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Gene: Sirt4 (sirtuin 4) Rattus norvegicus

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Symbol:

Sirt4

Name:

sirtuin 4

RGD ID:

1310413

Description:

Predicted to enable several functions, including NAD+ binding activity; NAD+ poly-ADP-ribosyltransferase activity; and acyltransferase activity, transferring groups other than amino-acyl groups. Involved in cellular response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; and negative regulation of protein processing involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial matrix. Biomarker of metabolic dysfunction-associated steatotic liver disease. Orthologous to human SIRT4 (sirtuin 4); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC304539; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); sirtuin 4 (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIRT4 (sirtuin 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Sirt4 (sirtuin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sirt4 (sirtuin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIRT4 (sirtuin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIRT4 (sirtuin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sirt4 (sirtuin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIRT4 (sirtuin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIRT4 (sirtuin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sirt4 (sirtuin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SIRT4 (sirtuin 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sirt4 (sirtuin 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sirt4 (sirtuin 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sir-2.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Sirt4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sir-2.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sirt4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	46,785,852 - 46,800,179 (+)	NCBI		GRCr8
mRatBN7.2	12	41,125,533 - 41,139,440 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,131,262 - 41,139,439 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	42,298,179 - 42,303,722 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	42,911,836 - 42,917,381 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	41,972,383 - 41,977,928 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	46,862,358 - 46,876,593 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	46,868,416 - 46,876,592 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	48,665,591 - 48,673,711 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	42,394,536 - 42,402,714 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	42,241,793 - 42,268,052 (+)	NCBI
Celera	12	42,754,699 - 42,762,759 (+)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiomegaly (ISO)

endomyocardial fibrosis (ISO)

Insulin Resistance (IEP)

metabolic dysfunction-associated steatotic liver disease (IEP)

NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, BRAIN ANOMALIES, DISTINCTIVE FACIES, AND ABSENT LANGUAGE (ISO)

short chain acyl-CoA dehydrogenase deficiency (ISO)

Weight Loss (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (EXP)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

aldehydo-D-glucose (EXP)

amiodarone (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

butyric acid (ISO)

camptothecin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

D-glucose (EXP)

DDE (ISO)

dexamethasone (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

fenvalerate (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

glucose (EXP)

hydrogen peroxide (EXP,ISO)

indometacin (ISO)

leflunomide (EXP)

lidocaine (EXP)

metformin (ISO)

methyl methanesulfonate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

monooxygen (ISO)

nicotinic acid (ISO)

Nutlin-3 (ISO)

oleic acid (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

reactive oxygen species (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sirolimus (EXP,ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

tetraphene (ISO)

titanium dioxide (ISO)

tributyrin (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to hypoxia (IEP)

DNA damage response (IEA,ISO)

glutamine metabolic process (IEA,ISO)

negative regulation of cardiac muscle cell apoptotic process (IMP)

negative regulation of fatty acid oxidation (IEA,ISO)

negative regulation of insulin secretion (IEA,ISO)

negative regulation of protein processing involved in protein targeting to mitochondrion (IMP)

peptidyl-lysine deacetylation (ISO)

positive regulation of lipid biosynthetic process (IEA,ISO)

regulation of glutamine family amino acid metabolic process (IEA,ISO)

regulation of pyruvate dehydrogenase activity (ISO)

tricarboxylic acid metabolic process (IEA,ISO)

Cellular Component

mitochondrial inner membrane (IEA,ISO)

mitochondrial matrix (IBA,IEA,ISO)

mitochondrion (IEA,ISO)

Molecular Function

histone deacetylase activity, NAD-dependent (IBA)

lipoamidase activity (IEA,ISO)

metal ion binding (IEA)

NAD binding (IEA)

NAD+ binding (IBA,IEA)

NAD+ poly-ADP-ribosyltransferase activity (IEA,ISO)

NAD-dependent protein biotinidase activity (IEA,ISO)

NAD-dependent protein lipoamidase activity (IEA,ISO)

NAD-dependent protein lysine deacetylase activity (ISO)

protein binding (ISO)

transferase activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

Sirtuin mediated pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats.	Chen YR, etal., Biochem Cell Biol. 2010 Aug;88(4):715-22. doi: 10.1139/O10-010.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Glutamate dehydrogenase 1 and SIRT4 regulate glial development.	Komlos D, etal., Glia. 2013 Mar;61(3):394-408. doi: 10.1002/glia.22442. Epub 2012 Dec 22.
4.	SIRT4 prevents hypoxia-induced apoptosis in H9c2 cardiomyoblast cells.	Liu B, etal., Cell Physiol Biochem. 2013;32(3):655-62. doi: 10.1159/000354469. Epub 2013 Sep 10.
5.	Physical and functional HAT/HDAC interplay regulates protein acetylation balance.	Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	NAD(+) in aging, metabolism, and neurodegeneration.	Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.

Additional References at PubMed

PMID:12477932	PMID:16079181	PMID:16959573	PMID:17715127	PMID:17923681	PMID:18054327	PMID:23562301	PMID:23663782	PMID:23746352	PMID:24043310	PMID:24535021	PMID:25525879
PMID:26365714	PMID:26767982	PMID:30661205	PMID:32865007	PMID:33636397

Genomics

Comparative Map Data

Sirt4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	46,785,852 - 46,800,179 (+)	NCBI		GRCr8
mRatBN7.2	12	41,125,533 - 41,139,440 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,131,262 - 41,139,439 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	42,298,179 - 42,303,722 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	42,911,836 - 42,917,381 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	41,972,383 - 41,977,928 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	46,862,358 - 46,876,593 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	46,868,416 - 46,876,592 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	48,665,591 - 48,673,711 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	42,394,536 - 42,402,714 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	42,241,793 - 42,268,052 (+)	NCBI
Celera	12	42,754,699 - 42,762,759 (+)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

SIRT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	120,291,780 - 120,313,249 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	120,302,316 - 120,313,249 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	120,729,992 - 120,751,052 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	119,224,546 - 119,235,428 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	119,202,882 - 119,213,764	NCBI
Celera	12	120,373,255 - 120,384,162 (+)	NCBI		Celera
Cytogenetic Map	12	q24.23-q24.31	NCBI
HuRef	12	117,748,504 - 117,759,368 (+)	NCBI		HuRef
CHM1_1	12	120,708,119 - 120,718,976 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	120,277,808 - 120,300,434 (+)	NCBI		T2T-CHM13v2.0

Sirt4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	115,616,065 - 115,628,322 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	115,616,069 - 115,622,784 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	115,478,006 - 115,490,264 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	115,478,010 - 115,484,725 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	115,928,019 - 115,934,493 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	115,739,009 - 115,751,007 (-)	NCBI		MGSCv36	mm8
Celera	5	112,577,219 - 112,584,001 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	56.1	NCBI

Sirt4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	11,324,479 - 11,334,817 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	11,322,812 - 11,334,786 (-)	NCBI	ChiLan1.0	ChiLan1.0

SIRT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	128,353,714 - 128,374,355 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	128,350,086 - 128,372,113 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	117,867,453 - 117,887,968 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	121,241,102 - 121,261,777 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	121,241,112 - 121,261,777 (+)	Ensembl	panpan1.1		panPan2

SIRT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	16,228,831 - 16,244,104 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	16,234,710 - 16,240,012 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	16,228,030 - 16,250,502 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	16,491,640 - 16,514,126 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	16,502,217 - 16,512,406 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	16,452,385 - 16,475,012 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	16,529,465 - 16,551,725 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	16,570,700 - 16,593,194 (+)	NCBI		UU_Cfam_GSD_1.0

Sirt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	146,129,984 - 146,134,550 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	626,938 - 633,466 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	628,875 - 633,425 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIRT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	40,290,288 - 40,303,879 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	40,290,288 - 40,303,887 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	42,839,907 - 42,856,609 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIRT4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	115,640,976 - 115,659,074 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	115,640,555 - 115,658,687 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	129,447,251 - 129,463,787 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sirt4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	13,335,442 - 13,352,201 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	13,329,662 - 13,352,151 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sirt4
113 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	57
Count of miRNA genes:	47
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000001523
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	23081340	44726024	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	32103174	45899022	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	28064433	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	28064433	45899022	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	23081340	43551788	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat

Markers in Region

RH132972

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	41,139,198 - 41,139,396 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	46,876,352 - 46,876,549	NCBI	Rnor6.0
Rnor_5.0	12	48,673,471 - 48,673,668	UniSTS	Rnor5.0
RGSC_v3.4	12	42,402,474 - 42,402,671	UniSTS	RGSC3.4
Celera	12	42,762,519 - 42,762,716	UniSTS
Cytogenetic Map	12	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271349	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001840594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001840596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001840597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001840598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491627	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491628	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056392	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010056393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_595325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_595326	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC167005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225779	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001523 ⟹ ENSRNOP00000001523

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	41,131,262 - 41,139,439 (+)	Ensembl
Rnor_6.0 Ensembl	12	46,868,416 - 46,876,592 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084421 ⟹ ENSRNOP00000073772

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	41,132,682 - 41,139,439 (+)	Ensembl
Rnor_6.0 Ensembl	12	46,869,836 - 46,876,587 (+)	Ensembl

RefSeq Acc Id:

NM_001107147 ⟹ NP_001100617

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,791,930 - 46,797,424 (+)	NCBI
mRatBN7.2	12	41,131,190 - 41,136,684 (+)	NCBI
Rnor_6.0	12	46,868,416 - 46,876,592 (+)	NCBI
Rnor_5.0	12	48,665,591 - 48,673,711 (+)	NCBI
RGSC_v3.4	12	42,394,536 - 42,402,714 (+)	RGD
Celera	12	42,754,699 - 42,762,759 (+)	RGD

Sequence:

show sequence

GAGCATTCTTACAAGGGATTCTATTTGTCCTCTTTTTTCTCGAGGGGACACGGAGGATTTGTCC
CAGCAAAACCCGACGGTTTAGCCGTTCACATGTAGCTGGAGAATGTCATGGAGAAAGCAGAGTC
CTGAGCTCATGGGTAGAAAAGGAAGCCAAGCCTAAAATGTGTGCCTGTCACTATATAACTCCTG
CATTATATCAAAGACTGGTCAAAGGTTTGTCTTTACGACTAGAAAACCAGGAAAAATGAGGGGG
TTGATTTTCAGGCCGACAAGGGGCCGTTGGATCACCCAGATGAGCCAGCTGCGTTCCCATGGAT
CCACAGGGTTATTTGTGCCGCCCAGCCCCCCTTTGGACCATGAAAAGATCAAAGAGTTACAGCG
CTTCATTAGCCTTTCCAAGAAACTGCTAGTGATGACAGGCGCGGGAATCTCCACCGAGTCCGGG
ATCCCAGACTACAGGTCAGAAAAGGTGGGACTCTACGCCCGCACTGACCGGAGACCCATCCAGC
ACATTGATTTCATCCGCAGTGCTCCGGTTCGCCAGCGCTACTGGGCCCGAAACTTTGTGGGCTG
GCCTCAGTTCTCCTCTCACCAGCCCAACCCAGCACACTGGGCTCTGAGCAACTGGGAGAAACTT
GGGAAGCTGCACTGGTTGGTGACCCAGAACGTGGACGCTCTGCATTCCAAGGCTGGGAATCAGC
GGTTGACGGAGCTGCACGGATGCATGCACAGGGTCCTGTGCCTGAGCTGTGGGGAGCAGACTGC
ACGCAGGGTGCTGCAGGACCGCTTCCAAGCCCTGAACCCCAGCTGGAGTGCCGAGGCGCAGGGC
GTGGCTCCCGACGGTGACGTGTTCCTCACGGAGGAGCAGGTCCGGAGCTTTCGGGTCCCGTGCT
GTGATCGATGCGGCGGCCCTCTGAAACCCGACGTCGTTTTCTTTGGGGACACGGTGAACCCGGA
CAAGGTTGACTTTGTGCACCAGCGTGTGAAAGAAGCTGACTCGCTGCTGGTGGTGGGATCGTCC
CTGCAGGTATACTCCGGTTACAGGTTCATCCTCACCGCCCGGGAGAAGAAGCTCCCAATCGCCA
TTCTGAACATCGGACCCACGAGGTCTGACGATTTGGCTTGCCTGAAGCTGGATTCGCGCTGTGG
AGAGCTGCTGCCCTTAATAGACCCACAGTGACAGCACCCTGATGTCCAAAGGCTGGAAAGGACT
TTCCTTTGGGTCCCGCTGCTAAAGACCCCTAAGGATTCCCCGCCTCTCCCCTTCAACTGGTGGA
AGCTTACTGTCTGCATCCTAGAGAGGCCCAAAGCCACGCCTAGGGGCCAGGCCGCCTGTGCATC
GTGCTATTTACAGAGATGAGGGCTGCCCCCTAAAGAACTTTCTCAAAGAAGTAGCTGCTCTTGA
TGGAGTAGCTGTGCCGCCTTCGGGTTACCAGCGAGAAGGATCAGCCAGAAGTTCGTAAACCAGA
ACAGTCTGTGAGGGGCCACGATCGCACTCATTCAGAAGGGCATTTATAATTCATTCATAATTCC
AAGTGGTCATGTGTGGCTGAAGCACTTTGATATTTCTGACGACATGAACAATAACCAACACGGA
TTTTTTTTATCAACCCAATAATAAATTATTTTTGTTAACAT

hide sequence

RefSeq Acc Id:

XM_063271349 ⟹ XP_063127419

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,786,339 - 46,798,210 (+)	NCBI

RefSeq Acc Id:

XM_063271350 ⟹ XP_063127420

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,793,140 - 46,797,138 (+)	NCBI

RefSeq Acc Id:

XR_001840596

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,786,252 - 46,800,179 (+)	NCBI
mRatBN7.2	12	41,125,540 - 41,139,440 (+)	NCBI
Rnor_6.0	12	46,862,358 - 46,876,593 (+)	NCBI

Sequence:

show sequence

AGAACATCTACTTTTAGACAAACAATATTCAGTCTCCGTAGAGACTGTCAAAAATTGCCAATGC
CGACTATATTTCAAGTCGTCATGGCGGGGTATTGGGAAAAGTTTTCAATTAGCAATAATCGCGC
CTCGGATAAACCTCATTGGCTACGATACTGCCACTGCGCAAAGCTGAAGAACGAGCGCGCTCGC
TCAGCCTCCCAGGGCTGACAACCTTCATCACAGTCACGGTGAGCTCCTGTCCACGCGCGACCGT
CGCGGGACGGCAACCGAACCCGGCGGCTCCATCTCAGTCACCTGCGTGGACAGGCTCCTGCCCG
TGGGCTATCTAGCGCCCGAACGTCCGTGGTTTCCAGACAACGCGGCAGCCGCTTGGGATGCTGG
GGACTCTTATGCAAATCGAGCCAACGTCATCGCGATGGCCCGGGTGGAGGCGCAAACGCGGCGG
GAGGAGGAATGAGGGGGTTGATTTTCAGGCCGACAAGGGGCCGTTGGATCACCCAGATGAGCCA
GCTGCGTTCCCATGGATCCACAGGGTTATTTGTGCCGCCCAGCCCCCCTTTGGACCATGAAAAG
ATCAAAGAGTTACAGCGCTTCATTAGCCTTTCCAAGAAACTGCTAGTGATGACAGGCGCGGGAA
TCTCCACCGAGTCCGGGATCCCAGACTACAGGTCAGAAAAGGTGGGACTCTACGCCCGCACTGA
CCGGAGACCCATCCAGCACATTGATTTCATCCGCAGTGCTCCGGTTCGCCAGCGCTACTGGGCC
CGAAACTTTGTGGGCTGGCCTCAGTTCTCCTCTCACCAGCCCAACCCAGCACACTGGGCTCTGA
GCAACTGGGAGAAACTTGGGAAGCTGCACTGGTTGGTGACCCAGAACGTGGACGCTCTGCATTC
CAAGGCTGGGAATCAGCGGTTGACGGAGCTGCACGGATGCATGCACAGGGTCCTGTGCCTGAGC
TGTGGGGAGCAGACTGCACGCAGGGTGCTGCAGGACCGCTTCCAAGCCCTGAACCCCAGCTGGA
GTGCCGAGGCGCAGGGCGTGGCTCCCGACGGTGACGTGTTCCTCACGGAGGAGCAGGTCCGGAG
CTTTCGGGTCCCGTGCTGTGATCGATGCGGCGGCCCTCTGAAACCCGACGTCGTTTTCTTTGGG
GACACGGTGAACCCGGACAAGGTTGACTTTGTGCACCAGCGTGTGAAAGAAGCTGACTCGCTGC
TGGTGGTGGGATCGTCCCTGCAGGTATACTCCGGTTACAGGTTCATCCTCACCGCCCGGGAGAA
GAAGCTCCCAATCGCCATTCTGAACATCGGACCCACGAGGTCTGACGATTTGGCTTGCCTGAAG
CTGGATTCGCGCTGTGGAGAGCTGCTGCCCTTAATAGACCCACAGTGACAGCACCCTGATGTCC
AAAGGCTGGAAAGGACTTTCCTTTGGGTCCCGCTGCTAAAGACCCCTAAGGATTCCCCGCCTCT
CCCCTTCAACTGGTGGAAGCTTACTGTCTGCATCCTAGAGAGGCCCAAAGCCACGCCTAGGGGC
CAGGCCGCCTGTGCATCGTGCTATTTACAGAGATGAGGGCTGCCCCCTAAAGAACTTTCTCAAA
GAAGTAGCTGCTCTTGATGGAGTAGCTGTGCCGCCTTCGGGTTACCAGCGAGAAGGATCAGCCA
GAAGTTCGTAAACCAGAACAGTCTGTGAGGGGCCACGATCGCACTCATTCAGAAGGGCATTTAT
AATTCATTCATAATTCCAAGTGGTCATGTGTGGCTGAAGCACTTTGATATTTCTGACGACATGA
ACAATAACCAACACGGATTTTTTTTATCAACCCAATAATAAATTATTTTTGTTAACATA

hide sequence

RefSeq Acc Id:

XR_001840598

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,785,852 - 46,800,179 (+)	NCBI
mRatBN7.2	12	41,128,795 - 41,139,440 (+)	NCBI
Rnor_6.0	12	46,865,995 - 46,876,593 (+)	NCBI

Sequence:

show sequence

GAGCCATCTCTCCAGCCCCAGTCAGTGCTCTTAATTGCAGAGGCATCTCTCCAGCCCCTCATTA
TGAGAATTTTAAAGCCCAGGGCCAGTTTCTTTTTGTTTTCTAAATGAAACGAACACCAGTGGCA
GAGCCTGGCTGGGACTCAGGACATGCAAGCTTCCAGGTCCCAAAGCCCCCTGTTCTGGAGATCA
TAGTTTACTGCACAGGGAGGGGATGCCCCCTTTGGAGAGTGAAGGCAGCAGGGAAGACCAGCAC
TGCCTTCCTCCCATAGCTCCGGACAGAGTATTATGAGCCACCCAATTGGCTATTGAATAAGGGG
AAAGGGTCCTTCGGCCGGTAACAAGGTCCCTGCCACTTCCCATTCTAAAAGGTACATACTCCGT
GGTGTGGTGTCTGACTTTAAAGTAATGTTACAGAGTGGCAGATTTTGCTGGCTCCACTTCAGGA
GTGGCCAAGATATGAGTAAACAGATCCCTAGGCCTCCCTCTCTCTAAACCAATGACCTTAGAAC
CCTGAGCCAGGCACGGCAGCCCGGATAGATGCAAGCCGGAAGCCAGCCTGGGCTATGGTATAGC
ACTGTCAGAACAAACAACCATAACAACAAAAAACAAATAATAATGATGATGATGATGATGATGA
TGATGATGATGATGATGATGATGATGATGATGATAACCAAAGCAAGACAACAATCTGCCCAGAG
ATTGGAGGCCCAGGGGAGTGTTGGGGATCCCCACATACCCCCTACTGTATTCCTTCTGAGACAG
GATCTGACAGAATCTCGATAAACATGGAGCTCCAGTCCTTTCACCAGGCTGAGAGTAAGCCAGC
CCCAGCCATCTGATTGCTCCCTGTCCTCCTTTGTGCTGGGAGGGCAATTTATGTGAGAGGTGGA
ATCCAGACCTATGTCCTCTTGCTTGGGCTGCAGTTCTGAACCTCGGGGCCATCTCTCTAGCACC
CATGATCTATTGTTTTTTAGAATCAAAATAGTGTGTGTGCATGTGGGCCAAATACGAGCTGGTG
CTCTCCTCCCACACTTGTGTGAGTCCCAGGGATCAGAGTTGTGCTGTCAAGCTGGTGGCAAGGG
CCCCTGTCAATATTTAACCTATGGTAGGAAATTTAAGCACTGTGCAGTGGAAGGGAACATAGGT
ACTTAAGAGGAAATCAAGTCCAATCTGCCGACGTGGTGGCACACACTGTTAGCCCATGTTCTAG
GGAGGCGGAGGTGGGAGAATCTCCATGAGTTCCAGGCCAGCCAAGGCTACGTAGTGAGAACCTG
TCTCAAAAAATTAAAACAAAAACAGAAGTGGGGGGAGGGGGAGGACCAATTATTTATTATTAAA
GGGGTCAGACTACACAGCGAAACCCTGTCTCAAAAAAACAAAAACAGAAAGGGTCTTTTGGGGA
GCGGGTCGGGAGCTGGCTCACTGGTTAAGTGCATTGTTTGCAGAGGACTCAGATTCCGTCCCAC
ATGGCAGTTCACAACCGGCTGCCACTCAAGTTCCAGGGGAGCTGACGCCCTCTTCTGGCCTTCT
GGAGCTCCTGTATGCTTGTTGGCAAAAACATTAAAAAAAATTTTTTTTTTAAATCTATTTTAAA
AAGCGTCTATGGTGGAGAAATGCCCACTAGTATGAACTCAGGCCTACCCTGGGCTAGGCTAACG
TGCTACCACTGAGCTATATAGCCCCAGCCCTATTACAGTATTATTTAGAGACCGAGGTCTCACT
AAATCACCCAGTCTGGTCTTGAACTCGTGATTCTTCCGCTTCAGCCTACTGAGTAGCAGAGATT
GTTGTCCCCTGCTACCAGTGAAAGTTTCTTGAAGACAGCGAATTCCTAAATTAGGGCTGTTTGG
ATCCTATTTTGCACGCCGGGCATGGGGAATATTAACCACTTCTTTGCGGGCCATGGTGGCAGAG
AAGCCTCTAATCCCAGGGTATGTGAGGTGGAGCCAGGAGGATCAGGAATTTGGAGTCGGACTAG
GCTACGTGAGACCTTCTCTCCAGCAAGCAACACAACCCAGAAAAAACGAACGAACGAACGAACG
AACGAACGAACGAACGAACGAACGAACGAACGAACGAACGAACGAACGAACGAACGAACGAACG
AACGAACGAACGAACGAACGAACGAACGAACGAACGAACGAACACACAAAAACCTCAAAAGGCA
ATAACTGCCTCAGGTGTCAGCAGCACACCGGAAACCTAAACTGAGCTGAACAGGAAAGACAATC
GGAAGACCGTGGTGGAGCGGCGTAGAACCTTGGCGTGGGAGACACGTAGGGTTCTGGGACTTGT
AGTTTTTTCCGTTATATCGGGTTCGTGGACTACACTTCCCAAGATGCACATGTAAGAAGCTAGT
CCCACTGTTGGGTGAGAAGAATGAGGGGGTTGATTTTCAGGCCGACAAGGGGCCGTTGGATCAC
CCAGATGAGCCAGCTGCGTTCCCATGGATCCACAGGGTTATTTGTGCCGCCCAGCCCCCCTTTG
GACCATGAAAAGATCAAAGAGTTACAGCGCTTCATTAGCCTTTCCAAGAAACTGCTAGTGATGA
CAGGCGCGGGAATCTCCACCGAGTCCGGGATCCCAGACTACAGGTCAGAAAAGGTGGGACTCTA
CGCCCGCACTGACCGGAGACCCATCCAGCACATTGATTTCATCCGCAGTGCTCCGGTTCGCCAG
CGCTACTGGGCCCGAAACTTTGTGGGCTGGCCTCAGTTCTCCTCTCACCAGCCCAACCCAGCAC
ACTGGGCTCTGAGCAACTGGGAGAAACTTGGGAAGCTGCACTGGTTGGTGACCCAGAACGTGGA
CGCTCTGCATTCCAAGGCTGGGAATCAGCGGTTGACGGAGCTGCACGGATGCATGCACAGGGTC
CTGTGCCTGAGCTGTGGGGAGCAGACTGCACGCAGGGTGCTGCAGGACCGCTTCCAAGCCCTGA
ACCCCAGCTGGAGTGCCGAGGCGCAGGGCGTGGCTCCCGACGGTGACGTGTTCCTCACGGAGGA
GCAGGTCCGGAGCTTTCGGGTCCCGTGCTGTGATCGATGCGGCGGCCCTCTGAAACCCGACGTC
GTTTTCTTTGGGGACACGGTGAACCCGGACAAGGTTGACTTTGTGCACCAGCGTGTGAAAGAAG
CTGACTCGCTGCTGGTGGTGGGATCGTCCCTGCAGGTATACTCCGGTTACAGGTTCATCCTCAC
CGCCCGGGAGAAGAAGCTCCCAATCGCCATTCTGAACATCGGACCCACGAGGTCTGACGATTTG
GCTTGCCTGAAGCTGGATTCGCGCTGTGGAGAGCTGCTGCCCTTAATAGACCCACAGTGACAGC
ACCCTGATGTCCAAAGGCTGGAAAGGACTTTCCTTTGGGTCCCGCTGCTAAAGACCCCTAAGGA
TTCCCCGCCTCTCCCCTTCAACTGGTGGAAGCTTACTGTCTGCATCCTAGAGAGGCCCAAAGCC
ACGCCTAGGGGCCAGGCCGCCTGTGCATCGTGCTATTTACAGAGATGAGGGCTGCCCCCTAAAG
AACTTTCTCAAAGAAGTAGCTGCTCTTGATGGAGTAGCTGTGCCGCCTTCGGGTTACCAGCGAG
AAGGATCAGCCAGAAGTTCGTAAACCAGAACAGTCTGTGAGGGGCCACGATCGCACTCATTCAG
AAGGGCATTTATAATTCATTCATAATTCCAAGTGGTCATGTGTGGCTGAAGCACTTTGATATTT
CTGACGACATGAACAATAACCAACACGGATTTTTTTTATCAACCCAATAATAAATTATTTTTGT
TAACATA

hide sequence

RefSeq Acc Id:

XR_005491627

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,793,140 - 46,800,179 (+)	NCBI
mRatBN7.2	12	41,128,791 - 41,139,440 (+)	NCBI

RefSeq Acc Id:

XR_005491628

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,786,235 - 46,800,179 (+)	NCBI
mRatBN7.2	12	41,125,533 - 41,139,440 (+)	NCBI

RefSeq Acc Id:

XR_010056387

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,793,173 - 46,800,179 (+)	NCBI

RefSeq Acc Id:

XR_010056388

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,785,852 - 46,800,179 (+)	NCBI

RefSeq Acc Id:

XR_010056389

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,785,852 - 46,800,179 (+)	NCBI

RefSeq Acc Id:

XR_010056390

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,793,164 - 46,798,460 (+)	NCBI

RefSeq Acc Id:

XR_010056391

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,785,852 - 46,800,179 (+)	NCBI

RefSeq Acc Id:

XR_010056392

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,785,852 - 46,800,179 (+)	NCBI

RefSeq Acc Id:

XR_010056393

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	46,793,140 - 46,798,465 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100617	(Get FASTA)	NCBI Sequence Viewer
	XP_063127419	(Get FASTA)	NCBI Sequence Viewer
	XP_063127420	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67005	(Get FASTA)	NCBI Sequence Viewer
	EDM13876	(Get FASTA)	NCBI Sequence Viewer
	EDM13877	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001523.4
	ENSRNOP00000073772
	ENSRNOP00000073772.2

RefSeq Acc Id:

NP_001100617 ⟸ NM_001107147

- UniProtKB:

A0A0G2K6D8 (UniProtKB/TrEMBL), A6J1T8 (UniProtKB/TrEMBL), G3V641 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRGLIFRPTRGRWITQMSQLRSHGSTGLFVPPSPPLDHEKIKELQRFISLSKKLLVMTGAGIST
ESGIPDYRSEKVGLYARTDRRPIQHIDFIRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNW
EKLGKLHWLVTQNVDALHSKAGNQRLTELHGCMHRVLCLSCGEQTARRVLQDRFQALNPSWSAE
AQGVAPDGDVFLTEEQVRSFRVPCCDRCGGPLKPDVVFFGDTVNPDKVDFVHQRVKEADSLLVV
GSSLQVYSGYRFILTAREKKLPIAILNIGPTRSDDLACLKLDSRCGELLPLIDPQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000073772 ⟸ ENSRNOT00000084421

Ensembl Acc Id:

ENSRNOP00000001523 ⟸ ENSRNOT00000001523

RefSeq Acc Id:	XP_063127419 ⟸ XM_063271349
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K6D8 (UniProtKB/TrEMBL), A6J1T8 (UniProtKB/TrEMBL), G3V641 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063127420 ⟸ XM_063271350
- Peptide Label:	isoform X2
- UniProtKB:	B2RZ30 (UniProtKB/TrEMBL)

Protein Domains

Deacetylase sirtuin-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V641-F1-model_v2	AlphaFold	G3V641	1-311	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698688

Promoter ID:

EPDNEW_R9213

Type:

single initiation site

Name:

Sirt4_1

Description:

sirtuin 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	46,868,353 - 46,868,413	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310413	AgrOrtholog
BioCyc Gene	G2FUF-18999	BioCyc
Ensembl Genes	ENSRNOG00000001151	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001523.7	UniProtKB/TrEMBL
	ENSRNOT00000084421	ENTREZGENE
	ENSRNOT00000084421.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1600.10	UniProtKB/TrEMBL
	TPP-binding domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7099421	IMAGE-MGC_LOAD
InterPro	DHS-like_NAD/FAD-binding_dom	UniProtKB/TrEMBL
	NAD-dep_deAcase_sirtuin	UniProtKB/TrEMBL
	NAD-dep_sirtuin_deacylases	UniProtKB/TrEMBL
	Sirtuin_cat_small_dom_sf	UniProtKB/TrEMBL
	Sirtuin_ClassII	UniProtKB/TrEMBL
	Ssirtuin_cat_dom	UniProtKB/TrEMBL
KEGG Report	rno:304539	UniProtKB/TrEMBL
MGC_CLONE	MGC:189175	IMAGE-MGC_LOAD
NCBI Gene	304539	ENTREZGENE
PANTHER	NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED	UniProtKB/TrEMBL
	NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED	UniProtKB/TrEMBL
Pfam	SIR2	UniProtKB/TrEMBL
PhenoGen	Sirt4	PhenoGen
PROSITE	SIRTUIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001151	RatGTEx
Superfamily-SCOP	SSF52467	UniProtKB/TrEMBL
UniProt	A0A0G2K6D8	ENTREZGENE, UniProtKB/TrEMBL
	A6J1T8	ENTREZGENE, UniProtKB/TrEMBL
	B2RZ30	ENTREZGENE, UniProtKB/TrEMBL
	G3V641	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-01	Sirt4	sirtuin 4	Sirt4	sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Sirt4	sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)	Sirt4	sirtuin 4 (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Sirt4	sirtuin 4 (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)	Sirt4_predicted	sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Sirt4_predicted	sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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