GPER1 (G protein-coupled estrogen receptor 1) - Rat Genome Database

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Gene: GPER1 (G protein-coupled estrogen receptor 1) Pan paniscus
Analyze
Symbol: GPER1
Name: G protein-coupled estrogen receptor 1
RGD ID: 32726829
Description: ENCODES a protein that exhibits chromatin binding (ortholog); estradiol binding (ortholog); G protein-coupled estrogen receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); apoptotic chromosome condensation (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN bisphenol A response pathway; epidermal growth factor/neuregulin signaling pathway; estrogen signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); COVID-19 (ortholog); Dysbiosis (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor 1-like; GPER; LOC100967334; LOC117974319
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v266,038,040 - 6,040,197 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,349,340 - 54,364,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,331,586 - 1,338,194 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,454,768 - 1,461,376 (+)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GPER1BonoboCOVID-19  ISOGPER1 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
GPER1BonoboDysbiosis amelioratesISOGper1 (Rattus norvegicus)9068941 RGDPMID:30354811 and REF_RGD_ID:39939000
GPER1Bonoboendometriosis  ISOGPER1 (Homo sapiens)9068941protein:increased expression:endometrium and cytoplasm (human)RGDPMID:22520060 and REF_RGD_ID:39939083
GPER1Bonoboendometriosis  ISOGper1 (Mus musculus)9068941protein:decreased expression:endometrium (mouse)RGDPMID:32152908 and REF_RGD_ID:39938861
GPER1Bonobogeneralized anxiety disorder severityISOGPER1 (Homo sapiens)9068941protein:increased expression:serum (human)RGDPMID:27512921 and REF_RGD_ID:39938860
GPER1Bonobomelanoma severityISOGPER1 (Homo sapiens)9068941protein:increased expression:skin (human)RGDPMID:28467693 and REF_RGD_ID:39939016
GPER1BonoboSpinal Cord Injuries  ISOGper1 (Rattus norvegicus)9068941 RGDPMID:22975889 and REF_RGD_ID:8552988
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GPER1BonoboBreast Neoplasms  ISOGPER1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24440569
GPER1BonoboHepatomegaly  ISOGPER1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:30641053
GPER1BonoboHyperalgesia  ISOGPER1 (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:25280432
GPER1Bonoboidiopathic pulmonary fibrosis  ISOGPER1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:30165855
GPER1Bonoboleiomyoma  ISOGPER1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:31468104
GPER1BonoboLiver Neoplasms  ISOGPER1 (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:30641053
GPER1BonoboMultiple Abnormalities  ISOGPER1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21984484


Biological Process
1 to 20 of 79 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GPER1Bonoboadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inISOGPER1 (Homo sapiens)9068941 PMID:15539556UniProtPMID:15539556
GPER1Bonoboadenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inISOGper1 (Mus musculus)9068941 PMID:21149639UniProtPMID:21149639
GPER1Bonoboapoptotic chromosome condensation involved_inISOGper1 (Rattus norvegicus)9068941PMID:23907461UniProtPMID:23907461 and REF_RGD_ID:8553942
GPER1Bonobocellular response to estradiol stimulus involved_inISOGPER1 (Homo sapiens)9068941 PMID:15539556 more ...UniProtPMID:15539556 more ...
GPER1Bonobocellular response to estradiol stimulus involved_inISOGper1 (Mus musculus)9068941 PMID:21149639 more ...UniProtPMID:21149639 more ...
GPER1Bonobocellular response to estradiol stimulus involved_inISOGper1 (Rattus norvegicus)9068941PMID:23283935UniProtPMID:23283935 and REF_RGD_ID:8553898
GPER1Bonobocellular response to estradiol stimulus involved_inISOGper1 (Rattus norvegicus)9068941PMID:23907461UniProtPMID:23907461 and REF_RGD_ID:8553942
GPER1Bonobocellular response to glucose stimulus involved_inISOGper1 (Mus musculus)9068941 PMID:21673097UniProtPMID:21673097
GPER1Bonobocellular response to mineralocorticoid stimulus involved_inISOGper1 (Rattus norvegicus)9068941PMID:23283935UniProtPMID:23283935 and REF_RGD_ID:8553898
GPER1Bonobocellular response to peptide hormone stimulus involved_inISOGPER1 (Homo sapiens)9068941 PMID:21427217UniProtPMID:21427217
GPER1Bonobocellular response to tumor necrosis factor involved_inISOGPER1 (Homo sapiens)9068941 PMID:23285008UniProtPMID:23285008
GPER1Bonoboestrogen receptor signaling pathway  ISOGper1 (Rattus norvegicus)9068941 RGDPMID:20445128 and REF_RGD_ID:4892084
GPER1BonoboG protein-coupled receptor signaling pathway involved_inISOGPER1 (Sus scrofa)9068941 PMID:23840305AgBasePMID:23840305
GPER1BonoboG protein-coupled receptor signaling pathway involved_inISOGPER1 (Homo sapiens)9068941 PMID:23840305AgBasePMID:23840305
GPER1Bonobomodulation of chemical synaptic transmission involved_inISOGper1 (Mus musculus)9068941 PMID:29421611SynGOPMID:29421611
GPER1Bonobonegative regulation of cell cycle process involved_inISOGPER1 (Sus scrofa)9068941 PMID:23840305AgBasePMID:23840305
GPER1Bonobonegative regulation of cell cycle process involved_inISOGPER1 (Homo sapiens)9068941 PMID:23840305AgBasePMID:23840305
GPER1Bonobonegative regulation of cell population proliferation involved_inISOGper1 (Rattus norvegicus)9068941PMID:23907461UniProtPMID:23907461 and REF_RGD_ID:8553942
GPER1Bonobonegative regulation of ERK1 and ERK2 cascade involved_inISOGPER1 (Sus scrofa)9068941 PMID:23840305AgBasePMID:23840305
GPER1Bonobonegative regulation of ERK1 and ERK2 cascade involved_inISOGPER1 (Homo sapiens)9068941 PMID:23840305AgBasePMID:23840305
1 to 20 of 79 rows

Cellular Component
1 to 20 of 37 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GPER1Bonoboaxon located_inISOGper1 (Rattus norvegicus)9068941PMID:22919059UniProtPMID:22919059 and REF_RGD_ID:8553395
GPER1Bonoboaxon terminus located_inISOGper1 (Rattus norvegicus)9068941PMID:22919059UniProtPMID:22919059 and REF_RGD_ID:8553395
GPER1Bonobocytoplasm located_inISOGper1 (Rattus norvegicus)9068941PMID:22919059UniProtPMID:22919059 and REF_RGD_ID:8553395
GPER1Bonobocytoplasm located_inISOGper1 (Mus musculus)9068941 PMID:21149639 and PMID:23871778UniProtPMID:21149639 and PMID:23871778
GPER1Bonobocytoplasmic vesicle membrane located_inISOGPER1 (Homo sapiens)9068941 PMID:21540189UniProtPMID:21540189
GPER1Bonobocytosol located_inISOGPER1 (Homo sapiens)9068941 HPAGO_REF:0000052
GPER1Bonobodendrite located_inISOGper1 (Rattus norvegicus)9068941PMID:22919059UniProtPMID:22919059 and REF_RGD_ID:8553395
GPER1Bonobodendritic shaft located_inISOGper1 (Rattus norvegicus)9068941PMID:22919059UniProtPMID:22919059 and REF_RGD_ID:8553395
GPER1Bonobodendritic shaft located_inISOGper1 (Rattus norvegicus)9068941PMID:23822769UniProtPMID:23822769 and REF_RGD_ID:8554508
GPER1Bonobodendritic spine head located_inISOGper1 (Rattus norvegicus)9068941PMID:22919059UniProtPMID:22919059 and REF_RGD_ID:8553395
GPER1Bonobodendritic spine membrane located_inISOGper1 (Rattus norvegicus)9068941PMID:22919059UniProtPMID:22919059 and REF_RGD_ID:8553395
GPER1Bonobodendritic spine membrane located_inISOGper1 (Rattus norvegicus)9068941PMID:23822769UniProtPMID:23822769 and REF_RGD_ID:8554508
GPER1Bonoboearly endosome located_inISOGPER1 (Homo sapiens)9068941 PMID:21540189UniProtPMID:21540189
GPER1Bonoboendoplasmic reticulum located_inISOGPER1 (Homo sapiens)9068941 PMID:15705806 and PMID:21540189UniProtPMID:15705806 and PMID:21540189
GPER1Bonoboendoplasmic reticulum membrane  ISOGper1 (Rattus norvegicus)9068941 RGDPMID:24262995 and REF_RGD_ID:39939015
GPER1BonoboGolgi apparatus located_inISOGper1 (Rattus norvegicus)9068941PMID:22919059UniProtPMID:22919059 and REF_RGD_ID:8553395
GPER1BonoboGolgi apparatus located_inISOGPER1 (Homo sapiens)9068941 PMID:15705806UniProtPMID:15705806
GPER1Bonobohippocampal mossy fiber to CA3 synapse is_active_inISOGper1 (Mus musculus)9068941 PMID:29421611SynGOPMID:29421611
GPER1Bonobointracellular membrane-bounded organelle located_inISOGPER1 (Homo sapiens)9068941 HPAGO_REF:0000052
GPER1Bonobokeratin filament located_inISOGPER1 (Homo sapiens)9068941 PMID:21149639UniProtPMID:21149639
1 to 20 of 37 rows

PMID:22301074   PMID:30032202  



GPER1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v266,038,040 - 6,040,197 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,349,340 - 54,364,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,331,586 - 1,338,194 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,454,768 - 1,461,376 (+)NCBIpanpan1.1PanPan1.1panPan2
GPER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3871,087,118 - 1,093,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl71,082,208 - 1,093,815 (+)EnsemblGRCh38hg38GRCh38
GRCh3771,126,754 - 1,133,446 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3671,092,969 - 1,099,977 (+)NCBINCBI36Build 36hg18NCBI36
Build 347899,752 - 906,692NCBI
Celera71,094,088 - 1,101,068 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef71,041,713 - 1,048,693 (+)NCBIHuRef
CHM1_171,126,080 - 1,133,090 (+)NCBICHM1_1
T2T-CHM13v2.071,192,020 - 1,198,681 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v271,180,870 - 1,187,850 (+)NCBI
Gper1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,408,905 - 139,413,555 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,408,906 - 139,413,555 (+)EnsemblGRCm39 Ensembl
GRCm385139,423,150 - 139,427,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,423,151 - 139,427,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,899,133 - 139,903,754 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,676,821 - 139,681,430 (+)NCBIMGSCv36mm8
Celera5136,477,197 - 136,481,822 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.58NCBI
Gper1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,331,073 - 20,336,527 (-)NCBIGRCr8
mRatBN7.21215,217,217 - 15,222,679 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,217,442 - 15,221,889 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,027,880 - 16,029,158 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,651,625 - 16,652,903 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,677,933 - 15,679,211 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,309,122 - 17,315,267 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,309,834 - 17,311,112 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,296,086 - 19,301,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,718,615 - 15,719,893 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,748,542 - 15,749,821 (-)NCBI
Celera1216,971,703 - 16,972,981 (-)NCBICelera
Cytogenetic Map12q11NCBI
Gper1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,790,798 - 8,794,902 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,790,798 - 8,794,902 (+)NCBIChiLan1.0ChiLan1.0
GPER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,792,072 - 15,796,922 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,792,897 - 15,794,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,265,181 - 17,311,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0615,922,801 - 15,968,766 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl615,922,807 - 15,927,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,725,481 - 15,771,429 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,652,239 - 15,698,182 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0615,940,139 - 15,986,136 (-)NCBIUU_Cfam_GSD_1.0
Gper1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,716,868 - 143,723,998 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,288,912 - 1,293,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367541,288,891 - 1,293,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3712,160 - 715,980 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13711,427 - 715,982 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23828,578 - 833,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,491,874 - 20,497,966 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,492,188 - 20,493,315 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,198,018 - 1,204,300 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gper1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,627,473 - 26,632,027 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,627,560 - 26,632,483 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.
RefSeq Transcripts XM_034963477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_034963477   ⟹   XP_034819368
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v266,038,040 - 6,040,197 (+)NCBI
NHGRI_mPanPan1754,356,087 - 54,364,886 (+)NCBI
Mhudiblu_PPA_v071,331,586 - 1,338,194 (+)NCBI
Protein RefSeqs XP_034819368 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_034819368   ⟸   XM_034963477



Database
Acc Id
Source(s)
NCBI Gene LOC117974319 ENTREZGENE


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-25 GPER1  G protein-coupled estrogen receptor 1  LOC117974319  G-protein coupled estrogen receptor 1-like  Symbol and/or name change 5135510 APPROVED
2023-04-20 LOC117974319  G-protein coupled estrogen receptor 1-like  LOC100967334  G-protein coupled estrogen receptor 1  Data merged from RGD:11967214 737654 PROVISIONAL
2020-07-01 LOC100967334  G-protein coupled estrogen receptor 1  GPER1  G protein-coupled estrogen receptor 1  Symbol and/or name change 5135510 APPROVED