Pilrb2l4 (paired immunoglobin like type 2 receptor beta 2 like 4) - Rat Genome Database

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Gene: Pilrb2l4 (paired immunoglobin like type 2 receptor beta 2 like 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Pilrb2l4
Name: paired immunoglobin like type 2 receptor beta 2 like 4
RGD ID: 1559588
Description: Predicted to enable MHC class I protein binding activity. Predicted to be located in cell periphery and membrane. Orthologous to human PILRA (paired immunoglobin like type 2 receptor alpha); INTERACTS WITH oxaliplatin; topotecan.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC304349; paired immunoglobin like type 2 receptor beta 2 like 1; paired immunoglobulin-like type 2 receptor beta; paired immunoglobulin-like type 2 receptor beta-2; Pilrb2l1; RGD1559588; similar to cell surface receptor FDFACT; uncharacterized protein RGD1559588
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,512,512 - 22,518,410 (+)NCBIGRCr8
mRatBN7.21217,398,844 - 17,404,810 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,398,915 - 17,404,795 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01219,890,546 - 19,896,468 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,890,749 - 19,894,166 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,714,324 - 19,719,920 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,943,654 - 21,949,648 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,981,785 - 17,984,938 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1219,322,040 - 19,328,040 (+)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pilrb2l4Ratoxaliplatin multiple interactionsEXP 6480464[Oxaliplatin co-treated with Topotecan] results in increased expression of PILRB2L4 mRNACTDPMID:25729387
Pilrb2l4Ratoxaliplatin increases expressionEXP 6480464Oxaliplatin results in increased expression of PILRB2L4 mRNACTDPMID:25729387
Pilrb2l4Rattopotecan multiple interactionsEXP 6480464[Oxaliplatin co-treated with Topotecan] results in increased expression of PILRB2L4 mRNACTDPMID:25729387


Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pilrb2l4Ratcell periphery located_inIEAARBA:ARBA000274431600115GO_REF:0000117UniProtGO_REF:0000117
Pilrb2l4Ratmembrane located_inIEAARBA:ARBA000287631600115GO_REF:0000117UniProtGO_REF:0000117
Pilrb2l4Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Pilrb2l4Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pilrb2l4RatMHC class I protein binding enablesIBAMGI:2450532 and PANTHER:PTN0003994881600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Pilrb2l4
84 total Variants

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:118
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000072303, ENSRNOT00000074970
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 49 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat

1 to 10 of 49 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 31 45 76 77 48 28 48 6 163 76 25 22 34 29


1 to 17 of 17 rows
RefSeq Transcripts XM_001075881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006221302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001845640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000064787   ⟹   ENSRNOP00000061816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1217,398,921 - 17,404,795 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072303   ⟹   ENSRNOP00000066310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1217,398,915 - 17,404,795 (+)Ensembl
Rnor_6.0 Ensembl1219,714,324 - 19,719,920 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074970   ⟹   ENSRNOP00000066641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1219,890,749 - 19,894,166 (+)Ensembl
RefSeq Acc Id: XM_006249038   ⟹   XP_006249100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,512,527 - 22,518,410 (+)NCBI
mRatBN7.21217,398,844 - 17,404,809 (+)NCBI
Rnor_6.01219,890,549 - 19,896,468 (+)NCBI
Rnor_5.01221,943,654 - 21,949,648 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089985   ⟹   XP_038945913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,512,524 - 22,518,410 (+)NCBI
mRatBN7.21217,398,911 - 17,404,785 (+)NCBI
RefSeq Acc Id: XM_039089986   ⟹   XP_038945914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,512,523 - 22,515,786 (+)NCBI
mRatBN7.21217,398,903 - 17,404,795 (+)NCBI
RefSeq Acc Id: XM_063271736   ⟹   XP_063127806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,512,522 - 22,518,410 (+)NCBI
RefSeq Acc Id: XM_063271737   ⟹   XP_063127807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,512,518 - 22,518,410 (+)NCBI
RefSeq Acc Id: XM_063271738   ⟹   XP_063127808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,512,526 - 22,518,410 (+)NCBI
RefSeq Acc Id: XM_063271739   ⟹   XP_063127809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,512,512 - 22,518,410 (+)NCBI
RefSeq Acc Id: XR_005491861
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81222,512,525 - 22,515,787 (+)NCBI
mRatBN7.21217,398,911 - 17,402,174 (+)NCBI
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: XP_006249100   ⟸   XM_006249038
- Peptide Label: isoform X4
- UniProtKB: M0R9X6 (UniProtKB/TrEMBL),   F7FGP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066641   ⟸   ENSRNOT00000074970
Ensembl Acc Id: ENSRNOP00000066310   ⟸   ENSRNOT00000072303
RefSeq Acc Id: XP_038945914   ⟸   XM_039089986
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038945913   ⟸   XM_039089985
- Peptide Label: isoform X1
- UniProtKB: F7FGP9 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-M0R9X6-F1-model_v2 AlphaFold M0R9X6 1-224 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 20 of 20 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19771 BioCyc
Ensembl Genes ENSRNOG00000045868 Ensembl
  ENSRNOG00000049331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064787 ENTREZGENE
  ENSRNOT00000064787.3 UniProtKB/TrEMBL
  ENSRNOT00000072303.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Immunoregulatory_rcpt-like UniProtKB/TrEMBL
KEGG Report rno:304349 UniProtKB/TrEMBL
NCBI Gene 304349 ENTREZGENE
PANTHER PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR UniProtKB/TrEMBL
  PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR BETA-RELATED UniProtKB/TrEMBL
PhenoGen Pilrb2l4 PhenoGen
RatGTEx ENSRNOG00000045868 RatGTEx
  ENSRNOG00000049331 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt F7FGP9 ENTREZGENE, UniProtKB/TrEMBL
  M0R9X6 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-13 Pilrb2l4  paired immunoglobin like type 2 receptor beta 2 like 4  Pilrb2l1  paired immunoglobin like type 2 receptor beta 2 like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-19 Pilrb2l1  paired immunoglobin like type 2 receptor beta 2 like 1  RGD1559588  similar to cell surface receptor FDFACT  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1559588  similar to cell surface receptor FDFACT   RGD1559588_predicted  similar to cell surface receptor FDFACT (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559588_predicted  similar to cell surface receptor FDFACT (predicted)  LOC304349  similar to cell surface receptor FDFACT  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC304349  similar to cell surface receptor FDFACT      Symbol and Name status set to provisional 70820 PROVISIONAL