Arl6 (ADP-ribosylation factor like GTPase 6)

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Gene: Arl6 (ADP-ribosylation factor like GTPase 6) Rattus norvegicus

Analyze

Symbol:

Arl6

Name:

ADP-ribosylation factor like GTPase 6

RGD ID:

1305535

Description:

Predicted to enable GTP binding activity. Predicted to be involved in several processes, including cilium assembly; intracellular protein transport; and protein localization to non-motile cilium. Predicted to act upstream of or within several processes, including fat cell differentiation; protein transport from ciliary membrane to plasma membrane; and retina layer formation. Predicted to be located in several cellular components, including cilium; cytosol; and microtubule cytoskeleton. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6); PARTICIPATES IN Arf family mediated signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ADP-ribosylation factor-like 6; ADP-ribosylation factor-like protein 6; LOC363760

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ARL6 (ADP ribosylation factor like GTPase 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Arl6 (ADP-ribosylation factor-like 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Arl6 (ADP ribosylation factor like GTPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ARL6 (ADP ribosylation factor like GTPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ARL6 (ADP ribosylation factor like GTPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Arl6 (ADP ribosylation factor like GTPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ARL6 (ADP ribosylation factor like GTPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ARL6 (ADP ribosylation factor like GTPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Arl6 (ADP ribosylation factor like GTPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ARL6 (ADP ribosylation factor like GTPase 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Arl6 (ADP-ribosylation factor-like 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	arl6 (ADP-ribosylation factor-like 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Arl6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	arl-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	40,711,878 - 40,738,254 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	40,712,022 - 40,737,937 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	49,443,864 - 49,464,528 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	42,115,134 - 42,135,798 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	41,243,787 - 41,264,451 (+)	NCBI	Rnor_WKY
Rnor_6.0	11	42,858,476 - 42,884,324 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	42,858,478 - 42,884,603 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	46,048,981 - 46,074,815 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	41,473,928 - 41,494,632 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	41,531,301 - 41,557,582 (+)	NCBI
Celera	11	40,554,175 - 40,574,879 (+)	NCBI		Celera
Cytogenetic Map	11	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bardet-Biedl syndrome (ISO)

Bardet-Biedl syndrome 1 (ISO)

Bardet-Biedl syndrome 3 (ISO)

cone-rod dystrophy (ISO)

Eye Abnormalities (ISO)

genetic disease (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa 55 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

bisphenol A (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

CGP 52608 (ISO)

clothianidin (ISO)

cyclosporin A (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

furan (EXP)

gentamycin (EXP)

indole-3-methanol (EXP)

ketamine (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

potassium dichromate (ISO)

quercetin (ISO)

resveratrol (ISO)

sunitinib (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

brain development (ISO)

cilium assembly (IBA,ISO)

fat cell differentiation (ISO)

intracellular protein transport (IBA)

protein localization to cilium (IBA,ISO)

protein localization to non-motile cilium (ISO)

protein transport from ciliary membrane to plasma membrane (ISO)

regulation of smoothened signaling pathway (ISO)

retina layer formation (ISO)

vesicle-mediated transport (IBA)

Wnt signaling pathway (ISO)

Cellular Component

axoneme (IBA)

cellular_component (ND)

cilium (ISO)

cytoplasm (ISO)

cytosol (ISO)

membrane (ISO)

microtubule cytoskeleton (ISO)

Molecular Function

GTP binding (IEA)

GTPase activity (IEA)

molecular_function (ND)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Arf family mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome.	Fan Y, etal., Nat Genet. 2004 Sep;36(9):989-93. Epub 2004 Aug 15.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit.	Ingley E, etal., FEBS Lett. 1999 Oct 1;459(1):69-74.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:17379567	PMID:17646400	PMID:19056867	PMID:20207729	PMID:20333246	PMID:22139371	PMID:23376485	PMID:24939912

Genomics

Comparative Map Data

Arl6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	11	40,711,878 - 40,738,254 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	40,712,022 - 40,737,937 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	49,443,864 - 49,464,528 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	11	42,115,134 - 42,135,798 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	11	41,243,787 - 41,264,451 (+)	NCBI	Rnor_WKY
Rnor_6.0	11	42,858,476 - 42,884,324 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	42,858,478 - 42,884,603 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	46,048,981 - 46,074,815 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	41,473,928 - 41,494,632 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	41,531,301 - 41,557,582 (+)	NCBI
Celera	11	40,554,175 - 40,574,879 (+)	NCBI		Celera
Cytogenetic Map	11	q12	NCBI

ARL6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	97,764,521 - 97,801,242 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	97,764,521 - 97,801,229 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	97,483,365 - 97,520,086 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	98,966,285 - 99,000,063 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	98,966,284 - 99,000,061	NCBI
Celera	3	95,873,167 - 95,906,953 (+)	NCBI		Celera
Cytogenetic Map	3	q11.2	NCBI
HuRef	3	94,853,270 - 94,889,996 (+)	NCBI		HuRef
CHM1_1	3	97,446,398 - 97,483,119 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	100,468,299 - 100,505,006 (+)	NCBI		T2T-CHM13v2.0

Arl6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	59,433,312 - 59,459,772 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	59,433,312 - 59,459,754 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	59,612,949 - 59,639,409 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	59,612,949 - 59,639,391 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	59,613,147 - 59,639,165 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	59,555,581 - 59,581,416 (-)	NCBI		MGSCv36	mm8
Celera	16	59,964,613 - 59,990,692 (-)	NCBI		Celera
Cytogenetic Map	16	C1.3	NCBI

Arl6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	360,600 - 380,900 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	360,898 - 387,563 (-)	NCBI	ChiLan1.0	ChiLan1.0

ARL6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	3	101,519,718 - 101,556,419 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	101,519,718 - 101,556,419 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	3	94,832,577 - 94,870,531 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ARL6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	4,797,944 - 4,857,566 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	4,800,917 - 4,839,635 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	4,978,946 - 5,038,532 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	4,907,747 - 4,967,366 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	4,907,537 - 4,955,060 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	4,784,258 - 4,843,859 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	4,844,615 - 4,904,175 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	5,118,965 - 5,178,560 (+)	NCBI		UU_Cfam_GSD_1.0

Arl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	152,408,598 - 152,438,647 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936666	3,076,778 - 3,103,649 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936666	3,077,006 - 3,102,469 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARL6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	162,504,109 - 162,556,280 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	162,509,451 - 162,556,675 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	172,774,280 - 172,821,154 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARL6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	82,909,453 - 82,946,253 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	82,905,910 - 82,946,149 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	83,638,973 - 83,678,694 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arl6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624789	10,229,793 - 10,254,364 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624789	10,223,339 - 10,252,889 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Arl6
119 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	103
Count of miRNA genes:	85
Interacting mature miRNAs:	86
Transcripts:	ENSRNOT00000002293
Prediction methods:	Microtar, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
1641927	Alcrsp10	Alcohol response QTL 10			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	11	8436674	53436674	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	16472047	44285911	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	29528418	60324829	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat

Markers in Region

RH133556

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	40,737,649 - 40,737,840 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	42,884,051 - 42,884,241	NCBI	Rnor6.0
Rnor_5.0	11	46,074,542 - 46,074,732	UniSTS	Rnor5.0
RGSC_v3.4	11	41,499,441 - 41,499,631	UniSTS	RGSC3.4
Celera	11	40,579,688 - 40,579,878	UniSTS
RH 3.4 Map	11	300.9	UniSTS
Cytogenetic Map	11	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		8	10	4	6	4			74	35	41	10
Low	3	35	47	37	13	37	8	11				1	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108842	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248192	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC162029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000002293 ⟹ ENSRNOP00000002293

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	40,712,022 - 40,737,937 (+)	Ensembl
Rnor_6.0 Ensembl	11	42,858,478 - 42,884,603 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102337 ⟹ ENSRNOP00000080618

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	40,712,022 - 40,732,159 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110067 ⟹ ENSRNOP00000091133

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	40,712,022 - 40,737,901 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110959 ⟹ ENSRNOP00000087563

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	40,712,159 - 40,737,919 (+)	Ensembl

RefSeq Acc Id:

NM_001108842 ⟹ NP_001102312

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	40,712,139 - 40,732,845 (+)	NCBI
Rnor_6.0	11	42,858,742 - 42,879,242 (+)	NCBI
Rnor_5.0	11	46,048,981 - 46,074,815 (+)	NCBI
RGSC_v3.4	11	41,473,928 - 41,494,632 (+)	RGD
Celera	11	40,554,175 - 40,574,879 (+)	RGD

Sequence:

show sequence

CGCCGCGCGCTGTGGCGCCTGCTCAGCCACTGATGCTCCCATCCCGGGTGAACCCGCCGGTAAC
CCCAACTTGTAGAAGAGGCTGTGCTTGGAGCAGAGTAACCTTCCTACGAAGGCATAGAGAGGAA
GGCTGAGGTTCCTGGGGAAGATCCCATCGCGGAGACGGGTGTAAGAGTGCGTCCCTTCCTGTCC
TTGTCAGCCCTATTGCCGCGGGATCGGCGTCAAAGATCAGTTGCTGTTTAAATATTTAAGCCAC
AATATGGGATTGCTGGACAGACTTTCAGGTTTACTTGGCCTGAAGAAGAAGGAGGTTCATGTTT
TATGCCTCGGGCTGGATAATAGTGGGAAAACAACAATCATTAACAAACTGAAACCCTCAAATGC
TCAAGTTCAAGATATAGTTCCAACCATAGGATTTAGCATAGAGAAATTCAAATCGTCCAGTTTG
TCTTTTACAGTGTTTGACATGTCAGGTCAAGGAAGGTACAGGAATCTCTGGGAACACTATTATA
AAGATGGACAAGCCATTATCTTTGTCGTTGACAGTAGTGATAAATTAAGAATGGTTGTGGCCAA
AGAAGAGCTTGATACCCTTCTAAATCACCCAGATATTAAGCACCGTCGAATTCCAATCTTGTTC
TTTGCAAACAAAATGGATCTTAGAGACGCAGTGACTTCTGTGAAAGTGTCTCAGCTGCTGTGTT
TAGAGAACATTAAAGATAAGCCGTGGCATATTTGTGCTAGTGATGCCCTCAAAGGAGAAGGACT
GCAGGAAGGCGTGGACTGGCTTCAAGGTATACCCCAAGCTGCTGCGTGTCTGTAGCCCGCTTCT
GTCTCATTCGTTCATTTCATCTTTATATTTTAATTTTATTACATCAATGCCCCTTCTTGTTTTT
ATTTCTGCTGTCAGAAAAAACAGTACAGTAAGTACCTGATACCTTGCTTCATTTATTTTATTAC
ATTTTTCTAGCAGATTTCTGTATTCAATAAATATAACAAATCTGG

hide sequence

RefSeq Acc Id:

XM_006248191 ⟹ XP_006248253

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	40,711,878 - 40,738,254 (+)	NCBI
Rnor_6.0	11	42,858,476 - 42,884,324 (+)	NCBI
Rnor_5.0	11	46,048,981 - 46,074,815 (+)	NCBI

Sequence:

show sequence

CTAGCACACTACCCGGCAGGCTGTGCGTGGGCCTACAGCTCCCACGCGTCCCAGCAGCAAAGGT
GCTTCCCCTCGATTCCCAGCTCATTGGCGGCCCCCCATGTCTTCTGTGCTCACACTCTCTGATA
GTTATTCTGCGGGAATCAGACCATTTTTTTTTAACCCAGAGCTCTTCAGCCGCAGGAAGGAGAA
CACGTCGGCGGACACCTAAAATGCCTGAATAGGCGTGGCTTTAGGACCGGAAGAAGCTCCCGTT
GCCAAGGGAACGCCGCGCGCTGTGGCGCCTGCTCAGCCACTGATGCTCCCATCCCGGGTGAACC
CGCCGGTAACCCCAACTTGTAGAAGAGGCTGTGCTTGGAGCAGAGTAACCTTCCTACGAAGGCA
TAGAGAGGAAGGCTGAGGTTCCTGGGGAAGATCCCATCGCGGAGACGGGTGTAAGAGTGCGTCC
CTTCCTGTCCTTGTCAGCCCTATTGCCGCGGGATCGGCGTCAAAGATCAGTTGCTGTTTAAATA
TTTAAGCCACAATATGGGATTGCTGGACAGACTTTCAGGTTTACTTGGCCTGAAGAAGAAGGAG
GTTCATGTTTTATGCCTCGGGCTGGATAATAGTGGGAAAACAACAATCATTAACAAACTGAAAC
CCTCAAATGCTCAAGTTCAAGATATAGTTCCAACCATAGGATTTAGCATAGAGAAATTCAAATC
GTCCAGTTTGTCTTTTACAGTGTTTGACATGTCAGGTCAAGGAAGGTACAGGAATCTCTGGGAA
CACTATTATAAAGATGGACAAGCCATTATCTTTGTCGTTGACAGTAGTGATAAATTAAGAATGG
TTGTGGCCAAAGAAGAGCTTGATACCCTTCTAAATCACCCAGATATTAAGCACCGTCGAATTCC
AATCTTGTTCTTTGCAAACAAAATGGATCTTAGAGACGCAGTGACTTCTGTGAAAGTGTCTCAG
CTGCTGTGTTTAGAGAACATTAAAGATAAGCCGTGGCATATTTGTGCTAGTGATGCCCTCAAAG
GAGAAGGACTGCAGGAAGGCGTGGACTGGCTTCAAGAAAAAACAGTACAATCAGATCCAAGCTG
TGAAAACGTGAAAAGATAGTCACTGGAGACCTCAGCGATTCTCAATTAATGGTATCTATGTAAG
GCATACTGAATAATCTCAAATTTATTTTAAAAGATATATGCAACTAAGAATATTTTTACAACAT
TCTGCTTGCTTTTGTGGACTCTGGAAGAACATTTTAAGGACTTTAGGACTTGAGACATTATTAA
TCTGGCCATTAACTGTACAAAATCTAAGATTTCTTAGGAACTCCCTAGTCCCAGCTTCTTGTAA
AAATCTATACATTGTTATAATCAAAATGTATAAATACCACTTGTAAGCCATCTCGATATCCTGT
CATGACTTATATCTTTAATGTATTTTTATTTTTAATTGTCTTCTAAAAGTTTAGTTCATTGTAT
TACTTTGAAGTGCAAATTGTGTTAGGGAAACAGCCTTAAAGATTTATAAGGGATCACAAGTAAT
TAGTCTATATGTAATTTTTATTGTCACTATCAATAAAAAATGAAATATACCAA

hide sequence

RefSeq Acc Id:

XM_006248193 ⟹ XP_006248255

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	40,711,882 - 40,738,250 (+)	NCBI
Rnor_6.0	11	42,858,476 - 42,884,324 (+)	NCBI
Rnor_5.0	11	46,048,981 - 46,074,815 (+)	NCBI

Sequence:

show sequence

CTAGCACACTACCCGGCAGGCTGTGCGTGGGCCTACAGCTCCCACGCGTCCCAGCAGCAAAGGT
GCTTCCCCTCGATTCCCAGCTCATTGGCGGCCCCCCATGTCTTCTGTGCTCACACTCTCTGATA
GTTATTCTGCGGGAATCAGACCATTTTTTTTTAACCCAGAGCTCTTCAGCCGCAGGAAGGAGAA
CACGTCGGCGGACACCTAAAATGCCTGAATAGGCGTGGCTTTAGGACCGGAAGAAGCTCCCGTT
GCCAAGGGAACGCCGCGCGCTGTGGCGCCTGCTCAGCCACTGATGCTCCCATCCCGGGTGAACC
CGCCGGTAACCCCAACTTGTAGAAGAGGCTGTGCTTGGAGCAGAGTAACCTTCCTACGAAGGCA
TAGAGAGGAAGGCTGAGGTTCCTGGGGAAGATCCCATCGCGGAGACGGGTGTAAGAGTGCGTCC
CTTCCTGTCCTTGTCAGCCCTATTGCCGCGGGATCGGCGTCAAAGATCAGTTGCTGTTTAAATA
TTTAAGCCACAATATGGGATTGCTGGACAGACTTTCAGGTTTACTTGGCCTGAAGAAGAAGGAG
GTTCATGTTTTATGCCTCGGGCTGGATAATAGTGGGAAAACAACAATCATTAACAAACTGAAAC
CCTCAAATGCTCAAGTTCAAGATATAGTTCCAACCATAGGATTTAGCATAGAGAAATTCAAATC
GTCCAGTTTGTCTTTTACAGTGTTTGACATGTCAGGTCAAGGAAGGTACAGGAATCTCTGGGAA
CACTATTATAAAGATGGACAAGCCATTATCTTTGTCGTTGACAGTAGTGATAAATTAAGAATGG
TTGTGGCCAAAGAAGAGCTTGATACCCTTCTAAATCACCCAGATATTAAGCACCGTCGAATTCC
AATCTTGTTCTTTGCAAACAAAATGGATCTTAGAGACGCAGTGACTTCTGTGAAAGTGTCTCAG
CTGCTGTGTTTAGAGAACATTAAAGATAAGCCGTGGCATATTTGTGCTAGTGATGCCCTCAAAG
GAGAAGGACTGCAGGAAGGCGTGGACTGGCTTCAAGATCAGATCCAAGCTGTGAAAACGTGAAA
AGATAGTCACTGGAGACCTCAGCGATTCTCAATTAATGGTATCTATGTAAGGCATACTGAATAA
TCTCAAATTTATTTTAAAAGATATATGCAACTAAGAATATTTTTACAACATTCTGCTTGCTTTT
GTGGACTCTGGAAGAACATTTTAAGGACTTTAGGACTTGAGACATTATTAATCTGGCCATTAAC
TGTACAAAATCTAAGATTTCTTAGGAACTCCCTAGTCCCAGCTTCTTGTAAAAATCTATACATT
GTTATAATCAAAATGTATAAATACCACTTGTAAGCCATCTCGATATCCTGTCATGACTTATATC
TTTAATGTATTTTTATTTTTAATTGTCTTCTAAAAGTTTAGTTCATTGTATTACTTTGAAGTGC
AAATTGTGTTAGGGAAACAGCCTTAAAGATTTATAAGGGATCACAAGTAATTAGTCTATATGTA
ATTTTTATTGTCACTATCAATAAAAAATGAAATATACCAA

hide sequence

RefSeq Acc Id:

XM_039088539 ⟹ XP_038944467

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	11	40,717,077 - 40,738,254 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102312	(Get FASTA)	NCBI Sequence Viewer
	XP_006248253	(Get FASTA)	NCBI Sequence Viewer
	XP_006248255	(Get FASTA)	NCBI Sequence Viewer
	XP_038944467	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI62029	(Get FASTA)	NCBI Sequence Viewer
	EDM10987	(Get FASTA)	NCBI Sequence Viewer
	EDM10988	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001102312 ⟸ NM_001108842
- Sequence:	show sequence MGLLDRLSGLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQVQDIVPTIGFSIEKFKSSSLS FTVFDMSGQGRYRNLWEHYYKDGQAIIFVVDSSDKLRMVVAKEELDTLLNHPDIKHRRIPILFF ANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDALKGEGLQEGVDWLQGIPQAAACL hide sequence

RefSeq Acc Id:	XP_006248253 ⟸ XM_006248191
- Peptide Label:	isoform X1
- UniProtKB:	A0A8J8YB99 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGLLDRLSGLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQVQDIVPTIGFSIEKFKSSSLS FTVFDMSGQGRYRNLWEHYYKDGQAIIFVVDSSDKLRMVVAKEELDTLLNHPDIKHRRIPILFF ANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDALKGEGLQEGVDWLQEKTVQSDPSCENVK R hide sequence

RefSeq Acc Id:	XP_006248255 ⟸ XM_006248193
- Peptide Label:	isoform X2
- UniProtKB:	B1WC73 (UniProtKB/TrEMBL), F7F983 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGLLDRLSGLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQVQDIVPTIGFSIEKFKSSSLS FTVFDMSGQGRYRNLWEHYYKDGQAIIFVVDSSDKLRMVVAKEELDTLLNHPDIKHRRIPILFF ANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDALKGEGLQEGVDWLQDQIQAVKT hide sequence

RefSeq Acc Id:

ENSRNOP00000002293 ⟸ ENSRNOT00000002293

RefSeq Acc Id:	XP_038944467 ⟸ XM_039088539
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000087563 ⟸ ENSRNOT00000110959

RefSeq Acc Id:

ENSRNOP00000091133 ⟸ ENSRNOT00000110067

RefSeq Acc Id:

ENSRNOP00000080618 ⟸ ENSRNOT00000102337

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B1WC73-F1-model_v2	AlphaFold	B1WC73	1-186	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698103

Promoter ID:

EPDNEW_R8628

Type:

initiation region

Name:

Arl6_1

Description:

ADP-ribosylation factor like GTPase 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	42,858,735 - 42,858,795	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305535	AgrOrtholog
BioCyc Gene	G2FUF-21620	BioCyc
Ensembl Genes	ENSRNOG00000001689	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000002293	ENTREZGENE
	ENSRNOP00000002293.8	UniProtKB/TrEMBL
	ENSRNOP00000080618.1	UniProtKB/TrEMBL
	ENSRNOP00000087563.1	UniProtKB/TrEMBL
	ENSRNOP00000091133	ENTREZGENE
	ENSRNOP00000091133.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002293	ENTREZGENE
	ENSRNOT00000002293.8	UniProtKB/TrEMBL
	ENSRNOT00000102337.1	UniProtKB/TrEMBL
	ENSRNOT00000110067	ENTREZGENE
	ENSRNOT00000110067.1	UniProtKB/TrEMBL
	ENSRNOT00000110959.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9100375	IMAGE-MGC_LOAD
InterPro	Arl6	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase_ARF	UniProtKB/TrEMBL
	Small_GTPase_ARF/SAR	UniProtKB/TrEMBL
MGC_CLONE	MGC:187918	IMAGE-MGC_LOAD
NCBI Gene	363760	ENTREZGENE
PANTHER	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6	UniProtKB/TrEMBL
	PTHR11711	UniProtKB/TrEMBL
Pfam	Arf	UniProtKB/TrEMBL
PhenoGen	Arl6	PhenoGen
PRINTS	SAR1GTPBP	UniProtKB/TrEMBL
PROSITE	ARF	UniProtKB/TrEMBL
	RAB	UniProtKB/TrEMBL
SMART	ARF	UniProtKB/TrEMBL
	SAR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
TIGRFAMs	small_GTP	UniProtKB/TrEMBL
UniProt	A0A8I6G6V6_RAT	UniProtKB/TrEMBL
	A0A8I6GF94_RAT	UniProtKB/TrEMBL
	A0A8J8YB99	ENTREZGENE, UniProtKB/TrEMBL
	B1WC73	ENTREZGENE, UniProtKB/TrEMBL
	F7F983	ENTREZGENE
UniProt Secondary	F7F983	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-11-19	Arl6	ADP-ribosylation factor like GTPase 6	Arl6	ADP-ribosylation factor-like 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Arl6	ADP-ribosylation factor-like 6	Arl6_predicted	ADP-ribosylation factor-like 6 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Arl6_predicted	ADP-ribosylation factor-like 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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