Mepce (methylphosphate capping enzyme)

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Gene: Mepce (methylphosphate capping enzyme) Rattus norvegicus

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Symbol:

Mepce

Name:

methylphosphate capping enzyme

RGD ID:

1560550

Description:

Predicted to enable 7SK snRNA binding activity and RNA 5'-gamma-phosphate methyltransferase activity. Predicted to be involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of 7SK snRNP. Orthologous to human MEPCE (methylphosphate capping enzyme); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

7SK snRNA methylphosphate capping enzyme; 7SK snRNA methylphosphate capping enzyme-like; LOC100910540; LOC304361; similar to Hypothetical protein MGC28888

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MEPCE (methylphosphate capping enzyme)	RGD	RGD
Mus musculus (house mouse):	Mepce (methylphosphate capping enzyme)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Mepce (methylphosphate capping enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MEPCE (methylphosphate capping enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MEPCE (methylphosphate capping enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mepce (methylphosphate capping enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MEPCE (methylphosphate capping enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MEPCE (methylphosphate capping enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mepce (methylphosphate capping enzyme)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Mepce (methylphosphate capping enzyme)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MEPCE (methylphosphate capping enzyme)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch1073-157b13.1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	mepce (methylphosphate capping enzyme)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	sftpbb (surfactant protein Bb)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1239	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	Y17G7B.18	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	bin3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	24,548,596 - 24,553,315 (+)	NCBI		GRCr8
mRatBN7.2	12	18,911,796 - 18,916,515 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	18,911,796 - 18,916,514 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	20,066,920 - 20,071,639 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	20,679,795 - 20,684,514 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	19,744,124 - 19,748,843 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	21,721,246 - 21,725,965 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	21,981,755 - 21,986,473 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	12	21,721,837 - 21,725,435 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	23,742,114 - 23,746,833 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	19,848,913 - 19,853,632 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	20,717,705 - 20,722,424 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pleomorphic xanthoastrocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-deoxy-D-glucose (ISO)

6-propyl-2-thiouracil (EXP)

amitrole (EXP)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (ISO)

butanal (ISO)

cadmium dichloride (EXP)

caffeine (ISO)

carbon nanotube (ISO)

cocaine (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

diazinon (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

HC toxin (ISO)

iron dichloride (ISO)

leflunomide (ISO)

methimazole (EXP)

ozone (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

quercetin (ISO)

SB 431542 (ISO)

sulfadimethoxine (EXP)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of transcription by RNA polymerase II (ISO)

positive regulation of G1/S transition of mitotic cell cycle (ISO)

positive regulation of protein localization to Cajal body (ISO)

positive regulation of snRNA transcription by RNA polymerase II (ISO)

RNA methylation (ISO)

snRNA metabolic process (ISO)

snRNA modification (IBA,ISO)

Cellular Component

7SK snRNP (ISO)

nucleus (ISO)

ribonucleoprotein complex (ISO)

Molecular Function

7SK snRNA binding (ISO)

O-methyltransferase activity (IBA)

protein binding (ISO)

RNA 5'-gamma-phosphate methyltransferase activity (ISO)

RNA binding (ISO)

RNA methyltransferase activity (IBA,ISO)

S-adenosylmethionine-dependent methyltransferase activity (ISO)

snRNA binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8889548	PMID:17643375	PMID:19906723	PMID:22658674	PMID:22681889	PMID:23154982	PMID:24360279	PMID:28254838	PMID:30559425

Genomics

Comparative Map Data

Mepce
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	24,548,596 - 24,553,315 (+)	NCBI		GRCr8
mRatBN7.2	12	18,911,796 - 18,916,515 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	18,911,796 - 18,916,514 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	20,066,920 - 20,071,639 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	20,679,795 - 20,684,514 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	19,744,124 - 19,748,843 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	21,721,246 - 21,725,965 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	21,981,755 - 21,986,473 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	12	21,721,837 - 21,725,435 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	23,742,114 - 23,746,833 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	19,848,913 - 19,853,632 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	12	20,717,705 - 20,722,424 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

MEPCE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	100,428,790 - 100,434,118 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	100,428,322 - 100,434,126 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	100,026,413 - 100,031,741 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	99,865,465 - 99,869,677 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	94,756,212 - 94,761,548 (+)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	94,659,849 - 94,665,185 (+)	NCBI		HuRef
CHM1_1	7	99,957,026 - 99,962,362 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	101,668,175 - 101,674,196 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	99,386,498 - 99,391,834 (+)	NCBI

Mepce
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	137,780,168 - 137,785,915 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	137,780,168 - 137,785,917 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	137,781,906 - 137,786,701 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	137,781,906 - 137,787,655 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	138,223,134 - 138,227,929 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	138,011,709 - 138,015,961 (-)	NCBI		MGSCv36	mm8
Celera	5	134,768,335 - 134,773,130 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	76.7	NCBI

Mepce
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955573	526,613 - 530,286 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955573	526,083 - 531,222 (-)	NCBI	ChiLan1.0	ChiLan1.0

MEPCE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	118,342,164 - 118,347,440 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	166,607,596 - 166,612,072 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	92,457,967 - 92,463,102 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	105,859,584 - 105,865,312 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	105,861,205 - 105,864,739 (+)	Ensembl	panpan1.1		panPan2

MEPCE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	9,234,316 - 9,239,160 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	9,234,356 - 9,239,859 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	10,938,563 - 10,943,659 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	9,168,084 - 9,173,182 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	9,168,095 - 9,172,830 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	9,020,522 - 9,025,618 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	8,998,101 - 9,003,195 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	9,180,481 - 9,185,577 (-)	NCBI		UU_Cfam_GSD_1.0

Mepce
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	133,527,114 - 133,531,605 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	504,671 - 509,497 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	504,686 - 509,419 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MEPCE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	8,357,289 - 8,364,661 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	8,356,602 - 8,361,798 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	7,700,143 - 7,704,903 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MEPCE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	12,771,822 - 12,776,345 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	12,771,391 - 12,775,961 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	3,514,965 - 3,520,629 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mepce
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	16,641,484 - 16,644,989 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	16,640,777 - 16,645,788 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mepce
5 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	99
Count of miRNA genes:	74
Interacting mature miRNAs:	78
Transcripts:	ENSRNOT00000001871, ENSRNOT00000073353
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	1	19611090	Rat
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	15025183	20794014	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	8525423	28064601	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	15872653	32974238	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	11073825	24234895	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	13635523	30827399	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	13008296	19212979	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	36247923	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	8449490	28302290	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	28064557	Rat

Markers in Region

BE101310

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	18,914,771 - 18,914,954 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	21,724,222 - 21,724,404	NCBI	Rnor6.0
Rnor_6.0	12	21,984,731 - 21,984,913	NCBI	Rnor6.0
Rnor_5.0	12	24,001,779 - 24,001,961	UniSTS	Rnor5.0
Rnor_5.0	12	23,745,090 - 23,745,272	UniSTS	Rnor5.0
RGSC_v3.4	12	19,850,474 - 19,850,656	UniSTS	RGSC3.4
Celera	12	20,720,681 - 20,720,863	UniSTS
RH 3.4 Map	12	264.3	UniSTS
Cytogenetic Map	12	q12	UniSTS

WIAF-1510

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	12	23,746,595 - 23,746,749	NCBI	Rnor5.0
RGSC_v3.4	12	19,848,997 - 19,849,150	UniSTS	RGSC3.4
Cytogenetic Map	12	q12	UniSTS

RH125705

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	18,916,127 - 18,916,398 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	21,725,578 - 21,725,848	NCBI	Rnor6.0
Rnor_6.0	12	21,986,087 - 21,986,357	NCBI	Rnor6.0
Rnor_5.0	12	23,746,446 - 23,746,716	UniSTS	Rnor5.0
Rnor_5.0	12	24,003,135 - 24,003,405	UniSTS	Rnor5.0
RGSC_v3.4	12	19,849,030 - 19,849,300	UniSTS	RGSC3.4
Celera	12	20,722,037 - 20,722,307	UniSTS
Cytogenetic Map	12	q12	UniSTS

C78815

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	18,916,125 - 18,916,209 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	21,725,576 - 21,725,659	NCBI	Rnor6.0
Rnor_6.0	12	21,986,085 - 21,986,168	NCBI	Rnor6.0
Rnor_5.0	12	23,746,444 - 23,746,527	UniSTS	Rnor5.0
Rnor_5.0	12	24,003,133 - 24,003,216	UniSTS	Rnor5.0
RGSC_v3.4	12	19,849,219 - 19,849,302	UniSTS	RGSC3.4
Celera	12	20,722,035 - 20,722,118	UniSTS
Cytogenetic Map	12	q12	UniSTS

RH142264

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	18,916,282 - 18,916,482 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	21,725,733 - 21,725,932	NCBI	Rnor6.0
Rnor_6.0	12	21,986,242 - 21,986,441	NCBI	Rnor6.0
Rnor_5.0	12	23,746,601 - 23,746,800	UniSTS	Rnor5.0
Rnor_5.0	12	24,003,290 - 24,003,489	UniSTS	Rnor5.0
RGSC_v3.4	12	19,848,946 - 19,849,145	UniSTS	RGSC3.4
Celera	12	20,722,192 - 20,722,391	UniSTS
Cytogenetic Map	12	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hepatobiliary system	mesenchyme	mesoderm	nervous system	renal system	reproductive system
30	61	28	28	28	28	82	30	61	24	26

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA925609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001871 ⟹ ENSRNOP00000001871

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	18,911,796 - 18,916,514 (+)	Ensembl
Rnor_6.0 Ensembl	12	21,981,755 - 21,986,473 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000073353 ⟹ ENSRNOP00000067286

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	12	21,721,837 - 21,725,435 (+)	Ensembl

RefSeq Acc Id:

NM_001100678 ⟹ NP_001094148

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	24,548,596 - 24,553,315 (+)	NCBI
mRatBN7.2	12	18,911,796 - 18,916,515 (+)	NCBI
Rnor_6.0	12	21,721,246 - 21,725,965 (+)	NCBI
Rnor_5.0	12	23,742,114 - 23,746,833 (+)	NCBI
RGSC_v3.4	12	19,848,913 - 19,853,632 (-)	RGD
Celera	12	20,717,705 - 20,722,424 (+)	RGD

Sequence:

show sequence

GGGTGTCAAGGAGACCTTTTCACACCAGCTCCCGTTCCCCGCCTACGGTGGGTGGGATCTCACA
GCAGAGACAAAGGATATCAGTAGGGCTTGGACTTAGCAGCGAAGGGAAGTCGGGTGTCCGTGTG
GGGCGGTGGGCGTCTCGGGCTGGGGGAGGGTGAGGCTATTAGGGAGGGGGGGCTGTATTTAAAC
TCTCAGAGCCGTTAAGTTGGTTCGCACTCCCGATGCGCGCGCAGCCTGGGTGGTGGCGGAGCGC
GCATGCGTGGGTCCTGGGCGAGCGGAACGCGCGCCCGTCGTGCGCGCTCGCGGCAGAGTGGTAG
AGGCGGCGGAGAAAAGGGTGTCAGCGCACGCGCAGTTGGTTCCTCGGCTTGTCCGGGTCTCGCG
GGCATCTTGTTTTGGTCTCGCGGGCGAGTGGAGCGCGCTTGGTGTGTTGCGGGAGGGAGGTGGA
GGCGCTTGGGCGCGAGGCAGAGCTGCGCGCGCACTCGGGGAAGGAGGGAGTGAGGTGGTCTTAG
GAAGGGTTACAGGGGGGCTTCCCCTTGATCTCTTCTCAGTACCCTCGCTTGGGAAGGGGAAATT
AAACAGGGAGAGGAGATGATCGAGATGGCGGCGGAGAAGGAGCCCTTTCTGGTGCCAGCCCCAC
CGCCGCCGCTCAAAGATGAGTCGGGTGGAGGGGGCGGCCCCGAGGTGCGATCGCACCAAGAGGC
TGCCTCCGGGGAGCTCCTCGACGGGACAGAACGCGGGCCGGGCCCACGCGCGCACTCGGCCGGG
GCCACAGCCAGCGGAGGGGGCGGCCCCCAGGCACAGACGCATGGGGAGCCCCACGGGCGAGCTG
CCGCTCCTGCGGACGTGGGGGAGGAGCGCCGGGGAGGGGGCGGGACGGACCTGGGTCCCCCAGC
CCCTCCTCGACCTCGCAATGGCTACCAGCCCCACCGACCCCCAGTGGGTGGTGGGGGCAAAAGA
AGAAATAGCTGTAACGTGGGGGGAGGGAGCGGTGGAAGCTTCAAACATCCGGCCTTCAAGAGGC
GCCGGCGAGTGAATTCGGACTGCGACTCCGTGTTACCATCCAATTTCCTTCTGGGGGGTAATAT
ATTTGATCCACTGAACCTGAATAGCCTCCTGGATGAGGAAGTGAGTCGCGCACTCAATGCGGAG
ACCCCAAAGTCATCCCCACTTCCGGCCAAGGGGAGAGACCCTGTGGAGATCCTCATCCCAAAAG
ATATCACTGACCCACTCAGTCTCAACACGTGCACTGATGAAGCCCATGTAGTGCTTGCTTCACC
ACTCAAGATTGGTCGCAAGCGCCATAGACACCGGGGACCGCACCACCAGCAGCAGCAGGCATCT
GGAGGGAATGATAGCCAAGCTGTGCTGCCCACTGACCCTCTCACACCCTCAGTCCATGGGGAGG
GTGCTACGCAGCAGCACAGAGGCCAGAACCGAGATGACCCTCAACCCTATGAACTCAACACAGC
CATCAACTGCAGGGATGAAGTTGTGTCTCCCCTTCCGTCTGCCCTGCAGGGTTCCTCAGGCTCC
CTTTCTGCCCCTCCAGCTGCCTCAGTTACCTCTGCACCCTCTTCCTCCTCCTCCCGACATCGCA
AACGTCGCAGGACTTCCAGCAAGTCAGAGGCAGGGGCTAGGGGTGGAAGCCAGGGTTCCAAGGA
AAAGGGCAGAGGGAGTGGGGGAGGCCGTCACCACCACCCACTACCTGCAACTGGCTTCAAAAAG
CAACAGCTCAAGTTCCAGTATGGGAATTACTGCAAGTACTATGGCTATCGCAATCCTTCCTGTG
AGGACATGCGCCTTAGGGTATTGAAGCCTGAGTGGTTTCAAGGCCGGGACGTCCTAGATCTGGG
CTGCAACGTTGGCCATCTGACCCTAAGTATTGCCTGCAAGTGGGGCCCAGCCCGCATGGTGGGG
CTGGACATTGATCCACGACTTATCCACTCTGCCCGCCAAAATATCCGACACTACCTGTCCGAGG
AGCTTCGTCTCCAAGCTCAGACTTCTGAGGGGGACCCAGGGACAGAGGGGGAGGAAGGGACTAC
CACTGTCCGAAAAAGGAGCTGCTTCCCAGCCTCACTGACAGCCAGCCGGGGTCCCATCGCTGCA
CCCCATTTGCCCTTGGATGGAGCGGACACATCTGTCTTCCCCAACAATGTCGTCTTCGTCACGG
GTAACTATGTCCTGGACAGAGATGAGCTGGTGGATGCCCAAAGACCTGAGTATGATGTGGTGCT
CTGCTTCAGCCTCACCAAGTGGGTGCACCTGAACTGGGGTGATGAGGGGCTGAAGAGAATGTTC
CGCCGGATCTACCGGCATCTGCGACCTGGGGGCATTCTGGTCCTGGAGCCCCAACCGTGGTCGT
CCTACTGCAGGAGAAAGTCTCTCACAGAAACAATCTATAAGAACTACTTTCGAATCCAGCTGAA
GCCAGAACAGTTCAGCTCCTACCTGACATCTCCAGAGGTGGGTTTCTCCAGCTATGAGCTTGTG
GCCACACCAAGTAACACCTCCAGAGGCTTCCAGCGTCCGGTGTACTTGTTCCACAAGGCCCGAT
CTCCCAGCCACTGAGTGGCTTTCTGAGTTAGAAGTTGTGAAGAGGCTGCCCTTGCTGCTCCTGA
GGACCTGGAAGAAGAGGAAATTATCCCAAGGTCTTTCCTAACTCCAAAAAGTTTCTCCTTTTCT
TGGATCTGTAAAGAGCGCTTTTCCTAAGTTGCTACCCCACGTCTCCTCCCTGACACCTCTGGCA
CTTGAGCAAGCCCAGCTGTGCTGGAATTCCATCAGCTTCCTCTCCCAGCCTGCTGTGCTGGATG
GCATGGACTGTTTGCTGACTCTGTCCTCCTAGGGCATGGGAAGGGGGAATGTCAAATTCTCTAG
GCCCTTCCTCCTCTTCTCGGAAGATTTCCTGCTTCTCCTCAGCCTTTGTTCCTAGCTGCACTTA
AATGGACCATGGTTGGACTAAGGGTGTTAGAGGGGAAATTTGGTAAGGAGACACACAGGTACTG
TGAAAGTCCTTCTGCTGTCCCCGGTGGGAGGGAGCTGGGTTTGGAACATGAGAACAGCACAATA
AACTTGATAACTAGGGCAGTGGCCCCCCTGCAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001094148	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88435	(Get FASTA)	NCBI Sequence Viewer
	EDM13235	(Get FASTA)	NCBI Sequence Viewer
	EDM13236	(Get FASTA)	NCBI Sequence Viewer
	EDM13237	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001871.4

RefSeq Acc Id:

NP_001094148 ⟸ NM_001100678

- UniProtKB:

G3V656 (UniProtKB/TrEMBL), A6IZZ6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MIEMAAEKEPFLVPAPPPPLKDESGGGGGPEVRSHQEAASGELLDGTERGPGPRAHSAGATASG
GGGPQAQTHGEPHGRAAAPADVGEERRGGGGTDLGPPAPPRPRNGYQPHRPPVGGGGKRRNSCN
VGGGSGGSFKHPAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNSLLDEEVSRALNAETPKSS
PLPAKGRDPVEILIPKDITDPLSLNTCTDEAHVVLASPLKIGRKRHRHRGPHHQQQQASGGNDS
QAVLPTDPLTPSVHGEGATQQHRGQNRDDPQPYELNTAINCRDEVVSPLPSALQGSSGSLSAPP
AASVTSAPSSSSSRHRKRRRTSSKSEAGARGGSQGSKEKGRGSGGGRHHHPLPATGFKKQQLKF
QYGNYCKYYGYRNPSCEDMRLRVLKPEWFQGRDVLDLGCNVGHLTLSIACKWGPARMVGLDIDP
RLIHSARQNIRHYLSEELRLQAQTSEGDPGTEGEEGTTTVRKRSCFPASLTASRGPIAAPHLPL
DGADTSVFPNNVVFVTGNYVLDRDELVDAQRPEYDVVLCFSLTKWVHLNWGDEGLKRMFRRIYR
HLRPGGILVLEPQPWSSYCRRKSLTETIYKNYFRIQLKPEQFSSYLTSPEVGFSSYELVATPSN
TSRGFQRPVYLFHKARSPSH

hide sequence

Ensembl Acc Id:

ENSRNOP00000067286 ⟸ ENSRNOT00000073353

Ensembl Acc Id:

ENSRNOP00000001871 ⟸ ENSRNOT00000001871

Protein Domains

Bin3-type SAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V656-F1-model_v2	AlphaFold	G3V656	1-660	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560550	AgrOrtholog
BioCyc Gene	G2FUF-19722	BioCyc
Ensembl Genes	ENSRNOG00000001387	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000045911	Ensembl
Ensembl Transcript	ENSRNOT00000001871.6	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7125256	IMAGE-MGC_LOAD
InterPro	Bin3	UniProtKB/TrEMBL
	Bin3-like	UniProtKB/TrEMBL
	BIN3_SAM-bd_dom	UniProtKB/TrEMBL
	Methyltranfer_dom	UniProtKB/TrEMBL
	SAM-dependent_MTases-like	UniProtKB/TrEMBL
KEGG Report	rno:304361	UniProtKB/TrEMBL
MGC_CLONE	MGC:95069	IMAGE-MGC_LOAD
NCBI Gene	304361	ENTREZGENE
PANTHER	7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME	UniProtKB/TrEMBL
	PTHR12315	UniProtKB/TrEMBL
Pfam	Bin3	UniProtKB/TrEMBL
	Methyltransf_31	UniProtKB/TrEMBL
PhenoGen	Mepce	PhenoGen
PROSITE	BIN3_SAM	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001387	RatGTEx
	ENSRNOG00000045911	RatGTEx
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A6IZZ6	ENTREZGENE, UniProtKB/TrEMBL
	G3V656	ENTREZGENE, UniProtKB/TrEMBL
	Q5I0E0_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Mepce	methylphosphate capping enzyme	LOC100910540	7SK snRNA methylphosphate capping enzyme-like	Data merged from RGD:6497906	737654	PROVISIONAL
2012-07-05	LOC100910540	7SK snRNA methylphosphate capping enzyme-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-04	Mepce	methylphosphate capping enzyme	LOC304361	similar to Hypothetical protein MGC28888	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC304361	similar to Hypothetical protein MGC28888			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar