Gene: Myl2 (myosin light chain 2) Rattus norvegicus
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Symbol: Myl2
Name: myosin light chain 2
Description: ENCODES a protein that exhibits actin monomer binding (ortholog); calcium ion binding (ortholog); INVOLVED IN cardiac muscle contraction; cell growth involved in cardiac muscle cell development; regulation of the force of heart contraction; PARTICIPATES IN E-cadherin signaling pathway; N-cadherin signaling pathway; dilated cardiomyopathy pathway; ASSOCIATED WITH cardiomyopathy (ortholog); Death (ortholog); dilated cardiomyopathy (ortholog); FOUND IN contractile fiber; myofibril; actin cytoskeleton (ortholog); INTERACTS WITH (R)-adrenaline; 5-azacytidine; 7H-xanthine
AGR Description: Predicted to have actin monomer binding activity and calcium ion binding activity; involved in cardiac muscle contraction, cell growth involved in cardiac muscle cell development, and regulation of the force of heart contraction; localizes to the myofibril; predicted to colocalize with the actin cytoskeleton; orthologous to human MYL2 (myosin light chain 2).
Merged Description: Predicted to have actin monomer binding activity and calcium ion binding activity; involved in cardiac muscle contraction, cell growth involved in cardiac muscle cell development, and regulation of the force of heart contraction; localizes to the myofibril; predicted to colocalize with the actin cytoskeleton; orthologous to human MYL2 (myosin light chain 2); PARTICIPATES IN E-cadherin signaling pathway; N-cadherin signaling pathway; dilated cardiomyopathy pathway; INTERACTS WITH (R)-adrenaline; 5-azacytidine; 7H-xanthine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cardiac myosin light chain-2; Mlc-2; MLC-2s/v; MLC-2v; Mlc2; myosin light chain 2, slow skeletal/ventricular muscle isoform; myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light chain 2, regulatory, cardiac, slow; myosin, light polypeptide 2, regulatory, cardiac, slow
Orthologs:
Homo sapiens (human) : MYL2 (myosin light chain 2)  HGNC  Alliance
Mus musculus (house mouse) : Myl2 (myosin, light polypeptide 2, regulatory, cardiac, slow)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myl2 (myosin light chain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MYL2 (myosin light chain 2)
Canis lupus familiaris (dog) : MYL2 (myosin light chain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myl2 (myosin light chain 2)
Sus scrofa (pig) : MYL2 (myosin light chain 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01239,951,863 - 39,959,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01241,831,137 - 41,835,806 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,653,745 - 35,664,700 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1236,122,106 - 36,128,911 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Myl2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1564245
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.