Pms2 (PMS1 homolog 2, mismatch repair system component) - Rat Genome Database

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Gene: Pms2 (PMS1 homolog 2, mismatch repair system component) Rattus norvegicus
Analyze
Symbol: Pms2
Name: PMS1 homolog 2, mismatch repair system component
RGD ID: 1305483
Description: Predicted to enable ATP hydrolysis activity and single base insertion or deletion binding activity. Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in nucleus. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; hereditary nonpolyposis colorectal cancer type 4; mismatch repair cancer syndrome; ovarian cancer; and urinary bladder cancer. Orthologous to human PMS2 (PMS1 homolog 2, mismatch repair system component); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; mismatch repair pathway; INTERACTS WITH 2,6-dinitrotoluene; 4-hydroperoxycyclophosphamide; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC288479; mismatch repair endonuclease PMS2; PMS2 postmeiotic segregation increased 2; postmeiotic segregation increased 2; postmeiotic segregation increased 2 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,790,478 - 15,814,790 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1215,790,478 - 15,815,248 (-)EnsemblGRCr8
mRatBN7.21210,676,818 - 10,701,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1210,676,764 - 10,701,066 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1211,483,953 - 11,508,343 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,107,244 - 12,131,635 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,131,272 - 11,155,470 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01212,714,394 - 12,738,654 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,714,394 - 12,738,641 (-)Ensemblrn6Rnor6.0
Rnor_5.01214,757,747 - 14,781,994 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41211,004,507 - 11,028,754 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1212,474,260 - 12,498,506 (-)NCBICelera
RGSC_v3.11211,034,447 - 11,058,818 (-)NCBI
Cytogenetic Map12p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
mismatch repair complex  (IEA)
MutLalpha complex  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The expression of mismatched repair genes and their correlation with clinicopathological parameters and response to neo-adjuvant chemotherapy in breast cancer. Chintamani, etal., Int Semin Surg Oncol. 2007 Feb 14;4:5.
2. Evidence for a recessive inheritance of Turcot's syndrome caused by compound heterozygous mutations within the PMS2 gene. De Rosa M, etal., Oncogene. 2000 Mar 23;19(13):1719-23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes. Guey LT, etal., Eur Urol. 2009 Aug 12.
6. Paternal exposure to cyclophosphamide induces DNA damage and alters the expression of DNA repair genes in the rat preimplantation embryo. Harrouk W, etal., Mutat Res 2000 Nov 9;461(3):229-41.
7. Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome). Hendriks YM, etal., Gastroenterology. 2006 Feb;130(2):312-22.
8. DNA mismatch repair defects: role in colorectal carcinogenesis. Jacob S and Praz F, Biochimie. 2002 Jan;84(1):27-47.
9. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
10. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
11. Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patients. Mann A, etal., Eur J Cancer. 2008 Oct;44(15):2259-65. Epub 2008 Aug 22.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nicolaides NC, etal., Nature. 1994 Sep 1;371(6492):75-80.
14. The elevated expression of a mismatch repair protein is a predictor for biochemical recurrence after radical prostatectomy. Norris AM, etal., Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):57-64.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9500552   PMID:9618520   PMID:10359802   PMID:10429667   PMID:10430621   PMID:10871409   PMID:11313994   PMID:11809883   PMID:11828012   PMID:12477932   PMID:15480418   PMID:16204034  
PMID:16403449   PMID:16713580   PMID:16728433   PMID:23071719   PMID:23709753  


Genomics

Comparative Map Data
Pms2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,790,478 - 15,814,790 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1215,790,478 - 15,815,248 (-)EnsemblGRCr8
mRatBN7.21210,676,818 - 10,701,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1210,676,764 - 10,701,066 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1211,483,953 - 11,508,343 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,107,244 - 12,131,635 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,131,272 - 11,155,470 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01212,714,394 - 12,738,654 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1212,714,394 - 12,738,641 (-)Ensemblrn6Rnor6.0
Rnor_5.01214,757,747 - 14,781,994 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41211,004,507 - 11,028,754 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1212,474,260 - 12,498,506 (-)NCBICelera
RGSC_v3.11211,034,447 - 11,058,818 (-)NCBI
Cytogenetic Map12p11NCBI
PMS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3875,970,925 - 6,009,106 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl75,970,925 - 6,009,130 (-)Ensemblhg38GRCh38
GRCh3776,010,556 - 6,048,737 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,979,396 - 6,015,263 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3475,786,113 - 5,821,915NCBI
Celera75,957,552 - 5,958,444 (-)NCBICelera
Celera760,142,236 - 60,149,112 (-)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef75,894,376 - 5,920,472 (-)NCBIHuRef
CHM1_176,012,471 - 6,048,456 (-)NCBICHM1_1
T2T-CHM13v2.076,088,690 - 6,126,871 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v276,059,215 - 6,095,082 (-)NCBI
Pms2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,846,379 - 143,922,538 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,846,782 - 143,870,786 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl5143,869,853 - 143,922,537 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385143,909,901 - 143,972,745 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,909,964 - 143,933,968 (+)Ensemblmm10GRCm38
MGSCv375144,670,870 - 144,692,625 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365144,163,492 - 144,184,971 (+)NCBIMGSCv36mm8
Celera5140,892,468 - 140,914,240 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.82NCBI
Pms2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546013,762,955 - 13,790,070 (+)Ensembl
ChiLan1.0NW_00495546013,762,854 - 13,791,462 (+)NCBIChiLan1.0ChiLan1.0
PMS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2611,662,061 - 11,700,524 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1759,986,772 - 60,025,245 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v077,433,031 - 7,459,560 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.176,175,913 - 6,203,094 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl76,167,403 - 6,202,984 (-)EnsemblpanPan2panpan1.1
PMS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1611,411,062 - 11,438,767 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl611,349,453 - 11,438,940 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha613,036,823 - 13,064,755 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0611,411,303 - 11,439,261 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl611,411,472 - 11,438,840 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1611,287,969 - 11,315,948 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,267,257 - 11,295,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0611,493,877 - 11,521,829 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pms2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344139,477,659 - 139,505,890 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936750439,480 - 467,332 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936750439,396 - 468,747 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl35,118,018 - 5,145,628 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.135,118,002 - 5,145,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.235,179,132 - 5,206,754 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PMS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,174,359 - 15,209,962 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2815,172,100 - 15,209,852 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236661022,176 - 909,949 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pms2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474031,315,121 - 31,345,137 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pms2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1169,244,955 - 9,268,632 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pms2
224 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:157
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000067021
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)121186960016966542Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH141752  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21210,676,919 - 10,677,121 (+)MAPPERmRatBN7.2
Rnor_6.01212,714,495 - 12,714,696NCBIRnor6.0
Rnor_5.01214,757,848 - 14,758,049UniSTSRnor5.0
RGSC_v3.41211,004,608 - 11,004,809UniSTSRGSC3.4
Celera1212,474,361 - 12,474,562UniSTS
RH 3.4 Map12124.1UniSTS
Cytogenetic Map12p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000067021   ⟹   ENSRNOP00000061927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1215,795,218 - 15,814,720 (-)Ensembl
mRatBN7.2 Ensembl1210,676,764 - 10,701,066 (-)Ensembl
Rnor_6.0 Ensembl1212,714,394 - 12,738,641 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078603   ⟹   ENSRNOP00000069740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1215,790,478 - 15,815,248 (-)Ensembl
mRatBN7.2 Ensembl1210,676,835 - 10,701,058 (-)Ensembl
Rnor_6.0 Ensembl1212,714,408 - 12,738,620 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094513   ⟹   ENSRNOP00000079389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1215,790,478 - 15,814,720 (-)Ensembl
mRatBN7.2 Ensembl1210,676,833 - 10,701,000 (-)Ensembl
RefSeq Acc Id: NM_001105908   ⟹   NP_001099378
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,790,479 - 15,814,728 (-)NCBI
mRatBN7.21210,676,819 - 10,701,066 (-)NCBI
Rnor_6.01212,714,394 - 12,738,641 (-)NCBI
Rnor_5.01214,757,747 - 14,781,994 (-)NCBI
RGSC_v3.41211,004,507 - 11,028,754 (-)RGD
Celera1212,474,260 - 12,498,506 (-)RGD
Sequence:
RefSeq Acc Id: NM_001399795   ⟹   NP_001386724
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,790,478 - 15,814,720 (-)NCBI
mRatBN7.21210,676,818 - 10,701,058 (-)NCBI
RefSeq Acc Id: XM_017598288   ⟹   XP_017453777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,790,492 - 15,814,790 (-)NCBI
mRatBN7.21210,676,829 - 10,701,161 (-)NCBI
Rnor_6.01212,714,404 - 12,738,617 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089178   ⟹   XP_038945106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,790,492 - 15,814,790 (-)NCBI
mRatBN7.21210,676,829 - 10,701,161 (-)NCBI
RefSeq Acc Id: XM_039089179   ⟹   XP_038945107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,795,891 - 15,814,790 (-)NCBI
mRatBN7.21210,682,224 - 10,701,161 (-)NCBI
RefSeq Acc Id: XR_005491606
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,795,218 - 15,814,790 (-)NCBI
mRatBN7.21210,681,556 - 10,701,161 (-)NCBI
RefSeq Acc Id: XR_005491607
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,795,218 - 15,814,790 (-)NCBI
mRatBN7.21210,681,556 - 10,701,161 (-)NCBI
RefSeq Acc Id: XR_010056366
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81215,795,054 - 15,814,790 (-)NCBI
RefSeq Acc Id: NP_001099378   ⟸   NM_001105908
- Peptide Label: isoform 2
- UniProtKB: A6K1J3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453777   ⟸   XM_017598288
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000061927   ⟸   ENSRNOT00000067021
Ensembl Acc Id: ENSRNOP00000069740   ⟸   ENSRNOT00000078603
RefSeq Acc Id: XP_038945106   ⟸   XM_039089178
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038945107   ⟸   XM_039089179
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000079389   ⟸   ENSRNOT00000094513
RefSeq Acc Id: NP_001386724   ⟸   NM_001399795
- Peptide Label: isoform 1
- UniProtKB: B1H246 (UniProtKB/TrEMBL),   A0A0G2JW47 (UniProtKB/TrEMBL)
Protein Domains
DNA mismatch repair protein S5   MutL C-terminal dimerisation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1H246-F1-model_v2 AlphaFold B1H246 1-853 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698434
Promoter ID:EPDNEW_R8957
Type:multiple initiation site
Name:Pms2_1
Description:PMS1 homolog 2, mismatch repair system component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01212,738,606 - 12,738,666EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305483 AgrOrtholog
BioCyc Gene G2FUF-20025 BioCyc
Ensembl Genes ENSRNOG00000001040 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067021 ENTREZGENE
  ENSRNOT00000067021.4 UniProtKB/TrEMBL
  ENSRNOT00000078603 ENTREZGENE
  ENSRNOT00000078603.4 UniProtKB/TrEMBL
  ENSRNOT00000094513.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1370.100 UniProtKB/TrEMBL
  3.30.1540.20 UniProtKB/TrEMBL
  3.30.230.10 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8365723 IMAGE-MGC_LOAD
InterPro DNA_mismatch_repair UniProtKB/TrEMBL
  DNA_mismatch_repair_C UniProtKB/TrEMBL
  DNA_mismatch_repair_CS UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  MutL/Mlh/Pms UniProtKB/TrEMBL
  MutL_C UniProtKB/TrEMBL
  MutL_C_dimsub UniProtKB/TrEMBL
  MutL_C_regsub UniProtKB/TrEMBL
  MutL_C_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/TrEMBL
MGC_CLONE MGC:187611 IMAGE-MGC_LOAD
NCBI Gene 288479 ENTREZGENE
PANTHER MISMATCH REPAIR ENDONUCLEASE PMS2 UniProtKB/TrEMBL
  PTHR10073 UniProtKB/TrEMBL
Pfam DNA_mis_repair UniProtKB/TrEMBL
  HATPase_c_3 UniProtKB/TrEMBL
  MutL_C UniProtKB/TrEMBL
PharmGKB PMS2 RGD
PhenoGen Pms2 PhenoGen
PROSITE DNA_MISMATCH_REPAIR_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001040 RatGTEx
SMART DNA_mis_repair UniProtKB/TrEMBL
  MutL_C UniProtKB/TrEMBL
Superfamily-SCOP Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  SSF118116 UniProtKB/TrEMBL
  SSF55874 UniProtKB/TrEMBL
UniProt A0A0G2JW47 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZND0_RAT UniProtKB/TrEMBL
  A6K1J3 ENTREZGENE, UniProtKB/TrEMBL
  B1H246 ENTREZGENE, UniProtKB/TrEMBL
  D4A360_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-04 Pms2  PMS1 homolog 2, mismatch repair system component  Pms2  postmeiotic segregation increased 2 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-26 Pms2  postmeiotic segregation increased 2 (S. cerevisiae)  Pms2  PMS2 postmeiotic segregation increased 2 (S. cerevisiae)  Name changed 629549 APPROVED
2008-09-09 Pms2  PMS2 postmeiotic segregation increased 2 (S. cerevisiae)  Pms2  postmeiotic segregation increased 2 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pms2  postmeiotic segregation increased 2 (S. cerevisiae)   Pms2_predicted  postmeiotic segregation increased 2 (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pms2_predicted  postmeiotic segregation increased 2 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED