RGD Reference Report - Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. - Rat Genome Database

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Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines.

Authors: Allen, PB  Ouimet, CC  Greengard, P 
Citation: Allen PB, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9956-61.
RGD ID: 625590
Pubmed: PMID:9275233   (View Abstract at PubMed)
PMCID: PMC23308   (View Article at PubMed Central)

Dendritic spines receive the vast majority of excitatory synaptic contacts in the mammalian brain and are presumed to contain machinery for the integration of various signal transduction pathways. Protein phosphatase 1 (PP1) is greatly enriched in dendritic spines and has been implicated in both the regulation of ionic conductances and long-term synaptic plasticity. The molecular mechanism whereby PP1 is localized to spines is unknown. We have now characterized a novel protein that forms a complex with the catalytic subunit of PP1 and is a potent modulator of PP1 enzymatic activity in vitro. Within the brain this protein displays a remarkably distinct localization to the heads of dendritic spines and has therefore been named spinophilin. Spinophilin has the properties expected of a scaffolding protein localized to the cell membrane and contains a single consensus sequence in PSD95/DLG/zo-1, which implies cross-linking of PP1 to transmembrane protein complexes. We propose that spinophilin represents a novel targeting subunit for PP1, which directs the enzyme to those substrates in the dendritic spine compartment, e.g., neurotransmitter receptors, which mediate the regulation of synaptic function by PP1.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cerebral cortex development  IEP 625590 RGD 

Cellular Component

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Ppp1ca  (protein phosphatase 1 catalytic subunit alpha)
Ppp1cc  (protein phosphatase 1 catalytic subunit gamma)
Ppp1r9b  (protein phosphatase 1, regulatory subunit 9B)

Objects referenced in this article
Gene PPP1R3D protein phosphatase 1 regulatory subunit 3D Homo sapiens
Gene PPP1R9B protein phosphatase 1 regulatory subunit 9B Homo sapiens

Additional Information