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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2174
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp2a2
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Acc ID: CHEBI:29320
Term: calcium(0)
Definition: An elemental calcium that has formula Ca.
Chemical ID: MESH:D002118
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp2a2affects transportEXP 6480464CTDATP2A2 protein affects the transport of CalciumPMID:17287366
Atp2a2multiple interactionsEXP 6480464CTD[[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calcium; [Thapsigargin results in decreased activity of ATP2A2 protein] which results in decreased transport of CalciumPMID:16236312 PMID:19244478
Atp2a2affects abundanceISOAtp2a2 (Mus musculus)6480464CTDATP2A2 protein affects the abundance of CalciumPMID:19328205
Atp2a2affects exportISOAtp2a2 (Mus musculus)6480464CTDATP2A2 protein alternative form affects the export of CalciumPMID:11679415
Atp2a2affects uptakeISOAtp2a2 (Mus musculus)6480464CTDATP2A2 protein alternative form affects the uptake of CalciumPMID:11679415
Atp2a2multiple interactionsISOATP2A2 (Homo sapiens)6480464CTDCalcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 protein]PMID:33511738
Atp2a2multiple interactionsISOAtp2a2 (Mus musculus)6480464CTDCalcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 mRNA]; Calcium promotes the reaction [Clioquinol results in decreased expression of ATP2A2 protein]; PPP3R1 gene mutant form inhibits the reaction [ATP2A2 protein affects the transport of Calcium]PMID:19700627 PMID:33511738
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