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RGD ID: 619719
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mdh2
Name: malate dehydrogenase 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mdh2decreases response to substanceISOMDH2 (Homo sapiens)6480464CTDMDH2 mRNA results in decreased susceptibility to DoxorubicinPMID:16322897
Mdh2increases expressionISOMDH2 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of MDH2 mRNAPMID:29803840
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