Ppp1cc (protein phosphatase 1 catalytic subunit gamma)

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Gene: Ppp1cc (protein phosphatase 1 catalytic subunit gamma) Rattus norvegicus

Analyze

Symbol:

Ppp1cc

Name:

protein phosphatase 1 catalytic subunit gamma

RGD ID:

3377

Description:

Enables lamin binding activity; protein domain specific binding activity; and protein phosphatase 1 binding activity. Involved in positive regulation of glial cell proliferation. Acts upstream of or within neuron differentiation. Located in dendritic spine. Is active in glutamatergic synapse; postsynapse; and presynapse. Biomarker of congestive heart failure. Orthologous to human PPP1CC (protein phosphatase 1 catalytic subunit gamma); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; dopamine signaling pathway; glycogen biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium acetate; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

PP-1G; Ppp1cc1; protein phosphatase 1 catalytic subunit gamma isoform; protein phosphatase 1 catalytic subunit gamma isoform 1; Protein phosphatase 1 catalytic subunit gamma isoform 1 (possible existence of an alternative gene product Ppp1cc2); protein phosphatase 1, catalytic subunit, gamma isoform; protein phosphatase 1, catalytic subunit, gamma isozyme; protein phosphatase 1C catalytic subunit; protein serine-threonine phosphatase catalytic subunit PP-1b; serine/threonine-protein phosphatase PP1-gamma catalytic subunit

RGD Orthologs

Alliance Genes

More Info

more info ...

Candidate Gene For:

Lnnr1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	34,383,072 - 34,400,553 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	34,383,072 - 34,400,553 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	35,555,467 - 35,572,955 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	36,166,698 - 36,184,182 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	35,219,154 - 35,236,638 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	39,864,302 - 39,882,030 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	39,864,295 - 39,882,030 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	41,744,531 - 41,762,059 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	35,580,169 - 35,598,249 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	35,443,556 - 35,461,637 (-)	NCBI
Celera	12	36,054,251 - 36,071,363 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congestive heart failure (IEP)

genetic disease (ISO)

Ovarian Neoplasms (ISO)

Spinal Cord Injuries (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

all-trans-retinoic acid (ISO)

ammonium acetate (EXP)

ammonium chloride (EXP)

ampicillin (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

calyculin a (ISO)

cannabidiol (EXP)

carbon nanotube (ISO)

clofibric acid (EXP)

clozapine (EXP)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyproconazole (ISO)

deguelin (ISO)

dextran sulfate (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenvalerate (EXP)

gentamycin (EXP)

haloperidol (EXP)

hydrogen peroxide (ISO)

inulin (ISO)

ivermectin (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

metronidazole (EXP)

microcystin-LR (EXP)

N-methyl-4-phenylpyridinium (ISO)

neomycin (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

pyrimidifen (ISO)

resveratrol (ISO)

roflumilast (EXP)

rotenone (EXP,ISO)

salubrinal (ISO)

sodium azide (EXP)

Tautomycin (EXP,ISO)

trichloroethene (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blastocyst development (ISO)

cell division (IEA)

circadian regulation of gene expression (ISO,ISS)

entrainment of circadian clock by photoperiod (ISO,ISS)

glycogen metabolic process (IEA)

neuron differentiation (IDA)

positive regulation of glial cell proliferation (IMP)

regulation of circadian rhythm (ISO,ISS)

regulation of nucleocytoplasmic transport (ISO)

rhythmic process (IEA)

spermatogenesis (ISO)

Cellular Component

chromosome, telomeric region (ISO)

cleavage furrow (IEA)

cytoplasm (IBA,ISO)

cytosol (TAS)

dendritic spine (IDA)

glutamatergic synapse (IDA)

kinetochore (IEA)

microtubule organizing center (IEA)

midbody (IEA)

mitochondrial outer membrane (ISO)

mitochondrion (ISO,ISS)

nuclear speck (IEA)

nucleolus (IEA,ISO)

nucleoplasm (IEA)

nucleus (IBA,ISO)

postsynapse (IDA)

presynapse (IDA)

protein-containing complex (ISO)

PTW/PP1 phosphatase complex (ISO,ISS)

Molecular Function

lamin binding (IPI)

metal ion binding (IEA)

myosin phosphatase activity (IEA)

phosphatase activity (ISO,ISS)

phosphoprotein phosphatase activity (IEA)

protein binding (IPI,ISO)

protein domain specific binding (IMP,IPI)

protein kinase binding (ISO)

protein phosphatase 1 binding (IPI)

protein phosphatase binding (IDA)

protein serine/threonine phosphatase activity (IBA,ISO,ISS,TAS)

protein-containing complex binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calmodulin dependent kinase 2 signaling pathway (ISO)

dopamine signaling pathway (ISO)

glycogen biosynthetic pathway (ISO)

glycogen degradation pathway (ISO)

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

insulin signaling pathway (IEA)

long term potentiation (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines.	Allen PB, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9956-61.
2.	Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.	Burén S, etal., Cancer Cell. 2016 Aug 8;30(2):290-307. doi: 10.1016/j.ccell.2016.06.023.
3.	Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin.	Carmody LC, etal., FASEB J. 2008 Jun;22(6):1660-71. doi: 10.1096/fj.07-092841. Epub 2008 Jan 23.
4.	Functional diversity of protein phosphatase-1, a cellular economizer and reset button.	Ceulemans H and Bollen M, Physiol Rev. 2004 Jan;84(1):1-39.
5.	Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance.	Cid C, etal., Proteomics. 2007 Sep;7(17):3207-18.
6.	Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences.	Croci C, etal., J Biol Chem. 2003 Dec 12;278(50):50682-90. Epub 2003 Sep 30.
7.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8.	Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman.	Hafver TL, etal., J Biol Chem. 2016 Feb 26;291(9):4561-79. doi: 10.1074/jbc.M115.677898. Epub 2015 Dec 14.
9.	Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases.	Ishida A, etal., Br J Pharmacol. 2008 Jun;154(4):729-40. doi: 10.1038/bjp.2008.127. Epub 2008 May 5.
10.	Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.	Li T, etal., J Biol Chem. 2007 Mar 2;282(9):6619-28. Epub 2007 Jan 3.
11.	PPP1CC is associated with astrocyte and microglia proliferation after traumatic spinal cord injury in rats.	Liu X, etal., Pathol Res Pract. 2017 Nov;213(11):1355-1364. doi: 10.1016/j.prp.2017.09.020. Epub 2017 Sep 28.
12.	Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation.	McAvoy T, etal., Biochemistry. 1999 Sep 28;38(39):12943-9.
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines.	Ouimet CC, etal., Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3396-400.
16.	Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.	Patel KG, etal., J Neurosci 2001 Oct 15;21(20):7954-68.
17.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
18.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.	Santos M, etal., PLoS One. 2013 Oct 7;8(10):e76788. doi: 10.1371/journal.pone.0076788. eCollection 2013.
21.	Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas.	Sasaki K, etal., Jpn J Cancer Res 1990 Dec;81(12):1272-80.
22.	Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein.	Smith FD, etal., J Biol Chem 1999 Jul 9;274(28):19894-900.
23.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24.	The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.	Terry-Lorenzo RT, etal., J Biol Chem 2002 Aug 2;277(31):27716-24.
25.	Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton.	Terry-Lorenzo RT, etal., J Biol Chem 2002 Nov 29;277(48):46535-43. Epub 2002 Sep 21.
26.	DARPP-32, Jack of All Trades... Master of Which?	Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.

Additional References at PubMed

PMID:1653777	PMID:2174876	PMID:9755872	PMID:10585469	PMID:10880350	PMID:11739654	PMID:12065664	PMID:12931191	PMID:14640981	PMID:15016827	PMID:15247246	PMID:15908465
PMID:16629905	PMID:17369396	PMID:17936702	PMID:18372251	PMID:20124353	PMID:20516061	PMID:21423176	PMID:21630459	PMID:21700703	PMID:21712997	PMID:21930935	PMID:22681889
PMID:22801782	PMID:23531501	PMID:23612982	PMID:23789093	PMID:24270157

Genomics

Comparative Map Data

Ppp1cc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	34,383,072 - 34,400,553 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	34,383,072 - 34,400,553 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	35,555,467 - 35,572,955 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	36,166,698 - 36,184,182 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	35,219,154 - 35,236,638 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	39,864,302 - 39,882,030 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	39,864,295 - 39,882,030 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	41,744,531 - 41,762,059 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	35,580,169 - 35,598,249 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	35,443,556 - 35,461,637 (-)	NCBI
Celera	12	36,054,251 - 36,071,363 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

PPP1CC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	110,708,376 - 110,742,891 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	110,719,680 - 110,742,939 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	111,157,485 - 111,180,696 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	109,642,127 - 109,665,050 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	109,620,463 - 109,643,387	NCBI
Celera	12	110,784,396 - 110,807,538 (-)	NCBI		Celera
Cytogenetic Map	12	q24.11	NCBI
HuRef	12	108,174,950 - 108,198,121 (-)	NCBI		HuRef
CHM1_1	12	111,125,280 - 111,148,449 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	110,686,068 - 110,720,600 (-)	NCBI		T2T-CHM13v2.0

Ppp1cc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	122,296,297 - 122,313,336 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	122,296,341 - 122,313,336 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	122,154,967 - 122,175,273 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	122,158,278 - 122,175,273 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	122,608,288 - 122,625,278 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	122,418,896 - 122,435,886 (+)	NCBI		MGSCv36	mm8
Celera	5	119,247,786 - 119,264,874 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	62.2	NCBI

Ppp1cc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	7,578,782 - 7,606,132 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	7,582,605 - 7,605,340 (-)	NCBI	ChiLan1.0	ChiLan1.0

PPP1CC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	118,775,480 - 118,798,509 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	108,288,158 - 108,311,128 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	111,682,248 - 111,705,658 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	111,681,611 - 111,705,658 (-)	Ensembl	panpan1.1		panPan2

PPP1CC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	8,497,350 - 8,518,467 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	8,495,067 - 8,518,675 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	8,661,768 - 8,681,361 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	8,755,953 - 8,777,439 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	8,755,955 - 8,778,039 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	8,715,062 - 8,734,635 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	8,777,244 - 8,796,945 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	8,730,033 - 8,749,642 (-)	NCBI		UU_Cfam_GSD_1.0

Ppp1cc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	155,827,747 - 155,847,632 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	3,630,561 - 3,651,786 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936558	3,631,794 - 3,651,754 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPP1CC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	32,070,545 - 32,091,499 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	32,071,472 - 32,091,267 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	33,994,041 - 34,013,840 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPP1CC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	105,962,182 - 105,986,114 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	139,130,369 - 139,154,783 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppp1cc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	21,191,150 - 21,213,544 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	21,191,165 - 21,212,521 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ppp1cc
154 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	25
Count of miRNA genes:	21
Interacting mature miRNAs:	23
Transcripts:	ENSRNOT00000048851
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
737822	Alc10	Alcohol consumption QTL 10	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	19610870	40218516	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610889	35682913	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	19835789	38193007	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	24139202	36638073	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	28064433	40130419	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	28064433	45899022	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	28064433	46669029	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	28064557	40218380	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	28607526	37691617	Rat
1300162	Bp188	Blood pressure QTL 188	3.19		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	32103174	45899022	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001270983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB740494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D90165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D90166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DV727747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM102812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM122849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FN803249	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228186	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M58435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000048851 ⟹ ENSRNOP00000047912

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	34,383,072 - 34,400,553 (-)	Ensembl
Rnor_6.0 Ensembl	12	39,864,302 - 39,882,030 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000078761 ⟹ ENSRNOP00000071829

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	34,383,072 - 34,400,553 (-)	Ensembl
Rnor_6.0 Ensembl	12	39,864,302 - 39,882,030 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083296 ⟹ ENSRNOP00000069518

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	34,383,072 - 34,399,864 (-)	Ensembl
Rnor_6.0 Ensembl	12	39,864,295 - 39,881,352 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094425 ⟹ ENSRNOP00000081567

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	34,383,072 - 34,390,345 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118479 ⟹ ENSRNOP00000076436

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	34,383,072 - 34,390,369 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119439 ⟹ ENSRNOP00000083502

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	34,383,072 - 34,390,076 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000120201 ⟹ ENSRNOP00000089719

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	34,383,072 - 34,391,103 (-)	Ensembl

RefSeq Acc Id:

NM_001270983 ⟹ NP_001257912

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	34,383,072 - 34,400,553 (-)	NCBI
Rnor_6.0	12	39,864,302 - 39,882,030 (-)	NCBI
Rnor_5.0	12	41,744,531 - 41,762,059 (-)	NCBI
Celera	12	36,054,251 - 36,071,363 (-)	NCBI

Sequence:

show sequence

CGCGCGCATCCGTGCGCCGCCCGAGGCTGGCCTGAGGAGTCGGCGGCCATTTTGTTCTTCTCGT
GGTTCCAGTGGCGAGAGGAGGAGGAAGCCGGGAGCGGGGCGGCTGGGGGGGGGACCCGCCGCGG
CTGCTGCTGCCACCGCCGCCGCCACCACCGCTCGTGGGGCTCGTGGCGTGAAGAAGGAGGACGA
GTGAGACCCGGGCGCGAGCCGGCGGCGGCGCCGCTGCGGGAGGGTCGGCGGCGGGACGGCGATG
GCGGATATCGATAAACTCAACATCGACAGTATCATCCAACGGCTGCTGGAAGTGAGAGGGTCCA
AGCCAGGCAAGAATGTCCAGCTCCAGGAGAATGAAATCCGGGGACTGTGCTTGAAGTCTCGGGA
GATCTTCCTCAGTCAGCCTATCCTTTTAGAACTTGAAGCACCACTCAAGATATGTGGTGACATC
CACGGGCAGTACTATGATTTGCTCCGTCTGTTTGAATACGGTGGCTTTCCTCCAGAAAGCAACT
ATTTGTTTCTCGGGGACTATGTGGACAGGGGCAAACAGTCACTAGAGACGATCTGCCTCTTGCT
GGCCTACAAAATCAAGTATCCGGAGAACTTTTTTCTTCTTAGAGGGAACCATGAGTGTGCCAGC
ATCAATAGAATCTACGGATTTTATGATGAGTGTAAGAGAAGATACAACATTAAGCTGTGGAAAA
CGTTCACAGACTGTTTTAACTGCTTACCGATAGCAGCCATCGTGGACGAGAAGATATTCTGCTG
TCATGGAGGTTTATCACCAGATCTTCAATCTATGGAGCAGATTCGGCGAATTATGAGACCAACT
GATGTACCAGATCAAGGTCTTCTTTGTGATCTTTTGTGGTCTGACCCCGATAAAGATGTCTTAG
GCTGGGGTGAAAATGACAGAGGAGTGTCCTTCACATTTGGTGCAGAAGTGGTTGCAAAATTTCT
CCATAAGCATGATTTGGATCTTATATGTAGAGCCCATCAGGTGGTTGAAGATGGATATGAGTTT
TTTGCAAAGAGGCAGTTAGTCACTCTGTTTTCTGCACCCAACTACTGTGGCGAGTTTGACAATG
CGGGCGCCATGATGAGTGTGGATGAGACCCTCATGTGCTCCTTCCAGATTTTAAAGCCTGCAGA
GAAAAAGAAGCCCAATGCCACGAGACCTGTCACACCGCCACGGGTTGGATCAGGCCTGAACCCG
TCCATTCAGAAAGCTTCAAATTATAGAAACAACACTGTCCTATACGAGTGATCGATAATGCTTT
CTTTGGCTACATTCTTTATTCTGCGGTGACATTGAGGCTTATAAATCAAAAGGAACTAACTTGC
CGTCCACCGGTTTATACAGAACTCACAGTATCTATGACTTTTTTAAACTACGACCTGTTAAAAT
GAATCTGTTTCCACAGATGCCCGTGTACAATGCCATGTGCTAAGAATGATTTCAGACTTATTAA
ATGCGAGCTTGTTAACCTGTC

hide sequence

RefSeq Acc Id:

NM_022498 ⟹ NP_071943

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	12	34,383,072 - 34,400,553 (-)	NCBI
Rnor_6.0	12	39,864,302 - 39,882,030 (-)	NCBI
Rnor_5.0	12	41,744,531 - 41,762,059 (-)	NCBI
RGSC_v3.4	12	35,580,169 - 35,598,249 (-)	RGD
Celera	12	36,054,251 - 36,071,363 (-)	NCBI

Sequence:

show sequence

CGCGCGCATCCGTGCGCCGCCCGAGGCTGGCCTGAGGAGTCGGCGGCCATTTTGTTCTTCTCGT
GGTTCCAGTGGCGAGAGGAGGAGGAAGCCGGGAGCGGGGCGGCTGGGGGGGGGACCCGCCGCGG
CTGCTGCTGCCACCGCCGCCGCCACCACCGCTCGTGGGGCTCGTGGCGTGAAGAAGGAGGACGA
GTGAGACCCGGGCGCGAGCCGGCGGCGGCGCCGCTGCGGGAGGGTCGGCGGCGGGACGGCGATG
GCGGATATCGATAAACTCAACATCGACAGTATCATCCAACGGCTGCTGGAAGTGAGAGGGTCCA
AGCCAGGCAAGAATGTCCAGCTCCAGGAGAATGAAATCCGGGGACTGTGCTTGAAGTCTCGGGA
GATCTTCCTCAGTCAGCCTATCCTTTTAGAACTTGAAGCACCACTCAAGATATGTGGTGACATC
CACGGGCAGTACTATGATTTGCTCCGTCTGTTTGAATACGGTGGCTTTCCTCCAGAAAGCAACT
ATTTGTTTCTCGGGGACTATGTGGACAGGGGCAAACAGTCACTAGAGACGATCTGCCTCTTGCT
GGCCTACAAAATCAAGTATCCGGAGAACTTTTTTCTTCTTAGAGGGAACCATGAGTGTGCCAGC
ATCAATAGAATCTACGGATTTTATGATGAGTGTAAGAGAAGATACAACATTAAGCTGTGGAAAA
CGTTCACAGACTGTTTTAACTGCTTACCGATAGCAGCCATCGTGGACGAGAAGATATTCTGCTG
TCATGGAGGTTTATCACCAGATCTTCAATCTATGGAGCAGATTCGGCGAATTATGAGACCAACT
GATGTACCAGATCAAGGTCTTCTTTGTGATCTTTTGTGGTCTGACCCCGATAAAGATGTCTTAG
GCTGGGGTGAAAATGACAGAGGAGTGTCCTTCACATTTGGTGCAGAAGTGGTTGCAAAATTTCT
CCATAAGCATGATTTGGATCTTATATGTAGAGCCCATCAGGTGGTTGAAGATGGATATGAGTTT
TTTGCAAAGAGGCAGTTAGTCACTCTGTTTTCTGCACCCAACTACTGTGGCGAGTTTGACAATG
CGGGCGCCATGATGAGTGTGGATGAGACCCTCATGTGCTCCTTCCAGATTTTAAAGCCTGCAGA
GAAAAAGAAGCCCAATGCCACGAGACCTGTCACACCGCCACGGGGTATGATCACAAAGCAAGCA
AAGAAATAGATGTCACTTGACACTGCCTAGTGGGACTTGTAACATAGCGTACATAACCTTCCTT
TTTAAACTGTGATGTGTGCTGGTCAGCTTGCCCAGGTAGACCTGTCGGGCCCTCCCTTCTCCAT
TTTGATTATTGCTGGCACTTGCTGGTTATAGCAGCAAGTGAAGCATTTCATTCTCAAGAAAGCG
GTTTGTTTTGTTTGTTTTTAACCTCTGTTCCCTTTGTGGACAGCTCTGATGATGGTGTTAAGCT
GTACACCTTGGCAGTTTATCCTGTCCGAGGGGAAAGTGTACAATTGATCTTTTTTTTTAAATTT
AGTATGAATCATGAATAATGTAAATGCTTGTTTTCTTTAGGATATAAAGAGAGCCCTAGGGTGC
GTGAGTCTGTACATGTAATTGTCATAAATGCATTCTGTTGATACAAACCACTGTGAACAGTTTT
TCCAAGTTTGTTTGACAGGGACTGCTTTCCCTCACTGTCTCATCCTGTACAAACTAGTGTCTGC
AGCTGTGGCAGCAGGAGCAACCTGCCACCCTGCCACCCACACTGCCCAGGCTGTCTGAAGCACA
CTCCCTCCCACTGCACACTTAACTGACGATTAAAGCCATTCTTTTCAATGTCTGTGATTCCTTC
CTAAAGCCAAAGTTTCTGTTGGACTGTATTGGCACACCCTGGACATGAGGTGGCCAGGGCACCA
AGGCTGCGTGCACAGGCCGCCTCCGTGGGGACTCAGAAAGAAGCAGGTTATTTTAACTAGCAAT
AGTGATGTAGTGCTGGGTAAGCTATTAATGGTGGAAGTTAATGAGACATTGTACAGTGCCCATA
TAGTCTATTCACTGAGTAATCTTTTTACAGTTGGATCAGGCCTGAACCCGTCCATTCAGAAAGC
TTCAAATTATAGAAACAACACTGTCCTATACGAGTGATCGATAATGCTTTCTTTGGCTACATTC
TTTATTCTGCGGTGACATTGAGGCTTATAAATCAAAAGGAACTAACTTGCCGTCCACCGGTTTA
TACAGAACTCACAGTATCTATGACTTTTTTAAACTACGACCTGTTAAAATGAATCTGTTTCCAC
AGATGCCCGTGTACAATGCCATGTGCTAAGAATGATTTCAGACTTATTAAATGCGAGCTTGTTA
ACCTGTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001257912	(Get FASTA)	NCBI Sequence Viewer
	NP_071943	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41906	(Get FASTA)	NCBI Sequence Viewer
	AAH78825	(Get FASTA)	NCBI Sequence Viewer
	BAA14196	(Get FASTA)	NCBI Sequence Viewer
	BAA14197	(Get FASTA)	NCBI Sequence Viewer
	EDM13704	(Get FASTA)	NCBI Sequence Viewer
	EDM13706	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000047912
	ENSRNOP00000069518.1
	ENSRNOP00000071829
	ENSRNOP00000076436.1
	ENSRNOP00000081567.1
	ENSRNOP00000083502.1
	ENSRNOP00000089719.1
GenBank Protein	P63088	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_071943 ⟸ NM_022498
- Peptide Label:	isoform 1
- UniProtKB:	P63088 (UniProtKB/Swiss-Prot), A6J1B7 (UniProtKB/TrEMBL), A0A8I5ZJ60 (UniProtKB/TrEMBL)
- Sequence:	show sequence MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGD IHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA SINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRP TDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYE FFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQ AKK hide sequence

RefSeq Acc Id:	NP_001257912 ⟸ NM_001270983
- Peptide Label:	isoform 2
- UniProtKB:	Q6AYZ4 (UniProtKB/TrEMBL), A0A0G2JVK2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGD IHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA SINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRP TDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYE FFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRVGSGLN PSIQKASNYRNNTVLYE hide sequence

RefSeq Acc Id:

ENSRNOP00000069518 ⟸ ENSRNOT00000083296

RefSeq Acc Id:

ENSRNOP00000047912 ⟸ ENSRNOT00000048851

RefSeq Acc Id:

ENSRNOP00000071829 ⟸ ENSRNOT00000078761

RefSeq Acc Id:

ENSRNOP00000081567 ⟸ ENSRNOT00000094425

RefSeq Acc Id:

ENSRNOP00000083502 ⟸ ENSRNOT00000119439

RefSeq Acc Id:

ENSRNOP00000076436 ⟸ ENSRNOT00000118479

RefSeq Acc Id:

ENSRNOP00000089719 ⟸ ENSRNOT00000120201

Protein Domains

Serine/threonine specific protein phosphatases

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P63088-F1-model_v2	AlphaFold	P63088	1-323	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698651

Promoter ID:

EPDNEW_R9176

Type:

multiple initiation site

Name:

Ppp1cc_1

Description:

protein phosphatase 1 catalytic subunit gamma

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	39,881,971 - 39,882,031	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3377	AgrOrtholog
BIND	130595
	130599
BioCyc Gene	G2FUF-19237	BioCyc
Ensembl Genes	ENSRNOG00000001269	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000048851	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000078761	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000083296.2	UniProtKB/TrEMBL
	ENSRNOT00000094425.1	UniProtKB/TrEMBL
	ENSRNOT00000118479.1	UniProtKB/TrEMBL
	ENSRNOT00000119439.1	UniProtKB/TrEMBL
	ENSRNOT00000120201.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.21.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7112668	IMAGE-MGC_LOAD
InterPro	Calcineurin-like_PHP_ApaH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Metallo-depent_PP-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr-sp_prot-phosphatase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	STPPase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24669	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93440	IMAGE-MGC_LOAD
NCBI Gene	24669	ENTREZGENE
PANTHER	PTHR11668:SF204	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SERINE/THREONINE PROTEIN PHOSPHATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Metallophos	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	STPPase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ppp1cc	PhenoGen
PRINTS	STPHPHTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	SER_THR_PHOSPHATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001269	RatGTEx
SMART	PP2Ac	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JVK2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZJ60	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZSW1_RAT	UniProtKB/TrEMBL
	A0A8I5ZX24_RAT	UniProtKB/TrEMBL
	A0A8I6ACH2_RAT	UniProtKB/TrEMBL
	A6J1B7	ENTREZGENE, UniProtKB/TrEMBL
	P63088	ENTREZGENE, UniProtKB/Swiss-Prot
	Q6AYZ4	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	O09186	UniProtKB/Swiss-Prot
	O09189	UniProtKB/Swiss-Prot
	P37139	UniProtKB/Swiss-Prot
	Q64679	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Ppp1cc	protein phosphatase 1 catalytic subunit gamma	Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isozyme	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-02	Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isozyme	Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Ppp1cc	Protein phosphatase 1, catalytic subunit, gamma isoform 1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	recruited to the synapse by binding with neurabins, which are protein phosphatase-1 subunit targeting proteins	729440
gene_expression	expressed in the dendrite spines, localized in PSD (post-synaptic density)	625568
gene_function	phosphorylates receptors, ion channels, and signaling proteins	625568
gene_process	interacts with neurabins to regulate synaptic activity	625568

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)