map Data
Gabrr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21140,902,812 - 40,955,263 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,902,812 - 40,955,263 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,634,771 - 49,694,334 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01142,306,048 - 42,365,611 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01141,434,713 - 41,494,277 (-)NCBIRnor_WKY
Rnor_6.01143,046,987 - 43,099,754 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,046,987 - 43,099,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,236,525 - 46,289,103 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41141,667,754 - 41,720,246 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11141,725,342 - 41,777,835 (-)NCBI
Celera1140,744,702 - 40,797,196 (-)NCBICelera
Cytogenetic Map11q12NCBI
GABRR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38397,985,102 - 98,035,315 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl397,985,102 - 98,035,315 (-)EnsemblGRCh38hg38GRCh38
GRCh37397,703,946 - 97,754,159 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36399,188,217 - 99,236,521 (-)NCBINCBI36Build 36hg18NCBI36
Celera396,095,069 - 96,143,378 (-)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef395,075,402 - 95,124,029 (-)NCBIHuRef
CHM1_1397,668,556 - 97,717,165 (-)NCBICHM1_1
T2T-CHM13v2.03100,690,399 - 100,739,013 (-)NCBIT2T-CHM13v2.0
Gabrr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391659,227,745 - 59,282,102 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1659,227,695 - 59,284,867 (+)EnsemblGRCm39 Ensembl
GRCm381659,407,382 - 59,461,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1659,407,332 - 59,464,504 (+)EnsemblGRCm38mm10GRCm38
MGSCv371659,407,208 - 59,461,565 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361659,349,638 - 59,406,760 (+)NCBIMGSCv36mm8
Celera1659,758,499 - 59,813,863 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
Gabrr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540797,769 - 143,157 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540797,769 - 143,157 (+)NCBIChiLan1.0ChiLan1.0
GABRR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1395,904,816 - 95,953,373 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0395,059,408 - 95,108,224 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13101,743,832 - 101,792,080 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3101,743,832 - 101,792,080 (-)Ensemblpanpan1.1panPan2
GABRR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1335,013,983 - 5,036,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha335,193,819 - 5,216,102 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0335,123,213 - 5,144,571 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1334,998,770 - 5,035,053 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0335,060,506 - 5,082,050 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0335,333,964 - 5,356,333 (-)NCBIUU_Cfam_GSD_1.0
Gabrr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602152,197,786 - 152,242,684 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366663,273,741 - 3,318,125 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366663,272,980 - 3,318,138 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13162,281,149 - 162,319,789 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113162,281,067 - 162,319,459 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GABRR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12282,658,575 - 82,712,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2282,661,366 - 82,712,282 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604183,899,065 - 83,954,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabrr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478910,446,071 - 10,506,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabrr3
345 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:32
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000002281
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat

Markers in Region
D11Rat71  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,946,188 - 40,946,344 (+)MAPPERmRatBN7.2
Rnor_6.01143,090,338 - 43,090,493NCBIRnor6.0
Rnor_5.01146,280,029 - 46,280,184UniSTSRnor5.0
RGSC_v3.41141,711,171 - 41,711,327RGDRGSC3.4
RGSC_v3.41141,711,172 - 41,711,327UniSTSRGSC3.4
RGSC_v3.11141,768,538 - 41,769,067RGD
Celera1140,788,124 - 40,788,287UniSTS
SHRSP x BN Map1113.7799RGD
SHRSP x BN Map1113.7799UniSTS
Cytogenetic Map11q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 22 6 11 6 1 1 11 1 13 3 1
Below cutoff 2 10 11 11 8 11 7 9 35 10 15 8 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002281   ⟹   ENSRNOP00000002281
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,902,812 - 40,955,263 (-)Ensembl
Rnor_6.0 Ensembl1143,046,987 - 43,099,412 (-)Ensembl
RefSeq Acc Id: NM_138897   ⟹   NP_620252
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21140,902,812 - 40,955,263 (-)NCBI
Rnor_6.01143,046,987 - 43,099,412 (-)NCBI
Rnor_5.01146,236,525 - 46,289,103 (-)NCBI
RGSC_v3.41141,667,754 - 41,720,246 (-)RGD
Celera1140,744,702 - 40,797,196 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620252 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA09322 (Get FASTA)   NCBI Sequence Viewer  
  EDM10994 (Get FASTA)   NCBI Sequence Viewer  
  P50573 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_620252   ⟸   NM_138897
- Peptide Label: precursor
- UniProtKB: P50573 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002281   ⟸   ENSRNOT00000002281

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50573-F1-model_v2 AlphaFold P50573 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621564 AgrOrtholog
BioCyc Gene G2FUF-21616 BioCyc
Ensembl Genes ENSRNOG00000001679 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000002281 ENTREZGENE
  ENSRNOP00000002281.4 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002281 ENTREZGENE
  ENSRNOT00000002281.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot
  Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
KEGG Report rno:192258 UniProtKB/Swiss-Prot
NCBI Gene 192258 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-3 UniProtKB/Swiss-Prot
  PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PhenoGen Gabrr3 PhenoGen
PRINTS GABAARECEPTR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
TIGRFAMs LIC UniProtKB/Swiss-Prot
UniProt GBRR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-28 Gabrr3  gamma-aminobutyric acid type A receptor subunit rho3  Gabrr3  gamma-aminobutyric acid type A receptor rho3 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-01-10 Gabrr3  gamma-aminobutyric acid type A receptor rho3 subunit  Gabrr3  gamma-aminobutyric acid (GABA) A receptor, rho 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Gabrr3  gamma-aminobutyric acid (GABA) A receptor, rho 3  Gabrr3  gamma-aminobutyric acid (GABA) receptor, rho 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gabrr3  gamma-aminobutyric acid (GABA) receptor, rho 3  Loc192258  GABA receptor rho-3 subunit  Symbol and Name updated 1299863 APPROVED
2002-08-07 Loc192258  GABA receptor rho-3 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in retina 633236