Gper1 (G protein-coupled estrogen receptor 1) - Rat Genome Database
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Gene: Gper1 (G protein-coupled estrogen receptor 1) Chinchilla lanigera
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Symbol: Gper1
Name: G protein-coupled estrogen receptor 1
RGD ID: 8865016
Description: ENCODES a protein that exhibits chromatin binding (ortholog); estradiol binding (ortholog); estrogen receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); apoptotic chromosome condensation (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN bisphenol A response pathway; epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); COVID-19 (ortholog); endometriosis (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: G-protein coupled estrogen receptor 1
Orthologs:
Homo sapiens (human) : GPER1 (G protein-coupled estrogen receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Gper1 (G protein-coupled estrogen receptor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gper1 (G protein-coupled estrogen receptor 1)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100967334 (G-protein coupled estrogen receptor 1)
Canis lupus familiaris (dog) : GPER1 (G protein-coupled estrogen receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gper1 (G protein-coupled estrogen receptor 1)
Sus scrofa (pig) : GPER1 (G protein-coupled estrogen receptor 1)
Chlorocebus sabaeus (African green monkey) : GPER1 (G protein-coupled estrogen receptor 1)
Heterocephalus glaber (naked mole-rat) : Gper1 (G protein-coupled estrogen receptor 1)
more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
apoptotic chromosome condensation  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
intracellular estrogen receptor signaling pathway  (ISO)
intracellular steroid hormone receptor signaling pathway  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of cell cycle arrest  (ISO)
negative regulation of cell cycle process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA metabolic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of leukocyte activation  (ISO)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of receptor binding  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
nuclear fragmentation involved in apoptotic nuclear change  (ISO)
obsolete positive regulation of blood vessel diameter  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cardiac vascular smooth muscle cell differentiation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inositol trisphosphate biosynthetic process  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of uterine smooth muscle contraction  (ISO)
positive regulation of voltage-gated sodium channel activity  (ISO)
serotonin receptor signaling pathway  (ISO)
steroid hormone mediated signaling pathway  (ISO)

Molecular Function

References


Genomics

Comparative Map Data
Gper1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBIChiLan1.0ChiLan1.0
GPER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl71,082,208 - 1,093,815 (+)EnsemblGRCh38hg38GRCh38
GRCh3871,087,118 - 1,093,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3771,126,443 - 1,133,451 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3671,092,969 - 1,099,977 (+)NCBINCBI36hg18NCBI36
Build 347899,752 - 906,692NCBI
Celera71,094,088 - 1,101,068 (+)NCBI
Cytogenetic Map7p22.3NCBI
HuRef71,041,713 - 1,048,693 (+)NCBIHuRef
CHM1_171,126,080 - 1,133,090 (+)NCBICHM1_1
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)NCBI
Gper1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,408,905 - 139,413,555 (+)NCBI
GRCm385139,423,150 - 139,427,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,423,151 - 139,427,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,899,133 - 139,903,754 (+)NCBIGRCm37mm9NCBIm37
MGSCv365139,676,821 - 139,681,430 (+)NCBImm8
Celera5136,477,197 - 136,481,822 (+)NCBICelera
Cytogenetic Map5G2NCBI
Gper1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01217,309,122 - 17,315,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,309,834 - 17,311,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,296,086 - 19,301,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,718,615 - 15,719,893 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11215,748,542 - 15,749,821 (-)NCBI
Celera1216,971,703 - 16,972,981 (-)NCBICelera
Cytogenetic Map12q11NCBI
LOC100967334
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.171,454,768 - 1,461,376 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v071,245,873 - 1,251,915 (+)NCBIMhudiblu_PPA_v0panPan3
GPER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl615,792,897 - 15,794,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1615,792,072 - 15,796,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gper1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367541,288,891 - 1,293,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3712,160 - 715,982 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13711,427 - 715,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23828,578 - 833,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPER1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2820,492,188 - 20,493,315 (-)Ensembl
ChlSab1.12820,491,874 - 20,497,966 (-)NCBI
Gper1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474026,627,560 - 26,632,483 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000007838   ⟹   ENSCLAP00000007719
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)Ensembl
RefSeq Acc Id: XM_005397796   ⟹   XP_005397853
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005397853 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005397853   ⟸   XM_005397796
- Sequence:
RefSeq Acc Id: ENSCLAP00000007719   ⟸   ENSCLAT00000007838


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005416 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000007719 ENTREZGENE
Ensembl Transcript ENSCLAT00000007838 ENTREZGENE
NCBI Gene Gper1 ENTREZGENE