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Gene: Atp2a2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) Rattus norvegicus
Symbol: Atp2a2
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
RGD ID: 2174
Description: Exhibits several functions, including ATP binding activity; calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential; and lutropin-choriogonadotropic hormone receptor binding activity. Involved in several processes, including calcium ion transport; regulation of cardiac muscle contraction; and relaxation of cardiac muscle. Localizes to several cellular components, including apical ectoplasmic specialization; extrinsic component of cytoplasmic side of plasma membrane; and sarcoplasmic reticulum. Predicted to colocalize with intercalated disc. Used to study abdominal obesity-metabolic syndrome 1; congestive heart failure; and type 2 diabetes mellitus. Biomarker of euthyroid sick syndrome; heart disease; hypothyroidism; pulmonary hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; calcium pump 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; Serca2; SercaII; SR Ca(2+)-ATPase 2
Is Marker For: QTLs:   Calcic1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01239,553,903 - 39,603,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,553,903 - 39,603,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,434,651 - 41,482,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,266,600 - 35,316,237 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,129,987 - 35,179,584 (+)NCBI
Celera1235,744,606 - 35,793,364 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Atp2a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2174
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.