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Gene: PPP1CA (protein phosphatase 1 catalytic subunit alpha) Pan paniscus

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Symbol:

PPP1CA

Name:

protein phosphatase 1 catalytic subunit alpha

RGD ID:

11933758

Description:

ENCODES a protein that exhibits phosphoprotein phosphatase activity (ortholog); protein phosphatase 1 binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN protein dephosphorylation (ortholog); regulation of glycogen biosynthetic process (ortholog); regulation of glycogen catabolic process (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; Bone morphogenetic proteins signaling pathway; dopamine signaling pathway; ASSOCIATED WITH congestive heart failure (ortholog); dilated cardiomyopathy (ortholog); FOUND IN centriole (ortholog); cytoplasm (ortholog); dendritic spine (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

serine/threonine-protein phosphatase PP1-alpha catalytic subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	68,625,172 - 68,628,881 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	69,667,749 - 69,671,458 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	62,756,659 - 62,760,369 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	66,068,007 - 66,071,579 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	66,068,007 - 66,071,611 (-)	Ensembl			panPan2	panpan1.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congestive heart failure (ISO)

dilated cardiomyopathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branching morphogenesis of an epithelial tube (IEA)

cell division (IEA)

cell-cell adhesion (IEA)

circadian regulation of gene expression (IEA)

double-strand break repair via alternative nonhomologous end joining (IEA)

entrainment of circadian clock by photoperiod (IEA)

glycogen metabolic process (IEA)

lung development (IEA)

negative regulation of transcription elongation by RNA polymerase II (IEA)

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (IEA)

positive regulation of glycogen biosynthetic process (IEA)

positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled (IEA)

positive regulation of transcription elongation by RNA polymerase II (IEA)

protein dephosphorylation (ISO)

protein stabilization (IEA)

regulation of circadian rhythm (IEA)

regulation of glycogen biosynthetic process (ISO)

regulation of glycogen catabolic process (ISO)

response to lead ion (ISO)

RNA polymerase II promoter clearance (IEA)

telomere maintenance (IEA)

telomere maintenance in response to DNA damage (IEA,ISO)

transcription by RNA polymerase II (IEA)

transcription elongation by RNA polymerase II (IEA)

Cellular Component

adherens junction (IEA)

centriole (ISO)

chromosome, telomeric region (IEA)

cytoplasm (IEA,ISO)

cytosol (IEA)

dendritic spine (ISO)

endoplasmic reticulum (ISO)

glutamatergic synapse (ISO)

glycogen granule (ISO)

neuronal cell body (ISO)

nucleolus (IEA)

nucleoplasm (IEA)

nucleus (IEA,ISO)

perikaryon (ISO)

plasma membrane (IEA)

postsynapse (ISO)

presynapse (ISO)

protein phosphatase type 1 complex (IEA,ISO)

PTW/PP1 phosphatase complex (IEA)

sperm end piece (ISO)

sperm midpiece (ISO)

Molecular Function

cadherin binding involved in cell-cell adhesion (IEA)

hydrolase activity (IEA)

iron ion binding (IEA)

metal ion binding (IEA)

phosphatase activity (IEA)

phosphoprotein phosphatase activity (IEA,ISO)

protein binding (ISO)

protein phosphatase 1 binding (ISO)

protein serine/threonine phosphatase activity (IEA)

protein-containing complex binding (ISO)

ribonucleoprotein complex binding (ISO)

RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity (IEA)

transition metal ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adenosine monophosphate-activated protein kinase (AMPK) signaling pathway (ISO)

Bone morphogenetic proteins signaling pathway (ISO)

dopamine signaling pathway (ISO)

follicle-stimulating hormone signaling pathway (ISO)

glycogen biosynthetic pathway (ISO)

glycogen degradation pathway (ISO)

histamine signaling pathway, immunological (ISO)

luteinizing hormone signaling pathway (ISO)

serotonin signaling pathway via receptors engaging G alphas protein family (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

PPP1CA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	68,625,172 - 68,628,881 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	69,667,749 - 69,671,458 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	62,756,659 - 62,760,369 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	66,068,007 - 66,071,579 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	66,068,007 - 66,071,611 (-)	Ensembl			panPan2	panpan1.1

PPP1CA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	67,398,183 - 67,401,858 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	67,398,179 - 67,421,183 (-)	Ensembl			hg38	GRCh38
GRCh37	11	67,165,654 - 67,169,329 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	66,922,228 - 66,925,952 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	66,922,227 - 66,925,952	NCBI
Celera	11	64,498,838 - 64,502,559 (-)	NCBI		Celera
Cytogenetic Map	11	q13.2	NCBI
HuRef	11	63,494,035 - 63,498,137 (-)	NCBI		HuRef
CHM1_1	11	67,048,688 - 67,052,412 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	67,392,298 - 67,395,973 (-)	NCBI		T2T-CHM13v2.0

Ppp1ca
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	4,242,173 - 4,245,418 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	4,242,064 - 4,245,419 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	4,192,174 - 4,195,419 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	4,192,065 - 4,195,420 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	4,192,174 - 4,195,419 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	4,192,174 - 4,195,419 (+)	NCBI		MGSCv36	mm8
Celera	19	4,063,314 - 4,066,560 (+)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	3.89	NCBI

Ppp1ca
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	210,914,576 - 210,918,193 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	210,914,567 - 210,918,193 (+)	Ensembl				GRCr8
mRatBN7.2	1	201,485,117 - 201,488,734 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	201,485,085 - 201,497,327 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	209,837,354 - 209,840,969 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	216,930,585 - 216,934,202 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	209,621,601 - 209,625,218 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	219,439,953 - 219,443,570 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	219,439,953 - 219,443,570 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	226,310,604 - 226,314,221 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	206,774,719 - 206,778,336 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	199,029,483 - 199,033,100 (+)	NCBI		Celera
RGSC_v3.1	1	206,928,171 - 206,931,789 (+)	NCBI
Cytogenetic Map	1	q43	NCBI

Ppp1ca
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	18,076,670 - 18,079,859 (+)	Ensembl
ChiLan1.0	NW_004955422	18,076,670 - 18,079,859 (+)	NCBI	ChiLan1.0	ChiLan1.0

PPP1CA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	50,062,352 - 50,065,166 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	50,062,352 - 50,065,166 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	48,672,765 - 48,675,579 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	50,984,259 - 50,987,073 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	50,984,297 - 50,987,279 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	50,197,606 - 50,200,420 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	49,772,313 - 49,775,127 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	50,566,605 - 50,569,419 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ppp1ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	5,903,630 - 5,906,145 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	2,344,552 - 2,348,494 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	2,345,982 - 2,348,494 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPP1CA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	5,119,939 - 5,123,617 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	5,120,202 - 5,123,168 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	3,838,730 - 3,841,695 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPP1CA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	6,862,536 - 6,866,212 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	6,862,540 - 6,865,855 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	104,147,620 - 104,151,329 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppp1ca
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	19,119,883 - 19,123,934 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624767	19,120,683 - 19,123,935 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ppp1ca
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	3,448,599 - 3,452,068 (-)	NCBI		Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003828806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000026373 ⟹ ENSPPAP00000005925

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	11	66,068,007 - 66,071,611 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000026378 ⟹ ENSPPAP00000005928

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	11	66,068,363 - 66,071,611 (-)	Ensembl

RefSeq Acc Id:

XM_003828806 ⟹ XP_003828854

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	9	68,625,172 - 68,628,881 (-)	NCBI
NHGRI_mPanPan1	11	69,667,749 - 69,671,458 (-)	NCBI
Mhudiblu_PPA_v0	11	62,756,659 - 62,760,369 (-)	NCBI
PanPan1.1	11	66,068,007 - 66,071,579 (-)	NCBI

Sequence:

show sequence

GATCATCGGGCGCCTGCTGGAAGTGCAGGGCTCGCGGCCTGGCAAGAATGTACAGCTGACAGAG
AACGAGATCCGCGGTCTGTGCTTGAAATCCCGGGAGATTTTCCTGAGCCAGCCCATTCTTCTGG
AGCTGGAGGCACCCCTCAAGATCTGCGGTGACATACACGGCCAGTACTACGACCTTCTGCGACT
ATTTGAGTATGGCGGTTTCCCTCCCGAGAGCAACTACCTCTTTCTGGGGGACTATGTGGACAGG
GGCAAGCAGTCCTTGGAGACCATCTGCCTGCTGCTGGCCTATAAGATCAAGTACCCCGAGAACT
TCTTCCTGCTCCGTGGGAACCACGAGTGTGCCAGCATCAACCGCATCTATGGTTTCTACGATGA
GTGCAAGAGACGCTACAACATCAAACTGTGGAAAACCTTCACTGACTGCTTCAACTGCCTGCCC
ATTGCGGCCATAGTGGACGAAAAGATCTTCTGCTGCCACGGAGGCCTGTCCCCGGACCTGCAGT
CTATGGAACAGATTCGGCGGATCATGCGGCCCACAGATGTGCCTGACCAGGGCCTGCTGTGTGA
CCTGCTGTGGTCTGACCCTGACAAGGACGTGCAGGGCTGGGGCGAGAACGACCGTGGCGTCTCT
TTTACCTTTGGAGCCGAGGTGGTGGCCAAGTTCCTCCACAAGCACGACTTGGACCTCATCTGCC
GAGCACACCAGGTGGTAGAAGACGGCTACGAGTTCTTTGCCAAGCGGCAGCTGGTGACACTTTT
CTCAGCTCCCAACTACTGTGGCGAGTTTGACAATGCTGGCGCCATGATGAGCGTGGACGAGACC
CTCATGTGCTCTTTCCAGATCCTCAAGCCCGCCGACAAGAACAAGGGGAAGTACGGGCAGTTCA
GTGGCCTGAACCCTGGGGGCCGACCCATCACCCCACCCCGCAATTCCGCCAAAGCCAAGAAATA
AATAGCCCCCGCACACCACCCTGTGCCCCAGATGATGGGTTGATTGTACAGAAATCGTGCTGCC
ATGCTGGGGGGGGGTTCACCCTGACCCCTCAGGCCCACCTGTCACGGGGAACATGGAGCCTTGG
TGTATTTTTCTTTTCTTTTTTAATGAATCAATAGCAGCGTCCAGTCCCCCAGGGCTGCTTCCTG
CCTGCACCTGTGGTGACTGTGAGCAGGATCCTGGGGCTGAGGCTGCAGCTCAGGGCAACGGCAG
GCCAGGTCGTGGGTCTCCAGCCGTGCTTGGCCTCAGGGCTGGCAGCCGGATCCTGGGGCAACCC
ATCTGGTCTCTTGAATAAAGGTCAAAGCTGGATTCTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003828854	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000005925.1
	ENSPPAP00000005928.1
	ENSPPAP00050053012

RefSeq Acc Id:	XP_003828854 ⟸ XM_003828806
- UniProtKB:	A0A2R8ZMZ1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICR AHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFS GLNPGGRPITPPRNSAKAKK hide sequence

Ensembl Acc Id:

ENSPPAP00000005925 ⟸ ENSPPAT00000026373

Ensembl Acc Id:

ENSPPAP00000005928 ⟸ ENSPPAT00000026378

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000023894	Ensembl, UniProtKB/TrEMBL
	ENSPPAG00050037868	ENTREZGENE
Ensembl Transcript	ENSPPAT00000026373.1	UniProtKB/TrEMBL
	ENSPPAT00000026378.1	UniProtKB/TrEMBL
	ENSPPAT00050080599	ENTREZGENE
Gene3D-CATH	3.60.21.10	UniProtKB/TrEMBL
InterPro	Calcineurin-like_PHP_ApaH	UniProtKB/TrEMBL
	Metallo-depent_PP-like	UniProtKB/TrEMBL
	PP1_catalytic_subunit	UniProtKB/TrEMBL
	Ser/Thr-sp_prot-phosphatase	UniProtKB/TrEMBL
	STPPase_N	UniProtKB/TrEMBL
NCBI Gene	PPP1CA	ENTREZGENE
PANTHER	PTHR11668:SF377	UniProtKB/TrEMBL
	SERINE/THREONINE PROTEIN PHOSPHATASE	UniProtKB/TrEMBL
Pfam	Metallophos	UniProtKB/TrEMBL
	STPPase_N	UniProtKB/TrEMBL
PRINTS	STPHPHTASE	UniProtKB/TrEMBL
PROSITE	SER_THR_PHOSPHATASE	UniProtKB/TrEMBL
SMART	PP2Ac	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56300	UniProtKB/TrEMBL
UniProt	A0A2R8ZLU9_PANPA	UniProtKB/TrEMBL
	A0A2R8ZMZ1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)