 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations |
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Analyze GeneStrainQTL List |
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MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsReferences - curated| 1. | Alam MR, etal., J Biol Chem 1996 Nov 8;271(45):28636-40. |
| 2. | Alam MR, etal., J Biol Chem 1997 May 9;272(19):12667-75. |
| 3. | Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027. |
| 4. | Colomer V, etal., Hum Mol Genet 1997 Sep;6(9):1519-25. |
| 5. | Hayashi-Takagi A, etal., Nat Neurosci. 2010 Mar;13(3):327-32. Epub 2010 Feb 7. |
| 6. | Johnson RC, etal., J Biol Chem 2000 Jun 23;275(25):19324-33. |
| 7. | Ma XM, etal., J Neurosci 2003 Nov 19;23(33):10593-603. |
| 8. | May V, etal., J Neurosci 2002 Aug 15;22(16):6980-90. |
| 9. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 10. | OMIM Disease Annotation Pipeline |
| 11. | Owczarek S, etal., Neural Plast. 2015;2015:167308. doi: 10.1155/2015/167308. Epub 2015 May 20. |
| 12. | Penzes P, etal., Neuron. 2001 Jan;29(1):229-42. |
| 13. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 14. | RGD automated data pipeline |
| 15. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 16. | RGD automated import pipeline for gene-chemical interactions |
| 17. | Xie Z, etal., Neuron. 2007 Nov 21;56(4):640-56. |
References - uncurated| PubMed | 9915831 10692441 10974569 12546821 14742910 15923627 16644733 18585704 18625710 18628310 19020030 19056867 19625617 19889983 20333733 21880917 22458534 22738176 23116210 23288169 23516288 23742124 23825406 25146373 25378388 25865668 26921771 27989699 28418645 30875016 |
Genomics
Comparative Map Data| Kalrn (Rattus norvegicus - Norway rat) |
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| KALRN (Homo sapiens - human) |
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| Kalrn (Mus musculus - house mouse) |
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| Kalrn (Chinchilla lanigera - long-tailed chinchilla) |
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| KALRN (Pan paniscus - bonobo/pygmy chimpanzee) |
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| KALRN (Canis lupus familiaris - dog) |
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| Kalrn (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| KALRN (Chlorocebus sabaeus - African green monkey) |
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| Kalrn (Heterocephalus glaber - naked mole-rat) |
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Position Markers| D11Mgh3 |
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| D11Arb4 |
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| D11Got53 |
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| BE102756 |
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| RH137364 |
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| BE110052 |
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| BF396995 |
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| AU046621 |
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| RH137626 |
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| RH138291 |
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| AU049016 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
| High | |||||||||||||
| Medium | 2 | 6 | 6 | 4 | 6 | 66 | 20 | 18 | 3 | ||||
| Low | 3 | 41 | 51 | 35 | 15 | 35 | 8 | 11 | 8 | 15 | 23 | 8 | 8 |
| Below cutoff |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_032062 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR07034411 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AABR07034412 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AABR07072246 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069756 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069757 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069758 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069759 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069760 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069761 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069762 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069763 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069764 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069765 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069766 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069767 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069768 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069769 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069770 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01069771 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC133403 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF046121 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF229255 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF230644 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF232668 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AF232669 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AY621095 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473967 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| LS482391 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U88156 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U88157 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| U94189 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | ENSRNOT00000016340 ⟹ ENSRNOP00000016340 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | ENSRNOT00000049292 ⟹ ENSRNOP00000039072 | ||||||||
| RefSeq Status: | |||||||||
| Type: | CODING | ||||||||
| Position: |
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| RefSeq Acc Id: | NM_032062 ⟹ NP_114451 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Position: |
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| Sequence: |
ATGACGGACCGCTTCTGGGACCAGTGGTATCTTTGGTATCTCCGCTTGCTTCGGCTTCTGGATChide sequence |
Protein Sequences| Protein RefSeqs | NP_114451 | (Get FASTA) | NCBI Sequence Viewer |
| GenBank Protein | AAB66366 | (Get FASTA) | NCBI Sequence Viewer |
| AAB66367 | (Get FASTA) | NCBI Sequence Viewer | |
| AAC03057 | (Get FASTA) | NCBI Sequence Viewer | |
| AAC15790 | (Get FASTA) | NCBI Sequence Viewer | |
| AAF66014 | (Get FASTA) | NCBI Sequence Viewer | |
| AAF66018 | (Get FASTA) | NCBI Sequence Viewer | |
| AAF66019 | (Get FASTA) | NCBI Sequence Viewer | |
| AAF69144 | (Get FASTA) | NCBI Sequence Viewer | |
| AAT39517 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11342 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11343 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11344 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11345 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11346 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11347 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11348 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM11349 | (Get FASTA) | NCBI Sequence Viewer | |
| P97924 | (Get FASTA) | NCBI Sequence Viewer | |
| SPT35768 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_114451 ⟸ NM_032062 |
| - UniProtKB: | P97924 (UniProtKB/Swiss-Prot) |
| - Sequence: |
MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTFPARThide sequence |
| RefSeq Acc Id: | ENSRNOP00000016340 ⟸ ENSRNOT00000016340 |
| RefSeq Acc Id: | ENSRNOP00000039072 ⟸ ENSRNOT00000049292 |
Protein Domains
CRAL-TRIO DH Fibronectin type-III Ig-like Ig-like C2-type PH Protein kinase SH3
TranscriptomeStrain Variation
Strain Sequence Variants (Rnor 6.0)
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:621865 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000001706 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000016340 | UniProtKB/Swiss-Prot |
| ENSRNOP00000039072 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000016340 | UniProtKB/Swiss-Prot |
| ENSRNOT00000049292 | ENTREZGENE, UniProtKB/TrEMBL | |
| Gene3D-CATH | 1.20.900.10 | UniProtKB/Swiss-Prot |
| 2.30.29.30 | UniProtKB/Swiss-Prot | |
| 2.60.40.10 | UniProtKB/Swiss-Prot | |
| 3.40.525.10 | UniProtKB/Swiss-Prot | |
| InterPro | CRAL-TRIO_dom | UniProtKB/Swiss-Prot |
| CRAL-TRIO_dom_sf | UniProtKB/Swiss-Prot | |
| DBL_dom_sf | UniProtKB/Swiss-Prot | |
| DH-domain | UniProtKB/Swiss-Prot | |
| FN3_dom | UniProtKB/Swiss-Prot | |
| FN3_sf | UniProtKB/Swiss-Prot | |
| Ig-like_dom | UniProtKB/Swiss-Prot | |
| Ig-like_dom_sf | UniProtKB/Swiss-Prot | |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig_I-set | UniProtKB/Swiss-Prot | |
| Ig_sub | UniProtKB/Swiss-Prot | |
| Ig_sub2 | UniProtKB/Swiss-Prot | |
| Kalirin | UniProtKB/Swiss-Prot | |
| Kinase-like_dom_sf | UniProtKB/Swiss-Prot | |
| PH-like_dom_sf | UniProtKB/Swiss-Prot | |
| PH_domain | UniProtKB/Swiss-Prot | |
| Prot_kinase_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_AS | UniProtKB/Swiss-Prot | |
| SH3-like_dom_sf | UniProtKB/Swiss-Prot | |
| SH3_domain | UniProtKB/Swiss-Prot | |
| Spectrin/alpha-actinin | UniProtKB/Swiss-Prot | |
| Spectrin_repeat | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:84009 | UniProtKB/Swiss-Prot |
| NCBI Gene | 84009 | ENTREZGENE |
| PANTHER | PTHR22826:SF49 | UniProtKB/Swiss-Prot |
| Pfam | CRAL_TRIO | UniProtKB/Swiss-Prot |
| CRAL_TRIO_2 | UniProtKB/TrEMBL | |
| fn3 | UniProtKB/Swiss-Prot | |
| I-set | UniProtKB/Swiss-Prot | |
| PF00169 | UniProtKB/Swiss-Prot | |
| Pkinase | UniProtKB/Swiss-Prot | |
| RhoGEF | UniProtKB/Swiss-Prot | |
| SH3_1 | UniProtKB/Swiss-Prot | |
| Spectrin | UniProtKB/Swiss-Prot | |
| PhenoGen | Kalrn | PhenoGen |
| PROSITE | CRAL_TRIO | UniProtKB/Swiss-Prot |
| DH_2 | UniProtKB/Swiss-Prot | |
| FN3 | UniProtKB/Swiss-Prot | |
| IG_LIKE | UniProtKB/Swiss-Prot | |
| PH_DOMAIN | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| SMART | FN3 | UniProtKB/Swiss-Prot |
| IGc2 | UniProtKB/Swiss-Prot | |
| RhoGEF | UniProtKB/Swiss-Prot | |
| S_TKc | UniProtKB/Swiss-Prot | |
| SEC14 | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| SM00233 | UniProtKB/Swiss-Prot | |
| SM00409 | UniProtKB/Swiss-Prot | |
| SPEC | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | SSF48065 | UniProtKB/Swiss-Prot |
| SSF48726 | UniProtKB/Swiss-Prot | |
| SSF49265 | UniProtKB/Swiss-Prot | |
| SSF50044 | UniProtKB/Swiss-Prot | |
| SSF52087 | UniProtKB/Swiss-Prot | |
| SSF56112 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.87882 | ENTREZGENE |
| UniProt | A0A2X0SFF1_RAT | UniProtKB/TrEMBL |
| F1LZV1_RAT | UniProtKB/TrEMBL | |
| KALRN_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
| UniProt Secondary | O70135 | UniProtKB/Swiss-Prot |
| Q6IV51 | UniProtKB/Swiss-Prot | |
| Q9JIF1 | UniProtKB/Swiss-Prot | |
| Q9JIF2 | UniProtKB/Swiss-Prot | |
| Q9JIG0 | UniProtKB/Swiss-Prot | |
| Q9JIH3 | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2005-03-14 | Kalrn | kalirin, RhoGEF kinase | Hapip | huntingtin-associated protein interacting protein (duo) | Symbol and Name updated to reflect Human and Mouse nomenclature | 1299863 | APPROVED |
| 2002-08-07 | Hapip | huntingtin-associated protein interacting protein (duo) | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_domains | contains dual Rho GTPase guanine nucleotide exchange factor (GEF) domains that interact with Rac1 and RhoA | 628431 |
| gene_expression | expressed mainly in the nervous system | 628431 |
| gene_physical_interaction | binds to the cytoplasmic domain of peptidylglycine alpha-amidating monooxygenase (PAM), a membrane protein mediating neuropeptide biosynthesis | 628431 |
| gene_process | participates in regulation of neuronal fiber extension and pathfinding during development | 628431 |
| gene_process | initiates new axons and axonal outgrowth via RhoG-mediated mechanisms | 628431 |
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| More on Kalrn | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 621865 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2019-11-27 |
| Status: | ACTIVE |
