Gene: Ppp1ca (protein phosphatase 1 catalytic subunit alpha) Rattus norvegicus | ![]() Analyze |
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![]() Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:732541 | 6480464 | [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of PPP1CA protein | CTD | PMID:18348186 | (S)-colchicine | increases expression | ISO | RGD:11132 | 6480464 | Colchicine results in increased expression of PPP1CA protein | CTD | PMID:16495211 | 1,3-dinitrobenzene | decreases expression | EXP | | 6480464 | 3-dinitrobenzene results in decreased expression of PPP1CA protein | CTD | PMID:24140754 | 14-Deoxy-11,12-didehydroandrographolide | decreases expression | ISO | RGD:732541 | 6480464 | 14-deoxy-11,12-didehydroandrographolide results in decreased expression of PPP1CA mRNA | CTD | PMID:22101062 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:11132 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PPP1CA promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:11132 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PPP1CA mRNA | CTD | PMID:21570461 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:11132 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PPP1CA mRNA | CTD | PMID:20188158 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:732541 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP1CA mRNA | CTD | PMID:28628672 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:732541 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of PPP1CA mRNA | CTD | PMID:12419474 | 5-fluorouracil | affects response to substance | ISO | RGD:732541 | 6480464 | PPP1CA protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | aluminium trichloride | decreases expression | EXP | | 6480464 | aluminum chloride results in decreased expression of PPP1CA protein | CTD | PMID:15113600 | amiloride | decreases phosphorylation | ISO | RGD:732541 | 6480464 | Amiloride results in decreased phosphorylation of PPP1CA protein | CTD | PMID:16059913 | amiloride | multiple interactions | ISO | RGD:732541 | 6480464 | Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of PPP1CA protein] | CTD | PMID:16059913 | aminoglutethimide | decreases expression | ISO | RGD:732541 | 6480464 | Aminoglutethimide results in decreased expression of PPP1CA protein | CTD | PMID:26102013 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PPP1CA mRNA | CTD | PMID:16483693 | arachidonic acid | decreases expression | ISO | RGD:11132 | 6480464 | Arachidonic Acid results in decreased expression of PPP1CA mRNA | CTD | PMID:16623957 | Aroclor 1254 | decreases expression | ISO | RGD:11132 | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PPP1CA mRNA | CTD | PMID:23650126 | arsenous acid | decreases expression | ISO | RGD:732541 | 6480464 | arsenic trioxide results in decreased expression of PPP1CA protein | CTD | PMID:25419056 | benzo[a]pyrene | multiple interactions | ISO | RGD:11132 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to PPP1CA promoter] | CTD | PMID:19654925 | benzo[a]pyrene | decreases expression | ISO | RGD:732541 | 6480464 | Benzo(a)pyrene results in decreased expression of PPP1CA mRNA | CTD | PMID:20106945 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PPP1CA mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PPP1CA gene | CTD | PMID:28505145 | bisphenol F | multiple interactions | ISO | RGD:732541 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP1CA mRNA | CTD | PMID:28628672 | calcium atom | affects expression | EXP | | 6480464 | Calcium affects the expression of PPP1CA mRNA | CTD | PMID:15913539 | calcium(0) | affects expression | EXP | | 6480464 | Calcium affects the expression of PPP1CA mRNA | CTD | PMID:15913539 | carbon nanotube | increases expression | ISO | RGD:732541 | 6480464 | Nanotubes, Carbon results in increased expression of PPP1CA protein | CTD | PMID:23026733 | choline | multiple interactions | ISO | RGD:11132 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1CA gene | CTD | PMID:20938992 | cobalt dichloride | decreases expression | ISO | RGD:732541 | 6480464 | cobaltous chloride results in decreased expression of PPP1CA mRNA | CTD | PMID:19320972 PMID:19376846 | cocaine | decreases expression | ISO | RGD:732541 | 6480464 | Cocaine results in decreased expression of PPP1CA mRNA | CTD | PMID:12629581 | cyhalothrin | increases expression | EXP | | 6480464 | cyhalothrin results in increased expression of PPP1CA protein | CTD | PMID:28495607 | dexamethasone | multiple interactions | ISO | RGD:732541 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP1CA mRNA | CTD | PMID:28628672 | diarsenic trioxide | decreases expression | ISO | RGD:732541 | 6480464 | arsenic trioxide results in decreased expression of PPP1CA protein | CTD | PMID:25419056 | dioxygen | decreases expression | ISO | RGD:11132 | 6480464 | Oxygen deficiency results in decreased expression of PPP1CA protein | CTD | PMID:25937538 | doxorubicin | increases expression | ISO | RGD:11132 | 6480464 | Doxorubicin results in increased expression of PPP1CA protein | CTD | PMID:18948619 | elemental selenium | increases expression | ISO | RGD:732541 | 6480464 | Selenium results in increased expression of PPP1CA mRNA | CTD | PMID:19244175 | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of PPP1CA mRNA | CTD | PMID:18035473 | folic acid | multiple interactions | ISO | RGD:11132 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1CA gene | CTD | PMID:20938992 | hyaluronic acid | multiple interactions | EXP | | 6480464 | [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in increased expression of PPP1CA protein | CTD | PMID:23178681 | hydrogen peroxide | affects expression | ISO | RGD:732541 | 6480464 | Hydrogen Peroxide affects the expression of PPP1CA mRNA | CTD | PMID:21179406 | hydrogen peroxide | multiple interactions | EXP | | 6480464 | [Hyaluronic Acid analog co-treated with Hydrogen Peroxide] results in increased expression of PPP1CA protein | CTD | PMID:23178681 | ibuprofen | multiple interactions | ISO | RGD:732541 | 6480464 | [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of PPP1CA protein | CTD | PMID:18348186 | indometacin | multiple interactions | ISO | RGD:732541 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP1CA mRNA | CTD | PMID:28628672 | L-methionine | multiple interactions | ISO | RGD:11132 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1CA gene | CTD | PMID:20938992 | lead(0) | affects expression | ISO | RGD:732541 | 6480464 | Lead affects the expression of PPP1CA mRNA | CTD | PMID:28903495 | lead(2+) | affects expression | ISO | RGD:732541 | 6480464 | Lead affects the expression of PPP1CA mRNA | CTD | PMID:28903495 | lovastatin | decreases expression | ISO | RGD:11132 | 6480464 | Lovastatin results in decreased expression of PPP1CA mRNA | CTD | PMID:20493250 | okadaic acid | multiple interactions | ISO | RGD:732541 | 6480464 | Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of PPP1CA protein] | CTD | PMID:16059913 | okadaic acid | decreases activity | EXP | | 6480464 | Okadaic Acid results in decreased activity of PPP1CA protein | CTD | PMID:15767308 | paracetamol | affects expression | ISO | RGD:11132 | 6480464 | Acetaminophen affects the expression of PPP1CA mRNA | CTD | PMID:17562736 | paraquat | decreases expression | ISO | RGD:11132 | 6480464 | Paraquat results in decreased expression of PPP1CA mRNA | CTD | PMID:21371552 | perfluorooctane-1-sulfonic acid | decreases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased expression of PPP1CA mRNA | CTD | PMID:20136073 | pyrrolidine dithiocarbamate | decreases expression | ISO | RGD:732541 | 6480464 | pyrrolidine dithiocarbamic acid results in decreased expression of PPP1CA mRNA | CTD | PMID:15477007 | resveratrol | decreases expression | ISO | RGD:11132 | 6480464 | resveratrol results in decreased expression of PPP1CA protein | CTD | PMID:25505154 | rotenone | decreases expression | ISO | RGD:11132 | 6480464 | Rotenone results in decreased expression of PPP1CA mRNA | CTD | PMID:23186747 | S-(1,2-dichlorovinyl)-L-cysteine | increases phosphorylation | ISO | RGD:11132 | 6480464 | S-(1,2-dichlorovinyl)cysteine results in increased phosphorylation of PPP1CA protein | CTD | PMID:16495211 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | RGD:11132 | 6480464 | S-(1,2-dichlorovinyl)cysteine results in decreased expression of PPP1CA protein | CTD | PMID:16495211 | sarin | decreases expression | ISO | RGD:732541 | 6480464 | Sarin results in decreased expression of PPP1CA mRNA | CTD | PMID:19522546 | selenium atom | increases expression | ISO | RGD:732541 | 6480464 | Selenium results in increased expression of PPP1CA mRNA | CTD | PMID:19244175 | sodium arsenite | decreases expression | ISO | RGD:732541 | 6480464 | sodium arsenite results in decreased expression of PPP1CA protein | CTD | PMID:15725613 | sodium azide | decreases expression | EXP | | 6480464 | Sodium Azide results in decreased expression of PPP1CA protein | CTD | PMID:15113600 | sodium dichromate | decreases expression | ISO | RGD:732541 | 6480464 | sodium bichromate results in decreased expression of PPP1CA mRNA | CTD | PMID:12760830 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:732541 | 6480464 | tert-Butylhydroperoxide results in decreased expression of PPP1CA mRNA | CTD | PMID:12419474 | trans-resveratrol | decreases expression | ISO | RGD:11132 | 6480464 | resveratrol results in decreased expression of PPP1CA protein | CTD | PMID:25505154 | valproic acid | increases methylation | ISO | RGD:732541 | 6480464 | Valproic Acid results in increased methylation of PPP1CA gene | CTD | PMID:29154799 | venlafaxine hydrochloride | increases expression | EXP | | 6480464 | Venlafaxine Hydrochloride results in increased expression of PPP1CA mRNA | CTD | PMID:25423262 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PPP1CA mRNA | CTD | PMID:19015723 | vitamin E | increases expression | ISO | RGD:732541 | 6480464 | Vitamin E results in increased expression of PPP1CA mRNA | CTD | PMID:19244175 | warfarin | decreases expression | ISO | RGD:11132 | 6480464 | Warfarin results in decreased expression of PPP1CA mRNA | CTD | PMID:20493250 | |
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1. | Allen PB, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9956-61. |
2. | Carr AN, etal., Mol Cell Biol 2002 Jun;22(12):4124-35. |
3. | Ceulemans H and Bollen M, Physiol Rev. 2004 Jan;84(1):1-39. |
4. | Hardie DG, etal., Trends Biochem Sci. 2011 Sep;36(9):470-7. doi: 10.1016/j.tibs.2011.06.004. Epub 2011 Jul 23. |
5. | Kitamura K, etal., J Biochem (Tokyo) 1991 Feb;109(2):307-10. |
6. | McAvoy T, etal., Biochemistry. 1999 Sep 28;38(39):12943-9. |
7. | MGD data from the GO Consortium |
8. | Monshausen M, etal., J Neurochem. 2002 May;81(3):557-64. |
9. | Moorhead G, etal., FEBS Lett. 1995 Apr 3;362(2):101-5. |
10. | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
11. | Ouimet CC, etal., Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3396-400. |
12. | Patel KG, etal., J Neurosci 2001 Oct 15;21(20):7954-68. |
13. | Pipeline to import KEGG annotations from KEGG into RGD |
14. | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
15. | Pipeline to import SMPDB annotations from SMPDB into RGD |
16. | Rahman A, etal., Neurotoxicology. 2012 Jun;33(3):370-83. doi: 10.1016/j.neuro.2012.02.014. Epub 2012 Mar 1. |
17. | RGD automated data pipeline |
18. | RGD automated import pipeline for gene-chemical interactions |
19. | Sasaki K, etal., Jpn J Cancer Res 1990 Dec;81(12):1272-80. |
20. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
21. | Terry-Lorenzo RT, etal., J Biol Chem 2002 Aug 2;277(31):27716-24. |
22. | Ulke-Lemee A, etal., Biochim Biophys Acta. 2007 Oct;1774(10):1339-50. Epub 2007 Aug 15. |
23. | Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011. |
PubMed | 2174876 7751917 9755872 9882488 11739654 12115603 14580336 14640981 15042703 15303970 15489334 20206270 20458337 20516061 21094159 21471512 21630459 21712997 21930935 22311981 22801782 22871113 23376485 24116158 24270157 25468996 |
Ppp1ca has been annotated in the following RGD Disease Portals. |
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Ppp1ca (Rattus norvegicus - Norway rat) |
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PPP1CA (Homo sapiens - human) |
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Ppp1ca (Mus musculus - house mouse) |
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Ppp1ca (Chinchilla lanigera - long-tailed chinchilla) |
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PPP1CA (Pan paniscus - bonobo/pygmy chimpanzee) |
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PPP1CA (Canis lupus familiaris - dog) |
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Ppp1ca (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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BE099677 |
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Ppp1ca |
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Ppp1ca |
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The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
RefSeq Transcripts | NM_031527 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
GenBank Nucleotide | AABR07006092 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AAHX01009229 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC070517 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473953 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D00859 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
D90163 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ221064 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ224860 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ226749 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ229461 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ231613 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ232496 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ233040 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ234898 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ235125 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M58437 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | NM_031527 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
AGGAGGCTGCAAGAGGGCGGGAGGCAGGAGAGGGCCCGGAGCTGGTGGGCCGGAGCGGCGGCGChide sequence |
Protein RefSeqs | NP_113715 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAA41908 | (Get FASTA) | NCBI Sequence Viewer |
AAH70517 | (Get FASTA) | NCBI Sequence Viewer | |
BAA00732 | (Get FASTA) | NCBI Sequence Viewer | |
BAA14194 | (Get FASTA) | NCBI Sequence Viewer | |
EDM12385 | (Get FASTA) | NCBI Sequence Viewer | |
EDM12386 | (Get FASTA) | NCBI Sequence Viewer | |
P62138 | (Get FASTA) | NCBI Sequence Viewer |
Protein Acc Id: | NP_113715 |
Sequence: |
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDhide sequence |
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Database | Acc Id | Source(s) |
BIND | 130598 | |
130600 | ||
Ensembl Genes | ENSRNOG00000018708 | ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Protein | ENSRNOP00000025282 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOP00000070775 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000025282 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOT00000091680 | UniProtKB/TrEMBL | |
Gene3D-CATH | 3.60.21.10 | UniProtKB/Swiss-Prot |
IMAGE_CLONE | IMAGE:7104674 | IMAGE-MGC_LOAD |
InterPro | M-pesterase | UniProtKB/Swiss-Prot |
Metallo-depent_PP-like | UniProtKB/Swiss-Prot | |
PPP1CA/PPP1CB | UniProtKB/Swiss-Prot | |
Ser/Thr-sp_prot-phosphatase | UniProtKB/Swiss-Prot | |
STPPase_N | UniProtKB/Swiss-Prot | |
KEGG Report | rno:24668 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:91638 | IMAGE-MGC_LOAD |
NCBI Gene | 24668 | ENTREZGENE |
PANTHER | PTHR11668:SF377 | UniProtKB/Swiss-Prot |
Pfam | Metallophos | UniProtKB/Swiss-Prot |
STPPase_N | UniProtKB/Swiss-Prot | |
PhenoGen | Ppp1ca | PhenoGen |
PRINTS | STPHPHTASE | UniProtKB/Swiss-Prot |
PROSITE | SER_THR_PHOSPHATASE | UniProtKB/Swiss-Prot |
SMART | PP2Ac | UniProtKB/Swiss-Prot |
UniGene | Rn.2024 | ENTREZGENE |
UniProt | A0A0G2JYS8_RAT | UniProtKB/TrEMBL |
P62138 | ENTREZGENE, UniProtKB/Swiss-Prot | |
UniProt Secondary | P08129 | UniProtKB/Swiss-Prot |
P20653 | UniProtKB/Swiss-Prot | |
P22802 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-02-17 | Ppp1ca | protein phosphatase 1 catalytic subunit alpha | Ppp1ca | protein phosphatase 1, catalytic subunit, alpha isozyme | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2011-08-02 | Ppp1ca | protein phosphatase 1, catalytic subunit, alpha isozyme | Ppp1ca | protein phosphatase 1, catalytic subunit, alpha isoform | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-06-10 | Ppp1ca | Protein phosphatase type 1 alpha, catalytic subunit | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_expression | expressed in the dendrite spines | 625568 |
gene_expression | mRNA expression is induced in chemically induced hepatocellular carcinoma | 729440 |
gene_physical_interaction | binds the neuronal actin binding proteins neurabin I and neurabin II | 625568 |
gene_process | interacts with neurabins to regulate synaptic activity | 625568 |
More on Ppp1ca | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
RGD Object Information | |
RGD ID: | 3375 |
Created: | 2000-05-25 |
Species: | Rattus norvegicus |
Last Modified: | 2018-04-10 |
Status: | ACTIVE |
© Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.