GPER1 (G protein-coupled estrogen receptor 1) - Rat Genome Database

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Gene: GPER1 (G protein-coupled estrogen receptor 1) Pan paniscus
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Symbol: GPER1
Name: G protein-coupled estrogen receptor 1
RGD ID: 32726829
Description: ENCODES a protein that exhibits chromatin binding (ortholog); estradiol binding (ortholog); G protein-coupled estrogen receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); apoptotic chromosome condensation (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN bisphenol A response pathway; epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); COVID-19 (ortholog); Dysbiosis (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor 1-like; GPER; LOC100967334; LOC117974319
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v266,038,040 - 6,040,197 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,349,340 - 54,364,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,331,586 - 1,338,194 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,454,768 - 1,461,376 (+)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
apoptotic chromosome condensation  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to mineralocorticoid stimulus  (ISO)
cellular response to peptide hormone stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
estrogen receptor signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of cell cycle process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of leukocyte activation  (ISO)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of receptor binding  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
nuclear fragmentation involved in apoptotic nuclear change  (ISO)
nuclear receptor-mediated steroid hormone signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cardiac vascular smooth muscle cell differentiation  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cysteine-type endopeptidase activity  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inositol trisphosphate biosynthetic process  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of uterine smooth muscle contraction  (ISO)
positive regulation of voltage-gated sodium channel activity  (ISO)
regulation of cell cycle  (ISO)
serotonin receptor signaling pathway  (ISO)
steroid hormone receptor signaling pathway  (ISO)
vasodilation  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GPER1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v266,038,040 - 6,040,197 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,349,340 - 54,364,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,331,586 - 1,338,194 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,454,768 - 1,461,376 (+)NCBIpanpan1.1PanPan1.1panPan2
GPER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3871,087,118 - 1,093,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl71,082,208 - 1,093,815 (+)EnsemblGRCh38hg38GRCh38
GRCh3771,126,754 - 1,133,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3671,092,969 - 1,099,977 (+)NCBINCBI36Build 36hg18NCBI36
Build 347899,752 - 906,692NCBI
Celera71,094,088 - 1,101,068 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef71,041,713 - 1,048,693 (+)NCBIHuRef
CHM1_171,126,080 - 1,133,090 (+)NCBICHM1_1
T2T-CHM13v2.071,192,020 - 1,198,681 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)NCBI
Gper1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,408,905 - 139,413,555 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,408,906 - 139,413,555 (+)EnsemblGRCm39 Ensembl
GRCm385139,423,150 - 139,427,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,423,151 - 139,427,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,899,133 - 139,903,754 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,676,821 - 139,681,430 (+)NCBIMGSCv36mm8
Celera5136,477,197 - 136,481,822 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.58NCBI
Gper1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,331,073 - 20,336,527 (-)NCBIGRCr8
mRatBN7.21215,217,217 - 15,222,679 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,217,442 - 15,221,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,027,880 - 16,029,158 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,651,625 - 16,652,903 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,677,933 - 15,679,211 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,309,122 - 17,315,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,309,834 - 17,311,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,296,086 - 19,301,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,718,615 - 15,719,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,748,542 - 15,749,821 (-)NCBI
Celera1216,971,703 - 16,972,981 (-)NCBICelera
Cytogenetic Map12q11NCBI
Gper1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBIChiLan1.0ChiLan1.0
GPER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,792,072 - 15,796,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,792,897 - 15,794,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,265,181 - 17,311,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0615,922,801 - 15,968,766 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl615,922,807 - 15,927,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,725,481 - 15,771,429 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,652,239 - 15,698,182 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0615,940,139 - 15,986,136 (-)NCBIUU_Cfam_GSD_1.0
Gper1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,716,868 - 143,723,998 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,288,912 - 1,293,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367541,288,891 - 1,293,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3712,160 - 715,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13711,427 - 715,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23828,578 - 833,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,491,874 - 20,497,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,492,188 - 20,493,315 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,198,018 - 1,204,300 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gper1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,627,473 - 26,632,027 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,627,560 - 26,632,483 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034963477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_034963477   ⟹   XP_034819368
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v266,038,040 - 6,040,197 (+)NCBI
NHGRI_mPanPan1754,356,087 - 54,364,886 (+)NCBI
Mhudiblu_PPA_v071,331,586 - 1,338,194 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034819368 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_034819368   ⟸   XM_034963477


Additional Information

Database Acc Id Source(s)
NCBI Gene LOC117974319 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-25 GPER1  G protein-coupled estrogen receptor 1  LOC117974319  G-protein coupled estrogen receptor 1-like  Symbol and/or name change 5135510 APPROVED
2023-04-20 LOC117974319  G-protein coupled estrogen receptor 1-like  LOC100967334  G-protein coupled estrogen receptor 1  Data merged from RGD:11967214 737654 PROVISIONAL
2020-07-01 LOC100967334  G-protein coupled estrogen receptor 1  GPER1  G protein-coupled estrogen receptor 1  Symbol and/or name change 5135510 APPROVED