RGD Reference Report - AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.

Authors: Lygren, B  Carlson, CR  Santamaria, K  Lissandron, V  McSorley, T  Litzenberg, J  Lorenz, D  Wiesner, B  Rosenthal, W  Zaccolo, M  Tasken, K  Klussmann, E 
Citation: Lygren B, etal., EMBO Rep. 2007 Nov;8(11):1061-7. Epub 2007 Sep 28.
RGD ID: 2312630
Pubmed: PMID:17901878   (View Abstract at PubMed)
PMCID: PMC2247390   (View Article at PubMed Central)
DOI: DOI:10.1038/sj.embor.7401081   (Journal Full-text)

The beta-adrenergic receptor/cyclic AMP/protein kinase A (PKA) signalling pathway regulates heart rate and contractility. Here, we identified a supramolecular complex consisting of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2), its negative regulator phospholamban (PLN), the A-kinase anchoring protein AKAP18delta and PKA. We show that AKAP18delta acts as a scaffold that coordinates PKA phosphorylation of PLN and the adrenergic effect on Ca(2+) re-uptake. Inhibition of the compartmentalization of this cAMP signalling complex by specific molecular disruptors interferes with the phosphorylation of PLN. This prevents the subsequent release of PLN from SERCA2, thereby affecting the Ca(2+) re-uptake into the sarcoplasmic reticulum induced by adrenergic stimuli.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of protein kinase A signaling  IMP 2312630 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein-containing complex  IDA 2312630; 2312630; 2312630 RGD 
sarcoplasmic reticulum  IDA 2312630; 2312630; 2312630 RGD 

Molecular Function

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein kinase A (PKA) signaling pathway   ISOAkap7 (Rattus norvegicus)2312630; 2312630 RGD 
protein kinase A (PKA) signaling pathway   IMP 2312630 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Akap7  (A-kinase anchoring protein 7)
Atp2a2  (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)
Pln  (phospholamban)

Genes (Mus musculus)
Akap7  (A kinase anchor protein 7)

Genes (Homo sapiens)
AKAP7  (A-kinase anchoring protein 7)


Additional Information