GPER1 (G protein-coupled estrogen receptor 1) - Rat Genome Database

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Gene: GPER1 (G protein-coupled estrogen receptor 1) Homo sapiens
Analyze
Symbol: GPER1
Name: G protein-coupled estrogen receptor 1
RGD ID: 735664
HGNC Page HGNC:4485
Description: Enables chromatin binding activity; nuclear estrogen receptor activity; and steroid hormone binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Located in several cellular components, including cytoplasmic vesicle; keratin filament; and nucleus. Biomarker of generalized anxiety disorder and melanoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CEPR; chemoattractant receptor-like 2; chemokine receptor-like 2; CMKRL2; constitutively expressed peptide-like receptor; DRY12; FEG-1; flow-induced endothelial G-protein coupled receptor 1; G protein-coupled receptor 30; G-protein coupled estrogen receptor 1; G-protein coupled receptor 30; GPCR-Br; GPER; GPR30; heptahelix receptor; IL8-related receptor DRY12; LERGU; LERGU2; leucine rich protein in GPR30 3'UTR; LyGPR; lymphocyte-derived G-protein coupled receptor; membrane estrogen receptor; mER; MGC99678
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3871,087,118 - 1,093,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl71,082,208 - 1,093,815 (+)EnsemblGRCh38hg38GRCh38
GRCh3771,126,754 - 1,133,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3671,092,969 - 1,099,977 (+)NCBINCBI36hg18NCBI36
Build 347899,752 - 906,692NCBI
Celera71,094,088 - 1,101,068 (+)NCBI
Cytogenetic Map7p22.3NCBI
HuRef71,041,713 - 1,048,693 (+)NCBIHuRef
CHM1_171,126,080 - 1,133,090 (+)NCBICHM1_1
T2T-CHM13v2.071,192,020 - 1,198,681 (+)NCBI
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
(S)-naringenin  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',4,5'-Tetrabromodiphenyl ether  (EXP)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,4'-thiodiphenol  (EXP)
4-nonylphenol  (EXP)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
chlordecone  (EXP)
chromium atom  (EXP)
cisplatin  (EXP)
clobetasol  (ISO)
cocaine  (ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
cumene  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP)
cytarabine  (EXP)
DDT  (EXP,ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
endosulfan  (ISO)
folic acid  (ISO)
fulvestrant  (EXP,ISO)
genistein  (EXP)
glyphosate  (ISO)
herbicide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP,ISO)
KT 5720  (ISO)
KT 5823  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methimazole  (ISO)
methylparaben  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
Nonylphenol  (EXP,ISO)
oxybenzone  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
perfluorononanoic acid  (EXP)
phenobarbital  (EXP)
potassium dichromate  (EXP)
propylparaben  (EXP)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP)
quinazolines  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP)
sulforaphane  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
Tetrachlorobisphenol A  (EXP)
toluene  (ISO)
triclocarban  (ISO)
tyrphostin AG 1478  (EXP,ISO)
urethane  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA,IEA)
apoptotic chromosome condensation  (ISS)
apoptotic process  (IEA)
cell differentiation  (IEA)
cellular response to estradiol stimulus  (IBA,IDA,IEA)
cellular response to glucose stimulus  (IEA,ISS)
cellular response to mineralocorticoid stimulus  (ISS)
cellular response to peptide hormone stimulus  (IDA)
cellular response to tumor necrosis factor  (IDA)
G protein-coupled receptor signaling pathway  (IEA,IMP,TAS)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
intracellular estrogen receptor signaling pathway  (ISO)
intracellular steroid hormone receptor signaling pathway  (IBA,IDA,ISO)
modulation of chemical synaptic transmission  (IEA)
negative regulation of cell cycle process  (IMP)
negative regulation of cell population proliferation  (ISS)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of fat cell differentiation  (IEA,ISS)
negative regulation of gene expression  (IMP,ISS)
negative regulation of inflammatory response  (IDA)
negative regulation of leukocyte activation  (IDA)
negative regulation of lipid biosynthetic process  (IEA,ISS)
negative regulation of protein kinase B signaling  (IMP)
negative regulation of receptor binding  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP)
nervous system development  (IEA)
neuronal action potential  (ISS)
nuclear fragmentation involved in apoptotic nuclear change  (ISS)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of cardiac vascular smooth muscle cell differentiation  (IMP)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISS)
positive regulation of cytosolic calcium ion concentration  (IEA,ISS)
positive regulation of endothelial cell apoptotic process  (ISS)
positive regulation of epidermal growth factor receptor signaling pathway  (IDA,IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,IEA,ISO,ISS)
positive regulation of extrinsic apoptotic signaling pathway  (ISS)
positive regulation of G protein-coupled receptor signaling pathway  (IDA)
positive regulation of gene expression  (IMP,ISO,ISS)
positive regulation of inositol trisphosphate biosynthetic process  (IDA)
positive regulation of insulin secretion  (IEA,ISS)
positive regulation of MAPK cascade  (IEA,ISS)
positive regulation of neurogenesis  (IEA,ISS)
positive regulation of neurotransmitter secretion  (ISS)
positive regulation of phosphatidylinositol 3-kinase signaling  (IDA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to plasma membrane  (IDA)
positive regulation of protein phosphorylation  (IDA,IEA,ISO,ISS)
positive regulation of release of cytochrome c from mitochondria  (ISS)
positive regulation of release of sequestered calcium ion into cytosol  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISS)
positive regulation of uterine smooth muscle contraction  (IDA)
positive regulation of voltage-gated sodium channel activity  (ISO)
regulation of cell cycle  (IEA,ISS)
regulation of cytosolic calcium ion concentration  (ISS)
serotonin receptor signaling pathway  (ISO)
signal transduction  (IEA)
steroid hormone mediated signaling pathway  (IDA,IEA)
vasodilation  (ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Breast cancer, estrogen receptor and ligands. Bai Z and Gust R, Arch Pharm (Weinheim). 2009 Mar;342(3):133-49.
2. Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes. Delfosse V, etal., Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14930-5. doi: 10.1073/pnas.1203574109. Epub 2012 Aug 27.
3. Serum levels of G protein-coupled estrogen receptor 1 (GPER1) in drug-naive patients with generalized anxiety disorder. Fındıklı E, etal., Psychiatry Res. 2016 Oct 30;244:312-6. doi: 10.1016/j.psychres.2016.04.098. Epub 2016 Jul 22.
4. Expression of G protein-coupled oestrogen receptor in melanoma and in pregnancy-associated melanoma. Fábián M, etal., J Eur Acad Dermatol Venereol. 2017 Sep;31(9):1453-1461. doi: 10.1111/jdv.14304. Epub 2017 Jun 20.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. G-protein coupled estrogen receptor 1 mediated estrogenic neuroprotection against spinal cord injury. Hu R, etal., Crit Care Med. 2012 Dec;40(12):3230-7. doi: 10.1097/CCM.0b013e3182657560.
7. Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells. Lucas TF, etal., Biol Reprod. 2010 Aug 1;83(2):307-17. Epub 2010 May 5.
8. The unfolding stories of GPR30, a new membrane-bound estrogen receptor. Maggiolini M and Picard D, J Endocrinol. 2010 Feb;204(2):105-14. Epub 2009 Sep 18.
9. Spatial and temporal changes in the expression of steroid hormone receptors in mouse model of endometriosis. Mishra A, etal., J Assist Reprod Genet. 2020 May;37(5):1069-1081. doi: 10.1007/s10815-020-01725-6. Epub 2020 Mar 9.
10. Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives. Rezg R, etal., Environ Int. 2014 Mar;64C:83-90. doi: 10.1016/j.envint.2013.12.007. Epub 2013 Dec 29.
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study. Samartzis N, etal., Reprod Biol Endocrinol. 2012 Apr 20;10:30. doi: 10.1186/1477-7827-10-30.
13. Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. Waghulde H, etal., Hypertension. 2018 Nov;72(5):1125-1132. doi: 10.1161/HYPERTENSIONAHA.118.11175.
14. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:8889548   PMID:8920907   PMID:9070864   PMID:9141481   PMID:9367686   PMID:9398636   PMID:9479505   PMID:11043579   PMID:11773440   PMID:11897506   PMID:12027886   PMID:12193550  
PMID:12446589   PMID:12477932   PMID:12690205   PMID:12744705   PMID:14632195   PMID:14675202   PMID:15090535   PMID:15245432   PMID:15489334   PMID:15511221   PMID:15539556   PMID:15705806  
PMID:15761144   PMID:15771623   PMID:15994455   PMID:16125968   PMID:16210518   PMID:16239258   PMID:16280047   PMID:16344560   PMID:16520733   PMID:17638621   PMID:17655271   PMID:17878253  
PMID:18240029   PMID:18289622   PMID:18467434   PMID:18467441   PMID:18566127   PMID:18794456   PMID:19153601   PMID:19179659   PMID:19342448   PMID:19432902   PMID:19549922   PMID:19744559  
PMID:19749156   PMID:19902352   PMID:19911269   PMID:19931550   PMID:20086172   PMID:20197310   PMID:20203690   PMID:20211987   PMID:20508064   PMID:20551055   PMID:20596598   PMID:20819778  
PMID:20960099   PMID:21149639   PMID:21170498   PMID:21196169   PMID:21266576   PMID:21269226   PMID:21273787   PMID:21278491   PMID:21354433   PMID:21427217   PMID:21540189   PMID:21607586  
PMID:21632639   PMID:21791623   PMID:21873635   PMID:21974818   PMID:22075757   PMID:22138208   PMID:22138413   PMID:22153880   PMID:22260839   PMID:22270964   PMID:22378861   PMID:22414008  
PMID:22415229   PMID:22425775   PMID:22430216   PMID:22495674   PMID:22495744   PMID:22496838   PMID:22576740   PMID:22781117   PMID:22792339   PMID:23012390   PMID:23038618   PMID:23056216  
PMID:23235274   PMID:23285008   PMID:23300088   PMID:23314808   PMID:23432876   PMID:23458722   PMID:23466742   PMID:23554355   PMID:23580092   PMID:23674134   PMID:23688258   PMID:23748028  
PMID:23840305   PMID:23907016   PMID:23921077   PMID:23951246   PMID:24037776   PMID:24104479   PMID:24169358   PMID:24275097   PMID:24289103   PMID:24319683   PMID:24421881   PMID:24451139  
PMID:24481325   PMID:24553912   PMID:24586950   PMID:24628533   PMID:24662263   PMID:24697543   PMID:24715381   PMID:24718279   PMID:24736568   PMID:24793639   PMID:24893701   PMID:24894716  
PMID:24962572   PMID:24966932   PMID:25005496   PMID:25012984   PMID:25031742   PMID:25039431   PMID:25063027   PMID:25096985   PMID:25167221   PMID:25200186   PMID:25275589   PMID:25287069  
PMID:25395619   PMID:25413376   PMID:25531203   PMID:25532911   PMID:25587872   PMID:25647524   PMID:25672442   PMID:25724739   PMID:25767029   PMID:25781607   PMID:25805831   PMID:25893606  
PMID:25922871   PMID:25928008   PMID:25969534   PMID:26090392   PMID:26093261   PMID:26190834   PMID:26193952   PMID:26200092   PMID:26225773   PMID:26250574   PMID:26253279   PMID:26281354  
PMID:26303299   PMID:26394816   PMID:26416628   PMID:26470790   PMID:26506594   PMID:26526233   PMID:26617848   PMID:26638889   PMID:26646587   PMID:26714890   PMID:26731262   PMID:26772481  
PMID:26773178   PMID:26815911   PMID:26842883   PMID:26888479   PMID:27026707   PMID:27071941   PMID:27072893   PMID:27111051   PMID:27115344   PMID:27163843   PMID:27171834   PMID:27213340  
PMID:27378491   PMID:27384677   PMID:27401115   PMID:27448983   PMID:27481507   PMID:27516013   PMID:27594673   PMID:27721408   PMID:27836733   PMID:27849354   PMID:27908592   PMID:27939762  
PMID:27940299   PMID:28061972   PMID:28118074   PMID:28126236   PMID:28440394   PMID:28450397   PMID:28466560   PMID:28476123   PMID:28535016   PMID:28596490   PMID:28734238   PMID:28849224  
PMID:28877783   PMID:29109960   PMID:29212519   PMID:29239277   PMID:29378226   PMID:29659348   PMID:29845209   PMID:30098262   PMID:30227306   PMID:30341688   PMID:30478301   PMID:30478785  
PMID:30538116   PMID:30538117   PMID:30575816   PMID:30626229   PMID:30641053   PMID:30646517   PMID:30728047   PMID:30760632   PMID:30836961   PMID:30862715   PMID:30866584   PMID:30879772  
PMID:31028714   PMID:31082617   PMID:31096733   PMID:31242463   PMID:31277940   PMID:31300420   PMID:31340060   PMID:31483053   PMID:31759407   PMID:31790688   PMID:31989268   PMID:31992771  
PMID:32052561   PMID:32087276   PMID:32112420   PMID:32296387   PMID:32302351   PMID:32321334   PMID:32323852   PMID:32324271   PMID:32444257   PMID:32487604   PMID:32783656   PMID:32813115  
PMID:32873626   PMID:32936384   PMID:32957524   PMID:33069770   PMID:33117280   PMID:33374170   PMID:33446553   PMID:33539880   PMID:33677756   PMID:33679613   PMID:33799631   PMID:33948934  
PMID:34182538   PMID:34273443   PMID:34297198   PMID:34299224   PMID:34329471   PMID:34363795   PMID:34657250   PMID:34773076   PMID:34943948   PMID:35061800   PMID:35162942  


Genomics

Comparative Map Data
GPER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3871,087,118 - 1,093,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl71,082,208 - 1,093,815 (+)EnsemblGRCh38hg38GRCh38
GRCh3771,126,754 - 1,133,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3671,092,969 - 1,099,977 (+)NCBINCBI36hg18NCBI36
Build 347899,752 - 906,692NCBI
Celera71,094,088 - 1,101,068 (+)NCBI
Cytogenetic Map7p22.3NCBI
HuRef71,041,713 - 1,048,693 (+)NCBIHuRef
CHM1_171,126,080 - 1,133,090 (+)NCBICHM1_1
T2T-CHM13v2.071,192,020 - 1,198,681 (+)NCBI
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)NCBI
Gper1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,408,905 - 139,413,555 (+)NCBIGRCm39mm39
GRCm39 Ensembl5139,408,906 - 139,413,555 (+)Ensembl
GRCm385139,423,150 - 139,427,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,423,151 - 139,427,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,899,133 - 139,903,754 (+)NCBIGRCm37mm9NCBIm37
MGSCv365139,676,821 - 139,681,430 (+)NCBImm8
Celera5136,477,197 - 136,481,822 (+)NCBICelera
Cytogenetic Map5G2NCBI
Gper1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21215,217,217 - 15,222,679 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1215,217,442 - 15,221,889 (-)Ensembl
Rnor_6.01217,309,122 - 17,315,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,309,834 - 17,311,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,296,086 - 19,301,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,718,615 - 15,719,893 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11215,748,542 - 15,749,821 (-)NCBI
Celera1216,971,703 - 16,972,981 (-)NCBICelera
Cytogenetic Map12q11NCBI
Gper1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBIChiLan1.0ChiLan1.0
LOC100967334
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.171,454,768 - 1,461,376 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v071,245,873 - 1,251,915 (+)NCBIMhudiblu_PPA_v0panPan3
GPER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,792,072 - 15,796,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,792,897 - 15,794,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,265,181 - 17,311,159 (-)NCBI
ROS_Cfam_1.0615,922,801 - 15,968,766 (-)NCBI
ROS_Cfam_1.0 Ensembl615,922,807 - 15,927,433 (-)Ensembl
UMICH_Zoey_3.1615,725,481 - 15,771,429 (-)NCBI
UNSW_CanFamBas_1.0615,652,239 - 15,698,182 (-)NCBI
UU_Cfam_GSD_1.0615,940,139 - 15,986,136 (-)NCBI
Gper1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,716,868 - 143,723,998 (-)NCBI
SpeTri2.0NW_0049367541,288,891 - 1,293,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3712,160 - 715,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13711,427 - 715,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23828,578 - 833,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,491,874 - 20,497,966 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,492,188 - 20,493,315 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660901,198,018 - 1,204,300 (+)NCBIVero_WHO_p1.0
Gper1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,627,473 - 26,632,027 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474026,627,560 - 26,632,483 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D7S2826  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3771,130,506 - 1,130,730UniSTSGRCh37
Build 3671,097,032 - 1,097,256RGDNCBI36
Celera71,098,121 - 1,098,347RGD
Cytogenetic Map7p22.3UniSTS
HuRef71,045,746 - 1,045,972UniSTS
CRA_TCAGchr7v271,184,903 - 1,185,129UniSTS
RH70704  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3771,132,480 - 1,132,685UniSTSGRCh37
Build 3671,099,006 - 1,099,211RGDNCBI36
Celera71,100,097 - 1,100,302RGD
Cytogenetic Map7p22.3UniSTS
HuRef71,047,722 - 1,047,927UniSTS
CRA_TCAGchr7v271,186,879 - 1,187,084UniSTS
GeneMap99-GB4 RH Map711.96UniSTS
RH11876  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3771,130,581 - 1,130,741UniSTSGRCh37
Build 3671,097,107 - 1,097,267RGDNCBI36
Celera71,098,196 - 1,098,358RGD
Cytogenetic Map7p22.3UniSTS
HuRef71,045,821 - 1,045,983UniSTS
CRA_TCAGchr7v271,184,978 - 1,185,140UniSTS
GeneMap99-GB4 RH Map712.18UniSTS
D7S2090E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3771,130,527 - 1,130,650UniSTSGRCh37
Build 3671,097,053 - 1,097,176RGDNCBI36
Celera71,098,142 - 1,098,267RGD
Cytogenetic Map7p22.3UniSTS
HuRef71,045,767 - 1,045,892UniSTS
CRA_TCAGchr7v271,184,924 - 1,185,049UniSTS
GeneMap99-GB4 RH Map712.69UniSTS
GPR30  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3771,132,159 - 1,132,370UniSTSGRCh37
Celera71,099,776 - 1,099,987UniSTS
HuRef71,047,401 - 1,047,612UniSTS
CRA_TCAGchr7v271,186,558 - 1,186,769UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1754
Count of miRNA genes:634
Interacting mature miRNAs:715
Transcripts:ENST00000297469, ENST00000397088, ENST00000397092, ENST00000401670, ENST00000413368
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1223 751 1029 225 625 224 1518 480 1430 139 253 834 2 772 1014
Low 1150 2067 682 391 1003 234 2648 1620 2265 244 1154 679 166 1 432 1712 1 1
Below cutoff 53 164 11 7 262 7 183 89 34 33 50 71 6 62 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001039966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001098201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF007171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF015257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF027956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY265807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY265808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY265809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC082766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM672716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA014990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC381205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U58828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U77827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X98510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y08162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000297469   ⟹   ENSP00000297469
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl71,086,876 - 1,093,815 (+)Ensembl
RefSeq Acc Id: ENST00000397088   ⟹   ENSP00000380277
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl71,088,113 - 1,093,810 (+)Ensembl
RefSeq Acc Id: ENST00000397092   ⟹   ENSP00000380281
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl71,086,807 - 1,093,815 (+)Ensembl
RefSeq Acc Id: ENST00000401670   ⟹   ENSP00000385151
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl71,082,208 - 1,092,881 (+)Ensembl
RefSeq Acc Id: ENST00000413368   ⟹   ENSP00000410487
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl71,086,807 - 1,091,949 (+)Ensembl
RefSeq Acc Id: ENST00000617001   ⟹   ENSP00000479553
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl71,091,628 - 1,093,809 (+)Ensembl
RefSeq Acc Id: ENST00000619052   ⟹   ENSP00000483756
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl71,092,938 - 1,093,741 (+)Ensembl
RefSeq Acc Id: NM_001039966   ⟹   NP_001035055
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3871,087,118 - 1,093,810 (+)NCBI
GRCh3771,126,443 - 1,133,451 (+)ENTREZGENE
Build 3671,092,969 - 1,099,977 (+)NCBI Archive
HuRef71,041,713 - 1,048,693 (+)ENTREZGENE
CHM1_171,126,080 - 1,133,090 (+)NCBI
T2T-CHM13v2.071,192,020 - 1,198,681 (+)NCBI
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001098201   ⟹   NP_001091671
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3871,088,113 - 1,093,810 (+)NCBI
GRCh3771,126,443 - 1,133,451 (+)ENTREZGENE
Build 3671,094,249 - 1,099,977 (+)NCBI Archive
HuRef71,041,713 - 1,048,693 (+)ENTREZGENE
CHM1_171,127,360 - 1,133,090 (+)NCBI
T2T-CHM13v2.071,193,015 - 1,198,681 (+)NCBI
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001505   ⟹   NP_001496
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3871,087,118 - 1,093,810 (+)NCBI
GRCh3771,126,443 - 1,133,451 (+)ENTREZGENE
Build 3671,092,969 - 1,099,977 (+)NCBI Archive
HuRef71,041,713 - 1,048,693 (+)ENTREZGENE
CHM1_171,126,080 - 1,133,090 (+)NCBI
T2T-CHM13v2.071,192,020 - 1,198,681 (+)NCBI
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001035055   ⟸   NM_001039966
- UniProtKB: Q99981 (UniProtKB/Swiss-Prot),   Q99527 (UniProtKB/Swiss-Prot),   A0A024R849 (UniProtKB/TrEMBL),   Q63ZY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001496   ⟸   NM_001505
- UniProtKB: Q99981 (UniProtKB/Swiss-Prot),   Q99527 (UniProtKB/Swiss-Prot),   A0A024R849 (UniProtKB/TrEMBL),   Q63ZY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001091671   ⟸   NM_001098201
- UniProtKB: Q99981 (UniProtKB/Swiss-Prot),   Q99527 (UniProtKB/Swiss-Prot),   A0A024R849 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000410487   ⟸   ENST00000413368
RefSeq Acc Id: ENSP00000297469   ⟸   ENST00000297469
RefSeq Acc Id: ENSP00000385151   ⟸   ENST00000401670
RefSeq Acc Id: ENSP00000479553   ⟸   ENST00000617001
RefSeq Acc Id: ENSP00000483756   ⟸   ENST00000619052
RefSeq Acc Id: ENSP00000380281   ⟸   ENST00000397092
RefSeq Acc Id: ENSP00000380277   ⟸   ENST00000397088
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99527-F1-model_v2 AlphaFold Q99527 1-375 view protein structure

Promoters
RGD ID:7209779
Promoter ID:EPDNEW_H10635
Type:initiation region
Name:GPER1_2
Description:G protein-coupled estrogen receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10636  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3871,086,816 - 1,086,876EPDNEW
RGD ID:7209781
Promoter ID:EPDNEW_H10636
Type:multiple initiation site
Name:GPER1_1
Description:G protein-coupled estrogen receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10635  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3871,088,113 - 1,088,173EPDNEW
RGD ID:6805726
Promoter ID:HG_KWN:55956
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Lymphoblastoid
Transcripts:NM_001039966,   NM_001505
Position:
Human AssemblyChrPosition (strand)Source
Build 3671,092,924 - 1,093,424 (+)MPROMDB
RGD ID:6805727
Promoter ID:HG_KWN:55957
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:NM_001098201
Position:
Human AssemblyChrPosition (strand)Source
Build 3671,094,081 - 1,094,581 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3 copy number gain See cases [RCV000051159] Chr7:54185..41875885 [GRCh38]
Chr7:54185..41915483 [GRCh37]
Chr7:149268..41882008 [NCBI36]
Chr7:7p22.3-14.1
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p22.3(chr7:54185-1843584)x1 copy number loss See cases [RCV000052253] Chr7:54185..1843584 [GRCh38]
Chr7:54185..1883220 [GRCh37]
Chr7:149268..1849746 [NCBI36]
Chr7:7p22.3
pathogenic|likely pathogenic|conflicting data from submitters
GRCh38/hg38 7p22.3(chr7:54185-1441125)x1 copy number loss See cases [RCV000052254] Chr7:54185..1441125 [GRCh38]
Chr7:54185..1480761 [GRCh37]
Chr7:149268..1447287 [NCBI36]
Chr7:7p22.3
pathogenic
GRCh38/hg38 7p22.3-22.1(chr7:45130-5880375)x1 copy number loss See cases [RCV000052249] Chr7:45130..5880375 [GRCh38]
Chr7:45130..5920006 [GRCh37]
Chr7:140213..5886532 [NCBI36]
Chr7:7p22.3-22.1
pathogenic
GRCh38/hg38 7p22.3-22.1(chr7:45130-6270185)x3 copy number gain See cases [RCV000053527] Chr7:45130..6270185 [GRCh38]
Chr7:45130..6309816 [GRCh37]
Chr7:140213..6276341 [NCBI36]
Chr7:7p22.3-22.1
pathogenic
GRCh38/hg38 7p22.3-15.3(chr7:53985-24361531)x3 copy number gain See cases [RCV000053528] Chr7:53985..24361531 [GRCh38]
Chr7:53985..24401150 [GRCh37]
Chr7:149068..24367675 [NCBI36]
Chr7:7p22.3-15.3
pathogenic
GRCh38/hg38 7p22.3-21.3(chr7:54185-8274834)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053529]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053529]|See cases [RCV000053529] Chr7:54185..8274834 [GRCh38]
Chr7:54185..8314464 [GRCh37]
Chr7:149268..8280989 [NCBI36]
Chr7:7p22.3-21.3
pathogenic
GRCh38/hg38 7p22.3-14.2(chr7:54185-37089712)x3 copy number gain See cases [RCV000053530] Chr7:54185..37089712 [GRCh38]
Chr7:54185..37129317 [GRCh37]
Chr7:149268..37095842 [NCBI36]
Chr7:7p22.3-14.2
pathogenic
GRCh38/hg38 7p22.3(chr7:54185-1206119)x3 copy number gain See cases [RCV000134140] Chr7:54185..1206119 [GRCh38]
Chr7:54185..1245755 [GRCh37]
Chr7:149268..1212281 [NCBI36]
Chr7:7p22.3
uncertain significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7p22.3-15.2(chr7:54185-26827634)x3 copy number gain See cases [RCV000136557] Chr7:54185..26827634 [GRCh38]
Chr7:54185..26867253 [GRCh37]
Chr7:149268..26833778 [NCBI36]
Chr7:7p22.3-15.2
pathogenic
GRCh38/hg38 7p22.3-22.2(chr7:54185-3324143)x1 copy number loss See cases [RCV000136789] Chr7:54185..3324143 [GRCh38]
Chr7:54185..3363775 [GRCh37]
Chr7:149268..3330301 [NCBI36]
Chr7:7p22.3-22.2
pathogenic
GRCh38/hg38 7p22.3-22.1(chr7:54185-6638027)x3 copy number gain See cases [RCV000136731] Chr7:54185..6638027 [GRCh38]
Chr7:54185..6677658 [GRCh37]
Chr7:149268..6644183 [NCBI36]
Chr7:7p22.3-22.1
pathogenic
GRCh38/hg38 7p22.3(chr7:791215-1993065)x3 copy number gain See cases [RCV000136691] Chr7:791215..1993065 [GRCh38]
Chr7:830852..2032700 [GRCh37]
Chr7:797378..1999226 [NCBI36]
Chr7:7p22.3
uncertain significance
GRCh38/hg38 7p22.3-21.3(chr7:45130-7252065)x3 copy number gain See cases [RCV000137524] Chr7:45130..7252065 [GRCh38]
Chr7:45130..7291696 [GRCh37]
Chr7:140213..7258221 [NCBI36]
Chr7:7p22.3-21.3
pathogenic
GRCh38/hg38 7p22.3(chr7:54185-1331046)x1 copy number loss See cases [RCV000137163] Chr7:54185..1331046 [GRCh38]
Chr7:54185..1370682 [GRCh37]
Chr7:149268..1337208 [NCBI36]
Chr7:7p22.3
pathogenic|uncertain significance
GRCh38/hg38 7p22.3(chr7:1085248-2530644)x4 copy number gain See cases [RCV000137818] Chr7:1085248..2530644 [GRCh38]
Chr7:1124884..2570278 [GRCh37]
Chr7:1091410..2536804 [NCBI36]
Chr7:7p22.3
uncertain significance
GRCh38/hg38 7p22.3-15.3(chr7:45130-25221165)x3 copy number gain See cases [RCV000137824] Chr7:45130..25221165 [GRCh38]
Chr7:45130..25260784 [GRCh37]
Chr7:140213..25227309 [NCBI36]
Chr7:7p22.3-15.3
pathogenic
GRCh38/hg38 7p22.3(chr7:689554-2031521)x3 copy number gain See cases [RCV000138319] Chr7:689554..2031521 [GRCh38]
Chr7:729191..2071156 [GRCh37]
Chr7:695717..2037682 [NCBI36]
Chr7:7p22.3
uncertain significance
GRCh38/hg38 7p22.3-22.2(chr7:54165-3258775)x1 copy number loss See cases [RCV000142995] Chr7:54165..3258775 [GRCh38]
Chr7:54165..3298407 [GRCh37]
Chr7:149248..3264933 [NCBI36]
Chr7:7p22.3-22.2
pathogenic
GRCh38/hg38 7p22.3(chr7:45130-1298050)x1 copy number loss See cases [RCV000143341] Chr7:45130..1298050 [GRCh38]
Chr7:45130..1337686 [GRCh37]
Chr7:140213..1304212 [NCBI36]
Chr7:7p22.3
uncertain significance
GRCh38/hg38 7p22.3-22.2(chr7:45130-3406236)x3 copy number gain See cases [RCV000143175] Chr7:45130..3406236 [GRCh38]
Chr7:45130..3445868 [GRCh37]
Chr7:140213..3412394 [NCBI36]
Chr7:7p22.3-22.2
uncertain significance
GRCh38/hg38 7p22.3-15.2(chr7:43360-27196404)x3 copy number gain See cases [RCV000143586] Chr7:43360..27196404 [GRCh38]
Chr7:43360..27236023 [GRCh37]
Chr7:138443..27202548 [NCBI36]
Chr7:7p22.3-15.2
pathogenic
GRCh38/hg38 7p22.3(chr7:54185-1843584)x1 copy number loss See cases [RCV000148193] Chr7:54185..1843584 [GRCh38]
Chr7:54185..1883220 [GRCh37]
Chr7:149268..1849746 [NCBI36]
Chr7:7p22.3
pathogenic
GRCh37/hg19 7p22.3-22.2(chr7:1004794-4063934)x4 copy number gain See cases [RCV000240233] Chr7:1004794..4063934 [GRCh37]
Chr7:7p22.3-22.2
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-22.1(chr7:43360-5443709)x3 copy number gain See cases [RCV000449281] Chr7:43360..5443709 [GRCh37]
Chr7:7p22.3-22.1
pathogenic
GRCh37/hg19 7p22.3-21.3(chr7:183556-12746636)x3 copy number gain See cases [RCV000449446] Chr7:183556..12746636 [GRCh37]
Chr7:7p22.3-21.3
pathogenic
GRCh37/hg19 7p22.3-21.1(chr7:43360-17656861)x3 copy number gain See cases [RCV000449347] Chr7:43360..17656861 [GRCh37]
Chr7:7p22.3-21.1
pathogenic
GRCh37/hg19 7p22.3-22.2(chr7:43360-2825753)x3 copy number gain See cases [RCV000447222] Chr7:43360..2825753 [GRCh37]
Chr7:7p22.3-22.2
likely pathogenic
GRCh37/hg19 7p22.3(chr7:1126463-1194990)x1 copy number loss See cases [RCV000446943] Chr7:1126463..1194990 [GRCh37]
Chr7:7p22.3
likely benign
GRCh37/hg19 7p22.3-15.3(chr7:43360-23674928)x3 copy number gain See cases [RCV000510652] Chr7:43360..23674928 [GRCh37]
Chr7:7p22.3-15.3
pathogenic
GRCh37/hg19 7p22.3-14.3(chr7:704573-29257946)x3 copy number gain See cases [RCV000510275] Chr7:704573..29257946 [GRCh37]
Chr7:7p22.3-14.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-22.2(chr7:43360-3642604)x1 copy number loss See cases [RCV000511648] Chr7:43360..3642604 [GRCh37]
Chr7:7p22.3-22.2
pathogenic
GRCh37/hg19 7p22.3-21.2(chr7:43360-14664158)x3 copy number gain See cases [RCV000511772] Chr7:43360..14664158 [GRCh37]
Chr7:7p22.3-21.2
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-21.3(chr7:43360-12098696)x3 copy number gain See cases [RCV000510950] Chr7:43360..12098696 [GRCh37]
Chr7:7p22.3-21.3
pathogenic
GRCh37/hg19 7p22.3-21.3(chr7:43360-11567351)x3 copy number gain See cases [RCV000512505] Chr7:43360..11567351 [GRCh37]
Chr7:7p22.3-21.3
pathogenic
GRCh37/hg19 7p22.3(chr7:43360-2057743)x1 copy number loss See cases [RCV000512381] Chr7:43360..2057743 [GRCh37]
Chr7:7p22.3
likely pathogenic
GRCh37/hg19 7p22.3(chr7:967185-1261141)x3 copy number gain not provided [RCV000682817] Chr7:967185..1261141 [GRCh37]
Chr7:7p22.3
likely benign
GRCh37/hg19 7p22.3(chr7:989696-1540461)x3 copy number gain not provided [RCV000682854] Chr7:989696..1540461 [GRCh37]
Chr7:7p22.3
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-21.3(chr7:10239-13116278)x3 copy number gain not provided [RCV000746277] Chr7:10239..13116278 [GRCh37]
Chr7:7p22.3-21.3
pathogenic
NM_001098201.3(GPER1):c.14C>T (p.Ser5Phe) single nucleotide variant not provided [RCV000949305] Chr7:1091742 [GRCh38]
Chr7:1131378 [GRCh37]
Chr7:7p22.3
benign
GRCh37/hg19 7p22.3(chr7:869147-1438686)x1 copy number loss See cases [RCV000790603] Chr7:869147..1438686 [GRCh37]
Chr7:7p22.3
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3(chr7:43360-1648288)x1 copy number loss not provided [RCV001005888] Chr7:43360..1648288 [GRCh37]
Chr7:7p22.3
pathogenic
GRCh37/hg19 7p22.3-22.2(chr7:36616-4298168)x1 copy number loss not provided [RCV000849273] Chr7:36616..4298168 [GRCh37]
Chr7:7p22.3-22.2
pathogenic
GRCh37/hg19 7p22.3-21.1(chr7:43376-19520619)x3 copy number gain not provided [RCV000848100] Chr7:43376..19520619 [GRCh37]
Chr7:7p22.3-21.1
pathogenic
NM_001098201.3(GPER1):c.47C>T (p.Pro16Leu) single nucleotide variant not provided [RCV001654546] Chr7:1091775 [GRCh38]
Chr7:1131411 [GRCh37]
Chr7:7p22.3
benign
GRCh37/hg19 7p22.3(chr7:44935-1750797)x1 copy number loss See cases [RCV001007408] Chr7:44935..1750797 [GRCh37]
Chr7:7p22.3
pathogenic
GRCh37/hg19 7p22.3(chr7:1065860-1812800)x3 copy number gain not provided [RCV001005889] Chr7:1065860..1812800 [GRCh37]
Chr7:7p22.3
uncertain significance
GRCh37/hg19 7p22.3(chr7:1108122-1812800)x3 copy number gain not provided [RCV001005890] Chr7:1108122..1812800 [GRCh37]
Chr7:7p22.3
uncertain significance
GRCh37/hg19 7p22.3(chr7:1063598-1614261)x3 copy number gain not provided [RCV001259995] Chr7:1063598..1614261 [GRCh37]
Chr7:7p22.3
uncertain significance
GRCh37/hg19 7p22.3(chr7:967185-1781553)x3 copy number gain not provided [RCV001259996] Chr7:967185..1781553 [GRCh37]
Chr7:7p22.3
uncertain significance
GRCh37/hg19 7p22.3(chr7:989697-2138529)x3 copy number gain not provided [RCV001833076] Chr7:989697..2138529 [GRCh37]
Chr7:7p22.3
uncertain significance
GRCh37/hg19 7p22.3(chr7:1081972-2179462)x3 copy number gain not provided [RCV000746314] Chr7:1081972..2179462 [GRCh37]
Chr7:7p22.3
uncertain significance
GRCh37/hg19 7p22.3(chr7:993173-1130584)x3 copy number gain not provided [RCV000746311] Chr7:993173..1130584 [GRCh37]
Chr7:7p22.3
benign
GRCh37/hg19 7p22.3(chr7:993881-1142977)x3 copy number gain not provided [RCV000746312] Chr7:993881..1142977 [GRCh37]
Chr7:7p22.3
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4485 AgrOrtholog
COSMIC GPER1 COSMIC
Ensembl Genes ENSG00000164850 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000297469 ENTREZGENE
  ENSP00000297469.3 UniProtKB/Swiss-Prot
  ENSP00000380277 ENTREZGENE
  ENSP00000380277.3 UniProtKB/Swiss-Prot
  ENSP00000380281 ENTREZGENE
  ENSP00000380281.1 UniProtKB/Swiss-Prot
  ENSP00000385151.1 UniProtKB/Swiss-Prot
  ENSP00000410487.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000297469 ENTREZGENE
  ENST00000297469.3 UniProtKB/Swiss-Prot
  ENST00000397088 ENTREZGENE
  ENST00000397088.4 UniProtKB/Swiss-Prot
  ENST00000397092 ENTREZGENE
  ENST00000397092.5 UniProtKB/Swiss-Prot
  ENST00000401670.1 UniProtKB/Swiss-Prot
  ENST00000413368.5 UniProtKB/TrEMBL
GTEx ENSG00000164850 GTEx
HGNC ID HGNC:4485 ENTREZGENE
Human Proteome Map GPER1 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2852 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2852 ENTREZGENE
OMIM 601805 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28873 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R849 ENTREZGENE, UniProtKB/TrEMBL
  C9J3W2_HUMAN UniProtKB/TrEMBL
  GPER1_HUMAN UniProtKB/Swiss-Prot
  Q63ZY2 ENTREZGENE, UniProtKB/TrEMBL
  Q99527 ENTREZGENE
  Q99981 ENTREZGENE
UniProt Secondary A8K6C5 UniProtKB/Swiss-Prot
  B5BUJ1 UniProtKB/Swiss-Prot
  O00143 UniProtKB/Swiss-Prot
  O43494 UniProtKB/Swiss-Prot
  Q13631 UniProtKB/Swiss-Prot
  Q6FHL1 UniProtKB/Swiss-Prot
  Q96F42 UniProtKB/Swiss-Prot
  Q99981 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-20 GPER1  G protein-coupled estrogen receptor 1  GPER    Symbol and/or name change 5135510 APPROVED
2011-08-16 GPER  G protein-coupled estrogen receptor 1  GPER  G protein-coupled estrogen receptor 1  Symbol and/or name change 5135510 APPROVED