RGD Reference Report - Serum levels of G protein-coupled estrogen receptor 1 (GPER1) in drug-naive patients with generalized anxiety disorder. - Rat Genome Database

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Serum levels of G protein-coupled estrogen receptor 1 (GPER1) in drug-naive patients with generalized anxiety disorder.

Authors: Fındıklı, Ebru  Camkurt, Mehmet Akif  Karaaslan, Mehmet Fatih  Kurutas, Ergul Belge  Altun, Hatice  İzci, Filiz  Fındıklı, Hüseyin Avni  Kardas, Selçuk 
Citation: Fındıklı E, etal., Psychiatry Res. 2016 Oct 30;244:312-6. doi: 10.1016/j.psychres.2016.04.098. Epub 2016 Jul 22.
RGD ID: 39938860
Pubmed: PMID:27512921   (View Abstract at PubMed)
DOI: DOI:10.1016/j.psychres.2016.04.098   (Journal Full-text)

Sex hormones, particularly estrogen, are suggested to play a role in the physiopathology of generalized anxiety disorder (GAD). Estrogen functions through the estrogen receptors alpha and beta and the recently discovered G protein-coupled estrogen receptor 1 (GPER1). This study aimed, for the first time, to evaluate serum GPER1 levels in drug-naive patients with GAD. This study included 40 newly diagnosed drug-naive patients with GAD aged between 18 and 50 years and 40 age- and gender-matched healthy controls. Medical histories were obtained, and physical examinations and laboratory tests were conducted; the Hamilton Anxiety Rating Scale (HAM-A) was also used for all participants. Serum GPER1 levels were measured. The serum GPER1 level was significantly higher in the patients with GAD than in the controls. A positive significant correlation was observed between the GPER1 level and the HAM-A score. The receiver operating characteristic analysis revealed a sensitivity, specificity, positive predictive value, and negative predictive value of 85.0%, 82.5%, 82.9%, and 84.6%, respectively, for the presence of anxiety when the serum GPER1 value was >=0.14 (the area under the curve was 0.904.). In conclusion, this study demonstrated that GPER1 levels were associated with the anxiety levels of patients, and that the serum GPER1 level was a valuable predictor of the presence of anxiety independent of gender.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GPER1Humangeneralized anxiety disorder severityIEP protein:increased expression:serum (human)RGD 
Gper1Ratgeneralized anxiety disorder severityISOGPER1 (Homo sapiens)protein:increased expression:serum (human)RGD 
Gper1Mousegeneralized anxiety disorder severityISOGPER1 (Homo sapiens)protein:increased expression:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gper1  (G protein-coupled estrogen receptor 1)

Genes (Mus musculus)
Gper1  (G protein-coupled estrogen receptor 1)

Genes (Homo sapiens)
GPER1  (G protein-coupled estrogen receptor 1)


Additional Information