BISPHENOL A RESPONSE PATHWAY (PW:0001511)

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Description

Bisphenols represent a large family of compounds used in the manufacture of various consumer products of which the most widely used is bisphenol A (BPA) - [2,2-bis(4-hydroxyphenyl)propane]. BPA is used in the production of many types of plastics, the lining of food containers, medical and dental devices, thermal paper. The high levels of BPA production underlie its presence in the environment. In addition, BPA can also be found in food due to its leaching out of containers. BPA is an endocrine

Pathway Diagram:

Elsevier Inc. Bisphenol A ---> thermal paper Bisphenol A ---> plastic wares Esr downstream effects Gper1 activation of growth factor signaling and downstream pathways reproductive/birth defects/developmental Esr1 Esr2 bisphenol A degradation pathway estrogen signaling pathway titanium dioxide nanoparticle response pathway anatase Bisphenol A BPA-adducts Bisphenol A ---- Gper1 Bisphenol A ---- Esr2 Bisphenol A ---> medical devices Bisphenol A --+> Esr2 Bisphenol A ---- Esr1 Bisphenol A --+> Esr1 Bisphenol A --+> Gper1 Bisphenol A ---> chromosomal aberrations bisphenol A degradation pathway ---| environmental contamination anatase ---> titanium dioxide nanoparticle response pathway DNA Damage medical devices thermal paper beverage/food cans plastic wares Bisphenol A ---> beverage/food cans photoelectrocatalysis photoelectrocatalysis ---| environmental contamination chromosomal aberrations Bisphenol A ---> BPA-adducts Bisphenol A ---> DNA Damage cardiovascular/kidney/respiratory Bisphenol A ---- cardiovascular/kidney/respiratory diabetes/obesity immunity/cancer food contamination environmental contamination
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Genes in Pathway:

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bisphenol A response pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:8547944
RGD:8548497
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:8547944
RGD:8548497
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:8547944
RGD:8548497

Pathway Gene Annotations

Disease Annotations Associated with Genes in the bisphenol A response pathway
Disease TermsGene Symbols
adenocarcinomaEsr1 , Esr2
adenomaEsr2
alopeciaEsr2
Alzheimer's diseaseEsr1 , Esr2
Animal Disease ModelsEsr1
Animal Mammary NeoplasmsEsr1 , Esr2
anxiety disorderEsr2
aortic valve stenosisEsr2
arteriosclerosisEsr1
asthmaEsr2
astrocytomaEsr1 , Esr2
atherosclerosisEsr1 , Esr2
atrial fibrillationEsr2
Autosomal Recessive Spinocerebellar Ataxia 8Esr1
Blast CrisisEsr2
bone diseaseEsr1
Bone FracturesEsr1
brain ischemiaEsr2
breast cancerEsr1 , Esr2
Breast Cancer, FamilialEsr1
Breast NeoplasmsEsr1 , Esr2 , Gper1
Bronchial HyperreactivityEsr1
carcinomaEsr1 , Esr2
Cardiac ArrhythmiasEsr2
cataract 33Esr1
Cell Transformation, NeoplasticEsr1
cerebellar ataxiaEsr1
Chronic PeriodontitisEsr1
Cocaine-Related DisordersEsr2
Cognitive DysfunctionEsr2
colitisEsr2
Colonic NeoplasmsEsr2
Colorectal NeoplasmsEsr2
contact dermatitisEsr2
coronary artery diseaseEsr1 , Esr2
Coronary DiseaseEsr2
Crohn's diseaseEsr2
cryptorchidismEsr1
cystitisEsr2
DeafnessEsr2
Diabetes Mellitus, Experimental Esr1
Diabetic NephropathiesEsr1
Disease ProgressionEsr1
Emery-Dreifuss muscular dystrophyEsr1
Endometrial NeoplasmsEsr1 , Esr2
Endometrioid CarcinomasEsr1
endometriosisEsr1 , Esr2
Estrogen ResistanceEsr1
Experimental ArthritisEsr1 , Esr2
Experimental Autoimmune EncephalomyelitisEsr2
Experimental MelanomaEsr2
Female InfertilityEsr1 , Esr2
Female Urogenital DiseasesEsr1
FeminizationEsr1
glomerulonephritisEsr1
glomerulosclerosisEsr2
Graves' diseaseEsr2
Hashimoto DiseaseEsr2
Hearing LossEsr2
hepatocellular carcinomaEsr1
Hot FlashesEsr2
HyperalgesiaEsr1 , Esr2
hypertensionEsr2
hypospadiasEsr2
in situ carcinomaEsr1 , Esr2
infertilityEsr1
inflammatory bowel diseaseEsr2
interstitial cystitisEsr2
Knee OsteoarthritisEsr1 , Esr2
Left Ventricular HypertrophyEsr2
leiomyomaEsr1
leukemiaEsr1
Leydig cell tumorEsr1
LithiasisEsr2
liver benign neoplasmEsr1
Lung InjuryEsr2
Lung NeoplasmsEsr1
lymphangioleiomyomatosisEsr1
macular degenerationEsr1
male infertilityEsr1
Mammary Neoplasms, ExperimentalEsr1 , Esr2
medulloblastomaEsr2
melanomaEsr1 , Esr2
mental depressionEsr2
MesotheliomaEsr1
Metabolic Bone DiseasesEsr1
migraineEsr1
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Esr1
Multiple AbnormalitiesGper1
Musculoskeletal PainEsr1
myasthenia gravisEsr2
myeloid leukemiaEsr2
myocardial infarctionEsr1
Myocardial Reperfusion InjuryEsr1 , Esr2
Neoplasm InvasivenessEsr1
Neoplasm MetastasisEsr1
Neoplasm Recurrence, LocalEsr1
neuroblastomaEsr1
non-small cell lung carcinomaEsr1
obesityEsr1 , Esr2
oligospermiaEsr1
osteoarthritisEsr1
Osteoarthritis, HandEsr1 , Esr2
Osteoarthritis, HipEsr1
osteoporosisEsr1 , Esr2
Osteoporotic FracturesEsr1 , Esr2
Ovarian NeoplasmsEsr1
Parkinson's diseaseEsr2
Parkinsonian DisordersEsr1
peritonitisEsr1 , Esr2
Pituitary NeoplasmsEsr2
pleurisyEsr1
Postmenopausal OsteoporosisEsr1 , Esr2
pre-eclampsiaEsr2
primary open angle glaucomaEsr2
prostate cancerEsr2
prostate carcinoma in situEsr1 , Esr2
prostatic hypertrophyEsr1 , Esr2
Prostatic NeoplasmsEsr1 , Esr2
pulmonary hypertensionEsr1 , Esr2
retinal degenerationEsr2
rheumatoid arthritisEsr2
SepsisEsr2
Shock, HemorrhagicEsr1 , Esr2
Spinal Cord InjuriesEsr1 , Esr2 , Gper1
Spinal FracturesEsr1
SplenomegalyEsr2
StrokeEsr2
Subarachnoid HemorrhageEsr1
substance-induced psychosisEsr1
systemic lupus erythematosusEsr2
systemic sclerodermaEsr1 , Esr2
transient cerebral ischemiaEsr1 , Esr2
transitional cell carcinomaEsr2
type 2 diabetes mellitusEsr1
ulcerative colitisEsr2
urinary bladder cancerEsr1 , Esr2
Urination DisordersEsr1 , Esr2
Varicose UlcerEsr1 , Esr2
vitiligoEsr1
Vulvar Lichen SclerosusEsr1 , Esr2
Pathway Annotations Associated with Genes in the bisphenol A response pathway
Phenotype Annotations Associated with Genes in the bisphenol A response pathway

References Associated with the bisphenol A response pathway:

Ontology Path Diagram:

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