Gene: Cpox (coproporphyrinogen oxidase) Rattus norvegicus
Analyze
Symbol:
Cpox
Name:
coproporphyrinogen oxidase
Description:
Exhibits coproporphyrinogen oxidase activity and identical protein binding activity. Involved in several processes, including protoporphyrinogen IX biosynthetic process; response to lead ion; and response to methylmercury. Localizes to the mitochondrial inner membrane and mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; INTERACTS WITH 2,6-dinitrotoluene; bisphenol A; finasteride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
coprogen oxidase; coproporphyrinogen-III oxidase, mitochondrial; coproporphyrinogenase; COX; LOC304024; MGC124847; oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CPOX (coproporphyrinogen oxidase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Cpox (coproporphyrinogen oxidase) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cpox (coproporphyrinogen oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CPOX (coproporphyrinogen oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CPOX (coproporphyrinogen oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cpox (coproporphyrinogen oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CPOX (coproporphyrinogen oxidase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
CPOX (coproporphyrinogen oxidase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Cpox (coproporphyrinogen oxidase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cpox (coproporphyrinogen oxidase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Coprox
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
HEM13
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 11 44,039,665 - 44,049,648 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 11 44,039,669 - 44,049,648 (-) Ensembl Rnor_5.0 11 47,229,581 - 47,239,564 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 11 42,748,703 - 42,758,686 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 11 42,807,556 - 42,935,211 (-) NCBI Celera 11 41,735,836 - 41,745,819 (-) NCBI Celera Cytogenetic Map 11 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
acute porphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by term: Acute Porphyria ClinVar PMID:15967199 , PMID:19339664 Coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:11309681 more ... Coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by term: Coproporphyria, digenic ClinVar PMID:16398658 Coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:7987309 more ... Coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:8990017 Coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:7987309 Coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:11309681 , PMID:12181641 Coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:12227458 Coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:12181641 Harderoporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:9454777 Harderoporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:21103937 Harderoporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by null ClinVar PMID:6886003 more ... hereditary coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by term: Hereditary coproporphyria ClinVar PMID:28492532 hereditary coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by OMIM:121300 ClinVar PMID:15967199 , PMID:19339664 hereditary coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by OMIM:121300 ClinVar hereditary coproporphyria ISO RGD:1323470 8554872 ClinVar Annotator: match by OMIM:121300 ClinVar PMID:11309681 , PMID:12181641
Imported Annotations - CTD
hereditary coproporphyria ISO RGD:1323470 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11831056 porphyria cutanea tarda ISO RGD:1323470 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11831056 Imported Annotations - OMIM
hereditary coproporphyria ISO RGD:1323470 7240710 OMIM
17alpha-ethynylestradiol increases expression ISO RGD:1323471 6480464 Ethinyl Estradiol results in increased expression of CPOX mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1323471 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CPOX mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1323471 6480464 [Tetrachlorodibenzodioxin co-treated with Estradiol] results in decreased expression of CPOX mRNA CTD PMID:18691609 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1323471 6480464 [Tetrachlorodibenzodioxin co-treated with Estradiol] results in decreased expression of CPOX mRNA more ... CTD PMID:15034205 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1323471 6480464 Tetrachlorodibenzodioxin results in decreased expression of CPOX mRNA CTD PMID:28213091 , PMID:29673856 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1323471 6480464 Tetrachlorodibenzodioxin affects the expression of CPOX mRNA CTD PMID:21570461 , PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1323471 6480464 Tetrachlorodibenzodioxin results in increased expression of CPOX mRNA, Tetrachlorodibenzodioxin results in increased expression of CPOX protein CTD PMID:15034205 more ... 2,4-diaminotoluene increases expression ISO RGD:1323471 6480464 2, 4-diaminotoluene results in increased expression of CPOX mRNA CTD PMID:20713471 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of CPOX mRNA CTD PMID:21346803 3,3',4,4',5-pentachlorobiphenyl increases expression ISO RGD:1323471 6480464 3 more ... CTD PMID:23994337 3-methylcholanthrene increases expression ISO RGD:1323471 6480464 Methylcholanthrene results in increased expression of CPOX mRNA CTD PMID:20713471 5-aminolevulinic acid hexyl ester increases expression ISO RGD:1323471 6480464 5-aminolevulinic acid hexyl ester analog results in increased expression of CPOX mRNA CTD PMID:20514459 aflatoxin B1 decreases methylation ISO RGD:1323470 6480464 Aflatoxin B1 results in decreased methylation of CPOX gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:1323470 6480464 Aflatoxin B1 results in decreased expression of CPOX mRNA CTD PMID:27153756 benzo[a]pyrene decreases expression ISO RGD:1323470 6480464 Benzo(a)pyrene results in decreased expression of CPOX mRNA CTD PMID:21632981 benzo[a]pyrene increases expression ISO RGD:1323471 6480464 Benzo(a)pyrene results in increased expression of CPOX mRNA CTD PMID:15034205 more ... benzo[a]pyrene decreases expression ISO RGD:1323471 6480464 Benzo(a)pyrene results in decreased expression of CPOX mRNA CTD PMID:15034205 benzo[a]pyrene multiple interactions ISO RGD:1323471 6480464 AHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of CPOX mRNA], AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CPOX mRNA] CTD PMID:15034205 beta-naphthoflavone increases expression ISO RGD:1323471 6480464 beta-Naphthoflavone results in increased expression of CPOX mRNA CTD PMID:23994337 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CPOX mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:1323470 6480464 bisphenol A affects the expression of CPOX mRNA CTD PMID:30903817 carbon nanotube increases expression ISO RGD:1323471 6480464 Nanotubes, Carbon analog results in increased expression of CPOX mRNA, Nanotubes, Carbon results in increased expression of CPOX mRNA CTD PMID:25554681 , PMID:25620056 cisplatin multiple interactions ISO RGD:1323470 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of CPOX mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:1323470 6480464 Cisplatin results in increased expression of CPOX mRNA CTD PMID:27392435 clofibrate multiple interactions ISO RGD:1323471 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of CPOX mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CPOX mRNA] CTD PMID:17585979 copper(II) sulfate decreases expression ISO RGD:1323470 6480464 Copper Sulfate results in decreased expression of CPOX mRNA CTD PMID:19549813 coproporphyrinogen III decreases carboxylation ISO RGD:1323470 6480464 CPOX protein results in decreased carboxylation of coproporphyrinogen III CTD PMID:19339664 coproporphyrinogen III multiple interactions ISO RGD:1323470 6480464 Mercury inhibits the reaction [CPOX protein results in decreased carboxylation of coproporphyrinogen III] CTD PMID:19339664 cyclosporin A decreases expression ISO RGD:1323470 6480464 Cyclosporine results in decreased expression of CPOX mRNA CTD PMID:25562108 dorsomorphin multiple interactions ISO RGD:1323470 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPOX mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1323470 6480464 Doxorubicin results in decreased expression of CPOX mRNA CTD PMID:29803840 enzyme inhibitor multiple interactions ISO RGD:1323470 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CPOX protein CTD PMID:23301498 ethanol affects splicing ISO RGD:1323471 6480464 Ethanol affects the splicing of CPOX mRNA CTD PMID:30319688 ferroheme b increases chemical synthesis ISO RGD:1323470 6480464 CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 finasteride increases expression EXP 6480464 Finasteride results in increased expression of CPOX mRNA CTD PMID:24136188 fluoranthene increases expression ISO RGD:1323471 6480464 fluoranthene results in increased expression of CPOX mRNA CTD PMID:28329830 fluoranthene multiple interactions ISO RGD:1323471 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of CPOX mRNA CTD PMID:28329830 flutamide increases expression EXP 6480464 Flutamide results in increased expression of CPOX mRNA CTD PMID:24136188 heme b increases chemical synthesis ISO RGD:1323470 6480464 CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 hyaluronic acid multiple interactions EXP 6480464 Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CPOX protein] CTD PMID:23178681 hydrogen peroxide multiple interactions EXP 6480464 Hyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of CPOX protein] CTD PMID:23178681 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of CPOX protein CTD PMID:23178681 mercury atom affects response to substance ISO RGD:1323470 6480464 CPOX polymorphism affects the susceptibility to Mercury more ... CTD PMID:16343843 , PMID:19339664 mercury atom decreases activity ISO RGD:1323470 6480464 Mercury results in decreased activity of CPOX protein CTD PMID:16214298 , PMID:19339664 mercury atom multiple interactions ISO RGD:1323470 6480464 [Mercury results in decreased activity of CPOX protein] which results in increased abundance of Coproporphyrins more ... CTD PMID:16214298 , PMID:19339664 mercury(0) affects response to substance ISO RGD:1323470 6480464 CPOX polymorphism affects the susceptibility to Mercury more ... CTD PMID:16343843 , PMID:19339664 mercury(0) decreases activity ISO RGD:1323470 6480464 Mercury results in decreased activity of CPOX protein CTD PMID:16214298 , PMID:19339664 mercury(0) multiple interactions ISO RGD:1323470 6480464 [Mercury results in decreased activity of CPOX protein] which results in increased abundance of Coproporphyrins more ... CTD PMID:16214298 , PMID:19339664 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of CPOX mRNA CTD PMID:30467583 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of CPOX mRNA CTD PMID:24136188 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CPOX mRNA CTD PMID:25729387 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of CPOX mRNA CTD PMID:25729387 paracetamol multiple interactions ISO RGD:1323471 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of CPOX mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CPOX mRNA] CTD PMID:17585979 paracetamol increases expression ISO RGD:1323470 6480464 Acetaminophen results in increased expression of CPOX mRNA CTD PMID:25704631 paracetamol affects expression ISO RGD:1323471 6480464 Acetaminophen affects the expression of CPOX mRNA CTD PMID:17562736 phenobarbital decreases expression ISO RGD:1323471 6480464 Phenobarbital results in decreased expression of CPOX mRNA CTD PMID:23091169 pirinixic acid multiple interactions ISO RGD:1323471 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CPOX mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:1323471 6480464 pirinixic acid results in increased expression of CPOX mRNA CTD PMID:17426115 more ... propiconazole decreases expression ISO RGD:1323471 6480464 propiconazole results in decreased expression of CPOX mRNA CTD PMID:21278054 protoporphyrinogen increases chemical synthesis ISO RGD:1323470 6480464 CPOX protein results in increased chemical synthesis of protoporphyrinogen CTD PMID:19339664 protoporphyrinogen increases chemical synthesis ISO RGD:1323471 6480464 CPOX protein results in increased chemical synthesis of protoporphyrinogen CTD PMID:11248690 protoporphyrinogen multiple interactions ISO RGD:1323470 6480464 Mercury inhibits the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen], TGFB1 protein promotes the reaction [CPOX protein results in increased chemical synthesis of protoporphyrinogen] CTD PMID:11248690 , PMID:19339664 SB 431542 multiple interactions ISO RGD:1323470 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPOX mRNA CTD PMID:27188386 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of CPOX mRNA CTD PMID:12325037 sodium fluoride decreases expression ISO RGD:1323471 6480464 Sodium Fluoride results in decreased expression of CPOX mRNA CTD PMID:27862939 sunitinib increases expression ISO RGD:1323470 6480464 Sunitinib results in increased expression of CPOX mRNA CTD PMID:31533062 testosterone increases expression ISO RGD:1323471 6480464 Testosterone results in increased expression of CPOX mRNA CTD PMID:21669218 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of CPOX mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of CPOX mRNA CTD PMID:25729387 trimellitic anhydride increases expression ISO RGD:1323471 6480464 trimellitic anhydride results in increased expression of CPOX mRNA CTD PMID:19042947 trovafloxacin decreases expression EXP 6480464 trovafloxacin results in decreased expression of CPOX mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:1323470 6480464 Valproic Acid affects the expression of CPOX mRNA CTD PMID:25979313 valproic acid multiple interactions ISO RGD:1323470 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CPOX mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:1323470 6480464 Valproic Acid results in increased expression of CPOX mRNA CTD PMID:23179753 more ... valproic acid decreases methylation ISO RGD:1323470 6480464 Valproic Acid results in decreased methylation of CPOX gene CTD PMID:29154799 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of CPOX mRNA CTD PMID:23034163
Gene-Chemical Interaction Annotations
