Rfc2 (replication factor C subunit 2) - Rat Genome Database

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Gene: Rfc2 (replication factor C subunit 2) Rattus norvegicus
Analyze
Symbol: Rfc2
Name: replication factor C subunit 2
RGD ID: 621198
Description: Predicted to enable enzyme binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC2 (replication factor C subunit 2); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; DNA replication pathway; INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activator 1 subunit C2; MGC95315; replication factor C (activator 1) 2; replication factor C (activator 1) 2 (40kD)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21222,120,449 - 22,133,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,120,010 - 22,133,557 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,263,632 - 23,276,828 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01223,874,713 - 23,887,909 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01222,941,263 - 22,954,609 (-)NCBIRnor_WKY
Rnor_6.01225,130,375 - 25,143,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,130,377 - 25,143,480 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,130,769 - 27,143,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,185,550 - 23,198,655 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,046,380 - 23,053,601 (-)NCBI
Celera1223,884,376 - 23,897,525 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
5-fluorouracil  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
glyphosate  (ISO)
ivermectin  (ISO)
Lasiocarpine  (ISO)
methyl methanesulfonate  (ISO)
monocrotaline  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression of replication factor C 40-kDa subunit is down-regulated during neonatal development in rat ventricular myocardium. Chim SS, etal., J Cell Biochem 2000 Jun 12;78(4):533-40.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Replication clamps and clamp loaders. Hedglin M, etal., Cold Spring Harb Perspect Biol. 2013 Apr 1;5(4):a010165. doi: 10.1101/cshperspect.a010165.
4. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9488738   PMID:12477932   PMID:12930902   PMID:24115439  


Genomics

Comparative Map Data
Rfc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21222,120,449 - 22,133,576 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,120,010 - 22,133,557 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,263,632 - 23,276,828 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01223,874,713 - 23,887,909 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01222,941,263 - 22,954,609 (-)NCBIRnor_WKY
Rnor_6.01225,130,375 - 25,143,480 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,130,377 - 25,143,480 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,130,769 - 27,143,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,185,550 - 23,198,655 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11223,046,380 - 23,053,601 (-)NCBI
Celera1223,884,376 - 23,897,525 (-)NCBICelera
Cytogenetic Map12q12NCBI
RFC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,231,502 - 74,254,399 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl774,231,499 - 74,254,458 (-)EnsemblGRCh38hg38GRCh38
GRCh37773,645,832 - 73,668,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,283,768 - 73,306,674 (-)NCBINCBI36Build 36hg18NCBI36
Build 34773,090,484 - 73,113,389NCBI
Celera769,125,398 - 69,148,304 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,527,267 - 69,550,345 (-)NCBIHuRef
CHM1_1773,790,894 - 73,813,879 (-)NCBICHM1_1
T2T-CHM13v2.0775,433,796 - 75,456,693 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,978,904 - 73,001,860 (-)NCBI
Rfc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,611,544 - 134,627,182 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,610,220 - 134,630,659 (+)EnsemblGRCm39 Ensembl
GRCm385134,582,690 - 134,598,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,581,366 - 134,601,805 (+)EnsemblGRCm38mm10GRCm38
MGSCv375135,058,560 - 135,074,198 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365134,867,317 - 134,882,955 (+)NCBIMGSCv36mm8
Celera5131,590,738 - 131,606,377 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.68NCBI
Rfc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545613,659,157 - 13,671,181 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545613,659,122 - 13,671,405 (+)NCBIChiLan1.0ChiLan1.0
RFC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1781,378,937 - 81,401,937 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl781,378,937 - 81,401,937 (-)Ensemblpanpan1.1panPan2
RFC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,119,203 - 6,159,293 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,119,164 - 6,160,886 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha67,819,017 - 7,857,620 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.065,935,190 - 5,973,800 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl65,951,322 - 5,974,387 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.165,926,219 - 5,964,926 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.065,873,708 - 5,912,408 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,037,183 - 6,075,802 (+)NCBIUU_Cfam_GSD_1.0
Rfc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,756,864 - 130,772,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365433,263,878 - 3,279,667 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365433,263,661 - 3,273,178 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RFC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,373,492 - 11,392,695 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1311,373,489 - 11,392,690 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2311,056,709 - 11,068,698 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RFC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,818,606 - 8,846,929 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,818,650 - 8,847,865 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660707,734,642 - 7,758,689 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rfc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474013,737,310 - 13,748,821 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474013,737,225 - 13,748,876 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rfc2
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:182
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000001989
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat

Markers in Region
RH133356  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,120,646 - 22,120,840 (+)MAPPERmRatBN7.2
Rnor_6.01225,130,573 - 25,130,766NCBIRnor6.0
Rnor_5.01227,130,967 - 27,131,160UniSTSRnor5.0
RGSC_v3.41223,185,748 - 23,185,941UniSTSRGSC3.4
Celera1223,884,574 - 23,884,767UniSTS
RH 3.4 Map12353.1UniSTS
Cytogenetic Map12q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 37 26 19 26 66 29 40 10
Low 15 20 15 15 8 11 8 6 1 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001989   ⟹   ENSRNOP00000001989
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,120,461 - 22,133,526 (-)Ensembl
Rnor_6.0 Ensembl1225,130,377 - 25,143,480 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094282   ⟹   ENSRNOP00000077503
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,120,010 - 22,133,557 (-)Ensembl
RefSeq Acc Id: NM_053786   ⟹   NP_446238
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21222,120,449 - 22,133,554 (-)NCBI
Rnor_6.01225,130,375 - 25,143,480 (-)NCBI
Rnor_5.01227,130,769 - 27,143,874 (-)NCBI
RGSC_v3.41223,185,550 - 23,198,655 (-)RGD
Celera1223,884,376 - 23,897,525 (-)RGD
Sequence:
RefSeq Acc Id: XR_005491587
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21222,120,449 - 22,133,576 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446238   ⟸   NM_053786
- UniProtKB: Q641W4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001989   ⟸   ENSRNOT00000001989
RefSeq Acc Id: ENSRNOP00000077503   ⟸   ENSRNOT00000094282
Protein Domains
Rep_fac_C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q641W4-F1-model_v2 AlphaFold Q641W4 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698569
Promoter ID:EPDNEW_R9094
Type:initiation region
Name:Rfc2_1
Description:replication factor C subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01225,143,453 - 25,143,513EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621198 AgrOrtholog
BioCyc Gene G2FUF-19579 BioCyc
Ensembl Genes ENSRNOG00000001457 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001989.4 UniProtKB/TrEMBL
  ENSRNOP00000077503 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001989.5 UniProtKB/TrEMBL
  ENSRNOT00000094282 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135071 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  DNA_pol3_clamp-load_cplx_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rep_factorC_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116468 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95315 IMAGE-MGC_LOAD
NCBI Gene 116468 ENTREZGENE
Pfam AAA UniProtKB/Swiss-Prot
  Rep_fac_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rfc2 PhenoGen
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48019 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q0Z2_RAT UniProtKB/TrEMBL
  Q641W4 ENTREZGENE
  Q9QXI2_RAT UniProtKB/TrEMBL
  RFC2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Rfc2  replication factor C subunit 2  Rfc2  replication factor C (activator 1) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rfc2  replication factor C (activator 1) 2    replication factor C (activator 1) 2 (40kD)  Name updated 1299863 APPROVED
2002-08-07 Rfc2  replication factor C (activator 1) 2 (40kD)      Symbol and Name status set to provisional 70820 PROVISIONAL