Cpox (coproporphyrinogen oxidase)

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Gene: Cpox (coproporphyrinogen oxidase) Rattus norvegicus

Analyze

Symbol:

Cpox

Name:

coproporphyrinogen oxidase

RGD ID:

1311817

Description:

Enables coproporphyrinogen oxidase activity and identical protein binding activity. Involved in several processes, including protoporphyrinogen IX biosynthetic process; response to lead ion; and response to methylmercury. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

coprogen oxidase; coproporphyrinogen-III oxidase, mitochondrial; coproporphyrinogenase; COX; LOC304024; MGC124847; oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CPOX (coproporphyrinogen oxidase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cpox (coproporphyrinogen oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cpox (coproporphyrinogen oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CPOX (coproporphyrinogen oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CPOX (coproporphyrinogen oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cpox (coproporphyrinogen oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CPOX (coproporphyrinogen oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CPOX (coproporphyrinogen oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cpox (coproporphyrinogen oxidase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CPOX (coproporphyrinogen oxidase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cpox (coproporphyrinogen oxidase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cpox (coproporphyrinogen oxidase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Coprox	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HEM13	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	41,936,585 - 41,946,568 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	41,936,591 - 41,946,746 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	50,684,226 - 50,694,252 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	43,345,792 - 43,355,818 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	42,474,428 - 42,484,454 (-)	NCBI	Rnor_WKY
Rnor_6.0	11	44,039,665 - 44,049,648 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	44,039,669 - 44,049,648 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	47,229,581 - 47,239,564 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	42,748,703 - 42,758,686 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	42,807,556 - 42,935,211 (-)	NCBI
Celera	11	41,735,836 - 41,745,819 (-)	NCBI		Celera
Cytogenetic Map	11	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute intermittent porphyria (ISO)

Coproporphyria (ISO)

Experimental Arthritis (IEP)

Harderoporphyria (ISO)

Hepatic Porphyrias (IEP)

hereditary coproporphyria (ISO)

liver disease (ISO)

porphyria cutanea tarda (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (EXP)

3-methylcholanthrene (ISO)

5-aminolevulinic acid hexyl ester (ISO)

7,12-dimethyltetraphene (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

coproporphyrinogen III (ISO)

cyclosporin A (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ferroheme b (ISO)

finasteride (EXP)

fluoranthene (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

heme b (ISO)

hyaluronic acid (EXP)

hydrogen peroxide (EXP)

Isocoproporphyrin (ISO)

ivermectin (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methapyrilene (EXP)

nefazodone (EXP)

nitrofen (EXP)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

protoporphyrinogen (ISO)

SB 431542 (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

thapsigargin (EXP)

topotecan (EXP)

trimellitic anhydride (ISO)

trovafloxacin (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

heme biosynthetic process (IDA,ISO)

protoporphyrinogen IX biosynthetic process (IBA,IDA,IEA)

response to arsenic-containing substance (IEP)

response to inorganic substance (IEP)

response to insecticide (IEP)

response to iron ion (IEP)

response to lead ion (IEP)

response to methylmercury (IEP)

Cellular Component

cytoplasm (IBA)

cytosol (IEA,ISO)

membrane (ISO)

mitochondrial inner membrane (IDA)

mitochondrial intermembrane space (IBA,IDA)

mitochondrion (IDA,ISO)

Molecular Function

coproporphyrinogen oxidase activity (IBA,IDA,IEA,ISO)

identical protein binding (IDA)

protein homodimerization activity (ISO,ISS)

structural constituent of eye lens (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acute intermittent porphyria pathway (ISO)

erythropoietic porphyria pathway (ISO)

heme biosynthetic pathway (IEA,ISO)

hereditary coproporphyria pathway (ISO)

porphyrin and chlorophyll metabolic pathway (IEA)

porphyrin metabolic pathway (ISO)

variegate porphyria pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Effects of iron deficiency and chronic iron overloading on mitochondrial heme biosynthetic enzymes in rat liver.	Abraham NG, etal., Biochim Biophys Acta. 1986 Mar 28;870(2):339-49.
2.	Decreased activity of liver coproporphyrinogen oxidase in hexachlorobenzene-induced porphyria.	Adjarov DG, Exp Pathol. 1990;40(2):117-22. doi: 10.1016/s0232-1513(11)80331-2.
3.	Biosynthesis of heme in mammals.	Ajioka RS, etal., Biochim Biophys Acta. 2006 Jul;1763(7):723-36. Epub 2006 Jun 3.
4.	Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors.	Barupala DP, etal., Arch Biochem Biophys. 2016 Feb 15;592:60-75. doi: 10.1016/j.abb.2016.01.010. Epub 2016 Jan 16.
5.	The mitochondrial location of protoporphyrinogen oxidase.	Deybach JC, etal., Eur J Biochem. 1985 Jun 3;149(2):431-5.
6.	Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria.	Fujita H, etal., Hum Mol Genet. 1994 Oct;3(10):1807-10.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	GenMAPP: Gene Map Annotator and Pathway Profiler	GenMAPP
9.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
10.	Hepatic drug metabolism and haem biosynthesis in lead-poisoned rats.	Goldberg A, etal., Br J Pharmacol. 1978 Apr;62(4):529-36.
11.	The mitochondrial localization of coproporphyrinogen III oxidase.	Grandchamp B, etal., Biochem J. 1978 Oct 15;176(1):97-102.
12.	A high-performance-liquid-chromatographic method for the assay of coproporphyrinogen oxidase activity in rat liver.	Li F, etal., Biochem J. 1986 Oct 15;239(2):481-4.
13.	Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in iron-overloaded and ethanol-treated rats.	Li F, etal., Biomed Chromatogr. 1990 Nov;4(6):253-6.
14.	Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations.	Loskove Y, etal., Mol Genet Metab. 2019 Nov;128(3):352-357. doi: 10.1016/j.ymgme.2018.10.008. Epub 2018 Oct 26.
15.	The site of inhibition of porphyrin biosynthesis by an isomer of diazinon in rats.	Nichol AW, etal., Biochem Pharmacol. 1983 Sep 15;32(18):2653-7.
16.	Harderoporphyria: a variant hereditary coproporphyria.	Nordmann Y, etal., J Clin Invest. 1983 Sep;72(3):1139-49. doi: 10.1172/JCI111039.
17.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
18.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
19.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
20.	GOA pipeline	RGD automated data pipeline
21.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
23.	Systematic analysis of coproporphyrinogen oxidase gene defects in hereditary coproporphyria and mutation update.	Rosipal R, etal., Hum Mutat. 1999;13(1):44-53. doi: 10.1002/(SICI)1098-1004(1999)13:1<44::AID-HUMU5>3.0.CO;2-Q.
24.	Hexachlorobenzene treatment on hepatic mitochondrial function parameters and intracellular coproporphyrinogen oxidase location.	Sopena YE, etal., Int J Toxicol. 2008 Nov;27(6):455-65.
25.	Function and structure of rat hepatic coproporphyrinogen oxidase.	Sorianello EM and Mazzetti MB, Comp Biochem Physiol B Biochem Mol Biol. 2000 Oct;127(2):155-64.
26.	Biochemical and genetic characterization of four cases of hereditary coproporphyria in Spain.	To-Figueras J, etal., Mol Genet Metab. 2005 Jun;85(2):160-3. doi: 10.1016/j.ymgme.2004.12.012. Epub 2005 Feb 25.
27.	Liver haem metabolism in adjuvant-induced arthritic rats.	Toda A, etal., Xenobiotica. 1996 Apr;26(4):415-23.
28.	Two novel mutations and coexistence of the 991C>T and the 1339C>T mutation on a single allele in the coproporphyrinogen oxidase gene in Swedish patients with hereditary coproporphyria.	Wiman A, etal., J Hum Genet. 2002;47(8):407-12. doi: 10.1007/s100380200059.
29.	Studies on the etiology of trace metal-induced porphyria: effects of porphyrinogenic metals on coproporphyrinogen oxidase in rat liver and kidney.	Woods JS and Southern MR, Toxicol Appl Pharmacol. 1989 Jan;97(1):183-90.

Additional References at PubMed

PMID:8407975	PMID:12470976	PMID:12477932	PMID:14651853	PMID:15482256	PMID:16176984	PMID:18614015	PMID:20080761

Genomics

Comparative Map Data

Cpox
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	41,936,585 - 41,946,568 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	41,936,591 - 41,946,746 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	50,684,226 - 50,694,252 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	43,345,792 - 43,355,818 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	42,474,428 - 42,484,454 (-)	NCBI	Rnor_WKY
Rnor_6.0	11	44,039,665 - 44,049,648 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	44,039,669 - 44,049,648 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	47,229,581 - 47,239,564 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	42,748,703 - 42,758,686 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	42,807,556 - 42,935,211 (-)	NCBI
Celera	11	41,735,836 - 41,745,819 (-)	NCBI		Celera
Cytogenetic Map	11	q12	NCBI

CPOX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	98,570,488 - 98,593,611 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	98,579,446 - 98,593,648 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	98,298,290 - 98,312,455 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	99,780,980 - 99,795,131 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	99,780,981 - 99,795,131	NCBI
Celera	3	96,689,942 - 96,704,107 (-)	NCBI		Celera
Cytogenetic Map	3	q11.2	NCBI
HuRef	3	95,670,419 - 95,684,588 (-)	NCBI		HuRef
CHM1_1	3	98,261,466 - 98,275,631 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	101,283,116 - 101,297,297 (-)	NCBI		T2T-CHM13v2.0

Cpox
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	58,490,571 - 58,500,754 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	58,490,655 - 58,537,999 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	58,670,208 - 58,680,391 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	58,670,292 - 58,717,636 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	58,670,321 - 58,680,504 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	58,612,835 - 58,622,904 (+)	NCBI		MGSCv36	mm8
Celera	16	58,961,121 - 58,971,379 (+)	NCBI		Celera
Cytogenetic Map	16	C1.2	NCBI

Cpox
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955427	152,894 - 164,030 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955427	152,397 - 163,570 (-)	NCBI	ChiLan1.0	ChiLan1.0

CPOX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	102,358,149 - 102,372,323 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	102,359,382 - 102,372,170 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	95,674,861 - 95,689,139 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

CPOX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	5,446,022 - 5,459,152 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	5,447,414 - 5,459,461 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	5,596,705 - 5,613,382 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	5,579,096 - 5,595,946 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	5,535,265 - 5,595,946 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	5,456,702 - 5,473,645 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	5,519,969 - 5,536,809 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	5,796,805 - 5,813,754 (-)	NCBI		UU_Cfam_GSD_1.0

Cpox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	151,514,512 - 151,526,977 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936630	4,412,273 - 4,425,520 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936630	4,412,099 - 4,424,867 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CPOX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	160,332,436 - 160,348,232 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	160,332,436 - 160,345,862 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	170,521,920 - 170,535,349 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CPOX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	82,252,163 - 82,265,827 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	82,251,972 - 82,267,350 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	84,286,976 - 84,301,373 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cpox
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624789	11,435,779 - 11,448,984 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624789	11,435,955 - 11,448,867 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cpox
41 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	151
Count of miRNA genes:	122
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000002257
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
1641927	Alcrsp10	Alcohol response QTL 10			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	11	8436674	53436674	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	16472047	44285911	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	29528418	60324829	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat

Markers in Region

RH131349

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	41,936,652 - 41,936,815 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	44,039,733 - 44,039,895	NCBI	Rnor6.0
Rnor_5.0	11	47,229,649 - 47,229,811	UniSTS	Rnor5.0
RGSC_v3.4	11	42,748,771 - 42,748,933	UniSTS	RGSC3.4
Celera	11	41,735,904 - 41,736,066	UniSTS
Cytogenetic Map	11	q12	UniSTS

AI071090

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	41,937,495 - 41,937,679 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	44,040,576 - 44,040,759	NCBI	Rnor6.0
Rnor_5.0	11	47,230,492 - 47,230,675	UniSTS	Rnor5.0
RGSC_v3.4	11	42,749,614 - 42,749,797	UniSTS	RGSC3.4
Celera	11	41,736,747 - 41,736,930	UniSTS
RH 3.4 Map	11	304.6	UniSTS
Cytogenetic Map	11	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	33	54	41	19	41	2	4	74	35	34	11	2
Low		10	3				6	7			7		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC107664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000002257 ⟹ ENSRNOP00000002257

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	41,936,591 - 41,946,746 (-)	Ensembl
Rnor_6.0 Ensembl	11	44,039,669 - 44,049,648 (-)	Ensembl

RefSeq Acc Id:

NM_001037095 ⟹ NP_001032172

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	41,936,585 - 41,946,568 (-)	NCBI
Rnor_6.0	11	44,039,665 - 44,049,648 (-)	NCBI
Rnor_5.0	11	47,229,581 - 47,239,564 (-)	NCBI
RGSC_v3.4	11	42,748,703 - 42,758,686 (-)	RGD
Celera	11	41,735,836 - 41,745,819 (-)	RGD

Sequence:

show sequence

CAATACCAGGGAGTCTCGGTCTCTAGATCCTGGGAGCTCCCGTGGATCTGCAGGATCCGCGCTG
CCCAGTCCCGGCGGGAGATGGCCTTGCGGCTGGGCCAGCTAGGCTCGGGCCCCTGGTGGCGAGC
GGTGCGAGGTGACTATGCACAGCTGCGCGCCCCGTCCCCTCGCAGCGCGTCCGCCTGCGTCTGC
CGGCTGCCTGGCACCGCCGGTACCCAGCCTCGCCGCGGGCTGGGCCACGGCTCCTCGGCTGGAG
GCGGGTCCCGGCTGGGGACCGGGCTGGCCGCGGCGCTGGCGGGGATGGCAGGGCTGGCAGCCGC
CGTCTTAGGGCACGTGCAGCGGGCGGAGATGGTGCCCAAGAGCTCGGGGGCGCGGAGCCCCTCA
CCTGGACGGCTGGAGGAGGACGGGGACGAGCTGGCCCGCCGCTGCAGCACCTTCATGTCCTCGC
CGGTGACCGAGCTGCGGGAGCTGGGGAGAAGGCCGGATGACATGAAGACCAAGATGGAGCTGAT
GATTATGGAGACCCAGGCCCAGGTGTGTCGGGCGCTGGCACAGGTAGACGGAGTCGCTGACTTC
TCTGTGGACCGATGGGAGAGGAAGGAAGGAGGTGGTGGCATCACCTGTGTGCTTCAGGACGGGC
GTGTGTTTGAGAAGGCCGGGGTGAACATTTCTGTCGTTCATGGGAATCTTTCTGAGGAGGCAGC
AAACCAAATGAGAAGCAGAGGAAAAGCCCTGAAGAAGAAAGATGGTAAATTGCCGTTTACTGCT
ATGGGTATAAGCTCCGTGATTCACCCTAAGAATCCTTATGCACCCACCATGCATTTCAACTATA
GATACTTCGAAGTAGAAGAAGCTGATGGTAAGATGCATTGGTGGTTTGGGGGTGGATGTGACCT
CACACCGACATACCTGAACCGAGAGGATGCCGTCCATTTCCACCGTACTCTGAAGGAAGCTTGC
GATCAGCACGGGCCAGACATCTACCCCAAATTTAAAAAATGGTGTGACGACTACTTCTTCATAG
CACATCGCGGGGAGCGGAGGGGCATCGGCGGCATCTTTTTCGATGACCTCGACTCTCCATCCAA
GGAGGAGGCGTTCCGCTTTGTGAAGACGTGTGCCGAGGCAGTGGTTCCTTCCTATGTTCCCATT
GTGAAAAAGCACTGTGATGACTCCTACACCCCCCAGGATAAGCTGTGGCAGCAGCTGAGGAGAG
GGCGGTATGTAGAGTTTAATCTGGTGTATGATCGGGGCACCAAGTTTGGCCTCTTTACTCCAGG
ATCCAGGATCGAAAGCATCTTGATGTCTTTACCTCTAACAGCAAGGTGGGAGTATATGCATTCC
CCTCCAGAGAATTCCAAAGAAGCTGAAATTCTGGAAGTGCTGCGCCATCCAAAGGACTGGGTGC
ACTGATGTGCAGAGCCTTGCTCCAGGGCCTGGTGGTCGCAGGTGGGGTCTTCCTGCACCCTGGC
CACCGTGTGGCAGGCAGTGTCTTCTGTGCCTTACCGTCCCCACCTTCTCCACCGTGGGCATTCC
TCTGTGTCAGGTGGTTTTGGTCTTTTCTAGTGCTGTGGCAAAGGTGGGTGGGGATATAAAAGTG
CCCAATTTGTTGTCCGTGAAATTCATTTGTACGTTTCTATGCAGTTTCTATGACCAGTCAATTT
GACATTGGGTTTCCAGGTCTTAAGTTAAGGGAGTGTAAATACTATGATACCCACCAGGAAACTC
ATTTTGTTTGTTGTTTGAAGTTCTAGTTTTTGCTACAGACATTTATCAGGGGATACATTTTATC
TTCATTAGTTCAGTCAGGCTGCCCTTCTTGGGAGCTTTAGAATGCAATTGGAAGCCAGGCAGTG
GTGGTGTACGCCTTTAATCCCAGTATTCAGGAAGAAGAGGTTGGTGGATATCTGTGAGTTTGAG
GCCAGCTTGGTCTACAAAGGGCGTTCTAGTATAGCCAGGGCTACACAGAGGAACCCTGTTTTGA
AAAAGCCAAAAACAAAACAAAAAGAAAAACACAAAAAAAGCAATTTGAAAAAACATGTTTTTCG
TTATTTTTGATGTAATTTCATGTATCTTTCTCTATAGAGCAGAATATGATAAAAGTACTCATTT
TTTTTTTTTAAAGATAGCTATTTAAGAGCTCCGGAAATATTCTTTAGTCAGTTCTTGCATTATA
TAATGTTGACCTAGTTTACAGCTGCAAATGGCATTACCATTATTTAAATAAGGGACGTCTTGAA
TGGTGAGGTTTTTGTGGGATTATAACCTGCTAACATTAGGATTCTATGTATTTTTTAAAGCAAA
ACTTACATCCCTGGATTCTGATACTTAAGAGTTTATTTTAGACATTTAGATATGGAAGATTAGA
CTAAGAACAAATGAAACACATTTTTCTCTTTAACTAAAAAGAACAAAGATAGTCTAAGAGGGGC
ATTTTATATTTTTTTAAAAAAATGAGCCAATAGAAATTGTCTTACTTTTCAGATTAGAGATTCT
TCAACTTTTACCTTTTCTTTTAAAAGTCACAGCAGATTTCTTAATGTGTGGTTTATCTGTCTAA
ATAATAGTATGACTGTGCTATGTTATTTGATTTATAATATATTGAATTTGTAAGGCACAATATA
TTATACATAGTTAAATATTATCCTGGAATATGTTAGATGTATATGATTGTGTTTGGCTCTTTTA
GGGTGAGAAAATCTACAAATTCTTCAACTTGTCTTACATAGACAGCTAATAAATTTTATTACAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001032172	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI07665	(Get FASTA)	NCBI Sequence Viewer
	EDM11016	(Get FASTA)	NCBI Sequence Viewer
	Q3B7D0	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001032172 ⟸ NM_001037095
- Peptide Label:	precursor
- UniProtKB:	Q3B7D0 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MALRLGQLGSGPWWRAVRGDYAQLRAPSPRSASACVCRLPGTAGTQPRRGLGHGSSAGGGSRLG TGLAAALAGMAGLAAAVLGHVQRAEMVPKSSGARSPSPGRLEEDGDELARRCSTFMSSPVTELR ELGRRPDDMKTKMELMIMETQAQVCRALAQVDGVADFSVDRWERKEGGGGITCVLQDGRVFEKA GVNISVVHGNLSEEAANQMRSRGKALKKKDGKLPFTAMGISSVIHPKNPYAPTMHFNYRYFEVE EADGKMHWWFGGGCDLTPTYLNREDAVHFHRTLKEACDQHGPDIYPKFKKWCDDYFFIAHRGER RGIGGIFFDDLDSPSKEEAFRFVKTCAEAVVPSYVPIVKKHCDDSYTPQDKLWQQLRRGRYVEF NLVYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPPENSKEAEILEVLRHPKDWVH hide sequence

RefSeq Acc Id:

ENSRNOP00000002257 ⟸ ENSRNOT00000002257

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3B7D0-F1-model_v2	AlphaFold	Q3B7D0	1-443	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698105

Promoter ID:

EPDNEW_R8630

Type:

initiation region

Name:

Cpox_1

Description:

coproporphyrinogen oxidase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	44,049,686 - 44,049,746	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311817	AgrOrtholog
BioCyc Gene	G2FUF-21570	BioCyc
Ensembl Genes	ENSRNOG00000001654	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000002257	ENTREZGENE
	ENSRNOP00000002257.5	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002257	ENTREZGENE
	ENSRNOT00000002257.7	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1500.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7936479	IMAGE-MGC_LOAD
InterPro	Coprogen_oxidase_aer	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Coprogen_oxidase_aer_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Coprogen_oxidase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:304024	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124847	IMAGE-MGC_LOAD
NCBI Gene	304024	ENTREZGENE
PANTHER	PTHR10755	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Coprogen_oxidas	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cpox	PhenoGen
PRINTS	COPRGNOXDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	COPROGEN_OXIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF102886	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2UHB5_RAT	UniProtKB/TrEMBL
	HEM6_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Cpox	coproporphyrinogen oxidase	Cpox_predicted	coproporphyrinogen oxidase (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Cpox_predicted	coproporphyrinogen oxidase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)