Atp2a2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) - Rat Genome Database

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Pathways
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Gene: Atp2a2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) Chinchilla lanigera
Analyze
Symbol: Atp2a2
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
RGD ID: 8799698
Description: ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); enzyme binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); autophagosome membrane docking (ortholog); calcium ion import into sarcoplasmic reticulum (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); acrokeratosis verruciformis (ortholog); Acute Experimental Pancreatitis (ortholog); FOUND IN apical ectoplasmic specialization (ortholog); calcium ion-transporting ATPase complex (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,233,336 - 7,295,754 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,233,336 - 7,295,754 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome assembly  (ISO)
autophagosome membrane docking  (ISO)
calcium ion import into sarcoplasmic reticulum  (ISO)
calcium ion transmembrane transport  (ISO)
calcium ion transport  (ISO)
calcium ion transport from cytosol to endoplasmic reticulum  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cellular response to heat  (ISO)
cellular response to oxidative stress  (ISO)
endoplasmic reticulum calcium ion homeostasis  (ISO)
ER-nucleus signaling pathway  (ISO)
intracellular calcium ion homeostasis  (ISO)
mitochondrion-endoplasmic reticulum membrane tethering  (ISO)
negative regulation of heart contraction  (ISO)
neuron cellular homeostasis  (ISO)
organelle localization by membrane tethering  (ISO)
organelle organization  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of endoplasmic reticulum calcium ion concentration  (ISO)
regulation of calcium ion-dependent exocytosis of neurotransmitter  (ISO)
regulation of cardiac muscle cell action potential involved in regulation of contraction  (ISO)
regulation of cardiac muscle cell membrane potential  (ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (ISO)
regulation of the force of heart contraction  (ISO)
relaxation of cardiac muscle  (ISO)
relaxation of skeletal muscle  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to lipopolysaccharide  (ISO)
response to peptide hormone  (ISO)
sarcoplasmic reticulum calcium ion transport  (ISO)
T-tubule organization  (ISO)
transition between fast and slow fiber  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Atp2a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,233,336 - 7,295,754 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,233,336 - 7,295,754 (+)NCBIChiLan1.0ChiLan1.0
ATP2A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812110,280,616 - 110,351,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12110,280,756 - 110,351,093 (+)EnsemblGRCh38hg38GRCh38
GRCh3712110,719,052 - 110,788,898 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612109,203,815 - 109,273,278 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412109,182,151 - 109,251,615NCBI
Celera12110,344,773 - 110,414,642 (+)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12107,737,670 - 107,807,502 (+)NCBIHuRef
CHM1_112110,686,837 - 110,756,707 (+)NCBICHM1_1
T2T-CHM13v2.012110,258,258 - 110,328,744 (+)NCBIT2T-CHM13v2.0
Atp2a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,591,576 - 122,640,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,591,576 - 122,640,288 (-)EnsemblGRCm39 Ensembl
GRCm385122,453,513 - 122,502,225 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,453,513 - 122,502,225 (-)EnsemblGRCm38mm10GRCm38
MGSCv375122,903,522 - 122,952,234 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365122,714,131 - 122,762,512 (-)NCBIMGSCv36mm8
Celera5119,532,083 - 119,580,718 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.38NCBI
Atp2a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81239,733,519 - 39,782,942 (+)NCBIGRCr8
mRatBN7.21234,072,710 - 34,122,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,072,683 - 34,122,101 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,245,140 - 35,294,551 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,856,569 - 35,905,979 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,908,881 - 34,958,289 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,553,903 - 39,603,326 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,553,903 - 39,603,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,434,651 - 41,482,924 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,266,600 - 35,316,237 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,129,987 - 35,179,584 (+)NCBI
Celera1235,744,606 - 35,793,364 (+)NCBICelera
Cytogenetic Map12q16NCBI
ATP2A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210118,347,938 - 118,415,869 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112118,344,305 - 118,412,270 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012107,857,009 - 107,924,938 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112111,249,039 - 111,316,532 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12111,246,508 - 111,311,923 (+)Ensemblpanpan1.1panPan2
ATP2A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,148,181 - 8,209,392 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,148,236 - 8,209,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,312,735 - 8,373,567 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,406,466 - 8,467,508 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,406,107 - 8,467,504 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,366,182 - 8,427,199 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,424,775 - 8,485,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,381,368 - 8,442,436 (+)NCBIUU_Cfam_GSD_1.0
Atp2a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118156,121,831 - 156,178,459 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365583,300,941 - 3,357,941 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365583,300,941 - 3,357,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP2A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1431,674,757 - 31,744,969 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11431,674,659 - 31,744,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,446,619 - 33,491,489 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21433,642,897 - 33,670,781 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP2A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,522,175 - 105,590,291 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11105,522,157 - 105,590,958 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037139,532,362 - 139,600,791 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp2a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,509,366 - 21,568,098 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474721,509,360 - 21,567,424 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021431   ⟹   ENSCLAP00000021230
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554827,233,336 - 7,295,754 (+)Ensembl
RefSeq Acc Id: XM_013503694   ⟹   XP_013359148
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554827,233,336 - 7,295,754 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001230987
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554827,233,336 - 7,295,754 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013359148 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021230
  ENSCLAP00000021230.1
Reference Protein Sequences
RefSeq Acc Id: XP_013359148   ⟸   XM_013503694
- UniProtKB: A0A8C2VVE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021230   ⟸   ENSCLAT00000021431
Protein Domains
Cation-transporting P-type ATPase C-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014542 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021431 ENTREZGENE
  ENSCLAT00000021431.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/TrEMBL
  Calcium-transporting ATPase, transmembrane domain UniProtKB/TrEMBL
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/TrEMBL
  ATPase_P-typ_cyto_dom_N UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  P-type_ATPase_IIA UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/TrEMBL
NCBI Gene Atp2a2 ENTREZGENE
PANTHER CALCIUM-TRANSPORTING ATPASE UniProtKB/TrEMBL
  SARCOPLASMIC/ENDOPLASMIC RETICULUM CALCIUM ATPASE 2 UniProtKB/TrEMBL
Pfam Cation_ATPase UniProtKB/TrEMBL
  Cation_ATPase_C UniProtKB/TrEMBL
  E1-E2_ATPase UniProtKB/TrEMBL
  Hydrolase UniProtKB/TrEMBL
PRINTS CATATPASE UniProtKB/TrEMBL
  NAKATPASE UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/TrEMBL
  SSF81653 UniProtKB/TrEMBL
  SSF81660 UniProtKB/TrEMBL
  SSF81665 UniProtKB/TrEMBL
UniProt A0A8C2VVE1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Atp2a2  ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2  Symbol and/or name change 5135510 APPROVED