Gper1 (G protein-coupled estrogen receptor 1) - Rat Genome Database

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Gene: Gper1 (G protein-coupled estrogen receptor 1) Rattus norvegicus
Analyze
Symbol: Gper1
Name: G protein-coupled estrogen receptor 1
RGD ID: 619845
Description: Enables G protein-coupled estrogen receptor activity and estradiol binding activity. Involved in several processes, including apoptotic nuclear changes; cellular response to organic cyclic compound; and positive regulation of signal transduction. Acts upstream of with a positive effect on vasodilation. Located in several cellular components, including dendrite; postsynaptic density; and presynaptic membrane. Orthologous to human GPER1 (G protein-coupled estrogen receptor 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; serotonin signaling pathway; INTERACTS WITH (S)-amphetamine; 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chemoattractant receptor-like 2; chemokine receptor-like 2; G protein-coupled receptor 30; G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; G-protein coupled receptor 41; Gper; Gpr30; GPR41; membrane estrogen receptor; mER
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Gper1em1Bj  
Genetic Models: SS-Gper1em1Bj-/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21215,217,217 - 15,222,679 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,217,442 - 15,221,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,027,880 - 16,029,158 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01216,651,625 - 16,652,903 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01215,677,933 - 15,679,211 (-)NCBIRnor_WKY
Rnor_6.01217,309,122 - 17,315,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,309,834 - 17,311,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,296,086 - 19,301,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,718,615 - 15,719,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,748,542 - 15,749,821 (-)NCBI
Celera1216,971,703 - 16,972,981 (-)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5'-Tetrabromodiphenyl ether  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,4'-thiodiphenol  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlordecone  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cumene  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glyphosate  (EXP)
herbicide  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
KT 5720  (EXP)
KT 5823  (ISO)
LY294002  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
mestranol  (ISO)
methimazole  (EXP)
methylparaben  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
Nonylphenol  (EXP,ISO)
oxybenzone  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
potassium dichromate  (ISO)
propylparaben  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quinazolines  (EXP)
raloxifene  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
toluene  (EXP)
triclocarban  (EXP)
tyrphostin AG 1478  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO,ISS)
apoptotic chromosome condensation  (IDA)
cell differentiation  (IEA)
cellular response to estradiol stimulus  (IBA,IDA,IEA,ISO,ISS)
cellular response to glucose stimulus  (IEA,ISO,ISS)
cellular response to mineralocorticoid stimulus  (IDA)
cellular response to peptide hormone stimulus  (IEA,ISO,ISS)
cellular response to tumor necrosis factor  (IEA,ISO,ISS)
G protein-coupled receptor signaling pathway  (ISO)
inflammatory response  (IEA)
innate immune response  (IEA)
intracellular estrogen receptor signaling pathway  (IMP)
intracellular steroid hormone receptor signaling pathway  (IBA,IDA,IEA,ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of cell cycle process  (IEA,ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO,ISS)
negative regulation of gene expression  (IDA,IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO,ISS)
negative regulation of leukocyte activation  (IEA,ISO,ISS)
negative regulation of lipid biosynthetic process  (IEA,ISO,ISS)
negative regulation of protein kinase B signaling  (IEA,ISO)
negative regulation of receptor binding  (IMP)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
nervous system development  (IEA)
neuronal action potential  (ISS)
nuclear fragmentation involved in apoptotic nuclear change  (IDA)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of cardiac vascular smooth muscle cell differentiation  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO,ISS)
positive regulation of endothelial cell apoptotic process  (IDA)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,IEA,IMP,ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IDA)
positive regulation of G protein-coupled receptor signaling pathway  (IEA,ISO,ISS)
positive regulation of gene expression  (IDA,IEA,IMP,ISO)
positive regulation of inositol trisphosphate biosynthetic process  (IEA,ISO,ISS)
positive regulation of insulin secretion  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of neurogenesis  (IEA,ISO,ISS)
positive regulation of neurotransmitter secretion  (ISS)
positive regulation of phosphatidylinositol 3-kinase signaling  (IDA,IEA,ISO)
positive regulation of protein import into nucleus  (IMP)
positive regulation of protein kinase B signaling  (IMP)
positive regulation of protein localization to plasma membrane  (IEA,ISO,ISS)
positive regulation of protein phosphorylation  (IEA,IMP,ISO)
positive regulation of release of cytochrome c from mitochondria  (IDA)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
positive regulation of uterine smooth muscle contraction  (IEA,ISO,ISS)
positive regulation of voltage-gated sodium channel activity  (IMP)
regulation of cell cycle  (ISO,ISS)
regulation of cytosolic calcium ion concentration  (ISS)
serotonin receptor signaling pathway  (IMP)
steroid hormone mediated signaling pathway  (ISO)
vasodilation  (IDA,IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Estrogen receptors are found in glia and at extranuclear neuronal sites in the dorsal striatum of female rats: evidence for cholinergic but not dopaminergic colocalization. Almey A, etal., Endocrinology. 2012 Nov;153(11):5373-83. doi: 10.1210/en.2012-1458. Epub 2012 Aug 23.
2. The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells. Alyea RA, etal., J Neurochem. 2008 Aug;106(4):1525-33. Epub 2008 May 19.
3. Breast cancer, estrogen receptor and ligands. Bai Z and Gust R, Arch Pharm (Weinheim). 2009 Mar;342(3):133-49.
4. Molecular cloning and tissue expression of a novel orphan G protein-coupled receptor from rat lung. Bonini JA, etal., Biochem Biophys Res Commun 1997 May 8;234(1):190-3.
5. Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells. Chimento A, etal., Cell Death Dis. 2013 Aug 1;4:e747. doi: 10.1038/cddis.2013.275.
6. Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes. Delfosse V, etal., Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14930-5. doi: 10.1073/pnas.1203574109. Epub 2012 Aug 27.
7. Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats. Deschamps AM and Murphy E, Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1806-13. Epub 2009 Aug 28.
8. Serum levels of G protein-coupled estrogen receptor 1 (GPER1) in drug-naive patients with generalized anxiety disorder. Fındıklı E, etal., Psychiatry Res. 2016 Oct 30;244:312-6. doi: 10.1016/j.psychres.2016.04.098. Epub 2016 Jul 22.
9. Expression of G protein-coupled oestrogen receptor in melanoma and in pregnancy-associated melanoma. Fábián M, etal., J Eur Acad Dermatol Venereol. 2017 Sep;31(9):1453-1461. doi: 10.1111/jdv.14304. Epub 2017 Jun 20.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor. Greenlee MM, etal., Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(11):L878-89. doi: 10.1152/ajplung.00008.2013. Epub 2013 Oct 4.
13. Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation. Gros R, etal., Am J Physiol Cell Physiol. 2013 Mar;304(6):C532-40. doi: 10.1152/ajpcell.00203.2012. Epub 2013 Jan 2.
14. G-protein coupled estrogen receptor 1 mediated estrogenic neuroprotection against spinal cord injury. Hu R, etal., Crit Care Med. 2012 Dec;40(12):3230-7. doi: 10.1097/CCM.0b013e3182657560.
15. 2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor. Koganti S, etal., Eur J Pharmacol. 2014 Jan 15;723:131-40. doi: 10.1016/j.ejphar.2013.10.064. Epub 2013 Nov 18.
16. G protein-coupled estrogen receptor1 (GPER1) may mediate Rho-kinase (ROCK-2) up-regulation in coronary endothelial cells. Kurt AH, etal., Endocr Regul. 2013 Apr;47(2):75-84. doi: 10.4149/endo_2013_02_75.
17. Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells. Lucas TF, etal., Biol Reprod. 2010 Aug 1;83(2):307-17. Epub 2010 May 5.
18. The unfolding stories of GPR30, a new membrane-bound estrogen receptor. Maggiolini M and Picard D, J Endocrinol. 2010 Feb;204(2):105-14. Epub 2009 Sep 18.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Spatial and temporal changes in the expression of steroid hormone receptors in mouse model of endometriosis. Mishra A, etal., J Assist Reprod Genet. 2020 May;37(5):1069-1081. doi: 10.1007/s10815-020-01725-6. Epub 2020 Mar 9.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives. Rezg R, etal., Environ Int. 2014 Mar;64C:83-90. doi: 10.1016/j.envint.2013.12.007. Epub 2013 Dec 29.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study. Samartzis N, etal., Reprod Biol Endocrinol. 2012 Apr 20;10:30. doi: 10.1186/1477-7827-10-30.
26. G-protein oestrogen receptor 1: trials and tribulations of a membrane oestrogen receptor. Srivastava DP and Evans PD, J Neuroendocrinol. 2013 Nov;25(11):1219-30. doi: 10.1111/jne.12071.
27. Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. Waghulde H, etal., Hypertension. 2018 Nov;72(5):1125-1132. doi: 10.1161/HYPERTENSIONAHA.118.11175.
28. Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus. Xu H, etal., Neuroscience. 2009 Feb 18;158(4):1599-607. doi: 10.1016/j.neuroscience.2008.11.028. Epub 2008 Nov 21.
Additional References at PubMed
PMID:15539556   PMID:15705806   PMID:16780796   PMID:17872373   PMID:18586395   PMID:19125412   PMID:19179659   PMID:19220308   PMID:19420011   PMID:19523168   PMID:19741198   PMID:19912997  
PMID:19931550   PMID:20132863   PMID:20347696   PMID:20434187   PMID:20551055   PMID:20596598   PMID:20696528   PMID:20969598   PMID:21149639   PMID:21242460   PMID:21365775   PMID:21427217  
PMID:21540189   PMID:21673097   PMID:21844484   PMID:21865584   PMID:22265196   PMID:22328091   PMID:22378360   PMID:22645130   PMID:22828404   PMID:23066016   PMID:23285008   PMID:23300088  
PMID:23545157   PMID:23610132   PMID:23659385   PMID:23673155   PMID:23674134   PMID:23836701   PMID:23840305   PMID:23871778   PMID:23950890   PMID:24115158   PMID:24594140   PMID:24736568  
PMID:24793639   PMID:25150623   PMID:25211590   PMID:25256868   PMID:25280432   PMID:25310566   PMID:25712524   PMID:25893735   PMID:25936661   PMID:26070386   PMID:26181370   PMID:26187146  
PMID:26241029   PMID:26345541   PMID:26371374   PMID:26391661   PMID:26408543   PMID:26497404   PMID:26628039   PMID:27080432   PMID:27173878   PMID:27249584   PMID:27311857   PMID:27608844  
PMID:27698063   PMID:27849354   PMID:27908726   PMID:28472669   PMID:28733475   PMID:29369009   PMID:29421611   PMID:30218860   PMID:30227089   PMID:30400046   PMID:30570746   PMID:30731078  
PMID:31728701   PMID:32007102   PMID:32272225   PMID:32303987   PMID:32321426   PMID:32632943   PMID:32908490   PMID:33127751   PMID:33193095   PMID:33345973   PMID:33629579   PMID:34076791  
PMID:34255932   PMID:34274445   PMID:34352396   PMID:34399010   PMID:35124781   PMID:35170266   PMID:35729568   PMID:35803362   PMID:36108979   PMID:36152742   PMID:36845134  


Genomics

Comparative Map Data
Gper1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21215,217,217 - 15,222,679 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,217,442 - 15,221,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,027,880 - 16,029,158 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01216,651,625 - 16,652,903 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01215,677,933 - 15,679,211 (-)NCBIRnor_WKY
Rnor_6.01217,309,122 - 17,315,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,309,834 - 17,311,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,296,086 - 19,301,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,718,615 - 15,719,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,748,542 - 15,749,821 (-)NCBI
Celera1216,971,703 - 16,972,981 (-)NCBICelera
Cytogenetic Map12q11NCBI
GPER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3871,087,118 - 1,093,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl71,082,208 - 1,093,815 (+)EnsemblGRCh38hg38GRCh38
GRCh3771,126,754 - 1,133,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3671,092,969 - 1,099,977 (+)NCBINCBI36Build 36hg18NCBI36
Build 347899,752 - 906,692NCBI
Celera71,094,088 - 1,101,068 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef71,041,713 - 1,048,693 (+)NCBIHuRef
CHM1_171,126,080 - 1,133,090 (+)NCBICHM1_1
T2T-CHM13v2.071,192,020 - 1,198,681 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)NCBI
Gper1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,408,905 - 139,413,555 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,408,906 - 139,413,555 (+)EnsemblGRCm39 Ensembl
GRCm385139,423,150 - 139,427,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,423,151 - 139,427,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,899,133 - 139,903,754 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,676,821 - 139,681,430 (+)NCBIMGSCv36mm8
Celera5136,477,197 - 136,481,822 (+)NCBICelera
Cytogenetic Map5G2NCBI
Gper1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBIChiLan1.0ChiLan1.0
GPER1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1754,349,340 - 54,364,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,331,586 - 1,338,194 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,454,768 - 1,461,376 (+)NCBIpanpan1.1PanPan1.1panPan2
GPER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,792,072 - 15,796,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,792,897 - 15,794,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,265,181 - 17,311,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0615,922,801 - 15,968,766 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl615,922,807 - 15,927,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,725,481 - 15,771,429 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,652,239 - 15,698,182 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0615,940,139 - 15,986,136 (-)NCBIUU_Cfam_GSD_1.0
Gper1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,716,868 - 143,723,998 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,288,912 - 1,293,427 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367541,288,891 - 1,293,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3712,160 - 715,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13711,427 - 715,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23828,578 - 833,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,491,874 - 20,497,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,492,188 - 20,493,315 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,198,018 - 1,204,300 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gper1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,627,473 - 26,632,027 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,627,560 - 26,632,483 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gper1
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:74
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000001732
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121300829619212979Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat


Genetic Models
This gene Gper1 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 32 24 8 18 8 4 5 68 29 27 11 4
Below cutoff 1 11 26 26 1 26 4 6 6 6 14 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001732   ⟹   ENSRNOP00000001732
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,217,442 - 15,221,889 (-)Ensembl
Rnor_6.0 Ensembl1217,309,834 - 17,311,112 (-)Ensembl
RefSeq Acc Id: NM_133573   ⟹   NP_598257
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21215,217,935 - 15,219,213 (-)NCBI
Rnor_6.01217,309,834 - 17,311,112 (-)NCBI
Rnor_5.01219,296,086 - 19,301,691 (-)NCBI
RGSC_v3.41215,718,615 - 15,719,893 (-)RGD
Celera1216,971,703 - 16,972,981 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248914   ⟹   XP_006248976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21215,217,217 - 15,222,679 (-)NCBI
Rnor_6.01217,309,122 - 17,315,267 (-)NCBI
Rnor_5.01219,296,086 - 19,301,691 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089048   ⟹   XP_038944976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21215,217,217 - 15,222,679 (-)NCBI
Protein Sequences
Protein RefSeqs NP_598257 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248976 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944976 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53208 (Get FASTA)   NCBI Sequence Viewer  
  EDL89767 (Get FASTA)   NCBI Sequence Viewer  
  O08878 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_598257   ⟸   NM_133573
- UniProtKB: G3V654 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248976   ⟸   XM_006248914
- Peptide Label: isoform X1
- UniProtKB: G3V654 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001732   ⟸   ENSRNOT00000001732
RefSeq Acc Id: XP_038944976   ⟸   XM_039089048
- Peptide Label: isoform X1
- UniProtKB: G3V654 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08878-F1-model_v2 AlphaFold O08878 1-375 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619845 AgrOrtholog
BioCyc Gene G2FUF-19895 BioCyc
Ensembl Genes ENSRNOG00000001287 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001732 ENTREZGENE
  ENSRNOP00000001732.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001732 ENTREZGENE
  ENSRNOT00000001732.4 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPER1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171104 UniProtKB/Swiss-Prot
NCBI Gene 171104 ENTREZGENE
PANTHER G-PROTEIN COUPLED ESTROGEN RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gper1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V654 ENTREZGENE, UniProtKB/TrEMBL
  GPER1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Gper1  G protein-coupled estrogen receptor 1  Gper  G protein-coupled estrogen receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Gper  G protein-coupled estrogen receptor 1  Gpr30  G protein-coupled receptor 30  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Gpr30  G protein-coupled receptor 30      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Gpr30  G protein-coupled receptor 30      Symbol and Name status set to provisional 70820 PROVISIONAL