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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2174
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp2a2
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp2a2affects response to substanceEXP 6480464CTDATP2A2 protein affects the susceptibility to PhenylephrinePMID:21952229
Atp2a2decreases activityEXP 6480464CTDPhenylephrine results in decreased activity of ATP2A2 proteinPMID:17287366
Atp2a2decreases expressionEXP 6480464CTDPhenylephrine results in decreased expression of ATP2A2 mRNA; Phenylephrine results in decreased expression of ATP2A2 proteinPMID:11577024 PMID:15795322 PMID:17287366 PMID:17592507 PMID:19244478 PMID:23939492
Atp2a2increases expressionEXP 6480464CTDPhenylephrine results in increased expression of ATP2A2 mRNAPMID:16236312
Atp2a2multiple interactionsEXP 6480464CTD(+)-JQ1 compound inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Phenylephrine results in increased expression of ATP2A2 protein]; [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] which results in increased expression of ATP2A2 protein; [Phenylephrine results in decreased expression of ATP2A2 protein] which results in decreased transport of Calcium; Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]; THRB protein affects the reaction [Phenylephrine results in decreased expression of ATP2A2 protein]; Triiodothyronine inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA]PMID:11577024 PMID:16236312 PMID:17592507 PMID:19244478 PMID:23939492
Atp2a2multiple interactionsISOAtp2a2 (Mus musculus)6480464CTD[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 proteinPMID:11499749
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