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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735664
Species: Homo sapiens
RGD Object: Gene
Symbol: GPER1
Name: G protein-coupled estrogen receptor 1
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GPER1multiple interactionsEXP 6480464CTDGPER1 protein affects the reaction [Raloxifene Hydrochloride affects the localization of FOXO3 protein]; GPER1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; GPER1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of MYC mRNA]PMID:22453024 PMID:26200092 PMID:26470790
GPER1increases activityISOGper1 (Rattus norvegicus)6480464CTDRaloxifene Hydrochloride results in increased activity of GPER1 proteinPMID:24782323
GPER1multiple interactionsISOGper1 (Rattus norvegicus)6480464CTD[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline binds to and results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein]; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 proteinPMID:24782323
GPER1multiple interactionsISOGper1 (Mus musculus)6480464CTDRaloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in increased expression of GPER1 mRNA]PMID:24846829
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