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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619719
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdh2
Name: malate dehydrogenase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdh2increases expressionEXP 6480464CTDbisphenol A results in increased expression of MDH2 mRNAPMID:25181051
Mdh2multiple interactionsEXP 6480464CTDbisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in decreased activity of MDH2 protein]PMID:38029875
Mdh2decreases expressionISOMDH2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of MDH2 proteinPMID:31675489 PMID:34186270
Mdh2increases expressionISOMDH2 (Homo sapiens)6480464CTDbisphenol A results in increased expression of MDH2 proteinPMID:37567409
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