RGD Reference Report - Calcium pumps in health and disease. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Calcium pumps in health and disease.

Authors: Brini, M  Carafoli, E 
Citation: Brini M and Carafoli E, Physiol Rev. 2009 Oct;89(4):1341-78. doi: 10.1152/physrev.00032.2008.
RGD ID: 7204695
Pubmed: PMID:19789383   (View Abstract at PubMed)
DOI: DOI:10.1152/physrev.00032.2008   (Journal Full-text)

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are thus essential to the correct functioning of the cell machinery. They have high affinity for Ca2+ and can efficiently regulate it down to very low concentration levels. Two of the pumps have been known for decades (the SERCA and PMCA pumps); one (the SPCA pump) has only become known recently. Each pump is the product of a multigene family, the number of isoforms being further increased by alternative splicing of the primary transcripts. The three pumps share the basic features of the catalytic mechanism but differ in a number of properties related to tissue distribution, regulation, and role in the cellular homeostasis of Ca2+. The molecular understanding of the function of the pumps has received great impetus from the solution of the three-dimensional structure of one of them, the SERCA pump. These spectacular advances in the structure and molecular mechanism of the pumps have been accompanied by the emergence and rapid expansion of the topic of pump malfunction, which has paralleled the rapid expansion of knowledge in the topic of Ca2+-signaling dysfunction. Most of the pump defects described so far are genetic: when they are very severe, they produce gross and global disturbances of Ca2+ homeostasis that are incompatible with cell life. However, pump defects may also be of a type that produce subtler, often tissue-specific disturbances that affect individual components of the Ca2+-controlling and/or processing machinery. They do not bring cells to immediate death but seriously compromise their normal functioning.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ATP2A1Humancalcium transport pathway   TAS  RGD 
ATP2A2Humancalcium transport pathway   TAS  RGD 
ATP2A3Humancalcium transport pathway   TAS  RGD 
ATP2B1Humancalcium transport pathway   TAS  RGD 
ATP2B2Humancalcium transport pathway   TAS  RGD 
ATP2B3Humancalcium transport pathway   TAS  RGD 
ATP2B4Humancalcium transport pathway   TAS  RGD 
ATP2C1Humancalcium transport pathway   TAS  RGD 
ATP2C2Humancalcium transport pathway   TAS  RGD 
Atp2a1Ratcalcium transport pathway   ISOATP2A1 (Homo sapiens) RGD 
Atp2a1Mousecalcium transport pathway   ISOATP2A1 (Homo sapiens) RGD 
Atp2a2Ratcalcium transport pathway   ISOATP2A2 (Homo sapiens) RGD 
Atp2a2Mousecalcium transport pathway   ISOATP2A2 (Homo sapiens) RGD 
Atp2a3Ratcalcium transport pathway   ISOATP2A3 (Homo sapiens) RGD 
Atp2a3Mousecalcium transport pathway   ISOATP2A3 (Homo sapiens) RGD 
Atp2b1Ratcalcium transport pathway   ISOATP2B1 (Homo sapiens) RGD 
Atp2b1Mousecalcium transport pathway   ISOATP2B1 (Homo sapiens) RGD 
Atp2b2Ratcalcium transport pathway   ISOATP2B2 (Homo sapiens) RGD 
Atp2b2Mousecalcium transport pathway   ISOATP2B2 (Homo sapiens) RGD 
Atp2b3Ratcalcium transport pathway   ISOATP2B3 (Homo sapiens) RGD 
Atp2b3Mousecalcium transport pathway   ISOATP2B3 (Homo sapiens) RGD 
Atp2b4Ratcalcium transport pathway   ISOATP2B4 (Homo sapiens) RGD 
Atp2b4Mousecalcium transport pathway   ISOATP2B4 (Homo sapiens) RGD 
Atp2c1Ratcalcium transport pathway   ISO RGD 
Atp2c1Mousecalcium transport pathway   ISO RGD 
Atp2c2Ratcalcium transport pathway   ISOATP2C2 (Homo sapiens) RGD 
Atp2c2Mousecalcium transport pathway   ISOATP2C2 (Homo sapiens) RGD 
ATP2A1Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ATP2A2Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ATP2A3Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ATP2B1Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ATP2B2Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ATP2B3Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ATP2B4Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ATP2C1Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
ATP2C2Humancalcium/calcium-mediated signaling pathway   TAS  RGD 
Atp2a1Mousecalcium/calcium-mediated signaling pathway   ISOATP2A1 (Homo sapiens) RGD 
Atp2a1Ratcalcium/calcium-mediated signaling pathway   ISOATP2A1 (Homo sapiens) RGD 
Atp2a2Mousecalcium/calcium-mediated signaling pathway   ISOATP2A2 (Homo sapiens) RGD 
Atp2a2Ratcalcium/calcium-mediated signaling pathway   ISOATP2A2 (Homo sapiens) RGD 
Atp2a3Mousecalcium/calcium-mediated signaling pathway   ISOATP2A3 (Homo sapiens) RGD 
Atp2a3Ratcalcium/calcium-mediated signaling pathway   ISOATP2A3 (Homo sapiens) RGD 
Atp2b1Mousecalcium/calcium-mediated signaling pathway   ISOATP2B1 (Homo sapiens) RGD 
Atp2b1Ratcalcium/calcium-mediated signaling pathway   ISOATP2B1 (Homo sapiens) RGD 
Atp2b2Ratcalcium/calcium-mediated signaling pathway   ISOATP2B2 (Homo sapiens) RGD 
Atp2b2Mousecalcium/calcium-mediated signaling pathway   ISOATP2B2 (Homo sapiens) RGD 
Atp2b3Mousecalcium/calcium-mediated signaling pathway   ISOATP2B3 (Homo sapiens) RGD 
Atp2b3Ratcalcium/calcium-mediated signaling pathway   ISOATP2B3 (Homo sapiens) RGD 
Atp2b4Mousecalcium/calcium-mediated signaling pathway   ISOATP2B4 (Homo sapiens) RGD 
Atp2b4Ratcalcium/calcium-mediated signaling pathway   ISOATP2B4 (Homo sapiens) RGD 
Atp2c1Mousecalcium/calcium-mediated signaling pathway   ISO RGD 
Atp2c1Ratcalcium/calcium-mediated signaling pathway   ISO RGD 
Atp2c2Ratcalcium/calcium-mediated signaling pathway   ISOATP2C2 (Homo sapiens) RGD 
Atp2c2Mousecalcium/calcium-mediated signaling pathway   ISOATP2C2 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Atp2a1  (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1)
Atp2a2  (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)
Atp2a3  (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)
Atp2b1  (ATPase plasma membrane Ca2+ transporting 1)
Atp2b2  (ATPase plasma membrane Ca2+ transporting 2)
Atp2b3  (ATPase plasma membrane Ca2+ transporting 3)
Atp2b4  (ATPase plasma membrane Ca2+ transporting 4)
Atp2c1  (ATPase secretory pathway Ca2+ transporting 1)
Atp2c2  (ATPase secretory pathway Ca2+ transporting 2)

Genes (Mus musculus)
Atp2a1  (ATPase, Ca++ transporting, cardiac muscle, fast twitch 1)
Atp2a2  (ATPase, Ca++ transporting, cardiac muscle, slow twitch 2)
Atp2a3  (ATPase, Ca++ transporting, ubiquitous)
Atp2b1  (ATPase, Ca++ transporting, plasma membrane 1)
Atp2b2  (ATPase, Ca++ transporting, plasma membrane 2)
Atp2b3  (ATPase, Ca++ transporting, plasma membrane 3)
Atp2b4  (ATPase, Ca++ transporting, plasma membrane 4)
Atp2c1  (ATPase, Ca++-sequestering)
Atp2c2  (ATPase, Ca++ transporting, type 2C, member 2)

Genes (Homo sapiens)
ATP2A1  (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1)
ATP2A2  (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)
ATP2A3  (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)
ATP2B1  (ATPase plasma membrane Ca2+ transporting 1)
ATP2B2  (ATPase plasma membrane Ca2+ transporting 2)
ATP2B3  (ATPase plasma membrane Ca2+ transporting 3)
ATP2B4  (ATPase plasma membrane Ca2+ transporting 4)
ATP2C1  (ATPase secretory pathway Ca2+ transporting 1)
ATP2C2  (ATPase secretory pathway Ca2+ transporting 2)


Additional Information