Gene: Sirt4 (sirtuin 4) Rattus norvegicus
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Symbol: Sirt4
Name: sirtuin 4
Description: ENCODES a protein that exhibits biotinidase activity (ortholog); lipoamidase activity (ortholog); NAD+ ADP-ribosyltransferase activity (ortholog); INVOLVED IN cellular response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; negative regulation of protein processing involved in protein targeting to mitochondrion; PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH Insulin Resistance; nonalcoholic fatty liver disease; Cardiomegaly (ortholog); FOUND IN mitochondrion; mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,4-dinitrotoluene; aldehydo-D-glucose
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC304539; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae); sirtuin 4 (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT4 (sirtuin 4)  HGNC  Alliance
Mus musculus (house mouse) : Sirt4 (sirtuin 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirt4 (sirtuin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT4 (sirtuin 4)
Canis lupus familiaris (dog) : SIRT4 (sirtuin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt4 (sirtuin 4)
Sus scrofa (pig) : SIRT4 (sirtuin 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01246,862,358 - 46,876,593 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01248,665,591 - 48,673,711 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,394,536 - 42,402,714 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11242,241,793 - 42,268,052 (+)NCBI
Celera1242,754,699 - 42,762,759 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
  
More on Sirt4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310413
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE



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