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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619845
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gper1
Name: G protein-coupled estrogen receptor 1
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gper1affects response to substanceISOGPER1 (Homo sapiens)6480464CTDGPER1 protein affects the susceptibility to afimoxifenePMID:19153601
Gper1increases activityISOGPER1 (Homo sapiens)6480464CTDafimoxifene results in increased activity of GPER1 proteinPMID:19153601
Gper1multiple interactionsISOGPER1 (Homo sapiens)6480464CTDGPER1 protein affects the reaction [afimoxifene results in increased cleavage of CCNE1 protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ATF3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of BHLHE40 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CCN2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of CEBPD mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DDIT4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of DUSP5 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EDN2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of EGR1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ERRFI1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOS mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of FOSB mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of IER2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ITPRIP mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of JUN mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1F mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1G mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT1X mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of MT2A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of NFKBIA mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of NR4A2 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of PPP1R15A mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of PTGER4 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RASD1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RGS16 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of RND1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TNF mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TNFAIP3 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of TUFT1 mRNA]; GPER1 protein affects the reaction [afimoxifene results in increased expression of ZFP36 mRNA]PMID:19153601 PMID:23624423
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