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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2174
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp2a2
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Acc ID: CHEBI:74460
Term: 5-chloro-7-iodoquinolin-8-ol
Definition: A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Chemical ID: MESH:D007464
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp2a2decreases expressionISOATP2A2 (Homo sapiens)6480464CTDClioquinol results in decreased expression of ATP2A2 mRNA; Clioquinol results in decreased expression of ATP2A2 proteinPMID:33511738
Atp2a2decreases expressionISOAtp2a2 (Mus musculus)6480464CTDClioquinol results in decreased expression of ATP2A2 mRNA; Clioquinol results in decreased expression of ATP2A2 proteinPMID:33511738
Atp2a2multiple interactionsISOATP2A2 (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Clioquinol results in decreased expression of ATP2A2 protein]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 protein]PMID:33511738
Atp2a2multiple interactionsISOAtp2a2 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Clioquinol results in decreased expression of ATP2A2 protein]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 protein]PMID:33511738
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