Mafk (MAF bZIP transcription factor K) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mafk (MAF bZIP transcription factor K) Rattus norvegicus
Analyze
Symbol: Mafk
Name: MAF bZIP transcription factor K
RGD ID: 628633
Description: Enables RING-like zinc finger domain binding activity. Involved in nervous system development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human MAFK (MAF bZIP transcription factor K); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding (Ensembl: lncRNA)
RefSeq Status: PROVISIONAL
Previously known as: transcription factor MafK; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian); v-maf musculoaponeurotic fibrosarcoma oncogene homolog K; v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81219,948,473 - 19,970,351 (-)NCBIGRCr8
mRatBN7.21214,834,628 - 14,856,414 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1214,833,984 - 14,837,048 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1214,832,249 - 14,858,888 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,643,621 - 15,654,344 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,267,374 - 16,278,097 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,292,794 - 15,303,525 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,923,989 - 16,934,706 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,923,990 - 16,934,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01218,914,796 - 18,936,523 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,312,420 - 15,323,137 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,342,348 - 15,353,065 (-)NCBI
Celera1216,593,511 - 16,604,228 (-)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-cinnamyl alcohol  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Bandrowski's base  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
chenodeoxycholic acid  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimercaprol  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
eugenol  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
isoeugenol  (ISO)
kojic acid  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
reactive oxygen species  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
xylitol  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Nioi P, etal., Mol Cell Biol. 2005 Dec;25(24):10895-906.
5. Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis. Ohta K, etal., Biochem J. 2007 Mar 15;402(3):559-66.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth. Torocsik B, etal., J Neurosci 2002 Oct 15;22(20):8971-80.
Additional References at PubMed
PMID:8622968   PMID:8887638   PMID:9150357   PMID:9240432   PMID:12220541   PMID:23332764  


Genomics

Comparative Map Data
Mafk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81219,948,473 - 19,970,351 (-)NCBIGRCr8
mRatBN7.21214,834,628 - 14,856,414 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1214,833,984 - 14,837,048 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1214,832,249 - 14,858,888 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,643,621 - 15,654,344 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,267,374 - 16,278,097 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,292,794 - 15,303,525 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,923,989 - 16,934,706 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,923,990 - 16,934,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01218,914,796 - 18,936,523 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,312,420 - 15,323,137 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,342,348 - 15,353,065 (-)NCBI
Celera1216,593,511 - 16,604,228 (-)NCBICelera
Cytogenetic Map12q11NCBI
MAFK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3871,530,702 - 1,543,043 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl71,530,702 - 1,543,043 (+)EnsemblGRCh38hg38GRCh38
GRCh3771,570,338 - 1,582,679 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3671,536,894 - 1,549,205 (+)NCBINCBI36Build 36hg18NCBI36
Build 3471,343,608 - 1,354,151NCBI
Celera71,537,624 - 1,549,935 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef71,499,263 - 1,503,161 (+)NCBIHuRef
CHM1_171,569,960 - 1,582,262 (+)NCBICHM1_1
T2T-CHM13v2.071,642,830 - 1,655,171 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v271,622,776 - 1,635,087 (+)NCBI
Mafk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,777,291 - 139,788,409 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,777,268 - 139,788,408 (+)EnsemblGRCm39 Ensembl
GRCm385139,791,536 - 139,802,653 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,791,513 - 139,802,653 (+)EnsemblGRCm38mm10GRCm38
MGSCv375140,267,490 - 140,278,606 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365140,044,010 - 140,055,126 (+)NCBIMGSCv36mm8
Celera5136,846,479 - 136,857,581 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.81NCBI
Mafk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554609,155,713 - 9,167,291 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554609,155,713 - 9,167,291 (+)NCBIChiLan1.0ChiLan1.0
MAFK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v266,480,254 - 6,492,566 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1754,804,956 - 54,817,267 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,778,862 - 1,791,163 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,902,411 - 1,909,774 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl71,904,031 - 1,909,774 (+)Ensemblpanpan1.1panPan2
MAFK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,421,918 - 15,426,650 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,424,095 - 15,425,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha616,889,609 - 16,901,307 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0615,547,885 - 15,559,587 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl615,547,886 - 15,559,718 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,350,661 - 15,362,365 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,277,453 - 15,289,141 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0615,564,445 - 15,576,148 (-)NCBIUU_Cfam_GSD_1.0
Mafk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,353,784 - 143,364,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,651,704 - 1,656,549 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367541,652,412 - 1,656,570 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAFK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl31,030,858 - 1,033,671 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.131,023,366 - 1,034,855 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.231,138,008 - 1,149,711 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAFK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,057,386 - 20,070,020 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,060,001 - 20,061,170 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,647,542 - 1,659,816 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mafk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474027,002,022 - 27,006,324 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,995,889 - 27,007,258 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mafk
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:153
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000001720
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121300829619212979Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat

Markers in Region
BI284461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21214,835,053 - 14,835,238 (+)MAPPERmRatBN7.2
Rnor_6.01216,924,415 - 16,924,599NCBIRnor6.0
Rnor_5.01218,915,222 - 18,915,406UniSTSRnor5.0
RGSC_v3.41215,312,846 - 15,313,030UniSTSRGSC3.4
Celera1216,593,937 - 16,594,121UniSTS
RH 3.4 Map12237.72UniSTS
Cytogenetic Map12q11UniSTS
Mafk  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21214,834,656 - 14,835,244 (+)MAPPERmRatBN7.2
Rnor_6.01216,924,018 - 16,924,605NCBIRnor6.0
Rnor_5.01218,914,825 - 18,915,412UniSTSRnor5.0
RGSC_v3.41215,312,449 - 15,313,036UniSTSRGSC3.4
Celera1216,593,540 - 16,594,127UniSTS
Cytogenetic Map12q11UniSTS
UniSTS:257105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21214,836,995 - 14,837,963 (+)MAPPERmRatBN7.2
Rnor_6.01216,926,357 - 16,927,324NCBIRnor6.0
Rnor_5.01218,917,164 - 18,918,131UniSTSRnor5.0
RGSC_v3.41215,314,788 - 15,315,755UniSTSRGSC3.4
Celera1216,595,879 - 16,596,846UniSTS
Cytogenetic Map12q11UniSTS
UniSTS:274182  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21214,836,595 - 14,837,978 (+)MAPPERmRatBN7.2
Rnor_6.01216,925,957 - 16,927,339NCBIRnor6.0
Rnor_5.01218,916,764 - 18,918,146UniSTSRnor5.0
RGSC_v3.41215,314,388 - 15,315,770UniSTSRGSC3.4
Celera1216,595,479 - 16,596,861UniSTS
Cytogenetic Map12q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 39 23 19 23 5 8 31 23 22 11 5
Low 18 18 18 3 3 43 12 19 3
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000001720   ⟹   ENSRNOP00000001720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1214,834,630 - 14,858,888 (-)Ensembl
Rnor_6.0 Ensembl1216,923,990 - 16,934,706 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1214,834,443 - 14,839,924 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1214,833,984 - 14,837,048 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1214,834,634 - 14,856,489 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1214,832,249 - 14,845,488 (-)Ensembl
RefSeq Acc Id: NM_145673   ⟹   NP_663706
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81219,948,475 - 19,959,192 (-)NCBI
mRatBN7.21214,834,628 - 14,845,345 (-)NCBI
Rnor_6.01216,923,989 - 16,934,706 (-)NCBI
Rnor_5.01218,914,796 - 18,936,523 (-)NCBI
RGSC_v3.41215,312,420 - 15,323,137 (-)RGD
Celera1216,593,511 - 16,604,228 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248915   ⟹   XP_006248977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81219,948,473 - 19,957,286 (-)NCBI
mRatBN7.21214,834,628 - 14,843,437 (-)NCBI
Rnor_6.01216,923,989 - 16,931,564 (-)NCBI
Rnor_5.01218,914,796 - 18,936,523 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089073   ⟹   XP_038945001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81219,948,473 - 19,970,351 (-)NCBI
mRatBN7.21214,834,628 - 14,856,414 (-)NCBI
Protein Sequences
Protein RefSeqs NP_663706 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248977 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945001 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH70906 (Get FASTA)   NCBI Sequence Viewer  
  AAM73877 (Get FASTA)   NCBI Sequence Viewer  
  EDL89750 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_663706   ⟸   NM_145673
- UniProtKB: Q6IRI7 (UniProtKB/TrEMBL),   Q8K4B3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248977   ⟸   XM_006248915
- Peptide Label: isoform X1
- UniProtKB: Q6IRI7 (UniProtKB/TrEMBL),   Q8K4B3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001720   ⟸   ENSRNOT00000001720
RefSeq Acc Id: XP_038945001   ⟸   XM_039089073
- Peptide Label: isoform X1
- UniProtKB: Q6IRI7 (UniProtKB/TrEMBL),   Q8K4B3 (UniProtKB/TrEMBL)
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IRI7-F1-model_v2 AlphaFold Q6IRI7 1-156 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698462
Promoter ID:EPDNEW_R8987
Type:multiple initiation site
Name:Mafk_1
Description:MAF bZIP transcription factor K
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01216,934,739 - 16,934,799EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628633 AgrOrtholog
BioCyc Gene G2FUF-19906 BioCyc
Ensembl Genes ENSRNOG00000001277 Ensembl
  ENSRNOG00000065794 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000117128 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103075 IMAGE-MGC_LOAD
InterPro bZIP_sf UniProtKB/TrEMBL
  Euk_TF_DNA_bd UniProtKB/TrEMBL
  TF_bZIP UniProtKB/TrEMBL
  TF_Maf UniProtKB/TrEMBL
  Transciption_factor_Maf UniProtKB/TrEMBL
KEGG Report rno:246760 UniProtKB/TrEMBL
MGC_CLONE MGC:91461 IMAGE-MGC_LOAD
NCBI Gene 246760 ENTREZGENE
PANTHER PTHR10129 UniProtKB/TrEMBL
  PTHR10129:SF26 UniProtKB/TrEMBL
Pfam bZIP_Maf UniProtKB/TrEMBL
PhenoGen Mafk PhenoGen
PROSITE BZIP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001277 RatGTEx
  ENSRNOG00000065794 RatGTEx
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP Euk_transcr_DNA UniProtKB/TrEMBL
  SSF57959 UniProtKB/TrEMBL
UniProt A6K1U2_RAT UniProtKB/TrEMBL
  Q6IRI7 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4B3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-18 Mafk  MAF bZIP transcription factor K  Mafk  v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Mafk  v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K  Mafk  v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Mafk  v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)  Mafk  v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Mafk  v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Mafk  v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in immature neurons 628386
gene_process involved in neuronal outgrowth and maintenance 628386
gene_process regulator of neuronal differentiation 628386
gene_product member of the Maf family of basic region and leucine zipper transciption factors 628386
gene_product member of the Maf family has a leucine zipper transcriptional repressor 628386
gene_regulation expression in immature neurons is induced by NGF 628386