Taok3 (TAO kinase 3) - Rat Genome Database

Name: Taok3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Taok3 (TAO kinase 3) Rattus norvegicus

Analyze

Symbol:

Taok3

Name:

TAO kinase 3

RGD ID:

1562861

Description:

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; neuron projection morphogenesis; and regulation of JNK cascade. Predicted to be active in cytoplasm. Orthologous to human TAOK3 (TAO kinase 3); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

axotomy-related gene 357 protein; JIK; JNK/SAPK-inhibitory kinase; jun kinase-inhibitory kinase; serine/threonine-protein kinase TAO3; thousand and one amino acid protein 3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TAOK3 (TAO kinase 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Mus musculus (house mouse):	Taok3 (TAO kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Taok3 (TAO kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TAOK3 (TAO kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TAOK3 (TAO kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Taok3 (TAO kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TAOK3 (TAO kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TAOK3 (TAO kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Taok3 (TAO kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SART3 (spliceosome associated factor 3, U4/U6 recycling protein)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TAOK3 (TAO kinase 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Taok3 (TAO kinase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	taok3a (TAO kinase 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	kin-18	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tao	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	taok3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	39,312,354 - 39,473,656 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	39,314,027 - 39,461,244 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	40,487,630 - 40,648,887 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	41,101,449 - 41,262,709 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	40,154,420 - 40,315,685 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	45,037,951 - 45,116,593 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	45,037,883 - 45,182,974 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	46,857,904 - 46,936,392 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	40,502,499 - 40,583,816 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	40,955,052 - 41,034,414 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbamazepine (ISO)

celastrol (ISO)

cobalt dichloride (ISO)

coumarin (ISO)

coumestrol (ISO)

diuron (EXP)

dorsomorphin (ISO)

emodin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

ethanol (ISO)

furan (EXP)

gedunin (ISO)

gentamycin (EXP)

glycidol (EXP)

inulin (ISO)

ivermectin (ISO)

methoxychlor (EXP)

Nor-9-carboxy-delta9-THC (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

raloxifene (ISO)

resveratrol (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

Tesaglitazar (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

troglitazone (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (ISO,ISS)

DNA repair (IEA)

MAPK cascade (IBA,IEA,ISO)

mitotic G2 DNA damage checkpoint signaling (IEA,ISO,ISS)

negative regulation of JNK cascade (IEA,ISO)

neuron projection morphogenesis (IBA)

phosphorylation (IEA)

positive regulation of JNK cascade (IEA,ISO)

positive regulation of stress-activated MAPK cascade (ISO,ISS)

regulation of MAPK cascade (IBA)

Cellular Component

cytoplasm (IBA)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA,ISO)

transferase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

p38 MAPK signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10559204	PMID:10924369	PMID:11278723	PMID:16092929	PMID:17396146

Genomics

Comparative Map Data

Taok3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	39,312,354 - 39,473,656 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	39,314,027 - 39,461,244 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	40,487,630 - 40,648,887 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	41,101,449 - 41,262,709 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	40,154,420 - 40,315,685 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	45,037,951 - 45,116,593 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	45,037,883 - 45,182,974 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	46,857,904 - 46,936,392 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	40,502,499 - 40,583,816 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	40,955,052 - 41,034,414 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

TAOK3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	118,149,801 - 118,372,907 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	118,149,801 - 118,372,907 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	118,587,606 - 118,810,712 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	117,071,989 - 117,295,133 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	118,218,692 - 118,443,700 (-)	NCBI		Celera
Cytogenetic Map	12	q24.23	NCBI
HuRef	12	115,597,575 - 115,819,970 (-)	NCBI		HuRef
CHM1_1	12	118,555,318 - 118,778,602 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	118,137,047 - 118,360,176 (-)	NCBI		T2T-CHM13v2.0

Taok3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	117,258,180 - 117,413,283 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	117,258,194 - 117,413,284 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	117,120,111 - 117,275,101 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	117,120,129 - 117,275,219 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	117,583,604 - 117,723,924 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	117,381,159 - 117,534,945 (+)	NCBI		MGSCv36	mm8
Celera	5	114,223,391 - 114,369,377 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	56.88	NCBI

Taok3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	13,103,357 - 13,211,315 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	13,020,618 - 13,207,539 (+)	NCBI	ChiLan1.0	ChiLan1.0

TAOK3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	126,212,526 - 126,436,204 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	115,730,619 - 115,954,149 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	119,109,642 - 119,332,679 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	119,109,642 - 119,226,502 (-)	Ensembl	panpan1.1		panPan2

TAOK3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	14,534,083 - 14,712,779 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	14,534,901 - 14,631,899 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	14,527,147 - 14,711,964 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	14,795,979 - 14,974,732 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	14,797,097 - 14,974,708 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	14,760,804 - 14,939,682 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	14,833,069 - 15,012,056 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	14,868,170 - 15,053,480 (-)	NCBI		UU_Cfam_GSD_1.0

Taok3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	147,618,018 - 147,806,440 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	2,222,866 - 2,304,151 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936668	2,116,804 - 2,305,331 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TAOK3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	34,409,070 - 34,513,025 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	34,322,016 - 34,514,234 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	36,452,203 - 36,675,287 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TAOK3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	113,485,871 - 113,717,213 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	113,484,330 - 113,704,271 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	131,386,279 - 131,613,306 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Taok3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	15,241,065 - 15,331,935 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	15,142,378 - 15,331,197 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Taok3
909 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	15
Count of miRNA genes:	15
Interacting mature miRNAs:	15
Transcripts:	ENSRNOT00000001503
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
737822	Alc10	Alcohol consumption QTL 10	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	19610870	40218516	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	28064433	40130419	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	28064433	45899022	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	28064433	46669029	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	28064557	40218380	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	32103174	45899022	Rat

Markers in Region

RH132162

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	39,314,108 - 39,314,323 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	45,037,978 - 45,038,192	NCBI	Rnor6.0
Rnor_5.0	12	46,857,931 - 46,858,145	UniSTS	Rnor5.0
RGSC_v3.4	12	40,502,513 - 40,502,727	UniSTS	RGSC3.4
Celera	12	40,955,134 - 40,955,348	UniSTS
RH 3.4 Map	12	728.6	UniSTS
Cytogenetic Map	12	q16	UniSTS

RH137431

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	39,316,810 - 39,316,995 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	45,040,692 - 45,040,876	NCBI	Rnor6.0
Rnor_5.0	12	46,860,003 - 46,860,187	UniSTS	Rnor5.0
RGSC_v3.4	12	40,505,247 - 40,505,431	UniSTS	RGSC3.4
Celera	12	40,957,767 - 40,957,951	UniSTS
RH 3.4 Map	12	731.51	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3		45	38	18	38			56	1	22	9
Low		43	12	3	1	3	8	11	18	34	19	2	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB195232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000001503 ⟹ ENSRNOP00000001503

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	39,314,027 - 39,461,244 (-)	Ensembl
Rnor_6.0 Ensembl	12	45,037,951 - 45,182,974 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000089043 ⟹ ENSRNOP00000074994

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	12	45,037,883 - 45,116,665 (-)	Ensembl

RefSeq Acc Id:

NM_001024254 ⟹ NP_001019425

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	39,312,354 - 39,473,656 (-)	NCBI
Rnor_6.0	12	45,037,951 - 45,116,593 (-)	NCBI
Rnor_5.0	12	46,857,904 - 46,936,392 (-)	NCBI
RGSC_v3.4	12	40,502,499 - 40,583,816 (-)	RGD
Celera	12	40,955,052 - 41,034,414 (-)	NCBI

Sequence:

show sequence

TCATGCTCAAGAAACCCGGGACTGAAGGTCTATAAGAATAAAAATTGTAGTCAATGAGAGAGAC
AGAGGGACTGGGTCGTCAAACAGCAGCGTGCCTGCTGCCACACTGGCCACCATGCGTAAAGGAG
TGCTGAAGGACCCCGAGATTGCCGAGCTGTTCTTCAAGGAGGACCCCGAAGAGCTCTTTATCGA
CCTGCATGAAATCGGACATGGCAGCTTTGGAGCCGTGTACTTCGCAACTAATGCGCACACCAAC
GAGGTGGTTGCTATTAAGAAAATGTCCTACAGTGGGAAGCAGACCCACGAGAAATGGCAAGATA
TCCTGAAGGAAGTTCGATTCCTCCAGCAGCTGAAGCACCCGAACACCATCGAGTACAAAGGCTG
TTATTTAAAGGAGCACACCGCTTGGTTGGTGATGGAGTACTGCTTAGGTTCAGCCTCTGACTTG
TTAGAAGTTCATAAGAAACCACTTCAGGAAGTAGAGATTGCTGCTATCACCCATGGTGCCTTGC
AGGGGCTGGCCTACCTCCACTTTCACTCCCTGATTCACAGGGACATTAAAGCAGGGAATATCCT
CCTCACAGAGCCAGGCCAGGTGAAGCTGGCTGACTTCGGGTCCGCTTCCATGGCTTCTCCTGCC
AACTCCTTCGTGGGGACTCCTTACTGGATGGCCCCAGAGGTGATCTTAGCCATGGACGAAGGGC
AGTACGACGGGAAAGTTGACATCTGGTCACTCGGCATCACCTGCATAGAGCTGGCGGAGCGGAA
GCCCCCCCTCTTCAACATGAACGCCATGAGCGCCCTCTACCACATCGCTCAGAATGACTCCCCC
ACGCTGCAGTCCAGAGAATGGACAGACTCCTTCAGGAGATTCGTTGATTACTGCTTGCACAAAA
TACCTCAGGAACGACCAGCCGCGGCGGAACTGTTGCGGCACGACTTCATTCGGAGGGAGCGGCC
GCCGAGGGTCCTCATTGACCTCATACAGAGGACGAAAGATGCTGTCCGAGAGCTGGACAACCTG
CAGTACAGGAAAATGAAGAAGATCCTCTTCCAGGAGACTCGGAACGGACCCCTGAATGAGTCAC
AAGAAGAGGAAGAAGACAGTGAGCAAGGAAGCAACCTGAACCGAGAGGTGGACAGTCTGGGGAG
CATCCACTCCATCCCCAGCGTGTCAGTGAGCACGGGCAGCCGGAGCAGCAGCGTGAACAGCATG
CAGGAGGTCATGGACGAGGGCAGCCCTGAGCTCGTCATGATGCAGGAGGATGAAGGCACAGTCA
ACTCCAGCTCCTCTATGGTACACAAGAAGGATCATGTATTCGTAAGGGATGAGGCGGGCCACGG
CGATCCCAGGCCTGAGCCGCGGCCTACCCAGTCAGTTCAGAGCCGGGCCCTCCACTATCGGAAC
CGAGAGCGCTTTGCCACGATCAAATCCGCGTCTTTGGTTACACGGCAGATCCACGAGCATGAGC
AGGAGAACGAGCTGCGGGAACAGATGTCAGGTTATAAGCGGATGCGGCGCCAGCACCAGAAGCA
GCTGATCGCCCTGGAGAACAAGCTGAAGGCTGAGATGGATGAGCACCGCCTCAAGCTCCAGAAG
GAGGTGGAGACGCATGCCAACAACTCGTCCATCGAGCTGGAGAAGCTGGCCAAGAAGCAAGTGG
CTACCATAGAAAAGGAGGCAAAGGTAGCCGCAGCGGATGAGAAGAAGTTCCAGCAGCAGATCCT
GGCCCAGCAGAAGAAGGACTTGACAACTTTCTTAGAAAGTCAGAAGAAGCAGTACAAGATTTGT
AAGGAGAAAATAAAAGAGGAAATGAACGAGGACCATAGCACACCCAAGAAGGAGAAGCAGGAGC
GCATATCGAAGCATAAAGAGAACCTGCAGCACACGCAGGCCGAGGAGGAAGCCCACCTGCTCAC
GCAACAGAGGCTGTACTACGACAGAAACTGCCGCTGCTTCAAGCGGAAAATAATGACCAAGCGC
CACGAGGTGGAACAGCAGAACATTCGGGAGGAACTAAATAAAAAGAGGACCCAGAAAGAAATGG
AGCACGCCATGCTGATCCGGCATGATGAATCCACCCGAGAGCTCGAGTACAGACAGCTGCACAC
ACTGCAGAAGCTCCGCATGGACCTGATCCGGTTACAGCACCAGACTGAGCTGGAGAACCAGCTG
GAGTACAATAAGAGGCGGGAGCGGGAGCTGCACCGGAAGCACGTCATGGAGCTTCGGCAACAGC
CGAAAAACTTAAAGGCCATGGAAATGCAAATTAAAAAGCAGTTTCAGGACACTTGCAAAGTACA
GACCAAACAGTACAAAGCACTCAAAAACCACCAGTTGGAAGTCACTCCAAAGAATGAGCACAAA
GCAATCCTAAAGACACTGAAGGAGGAGCAGACGAGGAAGCTGGCCATCTTGGCCGAGCAGTATG
AACAGAGTATAAACGAGATGATGGCCTCTCAAGCGTTACGGCTAGACGAGGCGCAAGAGGCAGA
ATGCCAGGCCTTGAGACTACAGCTCCAGCAGGAGATGGAGCTGCTCAACGCCTACCAGAGCAAA
ATCAAGATGCAAACGGAGGCCCAGCACGAGCGCGAGCTGCAGAAGCTAGAGCAGAGGGTGTCCC
TGCGCAGAGCGCATCTTGAGCAGAAGATTGAAGAGGAGCTGGCCGCCCTGCAGAAGGAACGCAG
TGAGAGGATCAAGACTCTCCTGGAAAGACAAGAGCGAGAGACCGAGACTTTTGACATGGAGAGC
CTCAGAATGGGGTTTGGGAATTTGGTGACATTAGATTTTCCTAAGGAGGACTATAGATGAGATT
AAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001019425	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAD97370	(Get FASTA)	NCBI Sequence Viewer
	EDM13832	(Get FASTA)	NCBI Sequence Viewer
	EDM13833	(Get FASTA)	NCBI Sequence Viewer
	EDM13834	(Get FASTA)	NCBI Sequence Viewer
	EDM13835	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001503
	ENSRNOP00000001503.8
GenBank Protein	Q53UA7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001019425 ⟸ NM_001024254

- UniProtKB:

Q53UA7 (UniProtKB/Swiss-Prot), A6J1P6 (UniProtKB/TrEMBL), F1LRI6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRKGVLKDPEIAELFFKEDPEELFIDLHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHE
KWQDILKEVRFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAIT
HGALQGLAYLHFHSLIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILA
MDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSREWTDSFRRFVDY
CLHKIPQERPAAAELLRHDFIRRERPPRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGP
LNESQEEEEDSEQGSNLNREVDSLGSIHSIPSVSVSTGSRSSSVNSMQEVMDEGSPELVMMQED
EGTVNSSSSMVHKKDHVFVRDEAGHGDPRPEPRPTQSVQSRALHYRNRERFATIKSASLVTRQI
HEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLA
KKQVATIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKK
EKQERISKHKENLQHTQAEEEAHLLTQQRLYYDRNCRCFKRKIMTKRHEVEQQNIREELNKKRT
QKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVME
LRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKAILKTLKEEQTRKLAIL
AEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLE
QRVSLRRAHLEQKIEEELAALQKERSERIKTLLERQERETETFDMESLRMGFGNLVTLDFPKED
YR

hide sequence

RefSeq Acc Id:

ENSRNOP00000074994 ⟸ ENSRNOT00000089043

RefSeq Acc Id:

ENSRNOP00000001503 ⟸ ENSRNOT00000001503

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q53UA7-F1-model_v2	AlphaFold	Q53UA7	1-898	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562861	AgrOrtholog
BioCyc Gene	G2FUF-19058	BioCyc
Ensembl Genes	ENSRNOG00000001138	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001503	ENTREZGENE
	ENSRNOT00000001503.8	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:304530	UniProtKB/Swiss-Prot
NCBI Gene	304530	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TAO KINASE 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Taok3	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001138	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6J1P6	ENTREZGENE, UniProtKB/TrEMBL
	F1LRI6	ENTREZGENE, UniProtKB/TrEMBL
	Q53UA7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Taok3	TAO kinase 3	JIK	JNK/SAPK-inhibitory kinase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	JIK	JNK/SAPK-inhibitory kinase			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)