Gene: Slc8a1 (solute carrier family 8 member A1) Rattus norvegicus
Analyze
Symbol:
Slc8a1
Name:
solute carrier family 8 member A1
RGD ID:
3717
Description:
Exhibits calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration; calcium:sodium antiporter activity; and ion antiporter activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including metal ion transport; regulation of heart contraction; and response to purine-containing compound. Localizes to several cellular components, including T-tubule; Z disc; and dendrite. Used to study brain ischemia. Biomarker of brain ischemia; congestive heart failure; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-noradrenaline; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 17alpha-ethynylestradiol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
na(+)/Ca(2+)-exchange protein 1; Na-Ca exchanger; Ncx; Ncx1; sodium/calcium exchanger 1; solute carrier family 8 (sodium/calcium exchanger) member 1; solute carrier family 8 (sodium/calcium exchanger), member 1; solute carrier family 8 member 1; solute carrier family 8, member 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SLC8A1 (solute carrier family 8 member A1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Slc8a1 (solute carrier family 8 (sodium/calcium exchanger), member 1) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Slc8a1 (solute carrier family 8 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SLC8A1 (solute carrier family 8 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SLC8A1 (solute carrier family 8 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Slc8a1 (solute carrier family 8 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SLC8A1 (solute carrier family 8 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
SLC8A1 (solute carrier family 8 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Slc8a1 (solute carrier family 8 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SLC8A2 (solute carrier family 8 member A2) HGNC
OrthoDB, OrthoMCL
Homo sapiens (human):
SLC8A3 (solute carrier family 8 member A3) HGNC
OrthoDB, OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
SLC8A1 (solute carrier family 8 member A1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Slc8a1 (solute carrier family 8 (sodium/calcium exchanger), member 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
slc8a1b (solute carrier family 8 member 1b)
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
ncx-1
Alliance
DIOPT (Hieranoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
Calx
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
ncx-2
Alliance
DIOPT (InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 4,244,076 - 4,564,262 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 4,258,991 - 4,520,604 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 6 4,208,126 - 4,495,690 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 4,421,046 - 4,691,716 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 4,421,045 - 4,691,719 (-) NCBI Celera 6 12,962,979 - 13,227,191 (+) NCBI Celera Cytogenetic Map 6 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Neurodevelopmental Disorders ISO RGD:731021 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868
Imported Annotations - CTD
megacolon ISO RGD:731021 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15185227 , PMID:17560225 Myocardial Ischemia ISO RGD:731021 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16214533 Myocardial Reperfusion Injury ISO RGD:731021 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15215644 status epilepticus ISO RGD:731021 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20888801 visual epilepsy ISO RGD:731021 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20888801
(R)-noradrenaline increases expression EXP 6480464 Norepinephrine results in increased expression of SLC8A1 mRNA, Norepinephrine results in increased expression of SLC8A1 protein CTD PMID:11179087 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactions ISO RGD:731022 6480464 [o, p'-DDT co-treated with DDT] results in increased expression of SLC8A1 mRNA CTD PMID:27325568 1,1-dichloroethene decreases expression ISO RGD:731022 6480464 vinylidene chloride results in decreased expression of SLC8A1 mRNA CTD PMID:26682919 1,2-dimethylhydrazine affects expression ISO RGD:731022 6480464 1, 2-Dimethylhydrazine affects the expression of SLC8A1 mRNA CTD PMID:22206623 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine multiple interactions EXP 6480464 Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of SLC8A1 mRNA] CTD PMID:25937560 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of SLC8A1 mRNA CTD PMID:20170705 , PMID:26865667 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of SLC8A1 mRNA CTD PMID:29097150 17beta-estradiol increases expression ISO RGD:731021 6480464 Estradiol results in increased expression of SLC8A1 mRNA CTD PMID:21795739 17beta-estradiol increases expression ISO RGD:731022 6480464 Estradiol results in increased expression of SLC8A1 protein CTD PMID:30061528 17beta-estradiol decreases expression ISO RGD:731022 6480464 Estradiol results in decreased expression of SLC8A1 mRNA CTD PMID:30061528 17beta-estradiol multiple interactions ISO RGD:731021 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of SLC8A1 mRNA, Progesterone inhibits the reaction [Estradiol results in increased expression of SLC8A1 mRNA] CTD PMID:21795739 , PMID:30165855 17beta-estradiol 3-benzoate increases methylation EXP 6480464 estradiol 3-benzoate results in increased methylation of SLC8A1 promoter CTD PMID:27415467 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:731022 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:731022 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731022 6480464 Tetrachlorodibenzodioxin affects the expression of SLC8A1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SLC8A1 mRNA CTD PMID:32109520 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2 more ... CTD PMID:32109520 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:731022 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of SLC8A1 mRNA CTD PMID:26251327 3-phenylprop-2-enal increases expression ISO RGD:731021 6480464 cinnamic aldehyde results in increased expression of SLC8A1 mRNA CTD PMID:19524605 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of SLC8A1 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of SLC8A1 mRNA CTD PMID:30723492 4,4'-sulfonyldiphenol increases expression ISO RGD:731022 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of SLC8A1 mRNA CTD PMID:30951980 4-tert-Octylphenol decreases expression ISO RGD:731022 6480464 4-tert-octylphenol results in decreased expression of SLC8A1 mRNA CTD PMID:30061528 acetamide increases expression EXP 6480464 acetamide results in increased expression of SLC8A1 mRNA CTD PMID:31881176 aflatoxin B1 decreases methylation ISO RGD:731021 6480464 Aflatoxin B1 results in decreased methylation of SLC8A1 gene CTD PMID:27153756 aldehydo-D-glucose multiple interactions EXP 6480464 [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein] which results in increased expression of SLC8A1 mRNA more ... CTD PMID:21293012 amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of SLC8A1 protein CTD PMID:12479229 , PMID:7573397 antirheumatic drug decreases expression ISO RGD:731021 6480464 Antirheumatic Agents results in decreased expression of SLC8A1 mRNA CTD PMID:24449571 Aroclor 1254 multiple interactions ISO RGD:731021 6480464 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)], Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)] CTD PMID:16009740 Aroclor 1254 increases response to substance ISO RGD:731021 6480464 SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine) CTD PMID:16009740 arsane affects methylation ISO RGD:731021 6480464 Arsenic affects the methylation of SLC8A1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:731021 6480464 Arsenic affects the methylation of SLC8A1 gene CTD PMID:25304211 aspartame multiple interactions ISO RGD:731022 6480464 [Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA, [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA CTD PMID:23783067 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of SLC8A1 gene CTD PMID:28931070 barium(0) affects transport ISO RGD:731022 6480464 SLC8A1 protein affects the transport of Barium CTD PMID:17560225 benzo[a]pyrene decreases expression ISO RGD:731021 6480464 Benzo(a)pyrene results in decreased expression of SLC8A1 mRNA CTD PMID:20064835 benzo[a]pyrene decreases methylation ISO RGD:731022 6480464 Benzo(a)pyrene results in decreased methylation of SLC8A1 exon, Benzo(a)pyrene results in decreased methylation of SLC8A1 intron CTD PMID:27901495 benzo[a]pyrene affects methylation ISO RGD:731021 6480464 Benzo(a)pyrene affects the methylation of SLC8A1 5' UTR, Benzo(a)pyrene affects the methylation of SLC8A1 promoter CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO RGD:731022 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC8A1 mRNA CTD PMID:27858113 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:731021 6480464 7 more ... CTD PMID:20382639 benzo[b]fluoranthene multiple interactions ISO RGD:731022 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC8A1 mRNA CTD PMID:27858113 benzo[e]pyrene decreases methylation ISO RGD:731021 6480464 benzo(e)pyrene results in decreased methylation of SLC8A1 intron CTD PMID:30157460 bepridil multiple interactions ISO RGD:731021 6480464 Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)] CTD PMID:16009740 bisphenol A affects expression ISO RGD:731021 6480464 bisphenol A affects the expression of SLC8A1 mRNA CTD PMID:20170705 bisphenol A decreases expression ISO RGD:731022 6480464 bisphenol A results in decreased expression of SLC8A1 mRNA CTD PMID:30061528 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SLC8A1 mRNA CTD PMID:30816183 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SLC8A1 mRNA CTD PMID:29097150 bisphenol A decreases expression ISO RGD:731021 6480464 bisphenol A results in decreased expression of SLC8A1 mRNA CTD PMID:27685785 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of SLC8A1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:731022 6480464 bisphenol A results in increased expression of SLC8A1 protein CTD PMID:23418087 bisphenol F increases expression ISO RGD:731022 6480464 bisphenol F results in increased expression of SLC8A1 mRNA CTD PMID:30951980 butanal increases expression ISO RGD:731021 6480464 butyraldehyde results in increased expression of SLC8A1 mRNA CTD PMID:26079696 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of SLC8A1 mRNA CTD PMID:19167457 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of SLC8A1 promoter CTD PMID:22457795 calcitriol increases expression ISO RGD:731022 6480464 Calcitriol results in increased expression of SLC8A1 mRNA CTD PMID:16857747 calcium atom multiple interactions EXP 6480464 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium] CTD PMID:18822394 calcium atom multiple interactions ISO RGD:731021 6480464 Calcium inhibits the reaction [SLC8A1 protein results in increased uptake of Nickel] CTD PMID:10329968 calcium atom multiple interactions ISO RGD:731022 6480464 PPP3R1 gene mutant form inhibits the reaction [SLC8A1 protein affects the transport of Calcium] CTD PMID:19700627 calcium atom increases transport EXP 6480464 SLC8A1 protein results in increased transport of Calcium CTD PMID:18822394 calcium(0) increases transport EXP 6480464 SLC8A1 protein results in increased transport of Calcium CTD PMID:18822394 calcium(0) multiple interactions EXP 6480464 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium] CTD PMID:18822394 calcium(0) multiple interactions ISO RGD:731021 6480464 Calcium inhibits the reaction [SLC8A1 protein results in increased uptake of Nickel] CTD PMID:10329968 calcium(0) multiple interactions ISO RGD:731022 6480464 PPP3R1 gene mutant form inhibits the reaction [SLC8A1 protein affects the transport of Calcium] CTD PMID:19700627 cefaloridine decreases expression EXP 6480464 Cephaloridine results in decreased expression of SLC8A1 mRNA CTD PMID:18500788 chrysene multiple interactions ISO RGD:731022 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC8A1 mRNA CTD PMID:27858113 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of SLC8A1 mRNA, cobaltous chloride results in increased expression of SLC8A1 protein CTD PMID:21293012 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of SLC8A1 mRNA, Copper results in increased expression of SLC8A1 mRNA CTD PMID:26033743 , PMID:30556269 copper atom multiple interactions ISO RGD:731021 6480464 [NSC 689534 binds to Copper] which results in decreased expression of SLC8A1 mRNA CTD PMID:20971185 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of SLC8A1 mRNA, Copper results in increased expression of SLC8A1 mRNA CTD PMID:26033743 , PMID:30556269 copper(0) multiple interactions ISO RGD:731021 6480464 [NSC 689534 binds to Copper] which results in decreased expression of SLC8A1 mRNA CTD PMID:20971185 D-glucose multiple interactions EXP 6480464 [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein] which results in increased expression of SLC8A1 mRNA more ... CTD PMID:21293012 DDT multiple interactions ISO RGD:731022 6480464 [o, p'-DDT co-treated with DDT] results in increased expression of SLC8A1 mRNA CTD PMID:27325568 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of SLC8A1 mRNA CTD PMID:23640034 dextran sulfate multiple interactions ISO RGD:731022 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC8A1 mRNA CTD PMID:29950665 dichloroacetic acid decreases expression ISO RGD:731022 6480464 Dichloroacetic Acid results in decreased expression of SLC8A1 mRNA CTD PMID:28962523 dioxygen multiple interactions EXP 6480464 [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein] which results in increased expression of SLC8A1 mRNA more ... CTD PMID:21293012 , PMID:25937560 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of SLC8A1 mRNA CTD PMID:25937560 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of SLC8A1 mRNA, Oxygen deficiency results in increased expression of SLC8A1 protein CTD PMID:17394575 , PMID:21293012 dorsomorphin multiple interactions ISO RGD:731021 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC8A1 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:731021 6480464 Doxorubicin results in decreased expression of SLC8A1 mRNA CTD PMID:28940058 , PMID:29803840 ethanol increases expression ISO RGD:731022 6480464 Ethanol results in increased expression of SLC8A1 mRNA CTD PMID:30319688 etoposide decreases expression ISO RGD:731021 6480464 Etoposide results in decreased expression of SLC8A1 mRNA CTD PMID:29397400 flutamide multiple interactions ISO RGD:731022 6480464 Flutamide inhibits the reaction [CD38 gene mutant form results in increased expression of SLC8A1 mRNA] CTD PMID:21840325 folic acid decreases expression ISO RGD:731022 6480464 Folic Acid results in decreased expression of SLC8A1 mRNA CTD PMID:25629700 fructose multiple interactions ISO RGD:731022 6480464 [Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA, troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of SLC8A1 mRNA] CTD PMID:28916335 geldanamycin increases expression ISO RGD:731021 6480464 geldanamycin results in increased expression of SLC8A1 mRNA CTD PMID:26705709 genistein decreases expression ISO RGD:731021 6480464 Genistein results in decreased expression of SLC8A1 mRNA CTD PMID:26865667 genistein increases expression ISO RGD:731022 6480464 Genistein results in increased expression of SLC8A1 mRNA CTD PMID:32186404 glucose multiple interactions EXP 6480464 [[Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of HIF1A protein] which results in increased expression of SLC8A1 mRNA more ... CTD PMID:21293012 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of SLC8A1 mRNA CTD PMID:24915197 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of SLC8A1 mRNA CTD PMID:11179087 isoprenaline multiple interactions ISO RGD:731022 6480464 EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA] more ... CTD PMID:15621046 maneb multiple interactions ISO RGD:731022 6480464 [Paraquat co-treated with Maneb] affects the expression of SLC8A1 mRNA CTD PMID:22563483 methapyrilene decreases methylation ISO RGD:731021 6480464 Methapyrilene results in decreased methylation of SLC8A1 intron CTD PMID:30157460 monosodium L-glutamate multiple interactions ISO RGD:731022 6480464 [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA, [Fats, Unsaturated co-treated with Sodium Glutamate] affects the expression of SLC8A1 mRNA CTD PMID:23783067 nickel atom increases uptake ISO RGD:731021 6480464 SLC8A1 protein results in increased uptake of Nickel CTD PMID:10329968 nickel atom decreases expression ISO RGD:731021 6480464 Nickel results in decreased expression of SLC8A1 mRNA CTD PMID:23195993 nickel atom multiple interactions ISO RGD:731021 6480464 Calcium inhibits the reaction [SLC8A1 protein results in increased uptake of Nickel], Sodium promotes the reaction [SLC8A1 protein results in increased uptake of Nickel] CTD PMID:10329968 O-methyleugenol decreases expression ISO RGD:731021 6480464 methyleugenol results in decreased expression of SLC8A1 mRNA CTD PMID:32234424 ouabain affects response to substance ISO RGD:731022 6480464 SLC8A1 affects the susceptibility to Ouabain CTD PMID:16166162 ouabain increases expression EXP 6480464 Ouabain results in increased expression of SLC8A1 protein CTD PMID:19897708 ouabain multiple interactions EXP 6480464 SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein] more ... CTD PMID:19897708 p-tert-Amylphenol decreases expression ISO RGD:731022 6480464 4-tert-octylphenol results in decreased expression of SLC8A1 mRNA CTD PMID:30061528 paracetamol affects expression ISO RGD:731021 6480464 Acetaminophen affects the expression of SLC8A1 mRNA CTD PMID:25458485 paraquat multiple interactions ISO RGD:731022 6480464 [Paraquat co-treated with Maneb] affects the expression of SLC8A1 mRNA, IGF1 gene mutant form inhibits the reaction [Paraquat results in decreased expression of SLC8A1 protein] CTD PMID:17979500 , PMID:22563483 paraquat decreases expression ISO RGD:731022 6480464 Paraquat results in decreased expression of SLC8A1 protein CTD PMID:17979500 pentanal increases expression ISO RGD:731021 6480464 pentanal results in increased expression of SLC8A1 mRNA CTD PMID:26079696 phenylephrine decreases expression EXP 6480464 Phenylephrine results in decreased expression of SLC8A1 protein CTD PMID:19244478 phenylephrine multiple interactions ISO RGD:731022 6480464 EGR1 protein affects the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 mRNA] more ... CTD PMID:15621046 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of SLC8A1 mRNA CTD PMID:11179087 phorbol 13-acetate 12-myristate multiple interactions EXP 6480464 Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of SLC8A1 mRNA] CTD PMID:19244478 potassium chromate decreases expression ISO RGD:731021 6480464 potassium chromate(VI) results in decreased expression of SLC8A1 mRNA CTD PMID:22714537 progesterone multiple interactions ISO RGD:731021 6480464 Progesterone inhibits the reaction [Estradiol results in increased expression of SLC8A1 mRNA] CTD PMID:21795739 propranolol multiple interactions ISO RGD:731022 6480464 Propranolol inhibits the reaction [[Isoproterenol co-treated with Phenylephrine] results in increased expression of SLC8A1 protein] CTD PMID:15621046 pyridaben increases expression ISO RGD:731022 6480464 pyridaben results in increased expression of SLC8A1 mRNA CTD PMID:22563483 resveratrol decreases expression ISO RGD:731022 6480464 resveratrol results in decreased expression of SLC8A1 mRNA CTD PMID:22610192 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of SLC8A1 protein CTD PMID:25425099 SB 431542 multiple interactions ISO RGD:731021 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC8A1 mRNA CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:731021 6480464 Silicon Dioxide analog results in decreased expression of SLC8A1 mRNA, Silicon Dioxide results in decreased expression of SLC8A1 mRNA CTD PMID:23623845 , PMID:23806026 sodium atom multiple interactions ISO RGD:731021 6480464 Sodium promotes the reaction [SLC8A1 protein results in increased uptake of Nickel] CTD PMID:10329968 succimer multiple interactions ISO RGD:731021 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC8A1 mRNA CTD PMID:26378955 sunitinib decreases expression ISO RGD:731021 6480464 Sunitinib results in decreased expression of SLC8A1 mRNA CTD PMID:31533062 testosterone decreases expression ISO RGD:731022 6480464 Testosterone results in decreased expression of SLC8A1 mRNA CTD PMID:20090667 tetraphene multiple interactions ISO RGD:731022 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SLC8A1 mRNA CTD PMID:27858113 thalidomide decreases expression ISO RGD:731022 6480464 Thalidomide results in decreased expression of SLC8A1 mRNA CTD PMID:26006729 , PMID:26217789 thapsigargin multiple interactions EXP 6480464 Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of SLC8A1 mRNA] CTD PMID:19244478 thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of SLC8A1 mRNA, Thapsigargin results in increased expression of SLC8A1 protein CTD PMID:19244478 thimerosal increases expression ISO RGD:731021 6480464 Thimerosal results in increased expression of SLC8A1 mRNA CTD PMID:27188386 titanium dioxide multiple interactions ISO RGD:731022 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of SLC8A1 mRNA CTD PMID:29950665 trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of SLC8A1 gene CTD PMID:27618143 trichostatin A increases expression ISO RGD:731021 6480464 trichostatin A results in increased expression of SLC8A1 mRNA CTD PMID:24935251 triclosan decreases expression ISO RGD:731021 6480464 Triclosan results in decreased expression of SLC8A1 mRNA CTD PMID:30510588 tunicamycin increases expression ISO RGD:731022 6480464 Tunicamycin results in increased expression of SLC8A1 mRNA CTD PMID:17127020 uranium atom decreases expression EXP 6480464 Uranium results in decreased expression of SLC8A1 mRNA CTD PMID:17118558 valproic acid decreases expression ISO RGD:731021 6480464 Valproic Acid results in decreased expression of SLC8A1 mRNA CTD PMID:23179753 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of SLC8A1 mRNA CTD PMID:29427782 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of SLC8A1 mRNA CTD PMID:29427782 valproic acid multiple interactions ISO RGD:731021 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC8A1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:731021 6480464 Valproic Acid results in increased expression of SLC8A1 mRNA CTD PMID:19101580 more ... vancomycin increases expression ISO RGD:731022 6480464 Vancomycin results in increased expression of SLC8A1 mRNA CTD PMID:18930951 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of SLC8A1 mRNA CTD PMID:23034163
Biological Process calcium ion export ISO RGD:731021 1624291 (PMID:19481548) RGD PMID:19481548 calcium ion export IDA 8554390 PMID:19481548 BHF-UCL calcium ion export ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 calcium ion homeostasis ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 calcium ion import ISO RGD:731021 1624291 (PMID:1374913), (PMID:19481548) RGD PMID:1374913 , PMID:19481548 calcium ion import IDA 8554390 PMID:19481548 BHF-UCL calcium ion import IDA 8553768 PMID:11916852 BHF-UCL calcium ion import ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 calcium ion import across plasma membrane IBA PANTHER:PTN000933900 more ... 13792537 PMID:21873635 GO_Central calcium ion transmembrane transport IMP 7175092 ; 7241256 RGD calcium ion transmembrane transport IGI UniProtKB:P48768 , UniProtKB:P70549 15090846 PMID:23628073 ARUK-UCL calcium ion transmembrane transport ISO RGD:731022 1624291 UniProtKB:Q6P9J9 (MGI:MGI:5634871 , PMID:25589784) RGD MGI:MGI:5634871 , PMID:25589784 calcium ion transmembrane transport ISO RGD:731021 1624291 UniProtKB:Q4KMQ2 (PMID:25589784) RGD PMID:25589784 calcium ion transmembrane transport ISO RGD:12334269 1624291 (PMID:17962412) RGD PMID:17962412 calcium ion transmembrane transport IDA 7175087 RGD calcium ion transport TAS 730112 RGD calcium ion transport IEA UniProtKB-KW:KW-0109 1600115 GO_REF:0000043 UniProt GO_REF:0000043 calcium ion transport ISO RGD:731022 1624291 MGI:MGI:3609617 (MGI:MGI:1334878 more ... RGD MGI:MGI:1334878 more ... calcium ion transport into cytosol IDA 2316984 RGD calcium ion transport into cytosol ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 cardiac muscle cell development ISO RGD:731022 1624291 MGI:MGI:4849923 (MGI:MGI:1927695 more ... RGD MGI:MGI:1927695 more ... cardiac muscle contraction ISO RGD:731022 1624291 MGI:MGI:97272 (MGI:MGI:3604156 , PMID:15308581) RGD MGI:MGI:3604156 , PMID:15308581 cell communication IEA InterPro:IPR003644 1600115 GO_REF:0000002 InterPro GO_REF:0000002 cell communication by electrical coupling involved in cardiac conduction IDA 8554732 PMID:21779914 BHF-UCL cellular calcium ion homeostasis IMP 1581355 RGD cellular calcium ion homeostasis IGI UniProtKB:P48768 , UniProtKB:P70549 15090846 PMID:23628073 ARUK-UCL cellular response to caffeine ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 cellular response to cAMP IDA 2316984 RGD cellular response to hypoxia IEP 1642726 RGD cellular response to reactive oxygen species ISO RGD:731021 1624291 (PMID:19481548) RGD PMID:19481548 cellular response to reactive oxygen species IDA 8554390 PMID:19481548 BHF-UCL cellular sodium ion homeostasis ISO RGD:731021 1624291 (PMID:1374913) RGD PMID:1374913 embryonic heart tube development ISO RGD:731022 1624291 MGI:MGI:4849923 (MGI:MGI:4867054 , PMID:21302256) RGD MGI:MGI:4867054 , PMID:21302256 embryonic placenta development ISO RGD:731022 1624291 MGI:MGI:4849923 (MGI:MGI:4867054 , PMID:21302256) RGD MGI:MGI:4867054 , PMID:21302256 heart morphogenesis ISO RGD:731022 1624291 MGI:MGI:97272 (MGI:MGI:3604156 , PMID:15308581) RGD MGI:MGI:3604156 , PMID:15308581 metal ion transport IBA MGI:MGI:107956 more ... 13792537 PMID:21873635 GO_Central muscle fiber development ISO RGD:731022 1624291 MGI:MGI:97272 (MGI:MGI:3604156 , PMID:15308581) RGD MGI:MGI:3604156 , PMID:15308581 negative regulation of cytosolic calcium ion concentration ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 negative regulation of protein serine/threonine kinase activity ISO RGD:731022 1624291 (MGI:MGI:6282180, PMID:29274751) RGD MGI:MGI:6282180 , PMID:29274751 positive regulation of bone mineralization ISO RGD:731021 1624291 (PMID:25589784) RGD PMID:25589784 positive regulation of cytosolic calcium ion concentration IMP 1581353 RGD positive regulation of fibroblast migration IMP 6771237 RGD positive regulation of the force of heart contraction ISO RGD:731021 1624291 (PMID:15105296) RGD PMID:15105296 post-embryonic development ISO RGD:731022 1624291 MGI:MGI:97272 (MGI:MGI:3604156 , PMID:15308581) RGD MGI:MGI:3604156 , PMID:15308581 regulation of calcium ion transport IMP 1581353 ; 1581354 RGD regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IDA 8554732 PMID:21779914 BHF-UCL regulation of gene expression ISO RGD:731022 1624291 (MGI:MGI:6282180, PMID:29274751) RGD MGI:MGI:6282180 , PMID:29274751 regulation of heart rate ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 regulation of postsynaptic cytosolic calcium ion concentration IEA GO:1905060 1600115 GO_REF:0000108 GOC GO_REF:0000108 regulation of sodium ion transport IMP 1581354 RGD regulation of the force of heart contraction ISO RGD:731022 1624291 MGI:MGI:3609617 (MGI:MGI:3607962 , PMID:12767889) RGD MGI:MGI:3607962 , PMID:12767889 relaxation of smooth muscle ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 response to ATP IDA 1642721 RGD response to drug IEP 1598724 RGD response to glucose IEP 1642722 RGD response to hydrogen peroxide IEP 1642724 RGD response to hypoxia IDA 1642729 RGD response to immobilization stress IEP 1642726 RGD response to muscle stretch ISO RGD:731021 1624291 (PMID:15105296) RGD PMID:15105296 response to nutrient IEP 1642718 RGD sodium ion export across plasma membrane IDA 8553768 PMID:11916852 BHF-UCL sodium ion export across plasma membrane IDA 8554390 PMID:19481548 BHF-UCL sodium ion export across plasma membrane ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 sodium ion export across plasma membrane ISO RGD:731021 1624291 (PMID:19481548) RGD PMID:19481548 sodium ion import across plasma membrane IDA 8553768 PMID:11916852 BHF-UCL sodium ion import across plasma membrane ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 sodium ion import across plasma membrane ISO RGD:731021 1624291 (PMID:1374913) RGD PMID:1374913 sodium ion transmembrane transport ISO RGD:12334269 1624291 (PMID:17962412) RGD PMID:17962412 sodium ion transmembrane transport IBA MGI:MGI:107956 more ... 13792537 PMID:21873635 GO_Central sodium ion transmembrane transport IEA GO:0005432 1600115 GO_REF:0000108 GOC GO_REF:0000108 sodium ion transmembrane transport ISO RGD:731021 1624291 UniProtKB:Q4KMQ2 (PMID:25589784) RGD PMID:25589784 sodium ion transport IDA 2316984 RGD sodium ion transport ISO RGD:731022 1624291 (MGI:MGI:1334878 more ... RGD MGI:MGI:1334878 more ... telencephalon development IEP 2316981 RGD vascular associated smooth muscle contraction ISO RGD:731022 1624291 (MGI:MGI:1927695, PMID:10967099) RGD MGI:MGI:1927695 , PMID:10967099 Cellular Component axon IDA 15090846 PMID:23628073 ARUK-UCL axon IBA MGI:MGI:107956 more ... 13792537 PMID:21873635 GO_Central axon terminus ISO RGD:731022 1624291 (MGI:MGI:6282180, PMID:29274751) RGD MGI:MGI:6282180 , PMID:29274751 basolateral plasma membrane ISO RGD:731022 1624291 (MGI:MGI:3608739, PMID:11423561) RGD MGI:MGI:3608739 , PMID:11423561 cell periphery ISO RGD:731021 1624291 (PMID:21321244) RGD PMID:21321244 cell projection IDA 2316976 RGD dendrite IDA 15090846 PMID:23628073 ARUK-UCL dendritic shaft IDA 7175092 RGD dendritic spine IDA 2316976 RGD integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 integral component of plasma membrane ISO RGD:731021 1624291 (PMID:1374913) RGD PMID:1374913 integral component of plasma membrane IBA MGI:MGI:107976 more ... 13792537 PMID:21873635 GO_Central integral component of postsynaptic membrane IDA 2316976 PMID:16914199 SynGO intercalated disc IDA 8553384 PMID:1514597 BHF-UCL intrinsic component of plasma membrane ISO RGD:12334269 1624291 (PMID:17962412) RGD PMID:17962412 intrinsic component of plasma membrane ISS UniProtKB:P23685 1600115 GO_REF:0000024 UniProt GO_REF:0000024 membrane ISO RGD:731022 1624291 (MGI:MGI:3640012, PMID:16407245) RGD MGI:MGI:3640012 , PMID:16407245 membrane IBA MGI:MGI:107956 more ... 13792537 PMID:21873635 GO_Central microtubule IDA 2316976 RGD mitochondrion IDA 2316976 RGD neuronal cell body IDA 15090846 PMID:23628073 ARUK-UCL nucleoplasm IEA UniProtKB:P32418 , ensembl:ENSP000003847631600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:731021 1624291 RGD GO_REF:0000052 plasma membrane IDA 1581354 ; 7175085 RGD plasma membrane IEA UniProtKB-SubCell:SL-0039 1600115 GO_REF:0000044 UniProt GO_REF:0000044 plasma membrane ISO RGD:731021 1624291 (PMID:26421717) RGD GO_REF:0000052, PMID:26421717 plasma membrane ISO RGD:731022 1624291 (MGI:MGI:3607962 more ... RGD MGI:MGI:3607962 more ... postsynapse IBA MGI:MGI:107956 more ... 13792537 PMID:21873635 GO_Central postsynaptic density ISO RGD:731022 1624291 (MGI:MGI:6282180, PMID:29274751) RGD MGI:MGI:6282180 , PMID:29274751 postsynaptic membrane IDA 7175092 PMID:17215351 SynGO sarcolemma IDA 2316982 RGD sarcolemma IBA MGI:MGI:107956 more ... 13792537 PMID:21873635 GO_Central sarcolemma ISO RGD:731022 1624291 (MGI:MGI:3525392 more ... RGD MGI:MGI:3525392 more ... sarcolemma IDA 8553384 PMID:1514597 BHF-UCL sarcolemma IDA 8554533 PMID:11053140 BHF-UCL synapse ISO RGD:731021 1624291 (PMID:21382638) RGD PMID:21382638 synapse ISO RGD:731022 1624291 (MGI:MGI:6282180, PMID:29274751) RGD MGI:MGI:6282180 , PMID:29274751 T-tubule IDA 2316982 RGD T-tubule ISO RGD:731022 1624291 (MGI:MGI:3528790 more ... RGD MGI:MGI:3528790 more ... T-tubule IDA 8553384 PMID:1514597 BHF-UCL T-tubule TAS 8554533 PMID:11053140 BHF-UCL Z disc IDA 8554533 PMID:11053140 BHF-UCL Z disc IDA 8553384 PMID:1514597 BHF-UCL Molecular Function ankyrin binding ISO RGD:731021 1624291 UniProtKB:Q01484 (PMID:17178715) RGD PMID:17178715 ankyrin binding ISO RGD:731022 1624291 UniProtKB:Q8C8R3 (MGI:MGI:4844023 , PMID:20610380) RGD MGI:MGI:4844023 , PMID:20610380 calcium ion binding ISO RGD:12334269 1624291 (PMID:17962412) RGD PMID:17962412 calcium ion binding ISS UniProtKB:P23685 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration ISO RGD:12334269 1624291 (PMID:1700476) RGD PMID:1700476 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration IMP 7175092 PMID:17215351 SynGO calcium:sodium antiporter activity IDA 730112 ; 7175087 RGD calcium:sodium antiporter activity IBA MGI:MGI:107956 more ... 13792537 PMID:21873635 GO_Central calcium:sodium antiporter activity IDA 8554390 PMID:19481548 BHF-UCL calcium:sodium antiporter activity ISO RGD:731021 1624291 (PMID:1374913), (PMID:19481548), (PMID:25589784) RGD PMID:1374913 more ... calcium:sodium antiporter activity ISO RGD:731022 1624291 (MGI:MGI:1927695 more ... RGD MGI:MGI:1927695 more ... calcium:sodium antiporter activity IDA 8553768 PMID:11916852 BHF-UCL calcium:sodium antiporter activity IEA InterPro:IPR002987 , InterPro:IPR004836 1600115 GO_REF:0000002 InterPro GO_REF:0000002 calcium:sodium antiporter activity ISO RGD:12334269 1624291 (PMID:17962412) RGD PMID:17962412 calcium:sodium antiporter activity IMP 7241256 ; 7175092 ; 1581354 RGD calmodulin binding ISO RGD:731021 1624291 (PMID:26421717) RGD PMID:26421717 calmodulin binding IEA UniProtKB-KW:KW-0112 1600115 GO_REF:0000043 UniProt GO_REF:0000043 cation:cation antiporter activity IBA MGI:MGI:107956 more ... 13792537 PMID:21873635 GO_Central cytoskeletal protein binding ISO RGD:731021 1624291 (PMID:16292983) RGD PMID:16292983 ion antiporter activity involved in regulation of postsynaptic membrane potential IMP 7175092 PMID:17215351 SynGO ion channel binding ISO RGD:731022 1624291 UniProtKB:Q61743 (MGI:MGI:4844023 , PMID:20610380) RGD MGI:MGI:4844023 , PMID:20610380 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000043 UniProt GO_REF:0000043 protein binding IPI RGD:620156 6767300 RGD protein binding ISO RGD:731021 1624291 UniProtKB:P23297 more ... RGD PMID:16292983 more ... protein binding ISO RGD:731022 1624291 PR:Q6PIE5 more ... RGD MGI:MGI:3525392 more ... protein binding IPI RGD:3377 11526267 RGD protein binding IPI RGD:2280 1582170 RGD protein binding IPI RGD:69306 1581354 RGD
Gene-Chemical Interaction Annotations
