Predicted to enable several functions, including NAD+ ADP-ribosyltransferase activity; acyltransferase activity, transferring groups other than amino-acyl groups; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in cellular response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; and negative regulation of protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Biomarker of non-alcoholic fatty liver disease. Orthologous to human SIRT4 (sirtuin 4); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
LOC304539; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); sirtuin 4 (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
[SIRT4 results in increased acetylation of and results in decreased activity of SOD2 protein] promotes the reaction [AGT protein modified form results in increased abundance of Reactive Oxygen Species], SIRT4 promotes the reaction [AGT protein modified form results in increased abundance of Reactive Oxygen Species]