Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:1557535 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KALRN mRNA | CTD | PMID:22206623 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:1557535 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:1557535 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1557535 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KALRN mRNA | CTD | PMID:18796159 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KALRN mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1557535 | 6480464 | Tetrachlorodibenzodioxin affects the expression of KALRN mRNA | CTD | PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of KALRN mRNA | CTD | PMID:22298810 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2,4-dinitrobenzenesulfonic acid | increases expression | ISO | RGD:1557535 | 6480464 | 2, 4-dinitrobenzenesulfonic acid results in increased expression of KALRN mRNA | CTD | PMID:30116771 | 2,4-dinitrobenzenesulfonic acid | multiple interactions | ISO | RGD:1557535 | 6480464 | [2, 4-dinitrobenzenesulfonic acid co-treated with GR 159897] results in increased expression of KALRN mRNA | CTD | PMID:30116771 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2, 6-dinitrotoluene affects the expression of KALRN mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of KALRN mRNA | CTD | PMID:30071829 | 3H-1,2-dithiole-3-thione | affects expression | EXP | | 6480464 | 1, 2-dithiol-3-thione affects the expression of KALRN mRNA | CTD | PMID:19162173 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of KALRN mRNA | CTD | PMID:24780913 | aflatoxin B1 | decreases expression | ISO | RGD:1601887 | 6480464 | Aflatoxin B1 results in decreased expression of KALRN mRNA | CTD | PMID:22100608 | aflatoxin B1 | increases methylation | ISO | RGD:1601887 | 6480464 | Aflatoxin B1 results in increased methylation of KALRN intron | CTD | PMID:30157460 | aflatoxin B2 | increases methylation | ISO | RGD:1601887 | 6480464 | aflatoxin B2 results in increased methylation of KALRN intron | CTD | PMID:30157460 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KALRN mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | ISO | RGD:1601887 | 6480464 | Antirheumatic Agents results in increased expression of KALRN mRNA | CTD | PMID:24449571 | arsane | affects methylation | ISO | RGD:1601887 | 6480464 | Arsenic affects the methylation of KALRN gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | RGD:1601887 | 6480464 | Arsenic affects the methylation of KALRN gene | CTD | PMID:25304211 | arsenite(3-) | decreases expression | ISO | RGD:1557535 | 6480464 | arsenite results in decreased expression of KALRN mRNA | CTD | PMID:18929588 | arsenite(3-) | multiple interactions | ISO | RGD:1557535 | 6480464 | TRP53 protein affects the reaction [arsenite results in decreased expression of KALRN mRNA] | CTD | PMID:18929588 | arsenous acid | increases expression | ISO | RGD:1601887 | 6480464 | Arsenic Trioxide results in increased expression of KALRN mRNA | CTD | PMID:20458559, PMID:26705709 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of KALRN gene | CTD | PMID:28931070 | benzo[a]pyrene | increases mutagenesis | ISO | RGD:1601887 | 6480464 | Benzoapyrene results in increased mutagenesis of KALRN gene | CTD | PMID:25435355 | benzo[a]pyrene | decreases expression | ISO | RGD:1601887 | 6480464 | Benzoapyrene results in decreased expression of KALRN mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | RGD:1601887 | 6480464 | Benzoapyrene affects the methylation of KALRN intron, Benzoapyrene affects the methylation of KALRN promoter | CTD | PMID:27901495, PMID:30157460 | benzo[a]pyrene | decreases methylation | ISO | RGD:1601887 | 6480464 | Benzoapyrene results in decreased methylation of KALRN exon | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | RGD:1601887 | 6480464 | Benzoapyrene results in increased expression of KALRN mRNA | CTD | PMID:26238291 | benzo[a]pyrene | decreases expression | ISO | RGD:1557535 | 6480464 | Benzoapyrene results in decreased expression of KALRN mRNA | CTD | PMID:21964900 | benzo[a]pyrene | increases expression | ISO | RGD:1557535 | 6480464 | Benzoapyrene results in increased expression of KALRN mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | increases expression | ISO | RGD:1601887 | 6480464 | 7 more ... | CTD | PMID:26238291 | benzo[e]pyrene | increases methylation | ISO | RGD:1601887 | 6480464 | benzoepyrene results in increased methylation of KALRN intron | CTD | PMID:30157460 | beta-naphthoflavone | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of KALRN mRNA | CTD | PMID:18164116 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of KALRN mRNA | CTD | PMID:25181051 | butanal | increases expression | ISO | RGD:1601887 | 6480464 | butyraldehyde results in increased expression of KALRN mRNA | CTD | PMID:26079696 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of KALRN mRNA | CTD | PMID:19167457 | carbon nanotube | affects expression | ISO | RGD:1557535 | 6480464 | Nanotubes, Carbon affects the expression of KALRN mRNA | CTD | PMID:25620056 | carbon nanotube | increases expression | ISO | RGD:1557535 | 6480464 | Nanotubes more ... | CTD | PMID:25554681, PMID:25620056 | chlordecone | increases expression | ISO | RGD:1557535 | 6480464 | Chlordecone results in increased expression of KALRN mRNA | CTD | PMID:29980752 | chromium(6+) | affects expression | ISO | RGD:1557535 | 6480464 | chromium hexavalent ion affects the expression of KALRN mRNA | CTD | PMID:28472532 | cisplatin | multiple interactions | ISO | RGD:1601887 | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of KALRN mRNA | CTD | PMID:27392435 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of KALRN mRNA | CTD | PMID:24386269 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of KALRN mRNA | CTD | PMID:20187946 | copper(II) sulfate | decreases expression | ISO | RGD:1601887 | 6480464 | Copper Sulfate results in decreased expression of KALRN mRNA | CTD | PMID:19549813 | diarsenic trioxide | increases expression | ISO | RGD:1601887 | 6480464 | Arsenic Trioxide results in increased expression of KALRN mRNA | CTD | PMID:20458559, PMID:26705709 | doxorubicin | decreases expression | ISO | RGD:1601887 | 6480464 | Doxorubicin results in decreased expression of KALRN mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of KALRN mRNA | CTD | PMID:29391264 | ethanol | affects splicing | ISO | RGD:1557535 | 6480464 | Ethanol affects the splicing of KALRN mRNA | CTD | PMID:30319688 | ethanol | multiple interactions | ISO | RGD:1557535 | 6480464 | Ethanol affects the expression of and affects the splicing of KALRN mRNA | CTD | PMID:30319688 | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of KALRN mRNA | CTD | PMID:18035473 | folic acid | decreases expression | ISO | RGD:1557535 | 6480464 | Folic Acid results in decreased expression of KALRN mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | RGD:1557535 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KALRN mRNA | CTD | PMID:22206623 | genistein | affects expression | ISO | RGD:1557535 | 6480464 | Genistein affects the expression of KALRN mRNA | CTD | PMID:32186404 | glyphosate | increases methylation | EXP | | 6480464 | glyphosate results in increased methylation of KALRN gene | CTD | PMID:31011160 | graphite | affects expression | EXP | | 6480464 | Graphite affects the expression of KALRN mRNA | CTD | PMID:29933104 | hydrogen peroxide | affects expression | ISO | RGD:1601887 | 6480464 | Hydrogen Peroxide affects the expression of KALRN mRNA | CTD | PMID:20044591 | kainic acid | increases expression | EXP | | 6480464 | Kainic Acid results in increased expression of KALRN mRNA | CTD | PMID:19700661 | lead diacetate | increases expression | ISO | RGD:1557535 | 6480464 | lead acetate results in increased expression of KALRN mRNA | CTD | PMID:20542052 | lead diacetate | decreases expression | ISO | RGD:1557535 | 6480464 | lead acetate results in decreased expression of KALRN mRNA | CTD | PMID:22609695 | leflunomide | increases expression | ISO | RGD:1601887 | 6480464 | leflunomide results in increased expression of KALRN mRNA | CTD | PMID:28988120 | melphalan | decreases expression | ISO | RGD:1601887 | 6480464 | Melphalan results in decreased expression of KALRN mRNA | CTD | PMID:22363485 | methapyrilene | increases methylation | ISO | RGD:1601887 | 6480464 | Methapyrilene results in increased methylation of KALRN intron | CTD | PMID:30157460 | methotrexate | increases expression | ISO | RGD:1601887 | 6480464 | Methotrexate results in increased expression of KALRN mRNA | CTD | PMID:24449571 | mono(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1557535 | 6480464 | mono-2-ethylhexylphthalate results in decreased expression of KALRN mRNA | CTD | PMID:22401849 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of KALRN mRNA, [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KALRN mRNA | CTD | PMID:18164116, PMID:20360939 | nickel atom | decreases expression | ISO | RGD:1601887 | 6480464 | Nickel results in decreased expression of KALRN mRNA | CTD | PMID:25583101 | paracetamol | affects expression | ISO | RGD:1557535 | 6480464 | Acetaminophen affects the expression of KALRN mRNA | CTD | PMID:17562736 | PCB138 | multiple interactions | ISO | RGD:1557535 | 6480464 | [2 more ... | CTD | PMID:25510870 | phenethyl caffeate | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of KALRN mRNA | CTD | PMID:20360939 | phenobarbital | affects expression | ISO | RGD:1557535 | 6480464 | Phenobarbital affects the expression of KALRN mRNA | CTD | PMID:23091169 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of KALRN mRNA | CTD | PMID:19162173 | pirinixic acid | decreases expression | ISO | RGD:1557535 | 6480464 | pirinixic acid results in decreased expression of KALRN mRNA | CTD | PMID:23811191 | sodium arsenite | affects methylation | ISO | RGD:1601887 | 6480464 | sodium arsenite affects the methylation of KALRN gene | CTD | PMID:28589171 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of KALRN mRNA | CTD | PMID:19281266 | sulindac sulfide | decreases expression | ISO | RGD:1601887 | 6480464 | sulindac sulfide results in decreased expression of KALRN mRNA | CTD | PMID:16184548 | tetrachloromethane | affects expression | ISO | RGD:1557535 | 6480464 | Carbon Tetrachloride affects the expression of KALRN mRNA | CTD | PMID:17484886 | titanium dioxide | increases expression | ISO | RGD:1557535 | 6480464 | titanium dioxide results in increased expression of KALRN mRNA | CTD | PMID:23557971 | triadimefon | decreases expression | ISO | RGD:1601887 | 6480464 | triadimefon results in decreased expression of KALRN mRNA | CTD | PMID:26705709 | trichostatin A | increases expression | ISO | RGD:1601887 | 6480464 | trichostatin A results in increased expression of KALRN mRNA | CTD | PMID:24935251 | trichostatin A | decreases expression | ISO | RGD:1601887 | 6480464 | trichostatin A results in decreased expression of KALRN mRNA | CTD | PMID:27188386 | valproic acid | decreases methylation | ISO | RGD:1601887 | 6480464 | Valproic Acid results in decreased methylation of KALRN gene | CTD | PMID:29154799 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of KALRN mRNA | CTD | PMID:29427782 | valproic acid | affects expression | ISO | RGD:1601887 | 6480464 | Valproic Acid affects the expression of KALRN mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | RGD:1601887 | 6480464 | Valproic Acid results in increased expression of KALRN mRNA | CTD | PMID:24935251 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of KALRN mRNA | CTD | PMID:19015723 | vorinostat | decreases expression | ISO | RGD:1601887 | 6480464 | vorinostat results in decreased expression of KALRN mRNA | CTD | PMID:27188386 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| 1. | Alam MR, etal., J Biol Chem 1996 Nov 8;271(45):28636-40. |
| 2. | Alam MR, etal., J Biol Chem 1997 May 9;272(19):12667-75. |
| 3. | Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027. |
| 4. | Colomer V, etal., Hum Mol Genet 1997 Sep;6(9):1519-25. |
| 5. | Hayashi-Takagi A, etal., Nat Neurosci. 2010 Mar;13(3):327-32. Epub 2010 Feb 7. |
| 6. | Johnson RC, etal., J Biol Chem 2000 Jun 23;275(25):19324-33. |
| 7. | Ma XM, etal., J Neurosci 2003 Nov 19;23(33):10593-603. |
| 8. | May V, etal., J Neurosci 2002 Aug 15;22(16):6980-90. |
| 9. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 10. | OMIM Disease Annotation Pipeline |
| 11. | Owczarek S, etal., Neural Plast. 2015;2015:167308. doi: 10.1155/2015/167308. Epub 2015 May 20. |
| 12. | Penzes P, etal., Neuron. 2001 Jan;29(1):229-42. |
| 13. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 14. | RGD automated data pipeline |
| 15. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 16. | RGD automated import pipeline for gene-chemical interactions |
| 17. | Xie Z, etal., Neuron. 2007 Nov 21;56(4):640-56. |
Additional References at PubMed
| PMID:9915831 | PMID:10692441 | PMID:10974569 | PMID:12546821 | PMID:14742910 | PMID:15923627 | PMID:16644733 | PMID:18585704 | PMID:18625710 | PMID:18628310 | PMID:19020030 | PMID:19056867 |
| PMID:19625617 | PMID:19889983 | PMID:20333733 | PMID:21880917 | PMID:22458534 | PMID:22738176 | PMID:23116210 | PMID:23288169 | PMID:23516288 | PMID:23742124 | PMID:23825406 | PMID:25146373 |
| PMID:25378388 | PMID:25865668 | PMID:26921771 | PMID:27989699 | PMID:28418645 | PMID:30053369 | PMID:30565792 | PMID:30875016 | PMID:32203420 |
Genomics
