Ran (RAN, member RAS oncogene family) - Rat Genome Database

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Gene: Ran (RAN, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Ran
Name: RAN, member RAS oncogene family
RGD ID: 620367
Description: Enables several functions, including dynein intermediate chain binding activity; guanyl ribonucleotide binding activity; and importin-alpha family protein binding activity. Involved in cellular response to mineralocorticoid stimulus; hippocampus development; and spermatid development. Located in male germ cell nucleus; manchette; and sperm flagellum. Part of nuclear pore. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family); PARTICIPATES IN CRM1 export pathway; microRNA pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-bromopropane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTP-binding nuclear protein Ran; GTPase Ran; ras-like protein TC4; ras-related nuclear protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81233,311,155 - 33,314,339 (-)NCBIGRCr8
mRatBN7.21227,674,049 - 27,678,598 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,674,050 - 27,678,276 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1228,814,245 - 28,817,373 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01229,424,809 - 29,427,937 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01228,483,802 - 28,486,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01231,319,556 - 31,324,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1231,320,624 - 31,323,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,245,991 - 33,250,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,736,786 - 28,739,921 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,600,176 - 28,603,309 (-)NCBI
Celera1229,370,202 - 29,373,337 (-)NCBICelera
Cytogenetic Map12q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
aconitine  (EXP)
actinomycin D  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
ampicillin  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
bucladesine  (ISO)
buspirone  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
clofibric acid  (EXP)
clopidogrel  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
dopamine  (EXP)
doxorubicin  (ISO)
ellagic acid  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fenoldopam  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
medroxyprogesterone acetate  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
metronidazole  (EXP)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (EXP,ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
triadimefon  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriole  (IEA,ISO)
chromatin  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA)
Flemming body  (ISO)
male germ cell nucleus  (IDA)
manchette  (IDA)
melanosome  (IEA)
midbody  (IEA,ISO)
nuclear envelope  (IEA,ISO)
nuclear pore  (IDA)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
protein-containing complex  (IDA,IEA,ISO)
recycling endosome  (IEA,ISO)
RISC complex  (ISO)
RNA nuclear export complex  (IEA,ISO)
sperm flagellum  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins p62 and Nsp1p. Clarkson WD, etal., J Mol Biol. 1996 Nov 8;263(4):517-24.
2. RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Delphin C, etal., Mol Biol Cell. 1997 Dec;8(12):2379-90.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Vasopressin V1a receptor is required for nucleocytoplasmic transport of mineralocorticoid receptor. Hori K, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1080-8. doi: 10.1152/ajprenal.00052.2012. Epub 2012 Jul 18.
5. Ran, a GTP-binding protein involved in nucleocytoplasmic transport and microtubule nucleation, relocates from the manchette to the centrosome region during rat spermiogenesis. Kierszenbaum AL, etal., Mol Reprod Dev 2002 Sep;63(1):131-40.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. A high-resolution structure of the pre-microRNA nuclear export machinery. Okada C, etal., Science. 2009 Nov 27;326(5957):1275-9.
10. Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenzanthracene. Papaconstantinou AD, etal., Int J Cancer. 2006 Jan 1;118(1):17-24.
11. Crystallographic and biochemical analysis of the Ran-binding zinc finger domain. Partridge JR and Schwartz TU, J Mol Biol. 2009 Aug 14;391(2):375-89. Epub 2009 Jun 6.
12. Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import. Percipalle P, etal., J Mol Biol. 1997 Mar 7;266(4):722-32.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Changes of hippocampal signaling protein levels during postnatal brain development in the rat. Weitzdorfer R, etal., Hippocampus. 2008;18(8):807-13.
20. Essential role of the small GTPase Ran in postnatal pancreatic islet development. Xia F, etal., PLoS One. 2011;6(11):e27879. doi: 10.1371/journal.pone.0027879. Epub 2011 Nov 17.
21. Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve. Yudin D, etal., Neuron. 2008 Jul 31;59(2):241-52. doi: 10.1016/j.neuron.2008.05.029.
22. Nuclear export and cytoplasmic maturation of ribosomal subunits. Zemp I and Kutay U, FEBS Lett. 2007 Jun 19;581(15):2783-93. Epub 2007 May 11.
23. KRP3A and KRP3B: candidate motors in spermatid maturation in the seminiferous epithelium. Zou Y, etal., Biol Reprod 2002 Mar;66(3):843-55.
Additional References at PubMed
PMID:1961752   PMID:8636225   PMID:8757804   PMID:9533885   PMID:9822603   PMID:10557333   PMID:11336674   PMID:11809816   PMID:12773398   PMID:14681208   PMID:15489334   PMID:15574332  
PMID:15602554   PMID:15689618   PMID:16449645   PMID:18266911   PMID:18347012   PMID:18691641   PMID:18938132   PMID:19056867   PMID:19166812   PMID:19946888   PMID:20458337   PMID:20478346  
PMID:21630459   PMID:21874009   PMID:22658674   PMID:22681889   PMID:22871113   PMID:23029267   PMID:23106098   PMID:23376485   PMID:23979707   PMID:24561039   PMID:24625528   PMID:25468996  
PMID:25779090   PMID:25946333   PMID:26272610   PMID:26308891   PMID:27541860   PMID:29040603   PMID:30053369   PMID:31075303   PMID:32357304  


Genomics

Comparative Map Data
Ran
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81233,311,155 - 33,314,339 (-)NCBIGRCr8
mRatBN7.21227,674,049 - 27,678,598 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,674,050 - 27,678,276 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1228,814,245 - 28,817,373 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01229,424,809 - 29,427,937 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01228,483,802 - 28,486,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01231,319,556 - 31,324,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1231,320,624 - 31,323,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,245,991 - 33,250,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,736,786 - 28,739,921 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,600,176 - 28,603,309 (-)NCBI
Celera1229,370,202 - 29,373,337 (-)NCBICelera
Cytogenetic Map12q13NCBI
RAN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812130,872,066 - 130,877,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12130,872,037 - 130,877,678 (+)EnsemblGRCh38hg38GRCh38
GRCh3712131,356,611 - 131,362,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612129,922,521 - 129,927,316 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412129,881,447 - 129,886,243NCBI
Celera12130,970,022 - 130,974,231 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12128,338,826 - 128,343,035 (+)NCBIHuRef
CHM1_112131,177,378 - 131,181,587 (+)NCBICHM1_1
T2T-CHM13v2.012130,911,164 - 130,916,776 (+)NCBIT2T-CHM13v2.0
Ran
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,097,264 - 129,101,388 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5129,097,133 - 129,101,387 (+)EnsemblGRCm39 Ensembl
GRCm385129,020,156 - 129,024,322 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,020,069 - 129,024,323 (+)EnsemblGRCm38mm10GRCm38
MGSCv375129,526,031 - 129,530,196 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365129,334,926 - 129,339,029 (+)NCBIMGSCv36mm8
Celera5126,055,157 - 126,059,295 (+)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map567.99NCBI
Ran
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554821,220,876 - 1,224,395 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554821,222,944 - 1,223,891 (-)NCBIChiLan1.0ChiLan1.0
RAN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210138,943,846 - 138,949,523 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112138,940,386 - 138,946,040 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012128,497,407 - 128,503,049 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112132,694,498 - 132,699,668 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12132,694,498 - 132,699,668 (+)Ensemblpanpan1.1panPan2
RAN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1261,435,077 - 1,436,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl261,434,720 - 1,436,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,635,546 - 1,637,515 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,680,668 - 1,683,666 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,679,342 - 1,685,209 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1261,617,356 - 1,619,315 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0261,714,300 - 1,716,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0261,621,482 - 1,623,431 (-)NCBIUU_Cfam_GSD_1.0
Ran
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118123,047,105 - 123,050,801 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366601,668,956 - 1,672,067 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366601,669,352 - 1,673,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1424,311,577 - 24,317,789 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11424,312,810 - 24,318,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21425,861,945 - 25,865,060 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111126,257,849 - 126,263,481 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037118,757,304 - 118,763,095 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ran
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474727,285,934 - 27,290,667 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474727,287,510 - 27,290,082 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ran
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:50
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000001247, ENSRNOT00000074908
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)122423477731894213Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001436423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF306457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001247   ⟹   ENSRNOP00000001247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1227,674,050 - 27,678,276 (-)Ensembl
Rnor_6.0 Ensembl1231,320,624 - 31,323,810 (-)Ensembl
RefSeq Acc Id: NM_053439   ⟹   NP_445891
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,311,155 - 33,314,290 (-)NCBI
mRatBN7.21227,675,113 - 27,678,248 (-)NCBI
Rnor_6.01231,320,620 - 31,323,755 (-)NCBI
Rnor_5.01233,245,991 - 33,250,540 (-)NCBI
RGSC_v3.41228,736,786 - 28,739,921 (-)RGD
Celera1229,370,202 - 29,373,337 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249285   ⟹   XP_006249347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,311,155 - 33,314,339 (-)NCBI
mRatBN7.21227,674,049 - 27,678,598 (-)NCBI
Rnor_6.01231,319,556 - 31,324,105 (-)NCBI
Rnor_5.01233,245,991 - 33,250,540 (-)NCBI
Sequence:
RefSeq Acc Id: NP_445891   ⟸   NM_053439
- UniProtKB: P62828 (UniProtKB/Swiss-Prot),   A6J0S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249347   ⟸   XM_006249285
- Peptide Label: isoform X1
- UniProtKB: P62828 (UniProtKB/Swiss-Prot),   A6J0S3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001247   ⟸   ENSRNOT00000001247

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62828-F1-model_v2 AlphaFold P62828 1-216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698593
Promoter ID:EPDNEW_R9118
Type:initiation region
Name:Ran_1
Description:RAN, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01231,323,770 - 31,323,830EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620367 AgrOrtholog
BioCyc Gene G2FUF-19469 BioCyc
Ensembl Genes ENSRNOG00000000938 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001247 ENTREZGENE
  ENSRNOT00000001247.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920235 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Ran_GTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:84509 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72745 IMAGE-MGC_LOAD
NCBI Gene 84509 ENTREZGENE
PANTHER GTP-BINDING NUCLEAR PROTEIN RAN UniProtKB/Swiss-Prot
  PTHR24071 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Ran PhenoGen
PRINTS GTPRANTC4 UniProtKB/Swiss-Prot
PROSITE RAN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000938 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A6J0S3 ENTREZGENE, UniProtKB/TrEMBL
  A6J0S4_RAT UniProtKB/TrEMBL
  P62828 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P17080 UniProtKB/Swiss-Prot
  P28746 UniProtKB/Swiss-Prot
  P28747 UniProtKB/Swiss-Prot
  Q9CSP3 UniProtKB/Swiss-Prot
  Q9CWI7 UniProtKB/Swiss-Prot
  Q9CZA2 UniProtKB/Swiss-Prot
  Q9UDJ5 UniProtKB/Swiss-Prot
  Q9UEU9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ran  RAN, member RAS oncogene family      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ran  RAN, member RAS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the manchette microtubules of elongating spermatids and later to the centrosome of maturing spermatids 727421