Atp2a2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) - Rat Genome Database

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Gene: Atp2a2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) Rattus norvegicus
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Symbol: Atp2a2
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
RGD ID: 2174
Description: Enables several functions, including ATP binding activity; P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential; and lutropin-choriogonadotropic hormone receptor binding activity. Involved in several processes, including calcium ion transport; regulation of cardiac muscle cell membrane potential; and regulation of cardiac muscle contraction. Located in several cellular components, including apical ectoplasmic specialization; perinuclear region of cytoplasm; and sarcoplasmic reticulum. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study abdominal obesity-metabolic syndrome 1; congestive heart failure; and type 2 diabetes mellitus. Biomarker of euthyroid sick syndrome; heart disease; hypothyroidism; pulmonary hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; Serca2; SercaII; SR Ca(2+)-ATPase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Calcic1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21234,072,710 - 34,122,142 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1234,072,683 - 34,122,101 (+)Ensembl
Rnor_6.01239,553,903 - 39,603,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,553,903 - 39,603,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,434,651 - 41,482,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,266,600 - 35,316,237 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,129,987 - 35,179,584 (+)NCBI
Celera1235,744,606 - 35,793,364 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (EXP)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
astragaloside IV  (EXP)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (EXP)
Candesartan cilexetil  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
carvedilol  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chrysene  (ISO)
cilostazol  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
delta-tocotrienol  (ISO)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibromine  (EXP)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dioxygen  (EXP)
diuron  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
ferrostatin-1  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
Goe 6976  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
indinavir  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
leflunomide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lycopene  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylseleninic acid  (ISO)
metoprolol  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP,ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
prazosin  (EXP)
procymidone  (EXP)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
razoxane  (EXP)
resveratrol  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarpogrelate  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
tributylstannane  (ISO)
trichloroacetic acid  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome assembly  (ISO,ISS)
autophagosome membrane docking  (ISO,ISS)
calcium ion import into sarcoplasmic reticulum  (IDA,ISO)
calcium ion transmembrane transport  (IBA,IDA,ISO)
calcium ion transport  (IDA)
calcium ion transport from cytosol to endoplasmic reticulum  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cellular calcium ion homeostasis  (IBA,ISO)
cellular response to heat  (IEP)
cellular response to oxidative stress  (ISO)
endoplasmic reticulum calcium ion homeostasis  (ISO)
ER-nucleus signaling pathway  (ISO)
ion transmembrane transport  (IBA)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO,ISS)
negative regulation of heart contraction  (ISO)
negative regulation of receptor binding  (ISO)
neuron cellular homeostasis  (ISO)
organelle localization by membrane tethering  (ISO,ISS)
organelle organization  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of endoplasmic reticulum calcium ion concentration  (ISO)
regulation of calcium ion-dependent exocytosis of neurotransmitter  (ISO)
regulation of cardiac muscle cell action potential involved in regulation of contraction  (IDA)
regulation of cardiac muscle cell membrane potential  (IDA)
regulation of cardiac muscle contraction by calcium ion signaling  (IBA,IDA,ISO)
regulation of muscle contraction  (TAS)
regulation of the force of heart contraction  (ISO)
relaxation of cardiac muscle  (IDA,ISO)
response to endoplasmic reticulum stress  (IEP)
response to lipopolysaccharide  (IEP)
response to peptide hormone  (IDA)
sarcoplasmic reticulum calcium ion transport  (IDA,ISO)
skeletal muscle contraction  (IEP)
T-tubule organization  (ISO)
transition between fast and slow fiber  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
Alzheimer's disease pathway  (IEA)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
arrhythmogenic right ventricular cardiomyopathy pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium transport pathway  (ISO)
calcium/calcium-mediated signaling pathway  (IEA,ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. Algenstaedt P, etal., J Biol Chem. 1997 Sep 19;272(38):23696-702.
2. Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection. Ambrosius B, etal., J Neuroinflammation. 2017 Apr 26;14(1):92. doi: 10.1186/s12974-017-0864-z.
3. Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts. Baker DL, etal., Circ Res. 1998 Dec 14-28;83(12):1205-14.
4. Oxidative stress in cardiomyocytes contributes to decreased SERCA2a activity in rats with metabolic syndrome. Balderas-Villalobos J, etal., Am J Physiol Heart Circ Physiol. 2013 Nov 1;305(9):H1344-53. doi: 10.1152/ajpheart.00211.2013. Epub 2013 Aug 30.
5. Calcium pumps in health and disease. Brini M and Carafoli E, Physiol Rev. 2009 Oct;89(4):1341-78. doi: 10.1152/physrev.00032.2008.
6. Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome. Campanha FV, etal., Arch Endocrinol Metab. 2016 Nov-Dec;60(6):582-586. doi: 10.1590/2359-3997000000208. Epub 2016 Oct 10.
7. The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein. Caspersen C, etal., J Biol Chem. 2000 Jul 21;275(29):22363-72.
8. Sildenafil and FDP-Sr attenuate diabetic cardiomyopathy by suppressing abnormal expression of myocardial CASQ2, FKBP12.6, and SERCA2a in rats. Cheng YS, etal., Acta Pharmacol Sin. 2011 Apr;32(4):441-8. Epub 2011 Mar 28.
9. Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle. Clark JH, etal., J Biol Chem. 2010 Apr 30;285(18):13542-9. doi: 10.1074/jbc.M110.101485. Epub 2010 Feb 21.
10. Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum. Ferrington DA, etal., Biochemistry 2002 Nov 5;41(44):13289-96.
11. Mitochondrial and sarcoplasmic reticulum abnormalities in cancer cachexia: altered energetic efficiency? Fontes-Oliveira CC, etal., Biochim Biophys Acta. 2013 Mar;1830(3):2770-8. doi: 10.1016/j.bbagen.2012.11.009.
12. Common genetic variants in selected Ca²¿ signaling genes and the risk of appropriate ICD interventions in patients with heart failure. Francia P, etal., J Interv Card Electrophysiol. 2013 Dec;38(3):169-77. doi: 10.1007/s10840-013-9827-1. Epub 2013 Sep 19.
13. Endoplasmic reticulum Ca2+-ATPase pump is up-regulated in calcium-transporting dental enamel cells: a non-housekeeping role for SERCA2b. Franklin IK, etal., Biochem J 2001 Aug 15;358(Pt 1):217-24.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. A novel Ca2+ pump expressed in brain, kidney, and stomach is encoded by an alternative transcript of the slow-twitch muscle sarcoplasmic reticulum Ca-ATPase gene. Identification of cDNAs encoding Ca2+ and other cation-transporting ATPases using an oligonucleotide probe derived from the ATP-binding site. Gunteski-Hamblin AM, etal., J Biol Chem 1988 Oct 15;263(29):15032-40.
16. Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension. Hadri L, etal., Circulation. 2013 Jul 30;128(5):512-23. doi: 10.1161/CIRCULATIONAHA.113.001585. Epub 2013 Jun 26.
17. Tail muscle parvalbumin content is decreased in chronic sacral spinal cord injured rats with spasticity. Harris RL, etal., Exp Physiol. 2011 Dec;96(12):1311-20. doi: 10.1113/expphysiol.2011.061614. Epub 2011 Sep 19.
18. Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+ signalling in young type 2 Zucker diabetic fatty rat heart. Howarth FC, etal., Exp Physiol. 2011 Mar;96(3):325-37. Epub 2011 Jan 7.
19. Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart. Howarth FC, etal., Mol Cell Biochem. 2012 Feb;361(1-2):267-80. Epub 2011 Oct 19.
20. Protective effect of oxymatrine on chronic rat heart failure. Hu ST, etal., J Physiol Sci. 2011 Sep;61(5):363-72. Epub 2011 Jun 22.
21. Variation in expression of calcium-handling proteins is associated with inter-individual differences in mechanical performance of rat (Rattus norvegicus) skeletal muscle. James RS, etal., J Exp Biol. 2011 Nov 1;214(Pt 21):3542-8. doi: 10.1242/jeb.058305.
22. Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction. Kagota S, etal., Can J Physiol Pharmacol. 2013 Feb;91(2):124-33. doi: 10.1139/cjpp-2012-0226. Epub 2013 Feb 15.
23. [Role of the M235T (c.704c>T) polymorphism of angiotensynogen gene as well as A724A (c.2171G>A) polymorphism of SERCA2a gene in ethiopathogenesis of left ventricular hypertrophy in essential hypertension]. Kiec-Wilk B, etal., Przegl Lek. 2010;67(3):151-6.
24. Molecular cloning and characterization of a Ca2+ + Mg2+-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum. Regulation of its expression by pressure overload and developmental stage. Komuro I, etal., J Clin Invest 1989 Apr;83(4):1102-8.
25. Association of cardiac injury with iron-increased oxidative and nitrative modifications of the SERCA2a isoform of sarcoplasmic reticulum Ca(2+)-ATPase in diabetic rats. Li X, etal., Biochimie. 2016 Aug;127:144-52. doi: 10.1016/j.biochi.2016.05.011. Epub 2016 May 21.
26. Characterization and expression of the rat heart sarcoplasmic reticulum Ca2+-ATPase mRNA. Lompre AM, etal., FEBS Lett 1989 May 22;249(1):35-41.
27. Efficient transduction of vascular smooth muscle cells with a translational AAV2.5 vector: a new perspective for in-stent restenosis gene therapy. Lompré AM, etal., Gene Ther. 2013 Sep;20(9):901-12. doi: 10.1038/gt.2013.13. Epub 2013 Mar 28.
28. AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. Lygren B, etal., EMBO Rep. 2007 Nov;8(11):1061-7. Epub 2007 Sep 28.
29. Ca2+ signaling machinery is present at intercellular junctions and structures associated with junction turnover in rat Sertoli cells. Lyon K, etal., Biol Reprod. 2017 Jun 1;96(6):1288-1302. doi: 10.1093/biolre/iox042.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Expression of Ca(2+) Transport Genes in Platelets and Endothelial Cells in Hypertension. Mountian I I, etal., Hypertension 2001 Jan;37(1):135-141.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Sakuntabhai A, etal., Nat Genet 1999 Mar;21(3):271-7.
39. Mechanisms underlying increases in SR Ca2+-ATPase activity after exercise in rat skeletal muscle. Schertzer JD, etal., Am J Physiol Endocrinol Metab 2003 Mar;284(3):E597-610.
40. Intracellular Ca2+ regulating proteins in vascular smooth muscle cells are altered with type 1 diabetes due to the direct effects of hyperglycemia. Searls YM, etal., Cardiovasc Diabetol. 2010 Feb 1;9:8. doi: 10.1186/1475-2840-9-8.
41. Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes. Shao CH, etal., Diabetes. 2011 Mar;60(3):947-59. Epub 2011 Feb 7.
42. Differential regulation of SR calcium transporters by thyroid hormone in rat atria and ventricles. Shenoy R, etal., Am J Physiol Heart Circ Physiol 2001 Oct;281(4):H1690-6.
43. Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2. Shintani Y, etal., EMBO Rep. 2014 Apr;15(4):438-45. doi: 10.1002/embr.201337945. Epub 2014 Mar 7.
44. Early energy metabolism-related molecular events in skeletal muscle of diabetic rats: The effects of l-arginine and SOD mimic. Stancic A, etal., Chem Biol Interact. 2017 Jun 25;272:188-196. doi: 10.1016/j.cbi.2017.05.003. Epub 2017 May 5.
45. Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats. Stenzig J, etal., J Mol Cell Cardiol. 2018 Jul;120:53-63. doi: 10.1016/j.yjmcc.2018.05.012. Epub 2018 May 21.
46. Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system. Thuerauf DJ, etal., J Biol Chem 2001 Dec 21;276(51):48309-17.
47. TNF-a down-regulates sarcoplasmic reticulum Ca²¿ ATPase expression and leads to left ventricular diastolic dysfunction through binding of NF-¿B to promoter response element. Tsai CT, etal., Cardiovasc Res. 2015 Mar 1;105(3):318-29. doi: 10.1093/cvr/cvv008.
48. The endoplasmic reticulum Ca2+-pump SERCA2b interacts with G protein-coupled receptors and enhances their expression at the cell surface. Tuusa JT, etal., J Mol Biol. 2007 Aug 17;371(3):622-38. Epub 2007 Mar 15.
49. Decreased cardiac SERCA2 expression, SR Ca uptake, and contractile function in hypothyroidism are attenuated in SERCA2 overexpressing transgenic rats. Vetter R, etal., Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H943-50. Epub 2011 Jan 7.
50. Molecular cloning and quantification of sarcoplasmic reticulum Ca(2+)-ATPase isoforms in rat muscles. Wu KD and Lytton J, Am J Physiol. 1993 Feb;264(2 Pt 1):C333-41.
51. Effect of Chaiqinchengqi decoction on sarco/endoplasmic reticulum Ca2+-ATPase mRNA expression of pancreatic tissues in acute pancreatitis rats. Xue P, etal., World J Gastroenterol. 2008 Apr 21;14(15):2343-8.
52. Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity. Yamaguchi M, etal., J Cell Biochem 2002;86(3):520-9.
53. Rats with Chronic, Stable Pulmonary Hypertension Tolerate Low Dose Sevoflurane Inhalation as Well as Normal Rats Do. Yin X, etal., PLoS One. 2016 May 4;11(5):e0154154. doi: 10.1371/journal.pone.0154154. eCollection 2016.
54. The modified Yi qi decoction protects cardiac ischemia-reperfusion induced injury in rats. Yu X, etal., BMC Complement Altern Med. 2017 Jun 21;17(1):330. doi: 10.1186/s12906-017-1829-6.
Additional References at PubMed
PMID:8889548   PMID:9038922   PMID:9887021   PMID:10555147   PMID:10587333   PMID:11402072   PMID:12481932   PMID:12606313   PMID:12659846   PMID:12756243   PMID:12773312   PMID:12804600  
PMID:13129932   PMID:14561754   PMID:14575311   PMID:14593108   PMID:14747299   PMID:14749390   PMID:15191357   PMID:15201701   PMID:15528241   PMID:15670758   PMID:15670840   PMID:15677742  
PMID:15766574   PMID:16081076   PMID:16081870   PMID:16087130   PMID:16113063   PMID:16185075   PMID:16402920   PMID:16407245   PMID:16517946   PMID:16648178   PMID:16786169   PMID:17131044  
PMID:17287366   PMID:17482761   PMID:17516033   PMID:17717121   PMID:18006556   PMID:18068335   PMID:18408128   PMID:18456736   PMID:18562801   PMID:18581135   PMID:18612190   PMID:18836677  
PMID:18948275   PMID:18978355   PMID:19151257   PMID:19340563   PMID:19617272   PMID:19714449   PMID:19738937   PMID:19932743   PMID:20724704   PMID:21106823   PMID:21113058   PMID:21278384  
PMID:21302294   PMID:21479763   PMID:21856903   PMID:21903937   PMID:21964539   PMID:22355118   PMID:22375059   PMID:22621761   PMID:23354458   PMID:23395171   PMID:23808942   PMID:24037709  
PMID:24137001   PMID:24625528   PMID:24684418   PMID:25095801   PMID:25188881   PMID:25452428   PMID:25625241   PMID:25731682   PMID:25772907   PMID:25822872   PMID:26068603   PMID:26086963  
PMID:26316108   PMID:26352986   PMID:26969192   PMID:27104787   PMID:27206677   PMID:27780728   PMID:27923914   PMID:28137585   PMID:28223472   PMID:28713824   PMID:28884444   PMID:29141547  
PMID:29476059   PMID:29947686   PMID:30188326   PMID:30717322   PMID:30721562   PMID:31373602   PMID:31409881   PMID:32353354   PMID:32357304   PMID:32704072   PMID:33130073   PMID:35331264  


Genomics

Candidate Gene Status
Atp2a2 is a candidate Gene for QTL Calcic1
Atp2a2 is a candidate Gene for QTL Calcic2
Comparative Map Data
Atp2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21234,072,710 - 34,122,142 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1234,072,683 - 34,122,101 (+)Ensembl
Rnor_6.01239,553,903 - 39,603,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,553,903 - 39,603,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,434,651 - 41,482,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,266,600 - 35,316,237 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,129,987 - 35,179,584 (+)NCBI
Celera1235,744,606 - 35,793,364 (+)NCBICelera
Cytogenetic Map12q16NCBI
ATP2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812110,281,247 - 110,351,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12110,280,756 - 110,351,093 (+)EnsemblGRCh38hg38GRCh38
GRCh3712110,719,052 - 110,788,898 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612109,203,815 - 109,273,278 (+)NCBINCBI36hg18NCBI36
Build 3412109,182,151 - 109,251,615NCBI
Celera12110,344,773 - 110,414,642 (+)NCBI
Cytogenetic Map12q24.11NCBI
HuRef12107,737,670 - 107,807,502 (+)NCBIHuRef
CHM1_112110,686,837 - 110,756,707 (+)NCBICHM1_1
T2T-CHM13v2.012110,258,889 - 110,328,744 (+)NCBI
Atp2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,591,576 - 122,640,288 (-)NCBIGRCm39mm39
GRCm39 Ensembl5122,591,576 - 122,640,288 (-)Ensembl
GRCm385122,453,513 - 122,502,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,453,513 - 122,502,225 (-)EnsemblGRCm38mm10GRCm38
MGSCv375122,903,522 - 122,952,234 (-)NCBIGRCm37mm9NCBIm37
MGSCv365122,714,131 - 122,762,512 (-)NCBImm8
Celera5119,532,083 - 119,580,718 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.38NCBI
Atp2a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,233,336 - 7,295,754 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,233,336 - 7,295,754 (+)NCBIChiLan1.0ChiLan1.0
ATP2A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112111,249,039 - 111,316,532 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12111,246,508 - 111,311,923 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012107,857,009 - 107,924,938 (+)NCBIMhudiblu_PPA_v0panPan3
ATP2A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,148,181 - 8,209,392 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,148,236 - 8,209,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,312,735 - 8,373,567 (+)NCBI
ROS_Cfam_1.0268,406,466 - 8,467,508 (+)NCBI
ROS_Cfam_1.0 Ensembl268,406,107 - 8,467,504 (+)Ensembl
UMICH_Zoey_3.1268,366,182 - 8,427,199 (+)NCBI
UNSW_CanFamBas_1.0268,424,775 - 8,485,590 (+)NCBI
UU_Cfam_GSD_1.0268,381,368 - 8,442,436 (+)NCBI
Atp2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118156,121,831 - 156,178,459 (-)NCBI
SpeTri2.0NW_0049365583,300,941 - 3,357,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1431,674,757 - 31,744,969 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11431,674,659 - 31,744,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,446,619 - 33,491,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21433,642,897 - 33,670,781 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,522,175 - 105,590,291 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl11105,522,157 - 105,590,958 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037139,532,362 - 139,600,791 (-)NCBIVero_WHO_p1.0
Atp2a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,509,366 - 21,568,098 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474721,509,360 - 21,567,424 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D12S2026  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,121,779 - 34,122,116 (+)MAPPERmRatBN7.2
Rnor_6.01239,602,964 - 39,603,300NCBIRnor6.0
Rnor_5.01241,482,562 - 41,482,898UniSTSRnor5.0
RGSC_v3.41235,315,875 - 35,316,211UniSTSRGSC3.4
Celera1235,793,002 - 35,793,338UniSTS
Cytogenetic Map12q16UniSTS
G15902  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,118,867 - 34,119,059 (+)MAPPERmRatBN7.2
Rnor_6.01239,600,052 - 39,600,243NCBIRnor6.0
Rnor_5.01241,479,650 - 41,479,841UniSTSRnor5.0
RGSC_v3.41235,312,963 - 35,313,154UniSTSRGSC3.4
Celera1235,790,090 - 35,790,281UniSTS
Cytogenetic Map12q16UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1064
Count of miRNA genes:349
Interacting mature miRNAs:486
Transcripts:ENSRNOT00000001738, ENSRNOT00000024347
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 33
Medium 3 16 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001110139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001110823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA900747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF031937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF043106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE119640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM387097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK355798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK356436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK356454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK358684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO404645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV765256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC583798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000001738   ⟹   ENSRNOP00000001738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,072,710 - 34,122,101 (+)Ensembl
Rnor_6.0 Ensembl1239,553,903 - 39,603,326 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000024347   ⟹   ENSRNOP00000024347
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,072,683 - 34,119,224 (+)Ensembl
Rnor_6.0 Ensembl1239,554,171 - 39,601,778 (+)Ensembl
RefSeq Acc Id: NM_001110139   ⟹   NP_001103609
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21234,072,710 - 34,122,142 (+)NCBI
Rnor_6.01239,553,903 - 39,603,326 (+)NCBI
Rnor_5.01241,434,651 - 41,482,924 (+)NCBI
RGSC_v3.41235,266,600 - 35,316,237 (+)RGD
Celera1235,744,606 - 35,793,364 (+)RGD
Sequence:
RefSeq Acc Id: NM_001110823   ⟹   NP_001104293
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21234,072,710 - 34,119,226 (+)NCBI
Rnor_6.01239,553,903 - 39,600,410 (+)NCBI
Rnor_5.01241,434,651 - 41,482,924 (+)NCBI
RGSC_v3.41235,266,600 - 35,316,237 (+)RGD
Celera1235,744,606 - 35,790,448 (+)NCBI
Sequence:
RefSeq Acc Id: NR_027839
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21234,072,710 - 34,122,142 (+)NCBI
Rnor_6.01239,553,903 - 39,603,326 (+)NCBI
Rnor_5.01241,434,651 - 41,482,924 (+)NCBI
RGSC_v3.41235,266,600 - 35,316,237 (+)RGD
Celera1235,744,606 - 35,793,364 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001103609   ⟸   NM_001110139
- Peptide Label: isoform a
- UniProtKB: P11507 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001104293   ⟸   NM_001110823
- Peptide Label: isoform b
- UniProtKB: P11507 (UniProtKB/Swiss-Prot),   P11508 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024347   ⟸   ENSRNOT00000024347
RefSeq Acc Id: ENSRNOP00000001738   ⟸   ENSRNOT00000001738

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11507-F1-model_v2 AlphaFold P11507 1-1043 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698642
Promoter ID:EPDNEW_R9166
Type:initiation region
Name:Atp2a2_1
Description:ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9167  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01239,553,907 - 39,553,967EPDNEW
RGD ID:13698643
Promoter ID:EPDNEW_R9167
Type:initiation region
Name:Atp2a2_2
Description:ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9166  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01239,554,336 - 39,554,396EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2174 AgrOrtholog
BioCyc Gene G2FUF-19256 BioCyc
Ensembl Genes ENSRNOG00000001285 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001738 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000024347.8 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001738 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000024347.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/Swiss-Prot
  3.40.50.1000 UniProtKB/Swiss-Prot
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/Swiss-Prot
  ATPase_P-typ_cation-transptr_N UniProtKB/Swiss-Prot
  ATPase_P-typ_cyto_dom_N UniProtKB/Swiss-Prot
  ATPase_P-typ_P_site UniProtKB/Swiss-Prot
  ATPase_P-typ_TM_dom_sf UniProtKB/Swiss-Prot
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/Swiss-Prot
  HAD-like_sf UniProtKB/Swiss-Prot
  HAD_sf UniProtKB/Swiss-Prot
  P-type_ATPase_IIA UniProtKB/Swiss-Prot
  P_typ_ATPase UniProtKB/Swiss-Prot
  P_typ_ATPase_HD_dom UniProtKB/Swiss-Prot
KEGG Report rno:29693 UniProtKB/Swiss-Prot
NCBI Gene 29693 ENTREZGENE
Pfam Cation_ATPase_C UniProtKB/Swiss-Prot
  Cation_ATPase_N UniProtKB/Swiss-Prot
PharmGKB ATP2A2 RGD
PhenoGen Atp2a2 PhenoGen
PRINTS HATPASE UniProtKB/Swiss-Prot
PROSITE ATPASE_E1_E2 UniProtKB/Swiss-Prot
SMART Cation_ATPase_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot
  SSF81653 UniProtKB/Swiss-Prot
  SSF81660 UniProtKB/Swiss-Prot
  SSF81665 UniProtKB/Swiss-Prot
TIGRFAMs ATPase-IIA1_Ca UniProtKB/Swiss-Prot
  ATPase_P-type UniProtKB/Swiss-Prot
UniProt A0A8L2QDW2_RAT UniProtKB/TrEMBL
  AT2A2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P11508 ENTREZGENE
UniProt Secondary P11508 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp2a2  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2  Atp2a2  ATPase, Ca++ transporting, cardiac muscle, slow twitch 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Atp2a2  ATPase, Ca++ transporting, cardiac muscle, slow twitch 2    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2   Symbol and Name status set to approved 625702 APPROVED
2003-04-14 Atp2a2  ATPase, Ca++ transporting, cardiac muscle, slow twitch 2   SercaII  sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2  Data Merged 628472 PENDING
2002-06-10 SercaII  sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Atp2a2  ATPase, Ca++ transporting, cardiac muscle, slow twitch 2       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in heart atria and ventricles 631306
gene_expression expressed in slow skeletal muscle 69761
gene_function transports calcium into the sarcoplasmic reticulum from the cytoplasm 68726
gene_function transports calcium into the sarcoplasmic reticulum from the cytoplasm 70642
gene_process plays a critical role in the contractile ability in cardiac myocytes 68726
gene_process plays a critical role in the contractile ability in cardiac myocytes 70642
gene_process involved in calcium cycling in the heart 631306
gene_process involved in sequestering calcium in endoplasmic reticulum stores in dental enamel-forming cells 1298687
gene_regulation expression induced by activation of ATF6 transcription factor and calcium depletion 70642
gene_regulation may be regulated by phospholamban 631306
gene_regulation expression level is responsive to thyroid hormone(T3)with atria demonstrating the largest change in protein content 631306