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Breast cancer, estrogen receptor and ligands.

Authors: Bai, Z  Gust, R 
Citation: Bai Z and Gust R, Arch Pharm (Weinheim). 2009 Mar;342(3):133-49.
Pubmed: (View Article at PubMed) PMID:19274700
DOI: Full-text: DOI:10.1002/ardp.200800174

This review emphasizes the relationship of breast cancer, estrogen receptor and ligands, especially the centrality of the estrogen receptor, which mediates on one hand the hormone-induced gene transcription and on the other hand the anti-estrogen action against breast cancer. The characterization of the estrogen receptor ligand-binding domain co-crystallized with agonists or antagonists provided a molecular basis to gain an insight into the regulation of estrogen receptor and, thereby, to describe the mechanism of the hormone therapy in treating breast cancer.


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RGD Object Information
RGD ID: 4892064
Created: 2011-02-01
Species: All species
Last Modified: 2011-02-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.