Gper1 (G protein-coupled estrogen receptor 1) - Rat Genome Database

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Gene: Gper1 (G protein-coupled estrogen receptor 1) Chinchilla lanigera
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Symbol: Gper1
Name: G protein-coupled estrogen receptor 1
RGD ID: 8865016
Description: ENCODES a protein that exhibits chromatin binding (ortholog); estradiol binding (ortholog); G protein-coupled estrogen receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); apoptotic chromosome condensation (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN bisphenol A response pathway; epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); COVID-19 (ortholog); Dysbiosis (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G-protein coupled estrogen receptor 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
apoptotic chromosome condensation  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
intracellular estrogen receptor signaling pathway  (ISO)
intracellular steroid hormone receptor signaling pathway  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of cell cycle process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of leukocyte activation  (ISO)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of receptor binding  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
nuclear fragmentation involved in apoptotic nuclear change  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cardiac vascular smooth muscle cell differentiation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inositol trisphosphate biosynthetic process  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of uterine smooth muscle contraction  (ISO)
positive regulation of voltage-gated sodium channel activity  (ISO)
regulation of cell cycle  (ISO)
serotonin receptor signaling pathway  (ISO)
steroid hormone mediated signaling pathway  (ISO)
vasodilation  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data
Gper1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBIChiLan1.0ChiLan1.0
GPER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3871,087,118 - 1,093,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl71,082,208 - 1,093,815 (+)EnsemblGRCh38hg38GRCh38
GRCh3771,126,754 - 1,133,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3671,092,969 - 1,099,977 (+)NCBINCBI36Build 36hg18NCBI36
Build 347899,752 - 906,692NCBI
Celera71,094,088 - 1,101,068 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef71,041,713 - 1,048,693 (+)NCBIHuRef
CHM1_171,126,080 - 1,133,090 (+)NCBICHM1_1
T2T-CHM13v2.071,192,020 - 1,198,681 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)NCBI
Gper1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,408,905 - 139,413,555 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,408,906 - 139,413,555 (+)EnsemblGRCm39 Ensembl
GRCm385139,423,150 - 139,427,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,423,151 - 139,427,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,899,133 - 139,903,754 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,676,821 - 139,681,430 (+)NCBIMGSCv36mm8
Celera5136,477,197 - 136,481,822 (+)NCBICelera
Cytogenetic Map5G2NCBI
Gper1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21215,217,217 - 15,222,679 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,217,442 - 15,221,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,027,880 - 16,029,158 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01216,651,625 - 16,652,903 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01215,677,933 - 15,679,211 (-)NCBIRnor_WKY
Rnor_6.01217,309,122 - 17,315,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,309,834 - 17,311,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,296,086 - 19,301,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,718,615 - 15,719,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,748,542 - 15,749,821 (-)NCBI
Celera1216,971,703 - 16,972,981 (-)NCBICelera
Cytogenetic Map12q11NCBI
LOC100967334
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.171,454,768 - 1,461,376 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v071,245,873 - 1,251,915 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GPER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,792,072 - 15,796,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,792,897 - 15,794,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,265,181 - 17,311,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0615,922,801 - 15,968,766 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl615,922,807 - 15,927,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,725,481 - 15,771,429 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,652,239 - 15,698,182 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0615,940,139 - 15,986,136 (-)NCBIUU_Cfam_GSD_1.0
Gper1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,716,868 - 143,723,998 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,288,912 - 1,293,427 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367541,288,891 - 1,293,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3712,160 - 715,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13711,427 - 715,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23828,578 - 833,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,491,874 - 20,497,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,492,188 - 20,493,315 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,198,018 - 1,204,300 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gper1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,627,473 - 26,632,027 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,627,560 - 26,632,483 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000007838   ⟹   ENSCLAP00000007719
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)Ensembl
RefSeq Acc Id: XM_005397796   ⟹   XP_005397853
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005397853 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005397853   ⟸   XM_005397796
- UniProtKB: A0A8C2UZP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000007719   ⟸   ENSCLAT00000007838
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005416 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000007719 ENTREZGENE
  ENSCLAP00000007719.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007838 ENTREZGENE
  ENSCLAT00000007838.1 UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Gper1 ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
UniProt A0A8C2UZP4 ENTREZGENE, UniProtKB/TrEMBL