Ppp1cc (protein phosphatase 1 catalytic subunit gamma) - Rat Genome Database

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Gene: Ppp1cc (protein phosphatase 1 catalytic subunit gamma) Rattus norvegicus
Analyze
Symbol: Ppp1cc
Name: protein phosphatase 1 catalytic subunit gamma
RGD ID: 3377
Description: Enables several functions, including lamin binding activity; protein C-terminus binding activity; and protein phosphatase 1 binding activity. Involved in positive regulation of glial cell proliferation. Acts upstream of or within neuron differentiation. Located in cytoplasm and dendritic spine. Is active in glutamatergic synapse; postsynapse; and presynapse. Biomarker of congestive heart failure. Orthologous to human PPP1CC (protein phosphatase 1 catalytic subunit gamma); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; dopamine signaling pathway; glycogen biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium acetate; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PP-1G; Ppp1cc1; protein phosphatase 1 catalytic subunit gamma isoform; protein phosphatase 1 catalytic subunit gamma isoform 1; Protein phosphatase 1 catalytic subunit gamma isoform 1 (possible existence of an alternative gene product Ppp1cc2); protein phosphatase 1, catalytic subunit, gamma isoform; protein phosphatase 1, catalytic subunit, gamma isozyme; protein phosphatase 1C catalytic subunit; protein serine-threonine phosphatase catalytic subunit PP-1b; serine/threonine-protein phosphatase PP1-gamma catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Lnnr1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21234,383,072 - 34,400,553 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,383,072 - 34,400,553 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,555,467 - 35,572,955 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01236,166,698 - 36,184,182 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01235,219,154 - 35,236,638 (-)NCBIRnor_WKY
Rnor_6.01239,864,302 - 39,882,030 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,864,295 - 39,882,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,744,531 - 41,762,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,580,169 - 35,598,249 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,443,556 - 35,461,637 (-)NCBI
Celera1236,054,251 - 36,071,363 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Allen PB, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9956-61.
2. Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms. Burén S, etal., Cancer Cell. 2016 Aug 8;30(2):290-307. doi: 10.1016/j.ccell.2016.06.023.
3. Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. Carmody LC, etal., FASEB J. 2008 Jun;22(6):1660-71. doi: 10.1096/fj.07-092841. Epub 2008 Jan 23.
4. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Ceulemans H and Bollen M, Physiol Rev. 2004 Jan;84(1):1-39.
5. Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. Cid C, etal., Proteomics. 2007 Sep;7(17):3207-18.
6. Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. Croci C, etal., J Biol Chem. 2003 Dec 12;278(50):50682-90. Epub 2003 Sep 30.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman. Hafver TL, etal., J Biol Chem. 2016 Feb 26;291(9):4561-79. doi: 10.1074/jbc.M115.677898. Epub 2015 Dec 14.
9. Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases. Ishida A, etal., Br J Pharmacol. 2008 Jun;154(4):729-40. doi: 10.1038/bjp.2008.127. Epub 2008 May 5.
10. Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. Li T, etal., J Biol Chem. 2007 Mar 2;282(9):6619-28. Epub 2007 Jan 3.
11. PPP1CC is associated with astrocyte and microglia proliferation after traumatic spinal cord injury in rats. Liu X, etal., Pathol Res Pract. 2017 Nov;213(11):1355-1364. doi: 10.1016/j.prp.2017.09.020. Epub 2017 Sep 28.
12. Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. McAvoy T, etal., Biochemistry. 1999 Sep 28;38(39):12943-9.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines. Ouimet CC, etal., Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3396-400.
16. Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1. Patel KG, etal., J Neurosci 2001 Oct 15;21(20):7954-68.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. Santos M, etal., PLoS One. 2013 Oct 7;8(10):e76788. doi: 10.1371/journal.pone.0076788. eCollection 2013.
21. Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas. Sasaki K, etal., Jpn J Cancer Res 1990 Dec;81(12):1272-80.
22. Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. Smith FD, etal., J Biol Chem 1999 Jul 9;274(28):19894-900.
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. Terry-Lorenzo RT, etal., J Biol Chem 2002 Aug 2;277(31):27716-24.
25. Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. Terry-Lorenzo RT, etal., J Biol Chem 2002 Nov 29;277(48):46535-43. Epub 2002 Sep 21.
26. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:1653777   PMID:2174876   PMID:9755872   PMID:10585469   PMID:10880350   PMID:11739654   PMID:12065664   PMID:12931191   PMID:14640981   PMID:15016827   PMID:15247246   PMID:15908465  
PMID:16629905   PMID:17369396   PMID:17936702   PMID:18372251   PMID:20124353   PMID:20516061   PMID:21423176   PMID:21630459   PMID:21700703   PMID:21712997   PMID:21930935   PMID:22681889  
PMID:22801782   PMID:23531501   PMID:23612982   PMID:23789093   PMID:24270157  


Genomics

Comparative Map Data
Ppp1cc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21234,383,072 - 34,400,553 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,383,072 - 34,400,553 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,555,467 - 35,572,955 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01236,166,698 - 36,184,182 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01235,219,154 - 35,236,638 (-)NCBIRnor_WKY
Rnor_6.01239,864,302 - 39,882,030 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,864,295 - 39,882,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,744,531 - 41,762,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,580,169 - 35,598,249 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,443,556 - 35,461,637 (-)NCBI
Celera1236,054,251 - 36,071,363 (-)NCBICelera
Cytogenetic Map12q16NCBI
PPP1CC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812110,708,376 - 110,742,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12110,719,680 - 110,742,939 (-)EnsemblGRCh38hg38GRCh38
GRCh3712111,157,485 - 111,180,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612109,642,127 - 109,665,050 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412109,620,463 - 109,643,387NCBI
Celera12110,784,396 - 110,807,538 (-)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12108,174,950 - 108,198,121 (-)NCBIHuRef
CHM1_112111,125,280 - 111,148,449 (-)NCBICHM1_1
T2T-CHM13v2.012110,697,385 - 110,720,600 (-)NCBIT2T-CHM13v2.0
Ppp1cc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,296,297 - 122,313,336 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,296,341 - 122,313,336 (+)EnsemblGRCm39 Ensembl
GRCm385122,154,967 - 122,175,273 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,158,278 - 122,175,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv375122,608,288 - 122,625,278 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365122,418,896 - 122,435,886 (+)NCBIMGSCv36mm8
Celera5119,247,786 - 119,264,874 (+)NCBICelera
Cytogenetic Map5FNCBI
Ppp1cc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,578,782 - 7,606,132 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,582,605 - 7,605,340 (-)NCBIChiLan1.0ChiLan1.0
PPP1CC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112111,682,248 - 111,705,658 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12111,681,611 - 111,705,658 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012108,288,158 - 108,311,128 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPP1CC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,497,350 - 8,518,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,495,067 - 8,518,675 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,661,768 - 8,681,361 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,755,953 - 8,777,439 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,755,955 - 8,778,039 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,715,062 - 8,734,635 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,777,244 - 8,796,945 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,730,033 - 8,749,642 (-)NCBIUU_Cfam_GSD_1.0
Ppp1cc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,827,747 - 155,847,632 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365583,631,794 - 3,651,754 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1CC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1432,070,545 - 32,091,499 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11432,071,472 - 32,091,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,994,041 - 34,013,840 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1CC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,962,182 - 105,986,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037139,130,369 - 139,154,783 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1cc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,191,150 - 21,213,544 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474721,191,165 - 21,212,521 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1cc
154 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:21
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000048851
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB740494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV727747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM102812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM122849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN803249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000048851   ⟹   ENSRNOP00000047912
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,383,072 - 34,400,553 (-)Ensembl
Rnor_6.0 Ensembl1239,864,302 - 39,882,030 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078761   ⟹   ENSRNOP00000071829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,383,072 - 34,400,553 (-)Ensembl
Rnor_6.0 Ensembl1239,864,302 - 39,882,030 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083296   ⟹   ENSRNOP00000069518
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,383,072 - 34,399,864 (-)Ensembl
Rnor_6.0 Ensembl1239,864,295 - 39,881,352 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094425   ⟹   ENSRNOP00000081567
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,383,072 - 34,390,345 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118479   ⟹   ENSRNOP00000076436
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,383,072 - 34,390,369 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119439   ⟹   ENSRNOP00000083502
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,383,072 - 34,390,076 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120201   ⟹   ENSRNOP00000089719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,383,072 - 34,391,103 (-)Ensembl
RefSeq Acc Id: NM_001270983   ⟹   NP_001257912
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21234,383,072 - 34,400,553 (-)NCBI
Rnor_6.01239,864,302 - 39,882,030 (-)NCBI
Rnor_5.01241,744,531 - 41,762,059 (-)NCBI
Celera1236,054,251 - 36,071,363 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022498   ⟹   NP_071943
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21234,383,072 - 34,400,553 (-)NCBI
Rnor_6.01239,864,302 - 39,882,030 (-)NCBI
Rnor_5.01241,744,531 - 41,762,059 (-)NCBI
RGSC_v3.41235,580,169 - 35,598,249 (-)RGD
Celera1236,054,251 - 36,071,363 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071943   ⟸   NM_022498
- Peptide Label: isoform 1
- UniProtKB: P63088 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257912   ⟸   NM_001270983
- Peptide Label: isoform 2
- UniProtKB: Q6AYZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069518   ⟸   ENSRNOT00000083296
RefSeq Acc Id: ENSRNOP00000047912   ⟸   ENSRNOT00000048851
RefSeq Acc Id: ENSRNOP00000071829   ⟸   ENSRNOT00000078761
RefSeq Acc Id: ENSRNOP00000081567   ⟸   ENSRNOT00000094425
RefSeq Acc Id: ENSRNOP00000083502   ⟸   ENSRNOT00000119439
RefSeq Acc Id: ENSRNOP00000076436   ⟸   ENSRNOT00000118479
RefSeq Acc Id: ENSRNOP00000089719   ⟸   ENSRNOT00000120201
Protein Domains
SER_THR_PHOSPHATASE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63088-F1-model_v2 AlphaFold P63088 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698651
Promoter ID:EPDNEW_R9176
Type:multiple initiation site
Name:Ppp1cc_1
Description:protein phosphatase 1 catalytic subunit gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01239,881,971 - 39,882,031EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3377 AgrOrtholog
BIND 130595
  130599
BioCyc Gene G2FUF-19237 BioCyc
Ensembl Genes ENSRNOG00000001269 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000047912 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000069518.1 UniProtKB/TrEMBL
  ENSRNOP00000071829 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000076436.1 UniProtKB/TrEMBL
  ENSRNOP00000081567.1 UniProtKB/TrEMBL
  ENSRNOP00000083502.1 UniProtKB/TrEMBL
  ENSRNOP00000089719.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048851 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000078761 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000083296.2 UniProtKB/TrEMBL
  ENSRNOT00000094425.1 UniProtKB/TrEMBL
  ENSRNOT00000118479.1 UniProtKB/TrEMBL
  ENSRNOT00000119439.1 UniProtKB/TrEMBL
  ENSRNOT00000120201.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112668 IMAGE-MGC_LOAD
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPP1CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STPPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24669 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93440 IMAGE-MGC_LOAD
NCBI Gene 24669 ENTREZGENE
PANTHER PTHR11668:SF204 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STPPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1cc PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PP2Ac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVK2_RAT UniProtKB/TrEMBL
  A0A8I5ZJ60_RAT UniProtKB/TrEMBL
  A0A8I5ZSW1_RAT UniProtKB/TrEMBL
  A0A8I5ZX24_RAT UniProtKB/TrEMBL
  A0A8I6ACH2_RAT UniProtKB/TrEMBL
  P63088 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6AYZ4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O09186 UniProtKB/Swiss-Prot
  O09189 UniProtKB/Swiss-Prot
  P37139 UniProtKB/Swiss-Prot
  Q64679 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppp1cc  protein phosphatase 1 catalytic subunit gamma  Ppp1cc  protein phosphatase 1, catalytic subunit, gamma isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ppp1cc  protein phosphatase 1, catalytic subunit, gamma isozyme  Ppp1cc  protein phosphatase 1, catalytic subunit, gamma isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppp1cc  Protein phosphatase 1, catalytic subunit, gamma isoform 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization recruited to the synapse by binding with neurabins, which are protein phosphatase-1 subunit targeting proteins 729440
gene_expression expressed in the dendrite spines, localized in PSD (post-synaptic density) 625568
gene_function phosphorylates receptors, ion channels, and signaling proteins 625568
gene_process interacts with neurabins to regulate synaptic activity 625568