Ppp1r9b (protein phosphatase 1, regulatory subunit 9B) - Rat Genome Database

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Gene: Ppp1r9b (protein phosphatase 1, regulatory subunit 9B) Rattus norvegicus
Analyze
Symbol: Ppp1r9b
Name: protein phosphatase 1, regulatory subunit 9B
RGD ID: 632281
Description: Enables several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; pallium development; and positive regulation of protein localization to cell periphery. Located in several cellular components, including dendritic spine; growth cone; and neuronal cell body. Biomarker of Parkinson's disease. Orthologous to human PPP1R9B (protein phosphatase 1 regulatory subunit 9B); INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Neb2; neurabin 2; neurabin-2; neurabin-II; neural tissue-specific F-actin-binding protein II; nuerabin 2; p130; PP1bp134; spinophilin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21079,938,055 - 79,954,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,938,066 - 79,954,083 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,887,200 - 84,903,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,385,269 - 84,401,276 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,778,362 - 79,794,325 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,800,704 - 82,816,735 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,800,704 - 82,816,731 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,616,223 - 82,632,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,674,797 - 83,690,639 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,689,166 - 83,705,009 (+)NCBI
Celera1078,712,214 - 78,727,757 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament depolymerization  (IEP)
actin filament organization  (IBA,ISO)
calcium-mediated signaling  (IBA,ISO)
cell migration  (ISO,ISS)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to morphine  (ISO,ISS)
cellular response to organic cyclic compound  (IEP)
cellular response to peptide  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebral cortex development  (IEP)
dendrite development  (ISO)
developmental process involved in reproduction  (IEP)
filopodium assembly  (ISO,ISS)
hippocampus development  (IEP)
learning  (IEP)
male mating behavior  (IEP)
negative regulation of cell growth  (ISO)
negative regulation of phosphoprotein phosphatase activity  (IDA,IMP)
neuron projection development  (IBA)
positive regulation of protein localization  (IDA)
positive regulation of protein localization to actin cortical patch  (IMP)
positive regulation of protein localization to plasma membrane  (IDA)
protein localization to actin cytoskeleton  (IMP)
protein localization to cell periphery  (IMP)
regulation of opioid receptor signaling pathway  (ISO,ISS)
regulation of protein phosphorylation  (ISO)
reproductive system development  (IEP)
response to amino acid  (IEP)
response to amphetamine  (IEP)
response to estradiol  (IEP)
response to immobilization stress  (IEP)
response to kainic acid  (IEP)
response to L-phenylalanine derivative  (IEP)
response to nicotine  (IEP)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IEP)
response to prostaglandin E  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)

References

References - curated
# Reference Title Reference Citation
1. Low expression of the putative tumour suppressor spinophilin is associated with higher proliferative activity and poor prognosis in patients with hepatocellular carcinoma. Aigelsreiter A, etal., Br J Cancer. 2013 May 14;108(9):1830-7. doi: 10.1038/bjc.2013.165. Epub 2013 Apr 16.
2. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Allen PB, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9956-61.
3. Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus. Alves SE, etal., Synapse. 2002 Aug;45(2):143-51.
4. Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: effects of the cannabinoid receptor 1 antagonist AM251. Aydin C, etal., Neuropharmacology. 2012 Dec;63(8):1335-45. doi: 10.1016/j.neuropharm.2012.08.016. Epub 2012 Aug 31.
5. The identification of a second actin-binding region in spinophilin/neurabin II. Barnes AP, etal., Brain Res Mol Brain Res. 2004 May 19;124(2):105-13.
6. A sensitizing D-amphetamine dose regimen induces long-lasting spinophilin and VGLUT1 protein upregulation in the rat diencephalon. Boikess SR, etal., Neurosci Lett. 2010 Jan 18;469(1):49-54. doi: 10.1016/j.neulet.2009.11.042. Epub 2009 Nov 20.
7. Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism. Brown AM, etal., Eur J Neurosci. 2005 Jul;22(1):247-56.
8. Association of protein phosphatase 1 gamma 1 with spinophilin suppresses phosphatase activity in a Parkinson disease model. Brown AM, etal., J Biol Chem. 2008 May 23;283(21):14286-94. doi: 10.1074/jbc.M801377200. Epub 2008 Mar 26.
9. Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin. Buchsbaum RJ, etal., J Biol Chem 2003 May 23;278(21):18833-41. Epub 2003 Jan 16.
10. Exploration of prostanoid receptor subtype regulating estradiol and prostaglandin E2 induction of spinophilin in developing preoptic area neurons. Burks SR, etal., Neuroscience. 2007 May 25;146(3):1117-27. Epub 2007 Apr 6.
11. Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Burnett PE, etal., Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8351-6.
12. Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. Carmody LC, etal., FASEB J. 2008 Jun;22(6):1660-71. doi: 10.1096/fj.07-092841. Epub 2008 Jan 23.
13. Clozapine and haloperidol differentially regulate dendritic spine formation and synaptogenesis in rat hippocampal neurons. Critchlow HM, etal., Mol Cell Neurosci. 2006 Aug;32(4):356-65. Epub 2006 Jul 17.
14. Prostaglandin E2 stimulates estradiol synthesis in the cerebellum postnatally with associated effects on Purkinje neuron dendritic arbor and electrophysiological properties. Dean SL, etal., Endocrinology. 2012 Nov;153(11):5415-27. doi: 10.1210/en.2012-1350. Epub 2012 Oct 9.
15. Spinophilin loss correlates with poor patient prognosis in advanced stages of colon carcinoma. Estevez-Garcia P, etal., Clin Cancer Res. 2013 Jul 15;19(14):3925-35. doi: 10.1158/1078-0432.CCR-13-0057. Epub 2013 May 31.
16. Spinophilin loss contributes to tumorigenesis in vivo. Ferrer I, etal., Cell Cycle. 2011 Jun 15;10(12):1948-55. Epub 2011 Jun 15.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, etal., Pflugers Arch. 2005 Oct;451(1):87-98. Epub 2005 Jul 16.
20. Methamphetamine enhances paced mating behaviors and neuroplasticity in the medial amygdala of female rats. Holder MK and Mong JA, Horm Behav. 2010 Aug;58(3):519-25. doi: 10.1016/j.yhbeh.2010.04.006. Epub 2010 Apr 24.
21. Phosphorylation of spinophilin modulates its interaction with actin filaments. Hsieh-Wilson LC, etal., J Biol Chem 2003 Jan 10;278(2):1186-94. Epub 2002 Nov 1.
22. Interaction of rat lin-10 with brain-enriched F-actin-binding protein, neurabin-II/spinophilin. Ide N, etal., Biochem Biophys Res Commun. 1998 Mar 6;244(1):258-62.
23. Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Ladurelle N, etal., Psychopharmacology (Berl). 2012 Jun;221(3):493-509. doi: 10.1007/s00213-011-2597-5. Epub 2011 Dec 8.
24. Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. Law AJ, etal., Am J Psychiatry. 2004 Oct;161(10):1848-55.
25. Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1). Ma P, etal., PLoS One. 2015 Mar 18;10(3):e0119496. doi: 10.1371/journal.pone.0119496. eCollection 2015.
26. Brain actin-associated protein phosphatase 1 holoenzymes containing spinophilin, neurabin, and selected catalytic subunit isoforms. MacMillan LB, etal., J Biol Chem. 1999 Dec 10;274(50):35845-54.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Down-regulation of spinophilin in lung tumours contributes to tumourigenesis. Molina-Pinelo S, etal., J Pathol. 2011 Sep;225(1):73-82. doi: 10.1002/path.2905. Epub 2011 May 19.
29. Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation. Nakanishi H, etal., J Cell Biol 1997 Nov 17;139(4):951-61.
30. Wistar rats subjected to chronic restraint stress display increased hippocampal spine density paralleled by increased expression levels of synaptic scaffolding proteins. Orlowski D, etal., Stress. 2012 Sep;15(5):514-23. doi: 10.3109/10253890.2011.643516. Epub 2012 Jan 10.
31. Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment. Ottis P, etal., PLoS One. 2013 Sep 19;8(9):e75112. doi: 10.1371/journal.pone.0075112. eCollection 2013.
32. RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes. Palavicini JP, etal., Cell Death Dis. 2013 Jun 13;4:e667. doi: 10.1038/cddis.2013.183.
33. The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Penzes P, etal., Neuron. 2001 Jan;29(1):229-42.
34. Flexibility in the PP1:spinophilin holoenzyme. Ragusa MJ, etal., FEBS Lett. 2011 Jan 3;585(1):36-40. doi: 10.1016/j.febslet.2010.11.022. Epub 2010 Nov 19.
35. Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Ragusa MJ, etal., Nat Struct Mol Biol. 2010 Apr;17(4):459-64. doi: 10.1038/nsmb.1786. Epub 2010 Mar 21.
36. GOA pipeline RGD automated data pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Neurabin-II/spinophilin. An actin filament-binding protein with one pdz domain localized at cadherin-based cell-cell adhesion sites. Satoh A, etal., J Biol Chem 1998 Feb 6;273(6):3470-5.
40. GnRH receptor gene expression in the developing rat hippocampus: transcriptional regulation and potential roles in neuronal plasticity. Schang AL, etal., Endocrinology. 2011 Feb;152(2):568-80. doi: 10.1210/en.2010-0840. Epub 2010 Dec 1.
41. Structure-function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin. Schüler H and Peti W, FEBS J. 2008 Jan;275(1):59-68. doi: 10.1111/j.1742-4658.2007.06171.x. Epub 2007 Nov 20.
42. Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. Smith FD, etal., J Biol Chem 1999 Jul 9;274(28):19894-900.
43. Gene expression profiling of nasal polyps associated with chronic sinusitis and aspirin-sensitive asthma. Stankovic KM, etal., Laryngoscope. 2008 May;118(5):881-9. doi: 10.1097/MLG.0b013e31816b4b6f.
44. In vivo dynamics of the F-actin-binding protein neurabin-II. Stephens DJ and Banting G, Biochem J. 2000 Jan 15;345 Pt 2:185-94.
45. Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin. Stephens DJ and Banting G, J Biol Chem. 1999 Oct 15;274(42):30080-6.
46. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. Terry-Lorenzo RT, etal., J Biol Chem 2002 Aug 2;277(31):27716-24.
47. Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. Terry-Lorenzo RT, etal., J Biol Chem 2002 Nov 29;277(48):46535-43. Epub 2002 Sep 21.
48. Glutamate AMPA/kainate receptors, not GABA(A) receptors, mediate estradiol-induced sex differences in the hypothalamus. Todd BJ, etal., Dev Neurobiol. 2007 Feb 15;67(3):304-15.
49. Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates. Wright CL, etal., Dev Neurobiol. 2008 Oct;68(12):1406-19. doi: 10.1002/dneu.20665.
50. Postpubertal decrease in hippocampal dendritic spines of female rats. Yildirim M, etal., Exp Neurol. 2008 Apr;210(2):339-48. Epub 2007 Nov 21.
51. Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. Zhao L, etal., J Pharmacol Exp Ther. 2006 Dec;319(3):1124-32. Epub 2006 Sep 1.
Additional References at PubMed
PMID:10194355   PMID:10922077   PMID:11154706   PMID:11278317   PMID:12477932   PMID:15218143   PMID:15228588   PMID:15514983   PMID:15743906   PMID:15793568   PMID:15996550   PMID:16930415  
PMID:17464283   PMID:18439408   PMID:19151759   PMID:19609226   PMID:20124353   PMID:20385205   PMID:24625528   PMID:25750125   PMID:27890541   PMID:29383693  


Genomics

Comparative Map Data
Ppp1r9b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21079,938,055 - 79,954,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,938,066 - 79,954,083 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1084,887,200 - 84,903,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,385,269 - 84,401,276 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,778,362 - 79,794,325 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,800,704 - 82,816,735 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,800,704 - 82,816,731 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01082,616,223 - 82,632,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,674,797 - 83,690,639 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11083,689,166 - 83,705,009 (+)NCBI
Celera1078,712,214 - 78,727,757 (+)NCBICelera
Cytogenetic Map10q26NCBI
PPP1R9B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,133,737 - 50,150,677 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,133,737 - 50,150,677 (-)EnsemblGRCh38hg38GRCh38
GRCh371748,211,101 - 48,228,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,566,100 - 45,582,876 (-)NCBINCBI36Build 36hg18NCBI36
Build 341745,567,694 - 45,582,873NCBI
Celera1744,671,218 - 44,687,998 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,578,978 - 43,595,756 (-)NCBIHuRef
CHM1_11748,275,419 - 48,292,198 (-)NCBICHM1_1
T2T-CHM13v2.01751,000,814 - 51,017,737 (-)NCBIT2T-CHM13v2.0
Ppp1r9b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,882,038 - 94,897,724 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,881,861 - 94,897,725 (+)EnsemblGRCm39 Ensembl
GRCm381194,991,212 - 95,006,898 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,991,035 - 95,006,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv371194,852,526 - 94,868,212 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361194,807,302 - 94,822,974 (+)NCBIMGSCv36mm8
Celera11104,604,585 - 104,620,251 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Ppp1r9b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,516,548 - 11,530,830 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,516,548 - 11,530,263 (+)NCBIChiLan1.0ChiLan1.0
PPP1R9B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11771,128,896 - 71,146,153 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,224,007 - 44,240,906 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,098,089 - 49,129,659 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,098,089 - 49,126,932 (-)Ensemblpanpan1.1panPan2
PPP1R9B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,135,982 - 26,152,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,137,464 - 26,151,810 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,529,124 - 25,544,951 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0926,930,469 - 26,946,307 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,930,469 - 26,946,307 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,698,261 - 25,714,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,956,940 - 25,972,777 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,086,858 - 26,102,695 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r9b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,560,948 - 25,577,086 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649011,497,389 - 11,514,191 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R9B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,319,124 - 26,336,562 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,319,123 - 26,337,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,358,245 - 26,375,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R9B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,188,400 - 43,205,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,188,022 - 43,205,680 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607713,904,402 - 13,921,606 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r9b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,124,159 - 6,137,955 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247956,124,273 - 6,137,776 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r9b
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:144
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000005498
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat

Markers in Region
BF405560  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,935,928 - 79,936,106 (+)MAPPERmRatBN7.2
Rnor_6.01082,798,567 - 82,798,744NCBIRnor6.0
Rnor_5.01082,614,086 - 82,614,263UniSTSRnor5.0
RGSC_v3.41083,672,660 - 83,672,837UniSTSRGSC3.4
Celera1078,709,633 - 78,709,810UniSTS
RH 3.4 Map10720.3UniSTS
Cytogenetic Map10q31UniSTS
BE117171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,944,130 - 79,944,307 (+)MAPPERmRatBN7.2
Rnor_6.01082,806,781 - 82,806,957NCBIRnor6.0
Rnor_5.01082,622,402 - 82,622,578UniSTSRnor5.0
RGSC_v3.41083,680,945 - 83,681,121UniSTSRGSC3.4
Celera1078,717,804 - 78,717,980UniSTS
RH 3.4 Map10719.0UniSTS
Cytogenetic Map10q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 38 22 19 22 2 4 74 33 41 11 2
Low 1 19 19 19 6 7 2 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000089497   ⟹   ENSRNOP00000074026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1079,938,066 - 79,954,083 (+)Ensembl
Rnor_6.0 Ensembl1082,800,704 - 82,816,731 (+)Ensembl
RefSeq Acc Id: NM_053474   ⟹   NP_445926
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,938,066 - 79,954,085 (+)NCBI
Rnor_6.01082,800,704 - 82,816,735 (+)NCBI
Rnor_5.01082,616,223 - 82,632,356 (+)NCBI
RGSC_v3.41083,674,797 - 83,690,639 (+)RGD
Celera1078,712,214 - 78,727,757 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086990   ⟹   XP_038942918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,938,055 - 79,952,554 (+)NCBI
RefSeq Acc Id: NP_445926   ⟸   NM_053474
- UniProtKB: O35274 (UniProtKB/Swiss-Prot),   B1H262 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074026   ⟸   ENSRNOT00000089497
RefSeq Acc Id: XP_038942918   ⟸   XM_039086990
- Peptide Label: isoform X1
- UniProtKB: B1H262 (UniProtKB/TrEMBL)
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35274-F1-model_v2 AlphaFold O35274 1-817 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697614
Promoter ID:EPDNEW_R8139
Type:initiation region
Name:Ppp1r9b_1
Description:protein phosphatase 1, regulatory subunit 9B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01082,800,655 - 82,800,715EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:632281 AgrOrtholog
BIND 130595
  130600
BioCyc Gene G2FUF-23572 BioCyc
Ensembl Genes ENSRNOG00000052113 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055032697 UniProtKB/Swiss-Prot
  ENSRNOG00060021417 UniProtKB/Swiss-Prot
  ENSRNOG00065017558 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000089497 ENTREZGENE
  ENSRNOT00000089497.2 UniProtKB/Swiss-Prot
  ENSRNOT00055056509 UniProtKB/Swiss-Prot
  ENSRNOT00060037218 UniProtKB/Swiss-Prot
  ENSRNOT00065029375 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7376917 IMAGE-MGC_LOAD
InterPro Neurabin-1/2_PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurabin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84686 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188268 IMAGE-MGC_LOAD
NCBI Gene 84686 ENTREZGENE
PANTHER PTHR16154 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16154:SF24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r9b PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052113 RatGTEx
  ENSRNOG00055032697 RatGTEx
  ENSRNOG00060021417 RatGTEx
  ENSRNOG00065017558 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1H262 ENTREZGENE, UniProtKB/TrEMBL
  NEB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ppp1r9b  protein phosphatase 1, regulatory subunit 9B  Neb2  nuerabin 2  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the PSD (post-synaptic density) 625568
gene_cellular_localization localized in the PSD (post-synaptic density) 625590
gene_cellular_localization localized in the PSD (post-synaptic density) 625591
gene_cellular_localization localized in the PSD (post-synaptic density) 625592
gene_domains contains a PSD95/DLG/zo-1(PDZ) domain 625568
gene_domains contains a PSD95/DLG/zo-1(PDZ) domain 625590
gene_domains contains a PSD95/DLG/zo-1(PDZ) domain 625591
gene_domains contains a PSD95/DLG/zo-1(PDZ) domain 625592
gene_expression purified from rat brain neural tissues 625592
gene_function binds to protein phosphatase1 625568
gene_function binds to protein phosphatase1 625590
gene_function binds to protein phosphatase1 625591
gene_function binds to protein phosphatase1 625592
gene_function binds to actin filaments 625568
gene_function binds to actin filaments 625590
gene_function binds to actin filaments 625591
gene_function binds to actin filaments 625592
gene_physical_interaction interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission 625568
gene_physical_interaction interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission 625590
gene_physical_interaction interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission 625591
gene_physical_interaction interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission 625592
gene_physical_interaction binds to protein phosphatase1  
gene_process regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD 625568
gene_process regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD 625591
gene_process involved in vesicular trafficking in developing and developed neurons and formation and maintenance of synaptic junctions 625568
gene_process involved in vesicular trafficking in developing and developed neurons and formation and maintenance of synaptic junctions 625590
gene_process involved in vesicular trafficking in developing and developed neurons and formation and maintenance of synaptic junctions 625591
gene_process involved in vesicular trafficking in developing and developed neurons and formation and maintenance of synaptic junctions 625592
gene_process interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission  
gene_product 4.6 kb in size 625568
gene_product 4.6 kb in size 625590
gene_product 4.6 kb in size 625591
gene_product 4.6 kb in size 625592
gene_regulation phosphorylated by PKA 625568
gene_regulation phosphorylated by PKA 625591
gene_regulation regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD and can be phosphorylated by PKA 625568
gene_regulation regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD and can be phosphorylated by PKA 625590
gene_regulation regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD and can be phosphorylated by PKA 625591
gene_regulation regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD and can be phosphorylated by PKA 625592